成人低级别胶质瘤分子标志物研究进展及展望

IF 2.6 4区医学 Q3 ONCOLOGY

Cancer journal Pub Date : 2025-01-01 DOI:10.1097/PPO.0000000000000758

Jessica L Fleming, Arnab Chakravarti

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引用次数: 0

摘要

摘要：鉴于最近更新的2021年世界卫生组织分类以及随机III期临床试验的长期结果，低级别胶质瘤患者的临床管理模式发生了重大转变。因此，我们现在能够更好地诊断并为患者分配最合适的治疗方案。本文综述了成人低级别胶质瘤最可靠的分子生物标志物，并讨论了该患者群体目前面临的挑战，未来相关生物学研究结合技术进步可以帮助克服这些挑战。

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Recent Advancements and Future Perspectives on Molecular Biomarkers in Adult Lower-Grade Gliomas.

Abstract: There has been a significant paradigm shift in the clinical management of lower-grade glioma patients given the recent updates to the 2021 World Health Organization classification along with long-term results from randomized phase III clinical trials. As a result, we are now better able to diagnose and assign patients to the most appropriate treatment course. This review provides a comprehensive summary of the most robust and reliable molecular biomarkers for adult lower-grade gliomas and discusses current challenges facing this patient population that future correlative biology studies combined with advancements in technologies could help overcome.

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来源期刊

Cancer journal 医学-肿瘤学

CiteScore

3.90

自引率

0.00%

发文量

102

审稿时长

7.5 months

期刊介绍： The Cancer Journal: The Journal of Principles & Practice of Oncology provides an integrated view of modern oncology across all disciplines. The Journal publishes original research and reviews, and keeps readers current on content published in the book Cancer: Principles & Practice of Oncology.