Diagnostic significance of CD10 marker to differentiate colorectal adenocarcinoma from adenomatous polyp: A pathological correlation.

Pub Date : 2024-01-01 DOI:10.22088/cjim.15.2.228

Ghasem Dehini, Hossein Ghorbani, Soraya Khafri, Javad Shokri Shirvani, Akramossadat Hosseini, Sahar Sadr Mohararpur, Tina Rouhi

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Abstract

Background: Colorectal cancer could be developed from adenomatous polyp. The study aimed to evaluate the diagnostic significance of stromal and epithelial CD10 (Neprilysin) expression in patients with colorectal adenocarcinoma and adenomatous polyps.

Methods: This cross-sectional study was conducted on 141 patients with colorectal adenocarcinoma and adenomatous polyps referred to Ayatollah Rouhani Hospital from March 2020 to March 2021. Differential diagnoses of colorectal adenocarcinoma and adenomatous polyps were made colonoscopically, and then samples were taken from the lesions. The pathologists confirmed the final diagnosis as colorectal adenocarcinoma, high-grade or low-grade adenomatous polyps. The stromal and epithelial CD10 expression was evaluated by immunohistochemistry. The data was analyzed by SPSS 22 software (p<0.05).

Results: Sixty-five (46.1%) of the cases were low-grade polyps that were included positive (4 cases; 6.20%) and negative (61 cases; 93.80%) CD10 expression (P=0.001), also 76 (53.9%) of them were either high-grade polyps (21 cases) or adenocarcinomas (21 cases). Also, epithelial CD10 expression was significantly higher in the well-differentiated adenocarcinoma (38 cases) group than moderate (13 cases) and poor (4 cases) groups (P =0.001). Moreover, the CD10 expression level in the adenomatous polyps (10 positive cases and 76 negative cases) was correlated with the degree of dysplasia (P = 0.001) and the presence of tumor invasion (8 positive cases and 133 negative cases) (P = 0.001).

Conclusion: The CD10 expression is associated with an increased degree of dysplasia and the presence of tumor invasion in patients with pre-neoplastic lesions and colorectal adenocarcinoma.

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CD10 标记对区分结直肠腺癌和腺瘤性息肉的诊断意义：病理相关性。

背景：大肠癌可能由腺瘤性息肉发展而来。本研究旨在评估结直肠腺癌和腺瘤性息肉患者基质和上皮 CD10（Neprilysin）表达的诊断意义：这项横断面研究的对象是 2020 年 3 月至 2021 年 3 月期间转诊至 Ayatollah Rouhani 医院的 141 名结直肠腺癌和腺瘤性息肉患者。通过结肠镜对结直肠腺癌和腺瘤性息肉进行鉴别诊断，然后从病变部位提取样本。病理学家最终确诊为结直肠腺癌、高级别或低级别腺瘤性息肉。基质和上皮 CD10 表达通过免疫组化进行评估。数据采用 SPSS 22 软件进行分析（pResults：其中 65 例（46.1%）为低分化息肉，包括 CD10 表达阳性（4 例，6.20%）和阴性（61 例，93.80%）（P=0.001）；76 例（53.9%）为高级别息肉（21 例）或腺癌（21 例）。此外，分化良好的腺癌组（38 例）的上皮 CD10 表达明显高于中度组（13 例）和较差组（4 例）（P=0.001）。此外，腺瘤性息肉（10 例阳性和 76 例阴性）中的 CD10 表达水平与发育不良程度（P = 0.001）和肿瘤侵犯（8 例阳性和 133 例阴性）（P = 0.001）相关：结论：CD10的表达与肿瘤前病变和结直肠腺癌患者的发育不良程度增加和肿瘤浸润的存在有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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