Caspian Journal of Internal Medicine最新文献_第9页

Mediatory role of the serum mineral level and discharge disability of stroke survivors. 血清矿物质水平与中风幸存者出院后残疾的中介作用。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.14

Soraya Khafri, Alijan Ahmadi Ahangar, Payam Saadat, Shayan Alijanpour, Mansor Babaei, Mohammadali Bayani, Alireza Firouzjahi, Farshad Fadaee Jouybari, Sepideh Hosseini Shirvani, Zahra Frajzadeh, Nafisseh Ezamie

{"title":"Mediatory role of the serum mineral level and discharge disability of stroke survivors.","authors":"Soraya Khafri, Alijan Ahmadi Ahangar, Payam Saadat, Shayan Alijanpour, Mansor Babaei, Mohammadali Bayani, Alireza Firouzjahi, Farshad Fadaee Jouybari, Sepideh Hosseini Shirvani, Zahra Frajzadeh, Nafisseh Ezamie","doi":"10.22088/cjim.15.1.14","DOIUrl":"10.22088/cjim.15.1.14","url":null,"abstract":"Background: Possible association between minerals contributing and mortality related to stroke were seen, but prospective data on the relation of vitamin D, magnesium and calcium serum levels with stroke were inconsistent. Consideration about the potential health effects of minerals and nutrients, the current study was conducted.Methods: This analytical cross-sectional study was conducted on 216 stroke survivors who were referred to the Ayatollah Rouhani Hospital of Babol, Iran. Demographic characteristics, clinical variables, and serum mineral levels were completed in the checklist. Admit score and discharge scale of these patients were determined according to the National Institute of Health Stroke Scale. A path model was constructed to explore the interrelationship between variables and to verify the relationship between variables and disability discharges.Results: Of 216 stroke patients, 185 (85.6%) cases were ischemic. The discharge status of 29 (12.9%) cases were severe or expired. The patients with moderate and severe admit scores, hemorrhagic stroke type, diabetes mellitus, hypertension and live in the village significantly had a poor discharge disability scale (all of p<0.05). Of all direct paths, Mg (β=-2.85), and among indirect paths, calcium(β=-3.59) had the highest effect on the discharge scale. Only mg had affected the discharge scale through direct and indirect (β=-2.45) paths and had the greatest reverse effect on the discharge scale (β=-5.30; totally).Conclusion: Hypomagnesemia and hypocalcemia play a mediatory role in poor outcomes. Especially, hypomagnesemia was the direct parameter for poor outcomes. The independent role of each mineral in this issue is difficult to define and suggested for future study.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 1","pages":"124-131"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of relationship between memory and temperament in 18-28 years old students. 评估 18-28 岁学生记忆力与气质之间的关系。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.334

Reihaneh Moeini, Maliheh Mohammadi Sagh, Mahbobeh Faramarzi, Payam Saadat, Morteza Mojahedi, Narjes Gorji, Alijan Ahmadi Ahangar

{"title":"Evaluation of relationship between memory and temperament in 18-28 years old students.","authors":"Reihaneh Moeini, Maliheh Mohammadi Sagh, Mahbobeh Faramarzi, Payam Saadat, Morteza Mojahedi, Narjes Gorji, Alijan Ahmadi Ahangar","doi":"10.22088/cjim.15.2.334","DOIUrl":"10.22088/cjim.15.2.334","url":null,"abstract":"Background: Mizaj (Temperament) is a concept to express individual differences in Persian medicine and according to this theory, there is a relationship between Mizaj type and the abilities of different body organs. This cross-sectional study aimed to investigate the relationship between the type of Mizaj and the memory score (Quotient).Methods: The target population was the 18 to 38 years old students of Babol University of Medical Sciences. Mojahedi's Mizaj questionnaire (MMQ) was used for determining the whole Mizaj. The physical Persian version of Wechsler Memory Scale III (WMS III) was used to assess memory score. The collected data were analyzed by SPSS Version 22 and the chi square (x2) and t-test were run and p- value 0.05 was considered as significant difference.Results: Forty-two of participants were females and 18 were males. The average age of them was 23.6 (21-27). The average of Memory Quotient (MQ) was 122.1 ± 5.7. The average of MQ in warm Mizaj was 125.46 ± 1.2 and in cold Mizaj was 118.79 ± 6.5. The difference between two groups is statistically significant (p< 0.001). The average of MQ in dry Mizaj was 124.16 ± 2.67 and in wet Mizaj was 118.40 ± 7.64. The difference between two groups is statistically significant (P= 0.005).Conclusion: The results showed there are significant relationship between memory score and warm/cold Mizaj and dry /wet Mizaj. It means students with warm or dry Mizaj had better memory score than students with cold or wet Mizaj. This relation was also detected between subtypes of memory and Mizaj expect between working memory and dry/wet Mizaj. These results are in accordance with theories in PM which indicate people with warm Mizaj and dry Mizaj have better memory and people with cold Mizaj and wet Mizaj have weaker memory and are more at risk of memory dysfunction.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 2","pages":"334-339"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional study on non-infectious dysfunction of hemodialysis cuffed catheter. 关于血液透析袖带导管非感染性功能障碍的横断面研究。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.439

Pouya Tayebi, Kosar Hasanzadeh, Masoumeh Asgharpour, Ali Bijani, Naghmeh Ziaie

{"title":"A cross-sectional study on non-infectious dysfunction of hemodialysis cuffed catheter.","authors":"Pouya Tayebi, Kosar Hasanzadeh, Masoumeh Asgharpour, Ali Bijani, Naghmeh Ziaie","doi":"10.22088/cjim.15.3.439","DOIUrl":"10.22088/cjim.15.3.439","url":null,"abstract":"Background: Dialysis cuffed catheter dysfunction results in inadequate dialysis, increased sepsis risk, and a shortened catheter life. It may be possible to prolong catheter function by identifying the causes of cuffed catheter dysfunction.Methods: This study was a cross-sectional descriptive study conducted in 2021-2022 on hemodialysis patients with jugular cuff catheters. The catheterizations were performed using the Seldinger technique and were confirmed by fluoroscopy. A 12-month follow-up was conducted with respect to the performance of the cuffed catheter.Results: A total of 123 patients underwent hemodialysis over 2 years via a cuffed catheter. Catheters were most commonly inserted into the right internal jugular vein, with lengths of 19 cm (tip to cuff). The rate of dysfunction of cuffed catheters was 27.6%. Catheter-related thrombosis was the most common cause in 10 cases (29.4%), followed by catheter tip fibrin sheath in 8 cases (23.5%) and catheter tip malposition in 8 cases (23.5%). Furthermore, 18 patients (52.94%) of cuffed catheter dysfunction occurred within 3 months of catheter placement, based on our study. The dysfunction of cuffed catheters on the left side 23 (67.64%) is more prevalent than the right side 11 (32.35%) (P=0.043); the malposition of catheter tips is more prevalent on the left side (P=0.023).Conclusion: Most commonly, cuffed catheter dysfunction is caused by thrombosis, fibrin sheath formation, and catheter tip malposition. Cuffed catheter failure can be reduced by carefully monitoring the catheter's path and tip position, searching for fibrin sheaths when investigating cuffed catheter failure, and preventing thrombotic events.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 3","pages":"439-443"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic variants of ABCB1 and CES1 genes on dabigatran metabolism in the Kazakh population. 哈萨克斯坦人群中 ABCB1 和 CES1 基因变异对达比加群代谢的影响。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.499

Ayan Abdrakhmanov, Elena Zholdybayeva, Aizhana Shaimerdinova, Gulmira Kulmambetova, Svetlana Abildinova, Rustam Albayev, Gulnara Tuyakova, Elena Rib, Zhanasyl Suleimen, Zhanar Abdrakhmanova, Makhabbat Bekbossynova

{"title":"Genetic variants of ABCB1 and CES1 genes on dabigatran metabolism in the Kazakh population.","authors":"Ayan Abdrakhmanov, Elena Zholdybayeva, Aizhana Shaimerdinova, Gulmira Kulmambetova, Svetlana Abildinova, Rustam Albayev, Gulnara Tuyakova, Elena Rib, Zhanasyl Suleimen, Zhanar Abdrakhmanova, Makhabbat Bekbossynova","doi":"10.22088/cjim.15.3.499","DOIUrl":"10.22088/cjim.15.3.499","url":null,"abstract":"Background: Allelic variants of genes encoding enzymes of the esterase system (CES1) and P-glycoprotein (ABCB1) can change the metabolism and pharmacokinetics of dabigatran. Therefore, they act as determining factors in the development of side effects, especially bleeding. We analyzed the genotype-phenotype relationship of ABCB1 (rs1045642, rs4148738, rs2032582, and rs1128503) and CES1 (rs8192935, rs71647871, and rs2244613) polymorphisms in patients with atrial fibrillation who had been treated with dabigatran.Methods: A total of 150 patients were recruited for this study. TaqMan technology was used for SNP genotyping.Results: Patients with the rs2244613 GG genotype had a lower concentration (55.27 ± 34.22 ng/ml) compared to those with the TT genotype (63.33 ± 52.25 ng/ml) (additive model, P = 0.000). Individuals with the rs8192935 AA genotype had a lower concentration (52.72 ± 30.45 ng/ml) compared to those with the GG genotype (79.78 ± 57 ng/ml) (additive model, P = 0.001). The APTT values among the different genotypes of the ABCB1 SNPs, rs4148738 and rs1045642, were significantly different (P = 0.035 and P = 0.024, respectively).Conclusion: Our research demonstrates that the CES1 polymorphisms, rs8192935 and rs2244613, are associated with the pharmacodynamics and pharmacokinetics of dabigatran in the Kazakh subpopulation.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 3","pages":"499-508"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Biomarkers for the diagnosis of diabetic nephropathy. 诊断糖尿病肾病的新型生物标记物。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.382

Marcio Concepción, Juan Quiroz, Jacsel Suarez, José Paz, Pela Roseboom, Sofia Ildefonso, Denis Cribilleros, Francisca Zavaleta, Julia Coronado, Luis Concepción

{"title":"Novel Biomarkers for the diagnosis of diabetic nephropathy.","authors":"Marcio Concepción, Juan Quiroz, Jacsel Suarez, José Paz, Pela Roseboom, Sofia Ildefonso, Denis Cribilleros, Francisca Zavaleta, Julia Coronado, Luis Concepción","doi":"10.22088/cjim.15.3.382","DOIUrl":"10.22088/cjim.15.3.382","url":null,"abstract":"Diabetes mellitus and its complications are a known public health problem nowadays. Diabetic nephropathy is one of the main complications and the result of multiple mechanisms, including: activation of the renin-angiotensin-aldosterone system, formation of advanced glycation end products and chronic inflammation that led to glomerular and tubulo-interstitial damage producing mesangial expansion and glomerulosclerosis, which finally results in chronic kidney disease. Early detection of diabetic nephropathy is essential for adequate intervention to stop, or at least slow down its progression. Multiple markers have been described, not only the classic ones such as serum creatinine, urea, and albuminuria, but at this point also novel biomarkers such as neutrophil gelatinase-associated lipocalin, tumor necrosis factor 1 receptor and monocyte chemoattractant protein-1, among others. The aim of this article was to provide an update review of the role of biomarkers in the diagnosis of diabetic nephropathy.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 3","pages":"382-391"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among the fulminant hepatitis A virus infection patients. 暴发性甲型肝炎病毒感染患者中葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症的患病率。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.451

Fardad Ejtehadi, Maryam Sadat Serpoosh, Iraj Shahramian, Ladan Aminlari, Ramin Niknam, Gholam Reza Sivandzadeh, Masoud Tahani, Amin Javadifar, Fateme Sharafi, Maryam Moini

{"title":"Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among the fulminant hepatitis A virus infection patients.","authors":"Fardad Ejtehadi, Maryam Sadat Serpoosh, Iraj Shahramian, Ladan Aminlari, Ramin Niknam, Gholam Reza Sivandzadeh, Masoud Tahani, Amin Javadifar, Fateme Sharafi, Maryam Moini","doi":"10.22088/cjim.15.3.451","DOIUrl":"10.22088/cjim.15.3.451","url":null,"abstract":"Background: Hepatitis A is a widespread viral infection with significant public health implications. Assessing glucose 6-phosphate dehydrogenase (G6PD) deficiency in hepatitis A patients is essential for various reasons, including prognosis, disease severity evaluation, encephalopathy risk identification, tailored management, and advancing scientific understanding. This study aimed to investigate the prevalence and clinical implications of G6PD impairment in individuals with fulminant hepatitis A.Methods: A cross-sectional descriptive analysis was conducted, involving hospitalized patients with fulminant hepatitis A. Demographic data, prevalence rates, and clinical findings were recorded in a database. The diagnosis of hepatitis A infection was confirmed using an anti-HAV IgM antibody test, and G6PD enzyme activity was measured with a fluorescent spot assay.Results: Out of 81 patients with hepatitis A, 57 (70.4%) were males, and 24 (29.5%) were females, with an average age of 24.6 years. Dark yellow urine and anorexia were the most common clinical symptoms. Notably, 30 (37%) patients lacked G6PD. The group with G6PD deficiency showed significantly higher rates of encephalopathy and mortality (P<0.01), along with elevated bilirubin (P=0.00), abnormal coagulation parameters, and low hemoglobin levels (P=0.00).Conclusion: In light of these findings, the present study proposes the implementation of routine G6PD level assessments and the evaluation of other relevant markers in regions where hepatitis A is endemic. Furthermore, the study underscores the need for vigilant monitoring of hemolysis and encephalopathy in affected patients to optimize clinical management and reduce morbidity and mortality associated with this condition.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 3","pages":"451-458"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using bone mineral apparent density for BMD adjustment in chronic diseases: Thalassemia an example. 使用骨矿物质表观密度调整慢性疾病的骨矿物质表观密度：以地中海贫血症为例

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.494

Mohammad-Reza Mohajeri-Tehrani, Hadis Gerami, Sara Shirazi, Mobina Ostadi, Bagher Larijani, Zohreh Hamidi

{"title":"Using bone mineral apparent density for BMD adjustment in chronic diseases: Thalassemia an example.","authors":"Mohammad-Reza Mohajeri-Tehrani, Hadis Gerami, Sara Shirazi, Mobina Ostadi, Bagher Larijani, Zohreh Hamidi","doi":"10.22088/cjim.15.3.494","DOIUrl":"10.22088/cjim.15.3.494","url":null,"abstract":"Background: Low BMD is a common problem in major thalassaemia patient, but the use of DXA in chronic disease children with smaller bones, has some problems. Utilizing bone mineral apparent density (BMAD) helps in preventing this obstacle. Testing the usefulness of this method in resolving the effects of bone size on BMD by comparing the BMD and BMAD of our thalassemics with results of our healthy ones, is our goal.Methods: Sample size was 110 cases with mean age of 9.6 ± 4.3 y/o and contained 73 males. Gauge of BMDs done by dual x-ray absorptiometry. Then BMAD was calculated. We did comparison of BMDs and BMADs results of thalassemic children with results of healthy Iranian pediatrics.Results: Mean of femoral BMD and BMAD, spinal BMD and BMAD was 0.579±0.134 g/cm2, 0.162±0.096 g/cm3, 0.563±0.118 g/cm2 and 0.107±0.015, respectively. When results of 9-18 patients compared with BMDs and BMADs of normal children, BMD of femur and BMD and BMAD of spine of patients found significantly lower (P-values, 0.003, <0.001, <0.001, respectively). BMAD of femur of patients was not significantly different from normals.Conclusion: When bone mineral density of femur modifies by bone mineral apparent density formula, the remarkable difference between BMD of patients and normals; vanishes. Utilizing bone mineral apparent density helps in interpretation of femoral dual X-ray absorptiometry at least in thalassemic patients. As the results of vertebrae, after modification by calculating BMAD, remains significantly different, we cannot bring forward BMAD for mentioned aim in the spine of thalassemics.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 3","pages":"494-498"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Educating correct ECG interpretation is a way to promote the satisfaction and competency the diagnostic service providers. 教育正确的心电图解读是提高诊断服务提供者满意度和能力的一种方式。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.16

Mehrdad Saravi, Amirmohammad Rezaei Majd, Mohammad Ali Qassemi Darzi, Yasaman Habibzadeh, Zeinab Hoseini Motlagh, Maryam Ghaemi-Amiri

{"title":"Educating correct ECG interpretation is a way to promote the satisfaction and competency the diagnostic service providers.","authors":"Mehrdad Saravi, Amirmohammad Rezaei Majd, Mohammad Ali Qassemi Darzi, Yasaman Habibzadeh, Zeinab Hoseini Motlagh, Maryam Ghaemi-Amiri","doi":"10.22088/cjim.15.1.16","DOIUrl":"10.22088/cjim.15.1.16","url":null,"abstract":"Background: Given electrocardiogram (ECG) interpretation as one of the diagnostical challenges for medical students and health professionals, this research was carried out to present an experience of web-based teaching method and novel approaches used for training of ECG interpretation.Methods: This online program was conducted in three days. The main content of the class was taught during one hour, and after that, the teacher spent enough time for responding the asked questions. The components of a normal ECG and different changes that can occur in these waves were taught through clinical case-based scenarios using the web platform and Adobe Connect software. The participants' satisfaction was assessed with a 12-item questionnaire, and the short-term retention of ECG interpretation skill was examined by comparing the posttest scores with pretest.Results: A total of 224 individuals completed the course. Total satisfaction score was 53.05±6.98 (out of the maximum score of 60). Based on the results of the paired t test, the interpretation skill scores of the participants increased significantly from 2.5 ± 1.57 to 6.96 ± 1.89. (p<0.001, CI = -4.8 to- 4.11).Conclusion: This web-based nationwide training program provided a supplementary resource for ECG learning among medical students and health-care providers.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 1","pages":"141-146"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factor V Leiden, MTHFR, and FXIIIVal34Leu gene polymorphisms and their association with clinical features and risk of diabetic retinopathy in patients with type 2 diabetes. 因子 V Leiden、MTHFR 和 FXIIIVal34Leu 基因多态性及其与 2 型糖尿病患者临床特征和糖尿病视网膜病变风险的关系。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.11

Atefeh Rahimi, Nastaran Moridi, Amin Golestani, Gholamreza Anani-Sarab, Fatemeh Salmani, Gholamhossein Yaqubi, Behzad Mesbahzadeh, Mohammad Ali Jalalifar, Mohammad Malekaneh, Seyed Mehdi Sajjadi

{"title":"Factor V Leiden, MTHFR, and FXIIIVal34Leu gene polymorphisms and their association with clinical features and risk of diabetic retinopathy in patients with type 2 diabetes.","authors":"Atefeh Rahimi, Nastaran Moridi, Amin Golestani, Gholamreza Anani-Sarab, Fatemeh Salmani, Gholamhossein Yaqubi, Behzad Mesbahzadeh, Mohammad Ali Jalalifar, Mohammad Malekaneh, Seyed Mehdi Sajjadi","doi":"10.22088/cjim.15.1.11","DOIUrl":"10.22088/cjim.15.1.11","url":null,"abstract":"Background: Diabetic retinopathy (DR) is expanding to epidemic levels globally due to the progressing prevalence of diabetes mellitus (DM). In this study, the association between factor V Leiden (FVL), MTHFRC677T, and FXIIIVal34Leu polymorphisms and diabetic retinopathy was investigated in Eastern Iran.Methods: This case-control study enlisted the participation of 300 people (diabetic patients=100, diabetic retinopathy patients=100, healthy controls=100), and polymorphisms were examined by Tetra primer ARMS-PCR.Results: The frequency of FVL (p=0.294) and FXIIIVal34Leu (P=0.349) polymorphism showed no significant results between the genotype frequency in the mentioned groups. In contrast, MTHFRC677T SNP was significantly different in diabetic patients and controls (P=0.008). The MTHFRC677T polymorphism was found to be connected with increased systolic blood pressure in patients who had the TT genotype (130.96±11.92mm/Hg; P=0.011).Conclusion: Our study recommended that the MTHFRC677T polymorphism may offer to DR development. Studies with larger sample sizes and a wider spectrum of populations are authorized to verify this finding.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 1","pages":"101-108"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A policy brief on improving the lifestyle of women with polycystic ovary syndrome. 关于改善多囊卵巢综合征妇女生活方式的政策简介。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.21

Mouloud Agajani Delavar, Sedighe Esmaeilzadeh, Zynab Farhadi, Parvaneh Mirabi

引用次数: 0