缓解肿瘤药物短缺的影响：从2023年卡铂和顺铂短缺中吸取的教训

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer journal Pub Date : 2025-09-01 Epub Date: 2025-09-25 DOI:10.1097/PPO.0000000000000786

Maxwell L Izen, June M McKoy, Linda Martin, Chadi Nabhan, Gretchen LeFever Watson, Joseph Magagnoli, Kenneth R Carson, Kevin Knopf, Edward Smith, Edward Zyszkowski, Mia Lynch, Demir Uslu, Peter Georgantopoulos, David Aboulafia, Charles L Bennett

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引用次数: 0

摘要

目的/背景：癌症药物短缺对癌症患者的治疗产生不利影响，最终影响癌症患者的生活。用于儿童癌症患者的抗癌药物的短缺得到了很好的描述。方法：回顾有关顺铂和卡铂短缺的已发表文献、新闻报道和灰色文献。结果：短缺是多因素的，反映了供应链中断，有限的生产冗余，以及对注射用非专利肿瘤药物的国外来源的依赖。讨论：这篇关于卡铂和顺铂短缺的报告扩展了先前对儿科肿瘤药物短缺的关注。需要改进供应链，并考虑生产在岸。

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Mitigating the Impact of Drug Shortages in Oncology: Lessons Learned From the 2023 Shortages of Carboplatin and Cisplatin.

Purpose/background: Cancer drug shortages adversely affect cancer patient care and ultimately cancer patient lives. Shortages of cancer drugs used for pediatric cancer patients are well described.

Methods: Review of published literature, news reports, and grey literature on cisplatin and carboplatin shortages.

Results: The shortages were multifactorial-reflecting supply chain disruption, limited redundancy in manufacturing, and dependence on out-of-country sources for injectable generic oncology drugs.

Discussion: This report of carboplatin and cisplatin shortages extends concerns noted earlier with pediatric oncology drug shortages. Improvements in supply chain and consideration of on-shoring manufacturing is needed.

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来源期刊

Cancer journal 医学-肿瘤学

CiteScore

3.90

自引率

0.00%

发文量

102

审稿时长

7.5 months

期刊介绍： The Cancer Journal: The Journal of Principles & Practice of Oncology provides an integrated view of modern oncology across all disciplines. The Journal publishes original research and reviews, and keeps readers current on content published in the book Cancer: Principles & Practice of Oncology.