Caspian Journal of Internal Medicine最新文献_第7页

Assessment of prevalence and risk factors of isolated coronary artery ectasia: A 5-year double-center retrospective study in Yazd, Iran. 评估孤立性冠状动脉异位症的患病率和风险因素：伊朗亚兹德一项为期 5 年的双中心回顾性研究。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.244

Hossein Nough, Fatemeh Moradi, Hamid Reza Varasteravan, Leila Afkhami, Marzieh Azimizadeh, Hamidreza Mohammadi, Mohammad Shafiee, Mahmood Emami, Naser Hossein Sartipzade, Farzan Safi Dahaj, Arman Nough

{"title":"Assessment of prevalence and risk factors of isolated coronary artery ectasia: A 5-year double-center retrospective study in Yazd, Iran.","authors":"Hossein Nough, Fatemeh Moradi, Hamid Reza Varasteravan, Leila Afkhami, Marzieh Azimizadeh, Hamidreza Mohammadi, Mohammad Shafiee, Mahmood Emami, Naser Hossein Sartipzade, Farzan Safi Dahaj, Arman Nough","doi":"10.22088/cjim.15.2.244","DOIUrl":"10.22088/cjim.15.2.244","url":null,"abstract":"Background: The prevalence of Coronary artery ectasia (CAE) varies from 0.‌3 to 5% in different countries. The prevalence of CAE has varied in different parts of the world and the study of risk factors can be effective in the process of diagnosis and treatment of patients, we reviewed patients who underwent coronary angiography for 5 years to determine the prevalence of isolated CAE and its associated risk factors.Methods: A retrospective analysis was conducted on 16600 patients who underwent coronary angiography at Shahid Sadoughi and Afshar hospitals between March 2015 to April 2020. Diagnosis and confirmation of CAE was defined as a vessel diameter greater than 1.5 times the normal diameter of the vessel, which must be confirmed by at least two cardiologists. Demographic variables, angiography and echocardiography reports were included in our final analysis.Results: Isolated CAE was diagnosed in 287 (1.7%) patients. After triple-vessel disease (53%), the left anterior descending artery (LAD) was the commonest affected vessel by ectasia 16% (46 cases). Diffuse isolated CAE was diagnosed in 52% of LAD, 76.6% of Right coronary artery (RCA), and 74.1% of left circumflex artery. A significant association was seen between the vessel involved and the nature of ectasia (p<0.001).Conclusion: In our study, the occurrence of isolated CAE was similar to other studies. This condition often affects all three major vessels of the coronary arteries, and is commonly categorized as type 1, which involves diffuse involvement of the arteries based on the Markis and Harikrishnan Classification.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 2","pages":"244-250"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D levels in non-pregnant women with a history of recurrent pregnancy loss with and without autoantibodies. 有和无自身抗体的非妊娠妇女的维生素 D 水平。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.266

Tooba Farazmand, Raheleh Rahbarian, Mitra Jalali, Amirali Ghahremani, Abdollah Razi, Hasan Namdar Ahmadabad

{"title":"Vitamin D levels in non-pregnant women with a history of recurrent pregnancy loss with and without autoantibodies.","authors":"Tooba Farazmand, Raheleh Rahbarian, Mitra Jalali, Amirali Ghahremani, Abdollah Razi, Hasan Namdar Ahmadabad","doi":"10.22088/cjim.15.2.266","DOIUrl":"10.22088/cjim.15.2.266","url":null,"abstract":"Background: The objective of this study was to compare the levels of vitamin D in non-pregnant women with a history of recurrent pregnancy loss (RPL) who were seropositive or seronegative for autoantibodies (autoAbs).Methods: The study examined 58 RPL patients with autoAbs (ANA, anti-TPO, or APAs), 34 RPL patients without autoAbs, and 58 healthy women with prior successful pregnancies and without autoantibodies. The levels of 25 (OH) D were measured using the sandwich ELISA technique.Results: Our results showed insufficient serum 25(OH) D levels in study groups, with significantly lower levels observed in RPL patients with or without autoAbs compared to healthy women (P=0.0006). In addition, RPL patients with autoAbs had significantly lower 25(OH) D levels compared to RPL patients without autoAbs. We also found that serum levels of 25(OH) D in RPL patients with autoAbs were significantly lower than in RPL patients without autoAbs (20.51 ± 1.15 ng/ml Vs. 23.69 ± 0.74 ng/ml, P=0.0356). Further analysis indicated that RPL patients who were positive for ANA, and APAs, except anti-TPO, had significantly lower than 25(OH)D serum levels than RPL patients without autoAbs.Conclusion: These findings suggest that RPL patients, especially those with APAs or ANA, have lower vitamin D levels compared to healthy women. This may indicate a link between maternal immune dysregulation due to vitamin D deficiency and the presence of autoantibodies in RPL.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 2","pages":"266-272"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between coronary artery calcification and COVID-19. 冠状动脉钙化与 COVID-19 之间的相关性。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.466

Saeed Abrotan, Seyed Farzad Jalali, Mohammadtaghi Hedayati-Godarzi, Iraj Jafaripour, Mehrdad Saravi, Naghmeh Ziaie, Roghayeh Pourkia, Kamyar Amin, Ali Bijani, Masomeh Bayani, Sorayya Khafri, Milad Bakhshi, Saeed Kargar-Soleimanabad, Erfan Ghadirzadeh

{"title":"Correlation between coronary artery calcification and COVID-19.","authors":"Saeed Abrotan, Seyed Farzad Jalali, Mohammadtaghi Hedayati-Godarzi, Iraj Jafaripour, Mehrdad Saravi, Naghmeh Ziaie, Roghayeh Pourkia, Kamyar Amin, Ali Bijani, Masomeh Bayani, Sorayya Khafri, Milad Bakhshi, Saeed Kargar-Soleimanabad, Erfan Ghadirzadeh","doi":"10.22088/cjim.15.3.466","DOIUrl":"10.22088/cjim.15.3.466","url":null,"abstract":"Background: Coronary heart disease (CHD) is an underlying cardiac condition contributing to increased COVID-19 mortality and morbidity which can be assessed by several diagnosis methods including coronary artery calcification (CAC). The goal of this study was to find out if there were potential links between CAC, clinical findings, severity of COVID-19, and in-hospital outcomes.Methods: This retrospective study evaluated 551 suspected patients admitted to teaching hospitals of the Babol University of Medical Sciences, Babol, Iran, from March to October 2021. Data included previous diseases, comorbidities, clinical examinations, routine laboratory tests, demographic characteristics, duration of hospitalization, and number of days under ventilation were recorded in a checklist.Results: Findings of current study provide evidence of a significant relationship between coronary artery calcification (CAC) and in-hospital mortality. Additionally, we observed significant correlations between CAC and several clinical parameters including age, duration of hospitalization, pulse rate, maximum blood pressure, erythrocyte sedimentation rate (ESR), blood urea nitrogen (BUN), neutrophil count, white blood cell (WBC) count, and oxygen saturation. However, we did not observe a significant association between CAC and the severity index of COVID-19. In addition, logistic regression tests did not find a significant value of CAC to predict in-hospital mortality.Conclusion: Our findings showed a significant relationship between CAC and in-hospital mortality.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 3","pages":"466-471"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrocardiographic parameters and mortality in patients with SARS-CoV-2 infection: A single center study. SARS-CoV-2 感染者的心电图参数和死亡率：单中心研究

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.444

Samaneh Karbalaie Esmaeilzad, Mohammad Taghi Hedayati, Naghmeh Ziaie, Hoda Shirafkan, Farzad Jalali, Iraj Jafaripoor, Kamyar Amin, Rogheyeh Pourkia, Zahra Jabbary, Saeid Abroutan, Mehrdad Saravi

{"title":"Electrocardiographic parameters and mortality in patients with SARS-CoV-2 infection: A single center study.","authors":"Samaneh Karbalaie Esmaeilzad, Mohammad Taghi Hedayati, Naghmeh Ziaie, Hoda Shirafkan, Farzad Jalali, Iraj Jafaripoor, Kamyar Amin, Rogheyeh Pourkia, Zahra Jabbary, Saeid Abroutan, Mehrdad Saravi","doi":"10.22088/cjim.15.3.444","DOIUrl":"10.22088/cjim.15.3.444","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) is a pandemic outbreak of RNA coronaviruses (SARS-CoV-2), associated with acute respiratory distress syndrome, multiple organ failure, and death. The surface electrocardiogram is the first line assessment of cardiac electrical system. We aimed to interpret classically the electrocardiographic parameters at admission and during hospital course and association of them with prognosis in patients admitted with diagnosis of infection with SARS-CoV-2.Methods: Surface electrocardiograms (ECG) were obtained from 180 patients with SARS-CoV-2 infection at a large tertiary referral university hospital at north of Iran in Babol. The electrocardiographic waves, intervals and segments in addition to supraventricular and ventricular arrhythmias were depicted. Our cohort included two groups: discharged alive and dead during the hospital course. We compared the ECG characteristics of patients who died vs. survived ones.Results: Some ECG parameters of 180 hospitalized patients were significantly associated with mortality, like heart rate (p< 0.001), bundle branch block (P= 0.035), fragmented QRS (P= 0.015), ST elevation (P= 0.004), T p-e duration (P= 0.006), premature atrial and ventricular complexes (P= 0.030, P= 0.004) and atrial fibrillation (P= 0.003).Conclusion: The SARS-CoV-2 infection had several impacts on cardiac electrical system which may monitored with a simple and easily accessible tool like ECG. This tool also helpful in the risk stratification of patients.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 3","pages":"444-450"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the auditory brainstem response test in patients with type 2 diabetes mellitus. 评估 2 型糖尿病患者的听觉脑干反应测试。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.527

Mahbubeh Sheikhzadeh, Fereshteh Bagheri, Mohammad Ali Bayani, Milad Kami, Mohsen Monadi

{"title":"Evaluation of the auditory brainstem response test in patients with type 2 diabetes mellitus.","authors":"Mahbubeh Sheikhzadeh, Fereshteh Bagheri, Mohammad Ali Bayani, Milad Kami, Mohsen Monadi","doi":"10.22088/cjim.15.3.527","DOIUrl":"10.22088/cjim.15.3.527","url":null,"abstract":"Background: Hearing loss is an unknown complication of diabetes mellitus (DM). The aim of this study was to evaluate hearing function using auditory brainstem response (ABR) in diabetic patients.Methods: The present case-control study was performed on thirty diabetic patients as a case group and thirty healthy individuals as a control group. Baseline demographic information, HbA1c level, and duration of diabetes were obtained from all diabetic patients. In all subjects, the ABR and pure-tone audiometry (PTA) tests were performed and the results were analyzed using the t-test and logistic regression.Results: The absolute latency of I was significantly lower in diabetes patients. The absolute latency of III and the interpeak latencies (IPL) I-III were significantly higher in diabetic patients. No significant relationship was noticed in the absolute latency of V and the IPL I-V among diabetic patients in the right and left ears (P>0.05).Conclusion: The results of this study suggested that diabetes may cause central auditory dysfunction manifested on the absolute latency of III, the IPL I-III and III-V.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 3","pages":"527-534"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum melatonin levels in type 2 diabetic patients with depressive symptoms compared to non-depressed individuals. 有抑郁症状的 2 型糖尿病患者与非抑郁症患者的血清褪黑激素水平比较。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.421

Neda Kazemipoor, Alireza Arefzadeh, Davood Dalil, Maryam Shiehmorteza, Seyyed Mohammad Hosseini

{"title":"Serum melatonin levels in type 2 diabetic patients with depressive symptoms compared to non-depressed individuals.","authors":"Neda Kazemipoor, Alireza Arefzadeh, Davood Dalil, Maryam Shiehmorteza, Seyyed Mohammad Hosseini","doi":"10.22088/cjim.15.3.421","DOIUrl":"10.22088/cjim.15.3.421","url":null,"abstract":"Background: Melatonin, mainly regulating the body's circadian rhythm, may have protective effects against type 2 diabetes mellitus (DM2)-induced depression due to its antioxidant and regulatory impact in the pathogenesis of both DM2 and depression. This study aimed to find the association of serum melatonin levels with depression in DM2 patients.Methods: A total of 50 DM2 patients were recruited in this retrospective cross-sectional study and divided into 25 patients with depression (DM2-DP) and 25 without depression symptoms (DM2-NDP). Depression was diagnosed using the Hospital Anxiety and Depression Scale (HADS) assessment. Fasting blood samples were collected and examined for the level of serum melatonin and other biomarkers. All statistical analysis was performed by SPSS software Version 22, and a p-value less than 0.05 was considered statistically significant for all tests.Results: The depression score was significantly lower in DM2-NDP than DM2-DP (p< 0.001). The mean weight was significantly lower in the DM2-DP group (P= 0.021). Total cholesterol, triglyceride, and anxiety scores were higher, and the melatonin level was lower in DM2-DP. The correlation of melatonin levels was positive with age, DBP, HbA1C, FBS, and TG. In contrast, it was negative with male gender, BMI, diabetes duration, SBP, TC, family history of DM, depression score, and anxiety score. However, no significant differences were seen.Conclusion: Lower melatonin may be associated with depression and anxiety in patients with DM2. The serum melatonin level might be a strong predictor of depression in DM2 patients.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 3","pages":"421-429"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units. 亚麻籽粉和氢氧化镁糖浆对重症监护室急性心肌梗死患者肠道功能的影响。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.234

Sahar Amjadi Suraki, Masoumeh Bagheri-Nesami, Maryam Nabati, Mahmood Moosazadeh, Emran Habibi

{"title":"Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units.","authors":"Sahar Amjadi Suraki, Masoumeh Bagheri-Nesami, Maryam Nabati, Mahmood Moosazadeh, Emran Habibi","doi":"10.22088/cjim.15.2.234","DOIUrl":"10.22088/cjim.15.2.234","url":null,"abstract":"Background: Flaxseed powder seems to improve bowel movements in these patients. Therefore, this study compares the effects of flaxseed powder and magnesium hydroxide on bowel movements of acute myocardial infarction patients hospitalized in ICU.Methods: The population of the present parallel randomized controlled clinical trial included 70 acute myocardial infarction patients hospitalized in ICU who had no history of chronic constipation. The patients in the intervention group were given three sachets of flaxseed powder (each sachet was 3 g) twice a day for four days. The patients in the control group were given 20 cc of magnesium hydroxide syrup each morning. The Bristol scale was used to describe stool consistency.Results: The mean and standard deviation of the number of bowel movements within five days after intervention are 1.86 ± 1.08 and 1.6 ± 0.65 in the intervention and the control groups, respectively. The frequency of normal stool consistency of the first bowel movement is 94.3% for the intervention group and 85.7% for the control group, which shows no significant differences between the two groups in terms of stool consistency and bowel movement frequency (P=0.510). The bowel movements started on average after 35.2±97.97 hours in the flaxseed group and 24.771±2.677 hours in the magnesium hydroxide group (P=0.023).Conclusion: The results showed that flaxseed powder increases bowel movement frequency and improves the patients' stool consistency, but the differences between the two groups are insignificant. Finally, the time to the first defecation was shorter in the magnesium hydroxide group.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 2","pages":"234-243"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sonographic assessment of Achilles tendon in patients with cutaneous psoriasis. 皮肤银屑病患者跟腱的超声评估。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.313

Anwar Sharifaskari, Azadeh Goodarzi, Navid Davoody, Nahid Kianmehr, Ali Sepyani, Anousheh Haghighi

{"title":"Sonographic assessment of Achilles tendon in patients with cutaneous psoriasis.","authors":"Anwar Sharifaskari, Azadeh Goodarzi, Navid Davoody, Nahid Kianmehr, Ali Sepyani, Anousheh Haghighi","doi":"10.22088/cjim.15.2.313","DOIUrl":"10.22088/cjim.15.2.313","url":null,"abstract":"Background: Psoriasis is a common, chronic, immune-‌‌‌‌‌‌mediated inflammatory disease with a variety of skin manifestations. The aim of this study was to determine the prevalence of subclinical Achilles tendon disorder in cutaneous psoriasis patients and compare it with healthy controls.Methods: This was a cross-sectional case-control study conducted on psoriasis patients that were referred to dermatology clinic. Thirty patients in the case group and 30 healthy controls were included in the study. Thickness of Achilles tendon enthesis was scanned by an expert rheumatologist using ultrasound equipped with a 5-14 MHz linear prob bilaterally.Results: The mean age of the patient and control groups was 43.97±16.82 years and 38.87±12.71 years, respectively (P=0.190). The mean thickness of the Achilles tendon enthesis in the dominant limb was 4.31±0.86 mm in the patient group and 4.10±0.54 mm in the control group. There was no significant difference between the two groups in terms of thickness of the Achilles tendon enthesis in the dominant limb (P=0.276). The mean thickness of the Achilles tendon enthesis in the non-dominant limb was 4.44±0.91 mm in the patient group and 4.14±0.59 mm in the control group. There was no significant difference between the two groups in terms of thickness of Achilles tendon enthesis in the non-dominant limb (P = 0.134).Conclusion: Although ultrasonography may be utilized for assessment of both structural and inflammatory changes, we revealed no difference in the mean thickness of Achilles tendon enthesis in patients with cutaneous psoriasis. Contradiction between clinical and ultrasonography features required further research.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 2","pages":"313-317"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic significance of ASXL1 mutations in acute myeloid leukemia: A systematic review and meta-analysis. 急性髓性白血病 ASXL1 基因突变的预后意义：系统综述与荟萃分析。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.202

Maryam Sheikhi, Mehrdad Rostami, Gordon Ferns, Hossein Ayatollahi, Payam Siyadat, Yasamin Ayatollahi, Zahra Khoshnegah

{"title":"Prognostic significance of ASXL1 mutations in acute myeloid leukemia: A systematic review and meta-analysis.","authors":"Maryam Sheikhi, Mehrdad Rostami, Gordon Ferns, Hossein Ayatollahi, Payam Siyadat, Yasamin Ayatollahi, Zahra Khoshnegah","doi":"10.22088/cjim.15.2.202","DOIUrl":"10.22088/cjim.15.2.202","url":null,"abstract":"Background: Although genetic mutations in additional sex-combs-like 1 (ASXL1) are prevalent in acute myeloid leukemia (AML), their exact impact on the AML prognosis remains uncertain. Hence, the present article was carried out to explore the prognostic importance of ASXL1 mutations in AML.Methods: We thoroughly searched electronic scientific databases to find eligible papers. Twenty-seven studies with an overall number of 8,953 participants were selected for the current systematic review. The hazard ratio (HR) and 95% confidence interval (CI) for overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) were extracted from all studies with multivariate or univariate analysis. Pooled HRs and p-values were also calculated as a part of our work.Results: The pooled HR for OS in multivariable analysis indicated that ASXL1 significantly diminished survival in AML patients (pooled HR: 1.67; 95% CI: 1.342-2.091).Conclusions: ASXL1 mutations may confer a poor prognosis in AML. Hence, they may be regarded as potential prognostic factors. However, more detailed studies with different ASXL1 mutations are suggested to shed light on this issue.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 2","pages":"202-214"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between melphalan chemotherapy with longitudinal global strain indices of the left ventricle in multiple myeloma patients: A velocity vector imaging (VVI) echocardiography study. 多发性骨髓瘤患者美法仑化疗与左心室纵向整体应变指数之间的相关性：速度矢量成像（VVI）超声心动图研究。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.25

Liaosadat Mirsafaee, Mohammad Dehghani Firouzabadi, Sayeh Parkhideh, Hassan Vahidnezhad, Fatemeh Dehghani Firouzabadi, Maryam Arab, David M Yousem, Mersedeh Karvandi

引用次数: 0