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Advances in the diagnosis and treatment of male infertility - an overview of current methods. 男性不育症的诊断与治疗进展——当前方法综述。
Casopis lekaru ceskych Pub Date : 2025-01-01
Marek Broul, Aneta Hujová, Michaela Liegertová
{"title":"Advances in the diagnosis and treatment of male infertility - an overview of current methods.","authors":"Marek Broul, Aneta Hujová, Michaela Liegertová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Male infertility is a multifactorial condition influenced by hormonal, anatomical, genetic, and lifestyle factors. Although the male factor contributes to up to 40% of infertility cases, the exact etiology often remains unknown (so-called idiopathic infertility). Current diagnostic approaches include detailed clinical evaluation, semen analysis, hormonal assessment, genetic testing, and imaging techniques. Significant progress has been achieved in sperm DNA fragmentation testing and oxidative stress evaluation, offering a broader insight into sperm quality. Treatment strategies vary depending on the underlying cause, ranging from pharmacological therapy and surgical interventions to assisted reproductive technologies. Rapid advances in regenerative medicine and gene therapy show promise for novel therapeutic options. A healthy lifestyle and risk factor management are integral to both prevention and treatment.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 2","pages":"43-49"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of the regulation of surrogacy from the point of view of civil, medical and criminal law. 从民法、医学和刑法的角度对代孕进行监管的重要性。
Casopis lekaru ceskych Pub Date : 2025-01-01
Lenka Teska Arnoštová, Jana Tlapák Navrátilová, Ingrid Galovcová
{"title":"The importance of the regulation of surrogacy from the point of view of civil, medical and criminal law.","authors":"Lenka Teska Arnoštová, Jana Tlapák Navrátilová, Ingrid Galovcová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Surrogate motherhood is one of the possible procedures to become a parent, However, it is not legally regulated. Practice shows that there are several problematic or controversial aspects that should be regulated in the interest of all participants, but especially the well-being of the child. The legislation should mainly concern the altruistic principle, the medical indications of the intended and surrogate mother, their medical examinations and approval by the court.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 2","pages":"50-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amiodarone-induced thyreopaties. Amiodarone-induced thyreopaties。
Casopis lekaru ceskych Pub Date : 2025-01-01
Adela Krausová
{"title":"Amiodarone-induced thyreopaties.","authors":"Adela Krausová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Amiodarone-induced thyroid dysfunction represents a serious complication of treatment with amiodarone, a frequently used potent antiarrhythmic drug. In clinical practice, there are two main forms: hypothyroidism and hyperthyroidism. Amiodarone-induced thyrotoxicosis is further divided into type 1 and type 2 with different pathogenesis, diagnostic findings and, most importantly for the patient, therapeutic approach. Due to frequent diagnostic overlap, a mixed form of amiodarone-induced thyrotoxicosis is also recognized, requiring a combination of both distinct treatment strategies, antithyroid drugs and glucocorticoids. Amiodarone-induced type 1 thyrotoxicosis necessitates prospective discontinuation of amiodarone therapy; in type 2 this step is usually not warranted. In hypothyroidism, substitution therapy with levothyroxine is sufficient without the need to stop antiarrhythmic treatment with amiodarone. Amiodarone-induced thyrotoxicosis may significantly increase the incidence of cardiovascular complications. If amiodarone treatment is discontinued solely for cardiological indications, patients without a history of thyroid disease usually experience restoration of normal thyroid function. However, in predisposed individuals, dysfunction may persist or recur following repeated iodine exposure.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 3","pages":"94-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How hematology has developed and where it is headed in Hradec Králové. 血液学是如何发展的以及它在Hradec的发展方向Králové。
Casopis lekaru ceskych Pub Date : 2025-01-01
Pavel Žák, Lukáš Smolej, Jaroslav Malý
{"title":"How hematology has developed and where it is headed in Hradec Králové.","authors":"Pavel Žák, Lukáš Smolej, Jaroslav Malý","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 5","pages":"205-212"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145502105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinic of Pediatric Surgery and Traumatology. 儿科外科与创伤科门诊。
Casopis lekaru ceskych Pub Date : 2025-01-01
Radek Štichhauer
{"title":"Clinic of Pediatric Surgery and Traumatology.","authors":"Radek Štichhauer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 5","pages":"223-226"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145502137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient blood management - past, present and future. 病人血液管理-过去，现在和未来。
Casopis lekaru ceskych Pub Date : 2025-01-01
Josip Slipac
{"title":"Patient blood management - past, present and future.","authors":"Josip Slipac","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Patient blood management (PBM) is a patient-centered, systematic, evidence-based, multidisciplinary, and multimodal approach to improve patient outcomes by managing and preserving the patient's own blood. The history of PBM dates back to the 19th century, while modern practice has been shaped by programs such as Dr. Denton Cooley's \"bloodless surgery\". Despite advances in transfusion medicine, the safety risks and side effects of transfusion have driven the development of PBM. Today, this program includes optimizing hematopoiesis, reducing blood loss, and improving the tolerance of anemia. PBM improves clinical outcomes and patient safety, and the World Health Organization recommends implementing this program in all countries of the world as a standard of care.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 1","pages":"32-34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classification of diabetic foot disease cases using Czech DRG system. 捷克DRG系统在糖尿病足病例分类中的应用。
Casopis lekaru ceskych Pub Date : 2025-01-01
Vladimíra Fejfarová, Pavlína Piťhová, Miroslav Koliba, Alexandra Jirkovská, Jarmila Jirkovská, Hana Kůsová, Miroslav Drienko, Irena Molinari, Miroslav Zvolský
{"title":"Classification of diabetic foot disease cases using Czech DRG system.","authors":"Vladimíra Fejfarová, Pavlína Piťhová, Miroslav Koliba, Alexandra Jirkovská, Jarmila Jirkovská, Hana Kůsová, Miroslav Drienko, Irena Molinari, Miroslav Zvolský","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The implementation of the DRG system into real podiatric practice presupposes the application and adherence to the rules for reporting hospitalizations related to diabetic foot syndrome. The reason is both the cultivation of reimbursements for relatively economically demanding hospitalizations of patients with this late complication and the availability of data providing a national overview of the development and prognosis of patients with diabetic foot syndrome in real-time.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 4","pages":"156-160"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
47th conference of the International Society of Oncology and Biomarkers - ISOBM: A new era of biomarkers in oncology. 第47届国际肿瘤和生物标志物学会会议- ISOBM：肿瘤生物标志物的新时代。
Casopis lekaru ceskych Pub Date : 2025-01-01
Judita Kinkorová, Ondřej Topolčan
{"title":"47th conference of the International Society of Oncology and Biomarkers - ISOBM: A new era of biomarkers in oncology.","authors":"Judita Kinkorová, Ondřej Topolčan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>From October 12-16, 2025, the 47th annual International Society of Oncology and Biomarkers (ISOBM) conference was held in Murnau, Bavaria, under the subtitle \"New Era of Biomarkers in Oncology\". The focus of the conference was the integration of modern technologies in oncology, including biomarker research, molecular diagnostics, and artificial intelligence applications in cancer care. The event welcomed more than 300 participants, 38 exhibitors, and 7 corporate partners from a total of 27 countries. The rich program featured presentations across 17 sessions, panel discussions, 12 workshops, and over 70 posters. The conference thus provided a multidisciplinary platform bringing together laboratory medicine, pathology, molecular biology, clinical oncology, and specialists in data processing and artificial intelligence.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 7-8","pages":"361-363"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence in biobanking: current situation and future perspectives. 人工智能在生物银行中的应用：现状与未来展望
Casopis lekaru ceskych Pub Date : 2025-01-01
Judita Kinkorová
{"title":"Artificial intelligence in biobanking: current situation and future perspectives.","authors":"Judita Kinkorová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Biobanks are essential infrastructures for biomedical research and personalized medicine. The exponential growth of heterogeneous data from various sources (genomics, imaging, electronic health records, environmental data) creates opportunities for artificial intelligence (AI) applications to improve data management, biomarker discovery, laboratory automation, and sample accessibility. This article reviews current trends, technical and ethical challenges, GDPR-related considerations, the role of FAIR (findable, accessible, interoperable, reusable) data principles and federated learning, the importance of explainable AI, and implications for the Czech healthcare system. Practical recommendations for safe and sustainable AI integration into biobanks are provided.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 7-8","pages":"328-332"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Change in the prevalence of overweight, obesity and severe obesity in seven-year-old children between 2019-2023 - project COSI. 2019-2023年期间7岁儿童超重、肥胖和严重肥胖患病率的变化——COSI项目
Casopis lekaru ceskych Pub Date : 2025-01-01
Tereza Metelcová, Tereza Svobodová, Marie Kunešová, Radka Taxová Braunerová, Markéta Vaňková
{"title":"Change in the prevalence of overweight, obesity and severe obesity in seven-year-old children between 2019-2023 - project COSI.","authors":"Tereza Metelcová, Tereza Svobodová, Marie Kunešová, Radka Taxová Braunerová, Markéta Vaňková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study is part of the World Health Organization's European initiative to monitor trends in overweight and obesity in children. Children have been monitored every two years using a consistent protocol since 2008. The COVID-19 pandemic (2019-2021) and related restrictions significantly altered daily life, including that of children. We compared the prevalence of overweight in seven-year-olds from the 5th monitoring period (Jan-Dec 2019) and the 6th period (Nov 2022-Mar 2024) to assess the impact of pandemic-related restrictions. Results showed no significant change in overall overweight or obesity prevalence between the two periods. In the 6th monitoring, 5.7% of boys and 6% of girls had overweight; 7.5% of boys and 7.3% of girls had obesity. Severe obesity was relatively high (3.8% for both sexes) but not significantly different from 2019. Abdominal obesity, indicated by a risk waist-to-height ratio, was found in 12.9% of boys and 12.2% of girls - also unchanged from the earlier monitoring. Overall, two years after lifting COVID-19 restrictions, overweight prevalence in 7-year-olds remained like pre-pandemic levels. However, the persistent prevalence of severe obesity is concerning and highlights the need for continued public health efforts.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"164 6","pages":"247-251"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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