Caspian Journal of Internal Medicine最新文献_第7页

Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among the fulminant hepatitis A virus infection patients. 暴发性甲型肝炎病毒感染患者中葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症的患病率。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.451

Fardad Ejtehadi, Maryam Sadat Serpoosh, Iraj Shahramian, Ladan Aminlari, Ramin Niknam, Gholam Reza Sivandzadeh, Masoud Tahani, Amin Javadifar, Fateme Sharafi, Maryam Moini

{"title":"Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among the fulminant hepatitis A virus infection patients.","authors":"Fardad Ejtehadi, Maryam Sadat Serpoosh, Iraj Shahramian, Ladan Aminlari, Ramin Niknam, Gholam Reza Sivandzadeh, Masoud Tahani, Amin Javadifar, Fateme Sharafi, Maryam Moini","doi":"10.22088/cjim.15.3.451","DOIUrl":"10.22088/cjim.15.3.451","url":null,"abstract":"Background: Hepatitis A is a widespread viral infection with significant public health implications. Assessing glucose 6-phosphate dehydrogenase (G6PD) deficiency in hepatitis A patients is essential for various reasons, including prognosis, disease severity evaluation, encephalopathy risk identification, tailored management, and advancing scientific understanding. This study aimed to investigate the prevalence and clinical implications of G6PD impairment in individuals with fulminant hepatitis A.Methods: A cross-sectional descriptive analysis was conducted, involving hospitalized patients with fulminant hepatitis A. Demographic data, prevalence rates, and clinical findings were recorded in a database. The diagnosis of hepatitis A infection was confirmed using an anti-HAV IgM antibody test, and G6PD enzyme activity was measured with a fluorescent spot assay.Results: Out of 81 patients with hepatitis A, 57 (70.4%) were males, and 24 (29.5%) were females, with an average age of 24.6 years. Dark yellow urine and anorexia were the most common clinical symptoms. Notably, 30 (37%) patients lacked G6PD. The group with G6PD deficiency showed significantly higher rates of encephalopathy and mortality (P<0.01), along with elevated bilirubin (P=0.00), abnormal coagulation parameters, and low hemoglobin levels (P=0.00).Conclusion: In light of these findings, the present study proposes the implementation of routine G6PD level assessments and the evaluation of other relevant markers in regions where hepatitis A is endemic. Furthermore, the study underscores the need for vigilant monitoring of hemolysis and encephalopathy in affected patients to optimize clinical management and reduce morbidity and mortality associated with this condition.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using bone mineral apparent density for BMD adjustment in chronic diseases: Thalassemia an example. 使用骨矿物质表观密度调整慢性疾病的骨矿物质表观密度：以地中海贫血症为例

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.3.494

Mohammad-Reza Mohajeri-Tehrani, Hadis Gerami, Sara Shirazi, Mobina Ostadi, Bagher Larijani, Zohreh Hamidi

{"title":"Using bone mineral apparent density for BMD adjustment in chronic diseases: Thalassemia an example.","authors":"Mohammad-Reza Mohajeri-Tehrani, Hadis Gerami, Sara Shirazi, Mobina Ostadi, Bagher Larijani, Zohreh Hamidi","doi":"10.22088/cjim.15.3.494","DOIUrl":"10.22088/cjim.15.3.494","url":null,"abstract":"Background: Low BMD is a common problem in major thalassaemia patient, but the use of DXA in chronic disease children with smaller bones, has some problems. Utilizing bone mineral apparent density (BMAD) helps in preventing this obstacle. Testing the usefulness of this method in resolving the effects of bone size on BMD by comparing the BMD and BMAD of our thalassemics with results of our healthy ones, is our goal.Methods: Sample size was 110 cases with mean age of 9.6 ± 4.3 y/o and contained 73 males. Gauge of BMDs done by dual x-ray absorptiometry. Then BMAD was calculated. We did comparison of BMDs and BMADs results of thalassemic children with results of healthy Iranian pediatrics.Results: Mean of femoral BMD and BMAD, spinal BMD and BMAD was 0.579±0.134 g/cm2, 0.162±0.096 g/cm3, 0.563±0.118 g/cm2 and 0.107±0.015, respectively. When results of 9-18 patients compared with BMDs and BMADs of normal children, BMD of femur and BMD and BMAD of spine of patients found significantly lower (P-values, 0.003, <0.001, <0.001, respectively). BMAD of femur of patients was not significantly different from normals.Conclusion: When bone mineral density of femur modifies by bone mineral apparent density formula, the remarkable difference between BMD of patients and normals; vanishes. Utilizing bone mineral apparent density helps in interpretation of femoral dual X-ray absorptiometry at least in thalassemic patients. As the results of vertebrae, after modification by calculating BMAD, remains significantly different, we cannot bring forward BMAD for mentioned aim in the spine of thalassemics.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Educating correct ECG interpretation is a way to promote the satisfaction and competency the diagnostic service providers. 教育正确的心电图解读是提高诊断服务提供者满意度和能力的一种方式。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.16

Mehrdad Saravi, Amirmohammad Rezaei Majd, Mohammad Ali Qassemi Darzi, Yasaman Habibzadeh, Zeinab Hoseini Motlagh, Maryam Ghaemi-Amiri

{"title":"Educating correct ECG interpretation is a way to promote the satisfaction and competency the diagnostic service providers.","authors":"Mehrdad Saravi, Amirmohammad Rezaei Majd, Mohammad Ali Qassemi Darzi, Yasaman Habibzadeh, Zeinab Hoseini Motlagh, Maryam Ghaemi-Amiri","doi":"10.22088/cjim.15.1.16","DOIUrl":"10.22088/cjim.15.1.16","url":null,"abstract":"Background: Given electrocardiogram (ECG) interpretation as one of the diagnostical challenges for medical students and health professionals, this research was carried out to present an experience of web-based teaching method and novel approaches used for training of ECG interpretation.Methods: This online program was conducted in three days. The main content of the class was taught during one hour, and after that, the teacher spent enough time for responding the asked questions. The components of a normal ECG and different changes that can occur in these waves were taught through clinical case-based scenarios using the web platform and Adobe Connect software. The participants' satisfaction was assessed with a 12-item questionnaire, and the short-term retention of ECG interpretation skill was examined by comparing the posttest scores with pretest.Results: A total of 224 individuals completed the course. Total satisfaction score was 53.05±6.98 (out of the maximum score of 60). Based on the results of the paired t test, the interpretation skill scores of the participants increased significantly from 2.5 ± 1.57 to 6.96 ± 1.89. (p<0.001, CI = -4.8 to- 4.11).Conclusion: This web-based nationwide training program provided a supplementary resource for ECG learning among medical students and health-care providers.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factor V Leiden, MTHFR, and FXIIIVal34Leu gene polymorphisms and their association with clinical features and risk of diabetic retinopathy in patients with type 2 diabetes. 因子 V Leiden、MTHFR 和 FXIIIVal34Leu 基因多态性及其与 2 型糖尿病患者临床特征和糖尿病视网膜病变风险的关系。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.11

Atefeh Rahimi, Nastaran Moridi, Amin Golestani, Gholamreza Anani-Sarab, Fatemeh Salmani, Gholamhossein Yaqubi, Behzad Mesbahzadeh, Mohammad Ali Jalalifar, Mohammad Malekaneh, Seyed Mehdi Sajjadi

{"title":"Factor V Leiden, MTHFR, and FXIIIVal34Leu gene polymorphisms and their association with clinical features and risk of diabetic retinopathy in patients with type 2 diabetes.","authors":"Atefeh Rahimi, Nastaran Moridi, Amin Golestani, Gholamreza Anani-Sarab, Fatemeh Salmani, Gholamhossein Yaqubi, Behzad Mesbahzadeh, Mohammad Ali Jalalifar, Mohammad Malekaneh, Seyed Mehdi Sajjadi","doi":"10.22088/cjim.15.1.11","DOIUrl":"10.22088/cjim.15.1.11","url":null,"abstract":"Background: Diabetic retinopathy (DR) is expanding to epidemic levels globally due to the progressing prevalence of diabetes mellitus (DM). In this study, the association between factor V Leiden (FVL), MTHFRC677T, and FXIIIVal34Leu polymorphisms and diabetic retinopathy was investigated in Eastern Iran.Methods: This case-control study enlisted the participation of 300 people (diabetic patients=100, diabetic retinopathy patients=100, healthy controls=100), and polymorphisms were examined by Tetra primer ARMS-PCR.Results: The frequency of FVL (p=0.294) and FXIIIVal34Leu (P=0.349) polymorphism showed no significant results between the genotype frequency in the mentioned groups. In contrast, MTHFRC677T SNP was significantly different in diabetic patients and controls (P=0.008). The MTHFRC677T polymorphism was found to be connected with increased systolic blood pressure in patients who had the TT genotype (130.96±11.92mm/Hg; P=0.011).Conclusion: Our study recommended that the MTHFRC677T polymorphism may offer to DR development. Studies with larger sample sizes and a wider spectrum of populations are authorized to verify this finding.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A policy brief on improving the lifestyle of women with polycystic ovary syndrome. 关于改善多囊卵巢综合征妇女生活方式的政策简介。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.21

Mouloud Agajani Delavar, Sedighe Esmaeilzadeh, Zynab Farhadi, Parvaneh Mirabi

引用次数: 0

Comparison between myocardial infarction with non-obstructive coronaries (MINOCA) and myocardial infarct patients with coronary artery disease (MI-CAD): A single-center retrospective cohort study. 冠状动脉无阻塞性心肌梗死（MINOCA）与冠状动脉疾病心肌梗死患者（MI-CAD）的比较：单中心回顾性队列研究。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.12

Abbas Andishmand, Mahmood Emami Meybodi, Seyedeh Mahdieh Namayandeh, Hamid Reza Mohammadi, Mojtaba Andishmand, Mohammad Ali Zarbakhsh, Marzieh Azimi Zade

{"title":"Comparison between myocardial infarction with non-obstructive coronaries (MINOCA) and myocardial infarct patients with coronary artery disease (MI-CAD): A single-center retrospective cohort study.","authors":"Abbas Andishmand, Mahmood Emami Meybodi, Seyedeh Mahdieh Namayandeh, Hamid Reza Mohammadi, Mojtaba Andishmand, Mohammad Ali Zarbakhsh, Marzieh Azimi Zade","doi":"10.22088/cjim.15.1.12","DOIUrl":"10.22088/cjim.15.1.12","url":null,"abstract":"Background: The coronary angiography results in a group of patients with myocardial infarction (MI) are normal or near-normal; which is diagnosed as myocardial infarction with non-obstructive coronary arteries (MINOCA). This study aimed to compare the mortality rate and risk factors between MINOCA and myocardial infarction with obstructive coronary artery (MI-CAD).Methods: This retrospective cohort study was conducted from January 1, 2018, to December 31, 2019. A total of 679 patients admitted to Afshar Hospital in Yazd with a diagnosis of ST-elevation myocardial infarction (STEMI) from 2018-2019 who underwent primary Percutaneous Coronary Intervention (PCI) were enrolled in the study. Demographic, and clinical variables, ECG finding and one-year mortality, were extracted using MI registry data from the Yazd Cardiac Research Center.Results: The estimated frequency of MINOCA was 4.6%. Patients with MINOCA (47.14±6.2) were younger than patients with MI-CAD (57.61±9.1) (P <0.0001). MINOCA patients (47.4±9.47) had a considerably greater left ventricular ejection fraction (LVEF) than MI-CAD patients (43.5±6.8) (P =0.018). The majority site of MI in MINOCA patients was located in the non-anterior wall (p <0.0001). A comparison of MINOCA and MI-CAD patients' one-year mortality revealed no significant difference (P =0.07).Conclusion: The prevalence of patients with MINOCA in Yazd was similar to other communities. Although these patients probably do not have a better prognosis, despite being younger and having better LV systolic function and lower CAD risk factors.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of HIV, HBV, HCV, HPV and syphilis among female sex workers in Kurdistan, west of Iran. 伊朗西部库尔德斯坦女性性工作者中艾滋病毒、乙肝病毒、丙肝病毒、人乳头瘤病毒和梅毒的流行情况。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.3

Somaye Mafakheri Bashmaq, Amjad Ahmadi, Behzad Mohsenpour, Khaled Rahmani, Modabber Arasteh, Narges Shams Alizadeh, Asrin Babahajian, Shoaib Advay, Asefeh Abbaszadeh

{"title":"Prevalence of HIV, HBV, HCV, HPV and syphilis among female sex workers in Kurdistan, west of Iran.","authors":"Somaye Mafakheri Bashmaq, Amjad Ahmadi, Behzad Mohsenpour, Khaled Rahmani, Modabber Arasteh, Narges Shams Alizadeh, Asrin Babahajian, Shoaib Advay, Asefeh Abbaszadeh","doi":"10.22088/cjim.15.1.3","DOIUrl":"10.22088/cjim.15.1.3","url":null,"abstract":"Background: Female sex workers (FSWs) in most societies run a high risk of health problems, including sexually transmitted infections (STIs) such as viral infections and syphilis. The present study examines the prevalence of viral infections and syphilis among FSWs.Methods: This cross-sectional study recruited 100 female sex workers (April 2019 to April 2020) who visited the Counseling Center for Behavioral Diseases or were selected via purposeful (snowball) sampling. A questionnaire (demographic information and STI risk factors) was completed in a face-to-face interview with the participants. Blood samples were then taken to test the markers for HBV, HCV Ab, HIV Ab, Rapid Plasma Reagin (RPR) for syphilis and a PCR was taken to test for HPV (in vaginal sex workers from the cervix and anal sex workers from the anal region). The data were analyzed in Stata 14.Results: Among 100 FSWs, 6 (6%) were infected with HIV, 1 (1%) with hepatitis B, and 2 (2%) were anti-HCV positive. 1 (1%) participant was suspected of having syphilis. Based on the PCR tests, 16 (16%) participants were infected with HPV. Moreover, 68 (68%) FSWs reported having unprotected sex.Conclusion: Due to the prevalence of viral infections and syphilis and unprotected sex in FSWs, immediate preventive measures are critical for this vulnerable group to control the transmission of these viral infections in society.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The glycosylated hemoglobin level and the severity of cardiovascular involvement in patients with the first episode of acute coronary syndrome. 首次急性冠状动脉综合征患者的糖化血红蛋白水平和心血管受累的严重程度。

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.1.4

Saman Khaleghi, Mohammad Ali Bayani, Naghmeh Ziaei, Mohammadtaghi Salehiomran, Soraya Khafri

{"title":"The glycosylated hemoglobin level and the severity of cardiovascular involvement in patients with the first episode of acute coronary syndrome.","authors":"Saman Khaleghi, Mohammad Ali Bayani, Naghmeh Ziaei, Mohammadtaghi Salehiomran, Soraya Khafri","doi":"10.22088/cjim.15.1.4","DOIUrl":"10.22088/cjim.15.1.4","url":null,"abstract":"Background: The current study was carried out aiming at investigating the relationship between glycosylated hemoglobin level and coronary atherosclerosis in patients with the first episode of acute coronary syndrome.Methods: This case-control study evaluated 450 patients with the first episode of acute coronary syndrome in Ayatollah Rouhani Hospital in Babol (Iran) from 2011 to 2018. Based on glycosylated hemoglobin, patients were divided into three groups of non-diabetic, pre-diabetic, and diabetic (n=150 in each group). Since SYNTAX score and Gensini score are employed to evaluate the extent of cardiovascular disease and predict CVD in patients with CAD over long-term follow-up, we calculated SYNTAX score and Gensini score based on angiographic results.Results: Concerning the factors related to the severity of cardiovascular involvement, the results revealed no significant difference between the diabetic and pre-diabetic groups in terms of the frequency of patients in terms of SYNTAX score, Gensini score, and the number of vessels involved (0.142 and 87, respectively, and P=0.102). However, this difference between the diabetic and non-diabetic groups, as well as between the pre-diabetic and non-diabetic groups was statistically significant (respectively for SYNTAX score, p< 0.001 and P=0.001; for Gensini score, P=0.013 and P=0.019; and for the number of vessels involved P=0.001and p<0.001).Conclusion: According to the findings of the current study, since there was no significant difference between diabetic and pre-diabetic patients in terms of the components indicating the severity of cardiovascular involvement, pre-diabetes itself may be associated with the severity of cardiovascular involvement as a predisposing factor.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deaddicta® for maintenance treatment of Opioid-dependence: A six-month follow-up. Deaddicta®用于阿片类药物依赖的维持治疗：六个月的随访

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.318

Abdolali Moosavyzadeh, Farzaneh Ghaffari, Mohammad Bagher Saberizafarghandi, Majid Talafi Noghani, Hossein Hassanpour, Fatemeh Emadi, Fatemeh Alijaniha, Zahra Bahaeddin, Leila Nasiri, Razieh Jafari Hajati, Mohsen Naseri

{"title":"Deaddicta® for maintenance treatment of Opioid-dependence: A six-month follow-up.","authors":"Abdolali Moosavyzadeh, Farzaneh Ghaffari, Mohammad Bagher Saberizafarghandi, Majid Talafi Noghani, Hossein Hassanpour, Fatemeh Emadi, Fatemeh Alijaniha, Zahra Bahaeddin, Leila Nasiri, Razieh Jafari Hajati, Mohsen Naseri","doi":"10.22088/cjim.15.2.318","DOIUrl":"10.22088/cjim.15.2.318","url":null,"abstract":"Background: Opioid dependence, is one of the world's most critical health problems. Deaddicta is a herbal product considered an effective treatment for opioid addiction. Deaddicta's efficacy in the maintenance treatment of patients with opioid use disorder has recently been demonstrated through a double-blind randomized controlled trial (RCT). This study aimed to evaluate the permanence of Deaddicta's efficacy six months after the end of the maintenance treatment for opioid dependence.Methods: This study was performed following the previous RCT on the maintenance treatment of opioid addicts. Out of 41 participants who completed the study for three months in the previous research, 15 from the intervention group (Deaddicta capsules, 1500 mg/day) returned for follow-up. They all previously fulfilled the DSM-IV criteria for addiction, were aged 18 to 65, and had discontinued Deaddicta for six months. The outcome measures included addiction severity, depression and anxiety levels, and craving score. The scores of each parameter were compared in three phases: before intervention; after three months of intervention; and six months after the end of the study.Results: Depression, anxiety, and craving scores decreased six months after the end of the previous study. This decrease was significant in the craving score (P = 0.011). No significant increase was observed in the frequency of use. The regression analysis showed a negative relationship between craving and the progression of phases.Conclusion: The Deaddicta product may have desirable and effective properties in decreasing temptation and, as a result, the maintenance treatment of opioid dependence.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial. 硒对自身免疫性甲状腺功能减退症患者抗 Tg 抗体的影响：随机对照试验

IF 1.4

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI: 10.22088/cjim.15.2.340

Mina AkbariRad, Zahra Mazloum Khorasani, Behnam Beizae, Hossein Ayatollahi, Maryam Emadzadeh, Mehrdad Sarabi, Nikoo Saeedi, Negar Nekooei

{"title":"Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial.","authors":"Mina AkbariRad, Zahra Mazloum Khorasani, Behnam Beizae, Hossein Ayatollahi, Maryam Emadzadeh, Mehrdad Sarabi, Nikoo Saeedi, Negar Nekooei","doi":"10.22088/cjim.15.2.340","DOIUrl":"10.22088/cjim.15.2.340","url":null,"abstract":"Background: The current study intends to assess the impact of oral selenium intake on anti-Tg antibody in individuals with autoimmune hypothyroidism.Methods: In this double-blinded randomized controlled trial, two groups of 72 autoimmune hypothyroid patients were randomly assigned; one group received levothyroxine (LT4) and oral selenium and the other group was given placebo with LT4. Anti-Tg antibody, free T4, anti-TPO antibody, and TSH were identified in both groups before the treatment and also 3 months after treatment and analysis of data was done by SPSS software.Results: After the intervention, the average amount of anti-Tg antibody decreased in both of the groups, and this decrease was noticeably greater in the intervention group (P = 0.03). In the intervention group, the TSH level decreased after the intervention (p < 0.05), and the free T4 level increased after the intervention (p < 0.05); the changes in these two variables were statistically significant.Conclusion: Consumption of selenium, compared to placebo, in patients with autoimmune hypothyroidism drastically reduces the level of anti-Tg antibody, and it significantly increases the free T4 level. Also, there is a greater decrease in the level of TSH compared to the control group.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0