{"title":"Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma.","authors":"Yasuo Otsuka, Yoriaki Komeda, Masayuki Takeda, Takayuki Takahama, Masashi Kono, Mamoru Takenaka, Satoru Hagiwara, Naoshi Nishida, Hiroshi Kashida, Masatoshi Kudo","doi":"10.1155/2023/2092157","DOIUrl":"https://doi.org/10.1155/2023/2092157","url":null,"abstract":"<p><p>A 76-year-old woman presented with lower abdominal pain and nausea and was referred to the gastroenterology department in our institution. Previous contrast-enhanced computed tomography (CE-CT) for follow-up after breast cancer surgery had indicated a soft tissue mass below the right diaphragm, which was considered a benign change. CE-CT performed at the first visit to our department revealed further thickening of the soft tissue mass with extension to the liver surface. In addition, ascites and nodules were observed in the abdominal cavity. Histopathological examination of a biopsy specimen revealed peritoneal invasion of atypical epithelioid cells with trabecular and glandular patterns. The tumor cells were positive for AE1/AE2, calretinin, WT-1, D2-40, HEG1, EMA, BAP1, and MTAP and negative for carcinoembryonic antigen, MOC-31, Ber-Ep4, ER, PgR, TTF-1, claudin 4, and desmin. A diagnosis of epithelioid mesothelioma was made. The patient received chemotherapy with cisplatin (75 mg/m<sup>2</sup>) and pemetrexed (500 mg/m<sup>2</sup>). After six courses of combined chemotherapy, pemetrexed was administered as a single agent. At the time of writing this report, she was undergoing over the 30th course of chemotherapy without any significant side effects. Diffuse malignant peritoneal mesothelioma is a rare, fatal, and progressive disease. Our patient achieved long-term survival of more than 5 years with maintenance therapy using single-agent pemetrexed.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2023 ","pages":"2092157"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9093581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Teressa, Asep Purnama, Joshua Henrina, Agustinus Wiraatmadja, Angela M B Boro, Candida I L Sam, Tersila A D Dedang, Alius Cahyadi
{"title":"Severe Malaria in an Adult Patient from Low-Endemic Area in Flores Island, East Nusa Tenggara.","authors":"Maria Teressa, Asep Purnama, Joshua Henrina, Agustinus Wiraatmadja, Angela M B Boro, Candida I L Sam, Tersila A D Dedang, Alius Cahyadi","doi":"10.1155/2023/1239318","DOIUrl":"https://doi.org/10.1155/2023/1239318","url":null,"abstract":"<p><p>Malaria is an infection caused by protozoa of the genus <i>Plasmodium</i>, commonly found in tropical and subtropical regions worldwide. <i>Plasmodium falciparum</i> causes the most severe form of the disease and may progress to life-threatening manifestations. This case describes a 26-year-old man who suffered cerebral malaria with multiple organ dysfunction and successfully recovered despite poor initial prognosis. Negligent and late diagnosis of malaria leads to severe complications and a worse prognosis. This case emphasizes despite living in a low-endemic malaria area, physicians should remain meticulous and consider malaria as differential diagnosis even after initially presenting with nonspecific symptoms. Consequently, malarial screening should be performed to modify the risk of mortality. Furthermore, close monitoring and early administration of intravenous artesunate are also particularly critical.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2023 ","pages":"1239318"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10826689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gross Hematuria following SARS-CoV-2 Vaccination.","authors":"Maryam Sattari, Jourdan Mckinnis, Amir Kazory","doi":"10.1155/2023/1225510","DOIUrl":"https://doi.org/10.1155/2023/1225510","url":null,"abstract":"<p><p>In the setting of the rapid development of currently available vaccines for coronavirus disease of 2019 (COVID-19), little is known about their less frequent potential side effects. Raising the awareness of clinicians and front-line healthcare workers about the less well-known potential side effects of vaccination is important. We describe the self-limited occurrence of gross hematuria in two elderly men on a combination of aspirin and another antiplatelet or anticoagulant following their second dose of the Moderna COVID-19 vaccination. While the bleeding seems to be self-limited, the long-term course currently remains elusive.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2023 ","pages":"1225510"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9456324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Case Reports in MedicinePub Date : 2022-11-23eCollection Date: 2022-01-01DOI: 10.1155/2022/5925839
Sami Nabhani, Eric Cheysson, Pamela Sabbah, Georges Baaklini
{"title":"Endovascular Management of a Deep Femoral Artery Perforating Branch Pseudoaneurysm after Total Hip Arthroplasty: A Case Study.","authors":"Sami Nabhani, Eric Cheysson, Pamela Sabbah, Georges Baaklini","doi":"10.1155/2022/5925839","DOIUrl":"https://doi.org/10.1155/2022/5925839","url":null,"abstract":"<p><p>Pseudoaneurysm of the profundal femoris artery (PFA) following total hip arthroplasty (THA) is a rare and unusual complication. Awareness of this complication and a high level of suspicion allow early diagnosis and treatment, thereby reducing the morbidity of this condition. We present a case of a pseudoaneurysm of a perforating branch of the PFA after revision THA which was treated successfully by selective coil embolization.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":" ","pages":"5925839"},"PeriodicalIF":0.8,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35209449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Case Reports in MedicinePub Date : 2022-11-16eCollection Date: 2022-01-01DOI: 10.1155/2022/8215335
Iris S Harrison, Kiran Lukose, Bhagwan Dass, Nila S Radhakrishnan
{"title":"Cutaneous Larvae Migrans Treated with a Single Dose of Ivermectin.","authors":"Iris S Harrison, Kiran Lukose, Bhagwan Dass, Nila S Radhakrishnan","doi":"10.1155/2022/8215335","DOIUrl":"https://doi.org/10.1155/2022/8215335","url":null,"abstract":"<p><p>Hookworm-related cutaneous larva migrans (HrCLM) is a clinical diagnosis based on a history of exposure to contaminated soil and is associated with a characteristic red serpiginous lesion that migrates within the <i>epidermis</i>. Our patient presented with a red, tortuous migratory rash with localized pruritus on the left plantar foot of 1-month duration. He lacked recent travel history outside the southeastern United States. Upon admission, he presented with peripheral blood eosinophilia, an uncommon feature of HrCLM. A single dose of ivermectin was sufficient for treatment, and symptoms resolved within 3 days. This case highlights the increased incidence of domestically acquired hookworm infections, explores this epidemiological shift, and emphasizes relevant differential diagnoses.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":" ","pages":"8215335"},"PeriodicalIF":0.8,"publicationDate":"2022-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40707966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Case Reports in MedicinePub Date : 2022-11-14eCollection Date: 2022-01-01DOI: 10.1155/2022/2032525
Apurva Vedire, Gautham Upadrasta, Ndausung Udongwo, Faseeha Rehman, Mohammad A Hossain
{"title":"Triple Jeopardy: Rapidly Progressive Glomerulonephritis Induced by Triple Seropositive Disease-A Rare Case.","authors":"Apurva Vedire, Gautham Upadrasta, Ndausung Udongwo, Faseeha Rehman, Mohammad A Hossain","doi":"10.1155/2022/2032525","DOIUrl":"https://doi.org/10.1155/2022/2032525","url":null,"abstract":"<p><p>The double-positive disease is the co-occurrence of antiglomerular basement membrane (anti-GBM) disease and antineutrophil cytoplasmic antibodies (ANCAs) and is an uncommon cause of renal failure. Our case of triple-positive disease is an even rarer cause of isolated renal failure, as it includes anti-GBM, antimyeloperoxidase (MPO), and antiproteinase 3 (PR3). We present a case of a 62-year-old Caucasian male with a history of multiple comorbidities, who presented to the emergency department (ED) with worsening dyspnea on exertion that started about one month prior to admission. He was found to be in renal failure secondary to triple-positive disease. We believe that the likely mechanism of our patient's triple-positive disease was a drug-induced ANCA vasculitis overlapping with Goodpasture's syndrome. We believe our case to be a valuable addition to the literature as it is a rare overlap syndrome without a previously established disease course or etiology.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":" ","pages":"2032525"},"PeriodicalIF":0.8,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40507995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Case Reports in MedicinePub Date : 2022-10-20eCollection Date: 2022-01-01DOI: 10.1155/2022/1513474
Kanhai Lalani, M Sudhakar Rao, Padmakumar Ramachandran, A J Ashwal, Abdul U K Razak, Tom Devasia, Ganesh Paramasivam, Pankti Parikh
{"title":"Single Coronary Artery from Right Sinus of Valsalva: A Single Center Experience of Seven Cases.","authors":"Kanhai Lalani, M Sudhakar Rao, Padmakumar Ramachandran, A J Ashwal, Abdul U K Razak, Tom Devasia, Ganesh Paramasivam, Pankti Parikh","doi":"10.1155/2022/1513474","DOIUrl":"https://doi.org/10.1155/2022/1513474","url":null,"abstract":"<p><strong>Background: </strong>Single coronary artery (SCA) is a rare anomaly with a prevalence of 0.024-0.066%. Some anomalies are merely benign anatomical variants, whereas some can result in myocardial ischemia or life-threatening arrhythmia. <i>Case Presentation</i>. We described seven cases in which all three major coronaries emerged from the right sinus of Valsalva via a single ostium and supplied the vast majority of the myocardium. A smaller branch arising from the left sinus supplied a modest quantity of myocardium in some of those few cases. These SCA variations do not exactly fit into any existing classification. It is unclear whether we need to modify previous classification systems or newer classification systems.</p><p><strong>Conclusions: </strong>SCA is divided based on its anomalous course and is usually a benign condition but it may present with cardiovascular complications. Clinicians should be aware of this entity along with the role of CT angiogram in its diagnosis and management.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":" ","pages":"1513474"},"PeriodicalIF":0.8,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40655870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Case Reports in MedicinePub Date : 2022-10-18eCollection Date: 2022-01-01DOI: 10.1155/2022/9365947
Mateo Zuluaga-Gómez, Daniela Giraldo-Campillo, Daniel González-Arroyave, Carlos M Ardila
{"title":"Ischemic Stroke Secondary to a Stab Wound to the Neck in a Young Adult.","authors":"Mateo Zuluaga-Gómez, Daniela Giraldo-Campillo, Daniel González-Arroyave, Carlos M Ardila","doi":"10.1155/2022/9365947","DOIUrl":"https://doi.org/10.1155/2022/9365947","url":null,"abstract":"<p><p>Vertebral artery dissection is a common cause of stroke in young adults without predisposing risk factors for cerebrovascular disease. We describe the case of a 28-year-old patient who presented with an ischemic stroke secondary to a stab wound to the neck that affected the vertebral artery. A physical examination revealed neurological deterioration (Glasgow 8/15), a sutured neck wound, no palpable hematoma, no thrills, and no active bleeding. A computed tomography angiography revealed a left vertebral artery arteriovenous fistula with a component of a pseudoaneurysm, for which a neurointerventional consultation was carried out. Due to neurological compromise, the airway was secured, and because the case involved a posterior fossa infarction with compression of the fourth ventricle and obstructive secondary hydrocephalus, an external ventricular shunt was inserted by neurosurgery. A fistula occlusion was performed with five Axium coils and a vial of Squid 12; the vertebral artery was catheterized, and a craniotomy was performed to manage hydrocephalus with a 12-mm H<sub>2</sub>O collecting system. The patient was discharged on the tenth day after admission with sequelae of left hemiparesis (predominantly brachial) and no other deficits. There was no hemorrhagic transformation on the control computed tomography scans and no further complications.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":" ","pages":"9365947"},"PeriodicalIF":0.8,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40651845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Case Reports in MedicinePub Date : 2022-10-14eCollection Date: 2022-01-01DOI: 10.1155/2022/4655804
José C Alvarez-Payares, Daniel Ribero, Luis Rodríguez, Carlos E Builes, Carolina Prieto, Clara Arango, Juan G Gamboa, Cristian Alvarez-Payares
{"title":"Late Systemic Lupus Erythematosus-Associated Insulin Resistance Syndrome: A Rare Cause of De Novo Diabetes Mellitus.","authors":"José C Alvarez-Payares, Daniel Ribero, Luis Rodríguez, Carlos E Builes, Carolina Prieto, Clara Arango, Juan G Gamboa, Cristian Alvarez-Payares","doi":"10.1155/2022/4655804","DOIUrl":"https://doi.org/10.1155/2022/4655804","url":null,"abstract":"<p><p>The association of type B insulin resistance syndrome (TBIRS) due to autoimmune diseases such as systemic lupus erythematosus (SLE) is uncommon. This is partly due to the lack of established criteria for the diagnosis of this resistance. However, some clinical aspects may suggest that the diagnosis does not necessarily have to be positive insulin receptor antibodies as such patients could respond to immunosuppressive treatment. <i>Methods</i>. We describe a case and have performed a literature review on PubMed/MEDLINE, EMBASE, and Google Scholar bibliographic databases to identify all case reports. All available studies from January 1975 through December 2020 were included. Data collected were tabulated, and outcomes were analyzed cumulatively. <i>Results</i>. Thirty-one cases of TBIRS associated with SLE have been described. These patients presented with catabolic symptoms and hyperglycemia in most cases, with an average time from the onset of symptoms of four months. In addition to that clinical characteristics related to SLE were variable, along with certain common characteristics such as acanthosis in 60% of patients. Almost all the patients had antibodies against insulin receptors. The insulin doses required by the patients ranged from 450 to 25,000 U daily. Remission was achieved in 80% of the patients with a two-year follow-up. Most patients associated with late-onset SLE, like our patient, achieved metabolic control after immunosuppressive treatment. <i>Conclusion</i>. High insulin resistance in patients with de novo diabetes mellitus (DM) without obesity should be considered as a possible clinical manifestation of an autoimmune disease such as SLE, with a good metabolic response to the immunosuppressive management established.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":" ","pages":"4655804"},"PeriodicalIF":0.8,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40654048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Case Reports in MedicinePub Date : 2022-10-05eCollection Date: 2022-01-01DOI: 10.1155/2022/4591024
Victoria Giglio, Zain Badar, Yasovineeth Bhogadi, Brian Van Adel, Gordon Yip
{"title":"Aortosternal Venous Compression: A Review of Two Cases.","authors":"Victoria Giglio, Zain Badar, Yasovineeth Bhogadi, Brian Van Adel, Gordon Yip","doi":"10.1155/2022/4591024","DOIUrl":"https://doi.org/10.1155/2022/4591024","url":null,"abstract":"<p><p>Aortosternal venous compression (AVC) is a rare venous compression syndrome that involves brachiocephalic venous compression due to its positioning between the sternum and the aorta. One of the features of AVC involves compression of the left innominate vein with variability in luminal caliber on inspiration and expiration. Imaging modalities such as computed tomography (CT) examination can aid in initial diagnosis; however, venography can be utilized for confirmatory diagnosis due to its higher specificity during the inspiratory and expiratory phases. Through findings demonstrated during venography, we herein present two cases of confirmed AVC secondary to an aberrant right subclavian artery. Characteristic imaging features in the diagnosis of AVC and its etiology are discussed.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":" ","pages":"4591024"},"PeriodicalIF":0.8,"publicationDate":"2022-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33514866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}