Caspian Journal of Internal Medicine最新文献_第8页

Intracranial inflammatory pseudotumour related to IgG4: A very rare case. 与 IgG4 有关的颅内炎性假瘤：一个非常罕见的病例。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.354

Ghassen Gader, Meissa Hamza, Ftima Jaziri, Ines Chelly, Ihsèn Zammel, Mouna Rkhami, Mohamed Badri

{"title":"Intracranial inflammatory pseudotumour related to IgG4: A very rare case.","authors":"Ghassen Gader, Meissa Hamza, Ftima Jaziri, Ines Chelly, Ihsèn Zammel, Mouna Rkhami, Mohamed Badri","doi":"10.22088/cjim.15.2.354","DOIUrl":"10.22088/cjim.15.2.354","url":null,"abstract":"Background: Intracranial inflammatory pseudotumours (IPT) are rare entities that frequently lead to misdiagnosis with malignant lesions. The identification of these lesions is difficult, but important to avoid inadvertent iatrogenicity and to adjust therapeutic protocols.Case presentation: We report the case of a 30-year-old man who presented a single tonic-clonic seizure. Brain imaging showed a right frontal lesion with intra and extra axial components. Facing the radiologic presentation, a brain tumor was suspected, thus the patient underwent surgery. Pathological exam concluded to a plasma cell granuloma. A whole-body CT-scan showed only a thoracic aortitis. Complete blood work studies came back negative. The patient was also tested for an array of antibodies among which antinuclear antibodies were positive (blood level superior to 1/100). CSF evaluation revealed clear fluid with normal glucose concentration, normal protein levels and lymphocytic pleocytosis. Finally, IgG-4 plasma levels were elevated which led to the diagnosis of an IgG4-RD. The patient was put under prednisolone with a favorable outcome.Conclusion: IPT have several etiologies, among which IgG4 related disease may be one of the less known as only 2 cases have previously been reported. Herein, we report a new case of a young man who presented for seizures related to an intracranial lesion of an IgG4 related disease. The challenge is to suspect such conditions to avoid unnecessary surgeries.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel therapeutic strategy for obesity through the gut microbiota-brain axis: A review article. 通过肠道微生物群-大脑轴治疗肥胖症的新策略：综述文章。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.215

Romina Kardan, Jaber Hemmati, Mohsen Nazari, Amjad Ahmadi, Babak Asghari, Mehdi Azizi, Mansoor Khaledi, Mohammad Reza Arabestani

引用次数: 0

Prevalence and risk factors of gastroesophageal reflux disease symptoms in Mazandaran, North of Iran: A Tabari cohort study. 伊朗北部马赞达兰地区胃食管反流病症状的患病率和风险因素：塔巴里队列研究

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.280

Iradj Maleki, Samaneh Borhani, Mahmood Moosazadeh, Reza Alizadeh-Navaei

{"title":"Prevalence and risk factors of gastroesophageal reflux disease symptoms in Mazandaran, North of Iran: A Tabari cohort study.","authors":"Iradj Maleki, Samaneh Borhani, Mahmood Moosazadeh, Reza Alizadeh-Navaei","doi":"10.22088/cjim.15.2.280","DOIUrl":"10.22088/cjim.15.2.280","url":null,"abstract":"Background: Gastro-esophageal reflux disease (GERD) is a very common complaint. It is a major health concern and there is paucity of information about the epidemiology of the disease and its risk factors in Iran, especially Mazandaran province (North of Iran). This study aimed at investigating the prevalence of regurgitation and the factors associated with this condition in Tabari cohort study.Methods: This was a cross-sectional study that analyzed data from Tabari cohort study. Information including the presence and frequency of heartburn and regurgitation, demographic characteristics, socioeconomic status, occupational history, history of chronic illnesses, history of alcohol and cigarette consumption were recorded.Results: The prevalence of GERD symptoms were 27.6% (20.4% in men, and 32.4% in women, p=0.0001). The frequency of typical symptoms was significantly higher in women than that in men. The risk of developing GERD symptoms were 1.7 times higher in women (p=0.0001). The highest prevalence of GERD symptoms was found in urban areas (41.8%, p=0.0001), in people with low educational levels (48%, p=0.0001), and in participants with history of depression symptoms (36.2%, p=0.0001). The prevalence of GERD symptoms was significantly high in individuals with higher BMI (29.5%, p=0.006), greater waist to hip ratio (29.1%, p=0.0001, p=0.0001), and high waist circumference (31.7%, p=0.0001).Conclusion: This study showed gender, region of residence, educational level, and depression symptoms as the main risk factors for developing GERD symptoms.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid diseases in children and adults with celiac disease: A cross-sectional study. 患有乳糜泻的儿童和成人的甲状腺疾病：一项横断面研究

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.307

Ramin Niknam, Heydar Baseri, Laleh Mahmoudi, Mohammad Reza Fattahi, Ebrahim Fallahzadeh Abarghooei, Ali Zamani

{"title":"Thyroid diseases in children and adults with celiac disease: A cross-sectional study.","authors":"Ramin Niknam, Heydar Baseri, Laleh Mahmoudi, Mohammad Reza Fattahi, Ebrahim Fallahzadeh Abarghooei, Ali Zamani","doi":"10.22088/cjim.15.2.307","DOIUrl":"10.22088/cjim.15.2.307","url":null,"abstract":"Background: There are few reports evaluating different factors, including the severity of duodenal histopathological findings and serological levels of celiac disease (CD), in increasing the probability of thyroid diseases (TD) in adults and children with CD, so, we designed this research.Methods: CD was defined as Marsh type 2 or higher in duodenal histopathology and serological levels of anti-transglutaminase antibodies (anti-tTG) equal to or greater than 18 IU/ml. To assess the likelihood of TD in CD patients, logistic regression analysis was employed.Results: 538 patients were included in this study. Of these, 354 (65.8%) were females and 184 (34.2%) were males. 370 (68.8%) patients were children. Overall, 57 (10.6%) patients had TD, of which 49 (9.1%) had hypothyroidism and 8 (1.5%) had hyperthyroidism. Adults had a significantly higher probability of developing TD than children (OR 1.9; 95% CI 1.1-3.4; P = 0.03). The odds of developing TD were also significantly higher in patients with family marriage in parents (OR 2.3; 95% CI 1.1-4.7; P = 0.03). Other variables such as gastrointestinal symptoms, anti-tTG levels, and severity of Marsh classification did not exhibit a substantial rise in the likelihood of TD development.Conclusion: The study findings indicated that the likelihood of developing TD in CD patients can be linked to advancing age and having family marriage in parents, while there was no significant association observed with anti-tTG levels, severity of histological damage, and gastrointestinal symptoms.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normal reference values for Tc-99m pertechnetate thyroid uptake in northern Iranian population: A single-center experience. 伊朗北部人群甲状腺摄取 Tc-99m 过硫酸盐的正常参考值：单中心经验。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.459

Amir Gholami, Nima Armaghan, Hoda Shirafkan, Mehrangiz Amiri, Seyyed Hossein Mousavie Anijdan

{"title":"Normal reference values for Tc-99m pertechnetate thyroid uptake in northern Iranian population: A single-center experience.","authors":"Amir Gholami, Nima Armaghan, Hoda Shirafkan, Mehrangiz Amiri, Seyyed Hossein Mousavie Anijdan","doi":"10.22088/cjim.15.3.459","DOIUrl":"10.22088/cjim.15.3.459","url":null,"abstract":"Background: The normal reference values for the thyroid uptake of radioactive iodine and Tc-99m pertechnetate in euthyroid patients vary by geographical location as well as the amount of iodine intake in the diet. The present study examines the normal reference values for thyroid uptake of Tc-99m pertechnetate in the North of Iran.Methods: The participants of this study were 64 patients (all over 20 years of age) who had referred to the Nuclear Medicine Center of the Shahid Beheshti Hospital for thyroid scan over the period between March 2018 and May 2020. It is worth mentioning that relying on laboratory test results, only patients with normal thyroid function were included in this cross-sectional study.Results: The median, the 5th and 95th percentiles and thyroid uptake range of 99mTc-pertechnetate in euthyroid patients were 0.9, 0.6 to 1.8% and 0.54 - 1.80%, respectively.Conclusion: The percentage of uptake in the thyroid gland in each geographical area varies based on race and diet content, so it is necessary to determine the percentage of uptake in each specific region and even check it periodically.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum vitamin D and PSA in elderly men in Amirkola. 阿米尔科拉老年男性的血清维生素 D 和 PSA。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.535

Parvin Sajadi Kaboudi, Maryam Halakoo, Khadijeh Ezoji, Hamid Shafee, Seyed Reza Hosseini, Ali Bijani

{"title":"Serum vitamin D and PSA in elderly men in Amirkola.","authors":"Parvin Sajadi Kaboudi, Maryam Halakoo, Khadijeh Ezoji, Hamid Shafee, Seyed Reza Hosseini, Ali Bijani","doi":"10.22088/cjim.15.3.535","DOIUrl":"10.22088/cjim.15.3.535","url":null,"abstract":"Background: Vitamin D is a modifiable risk factor in cancer and prostate diseases. In this study, we investigate the relationship between vitamin D and serum PSA in elderly men of Amirkola City.Methods: The current cross-sectional descriptive study was conducted on elderly men participating in the cohort study in Amirkola. Demographic information including age, sex, marital status and occupation were recorded and blood samples (5 cc of blood) were taken to measure PSA and vitamin D. A p -value less than 0.05 is statistically significant.Results: After applying the inclusion and exclusion criteria, 837 elderly men with mean age of 69.99 ± 7.72 years were included in the study. In terms of marital status, 779 (93.1%) were married and 59 (6.9%) were single. In the study of employment status, 476 (56.9%) self-employed, 331 (439.5%) retired, 8 (1.0 %) housewives, 14 (1.7%) unemployed and 8 (1.0 %) They were in an unknown situation. The mean level of vitamin D was 31.94 ± 28.57 ng / mL and the mean level of PSA was 1.94 ± 3.28 ng / dL. No significant relationship was found between vitamin D level and serum PSA in Pearson Correlation test (P = 0.16). Among the other variables studied, only age was related to PSA levels and PSA level increased with age (P = 0.001).Conclusion: No significant relationship was found between PSA serum level and vitamin D level, but the existence of vitamin D deficiency in most of the elderly studied needs attention.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of body mass index (BMI) and determination of optimum cut-off point in the diagnosis of endometrial hyperplasia in pre-menopausal women with abnormal uterine bleeding. 身体质量指数（BMI）的预测价值以及确定诊断绝经前异常子宫出血妇女子宫内膜增生症的最佳临界点。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.9

Sara Alizadeh Garna, Shahla Yazdani, Hadis Musavi, Mohammad Ranaei, Karimollah Hajian, Zinatossadat Bouzari

{"title":"Predictive value of body mass index (BMI) and determination of optimum cut-off point in the diagnosis of endometrial hyperplasia in pre-menopausal women with abnormal uterine bleeding.","authors":"Sara Alizadeh Garna, Shahla Yazdani, Hadis Musavi, Mohammad Ranaei, Karimollah Hajian, Zinatossadat Bouzari","doi":"10.22088/cjim.15.1.9","DOIUrl":"10.22088/cjim.15.1.9","url":null,"abstract":"Background: The suitable BMI cut-off point in persons with endometrial cancer or hyperplasia with abnormal uterine bleeding was investigated in this study.Methods: This case-control research was conducted on 1470 women with abnormal uterine bleeding in Ayatollah Rouhani Hospital,Babol between 2010 and 2012, with 312 participants included in the study. In terms of uterine biopsy results, patients were split into six groups: simple hyperplasia without atypia, simple hyperplasia with atypia, complicated hyperplasia with atypia, complex hyperplasia without atypia, endometrial cancer, and normal persons.Results: The mean age and BMI of patients in these three groups were not significantly different (P equal to 0.081 and 0.435, respectively). The kind of disease exhibited a strong relationship with menstruation (P 0.001). The body mass index (BMI) values did not have significant levels under the curve to determine the appropriate cut-off point in the diagnosis of hyperplasia plus endometrial cancer and endometrial cancer alone (P 0.380 and 0.124, respectively) and hyperplasia alone (P = 0.920). Based on logistic regression, age 50 years and older and irregular menstruation were significant with OR equal to 2.36 and 2.09 (P = 0.011) and HTN with OR equal to 0.44 (P = 0.026), respectively.Conclusion: BMI has little predictive value in the detection of endometrial cancer or hyperplasia, according to the findings, and other diagnostic and screening modalities should be utilized instead. The findings backed up the theory that old age and irregular menstruation are linked to an increased risk of endometrial cancer.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five-Year study on renal outcomes in biopsy-proven focal segmental glomerulosclerosis patients in Shiraz, Iran. 对伊朗设拉子市经活检证实的局灶节段性肾小球硬化症患者肾脏预后的五年研究。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.519

Maryam Pakfetrat, Leila Malekmakan, Mohamad Hossein Rezazadeh, Taraneh Tadayon, Maryam Bahmani, Amirali Nikoo

{"title":"Five-Year study on renal outcomes in biopsy-proven focal segmental glomerulosclerosis patients in Shiraz, Iran.","authors":"Maryam Pakfetrat, Leila Malekmakan, Mohamad Hossein Rezazadeh, Taraneh Tadayon, Maryam Bahmani, Amirali Nikoo","doi":"10.22088/cjim.15.3.519","DOIUrl":"10.22088/cjim.15.3.519","url":null,"abstract":"Background: Focal segmental glomerulosclerosis (FSGS) is a prevalent glomerular disease that often leads to nephrotic syndrome. It is characterized by consolidating a portion of the glomerular capillary tuft connected to Bowman's capsule. This retrospective cohort study aimed to determine the demographic characteristics, risk factors, and prognostic indicators associated with FSGS in Shiraz, Iran.Methods: The study included 53 primary FSGS patients aged over 18 years who were referred to clinics affiliated with Shiraz University of Medical Sciences. Data were collected through a comprehensive data-gathering sheet encompassing demographic information, medical history, laboratory test results, and histopathological findings. Statistical analysis was performed using SPSS 18, considering a significance level of p<0.05.Results: A five-year follow-up was conducted on the 53 patients, with the mean age of 41.0±13.3 years. The most common FSGS variants observed were \"not otherwise specified\" (NOS, 13.2%) and tip variant (7.5%). Older patients exhibited higher disease activity, whereas remission rates were higher among younger individuals (P=0.012). Patients achieving remission had lower creatinine and Pro/Cr ratios and higher glomerular filtration rates (p<0.05). Treatment involving a combination of corticosteroids and mycophenolate mofetil showed a significant correlation with remission (P=0.036).Conclusion: Older patients with higher creatinine levels, higher Pro/Cr ratios, and lower glomerular filtration rates at disease onset may require more aggressive treatment. Combination therapy with mycophenolate mofetil and corticosteroids yields better outcomes, leading to increased remission rates. These findings provide valuable insights for managing FSGS patients.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic significance of CD10 marker to differentiate colorectal adenocarcinoma from adenomatous polyp: A pathological correlation. CD10 标记对区分结直肠腺癌和腺瘤性息肉的诊断意义：病理相关性。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.228

Ghasem Dehini, Hossein Ghorbani, Soraya Khafri, Javad Shokri Shirvani, Akramossadat Hosseini, Sahar Sadr Mohararpur, Tina Rouhi

{"title":"Diagnostic significance of CD10 marker to differentiate colorectal adenocarcinoma from adenomatous polyp: A pathological correlation.","authors":"Ghasem Dehini, Hossein Ghorbani, Soraya Khafri, Javad Shokri Shirvani, Akramossadat Hosseini, Sahar Sadr Mohararpur, Tina Rouhi","doi":"10.22088/cjim.15.2.228","DOIUrl":"10.22088/cjim.15.2.228","url":null,"abstract":"Background: Colorectal cancer could be developed from adenomatous polyp. The study aimed to evaluate the diagnostic significance of stromal and epithelial CD10 (Neprilysin) expression in patients with colorectal adenocarcinoma and adenomatous polyps.Methods: This cross-sectional study was conducted on 141 patients with colorectal adenocarcinoma and adenomatous polyps referred to Ayatollah Rouhani Hospital from March 2020 to March 2021. Differential diagnoses of colorectal adenocarcinoma and adenomatous polyps were made colonoscopically, and then samples were taken from the lesions. The pathologists confirmed the final diagnosis as colorectal adenocarcinoma, high-grade or low-grade adenomatous polyps. The stromal and epithelial CD10 expression was evaluated by immunohistochemistry. The data was analyzed by SPSS 22 software (p<0.05).Results: Sixty-five (46.1%) of the cases were low-grade polyps that were included positive (4 cases; 6.20%) and negative (61 cases; 93.80%) CD10 expression (P=0.001), also 76 (53.9%) of them were either high-grade polyps (21 cases) or adenocarcinomas (21 cases). Also, epithelial CD10 expression was significantly higher in the well-differentiated adenocarcinoma (38 cases) group than moderate (13 cases) and poor (4 cases) groups (P =0.001). Moreover, the CD10 expression level in the adenomatous polyps (10 positive cases and 76 negative cases) was correlated with the degree of dysplasia (P = 0.001) and the presence of tumor invasion (8 positive cases and 133 negative cases) (P = 0.001).Conclusion: The CD10 expression is associated with an increased degree of dysplasia and the presence of tumor invasion in patients with pre-neoplastic lesions and colorectal adenocarcinoma.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homocysteine, Carotid Intima Media Thickness and NIHSS Score: Clinical Relevance in Indian Stroke Patients. 同型半胱氨酸、颈动脉内膜厚度和 NIHSS 评分：印度卒中患者的临床意义。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.259

Vatsal Navin Jain, Priyanka Rana, Kshitij Arun Bhoge, Swati Ghanghurde, Mahesh B Phad, Mohit Vijay Rojekar

{"title":"Homocysteine, Carotid Intima Media Thickness and NIHSS Score: Clinical Relevance in Indian Stroke Patients.","authors":"Vatsal Navin Jain, Priyanka Rana, Kshitij Arun Bhoge, Swati Ghanghurde, Mahesh B Phad, Mohit Vijay Rojekar","doi":"10.22088/cjim.15.2.259","DOIUrl":"10.22088/cjim.15.2.259","url":null,"abstract":"Background: Stroke is one of the leading causes of mortality and morbidity worldwide accounting for 85% of global deaths from stroke. This study aimed to evaluate the role of homocysteine (HCY) in modulating various stroke parameters and it's with carotid intima-media thickness (IMT).Methods: 78 patients of radiology-confirmed acute ischemic stroke were recruited for this study and National Institutes of Health Stroke Scale (NIHSS) score was evaluated upon admission. Blood samples were tested for serum HCY, fasting blood glucose (FBG) and lipid profile. Ultrasonography of neck ascertained IMT of Common (CCA) and internal carotid artery (ICA).Results: Average age of male and female subjects was 57.88 ± 13.97 & 59.16 ± 13.62 years respectively. 71.93% of stroke patients were hyperhomocysteinemic (HHcyc) and 24.36% were hyperlipidemic. Patients with NIHSS ≥ 5 had higher low-density lipoprotein cholesterol (LDLC) than those with NIHSS < 5. HCY cutoff of ≥ 15 μmol/L had 91.7% sensitivity & 66.7% specificity for predicting. HHcyc state was associated with increased ICA IMT. HHcyc state was best predicted by ICA IMT with which it is positively correlated (P-Value = 0.012).Conclusion: HHcyc state holds a good predictive value for severity of stroke. We also came to a conclusion that ICA IMT measurement may also reduce the need for a homocysteine test as it predicts higher HCY levels; this will reduce the burden on resources. We suggest that evaluating HCY and ICA IMT should be made part of the standard protocol for management of stroke.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0