Case Reports in Medicine最新文献

{"title":"Anaplastic Thyroid Carcinoma With Predominant Intrathoracic Progression: A Case Report.","authors":"Soichiro Ueda, Jin Kagatani, Yuriko Nakamura, Yu Asami, Shingo Tsuruoka, Natsumi Yazaki, Mamoru Sasaki","doi":"10.1155/carm/2164998","DOIUrl":"10.1155/carm/2164998","url":null,"abstract":"<p><p>While most thyroid cancers have a favorable prognosis, anaplastic thyroid carcinoma (ATC) is highly aggressive and results in a poor prognosis. ATC frequently arises from preexisting benign goiters or highly differentiated thyroid cancers, typically presenting with rapidly progressing local symptoms and often accompanied by distant metastasis. We report a case of ATC that rapidly progressed to intrapulmonary metastases and malignant pleural effusion. Despite a previous histological diagnosis of benign goiter and the absence of local symptoms at the final presentation, the patient died just 20 days after the onset of symptoms. In patients with thyroid tumors accompanied by rapid progression of intrathoracic lesions, ATC must be considered as a differential diagnosis, even if they were previously diagnosed with a benign goiter.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"2164998"},"PeriodicalIF":1.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ceftriaxone-Associated Cholelithiasis in a Premature Toddler From Ethiopia: A Case Report.","authors":"Kaleb Assefa Berhane, Selamawit Tesfaye, Meron Zeleke, Adu Dufera Moti, Dawit Taye Endalew, Lela Alemayehu Gebeyehu, Amanuel Getu Gebreselassie","doi":"10.1155/carm/6644319","DOIUrl":"10.1155/carm/6644319","url":null,"abstract":"<p><p>Ceftriaxone-associated cholelithiasis is an uncommon but well-recognized adverse effect in pediatric patients, resulting from precipitation of ceftriaxone-calcium complexes within bile. Although often asymptomatic and transient, its radiologic appearance may mimic true gallstones and lead to unnecessary surgical intervention. We report a 2-year-old male child, born prematurely at 34 weeks of gestation, who was incidentally diagnosed with gallbladder stones during follow-up evaluation after multiple hospital admissions for dehydration and presumed infections treated with high-dose intravenous ceftriaxone. The child was asymptomatic for biliary disease, with normal physical examination and laboratory findings. Abdominal ultrasonography demonstrated multiple mobile echogenic foci with posterior acoustic shadowing, the largest measuring 1.1 cm, without evidence of inflammation or biliary obstruction. Given the absence of symptoms and identifiable hemolytic or metabolic disorders, conservative management with close follow-up was adopted. Repeat ultrasonography after 12 weeks showed complete spontaneous resolution of the gallstones. This case highlights the importance of recognizing ceftriaxone-associated cholelithiasis in young children to help avoid unnecessary surgical intervention in appropriately selected asymptomatic patients through appropriate conservative management.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"6644319"},"PeriodicalIF":1.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Sarcoidosis With Chronic Massive Splenomegaly and Renal Involvement: A Case Report.","authors":"Golnaz Mobayen, Amirataollah Hiradfar, Azar Dastranji, Masoud Lahouty","doi":"10.1155/carm/1828310","DOIUrl":"10.1155/carm/1828310","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic sarcoidosis is a rare multisystem rheumatologic disorder that is diagnosed after ruling out other granulomatous diseases. Clinical manifestations and treatment in these pediatric patients are also a challenge. Treatment is typically based on corticosteroids and cytotoxic agents; however, no organ-specific treatment currently exists. Recent studies have demonstrated the effectiveness of anti-TNF drugs in treating pulmonary and extrapulmonary sarcoidosis.</p><p><strong>Case presentation: </strong>We report the case of a 16-year-old boy who, since the age of 12, presented with cytopenia, constitutional symptoms, and abdominal pain without a definitive diagnosis. At Age 16, he developed massive splenomegaly with lung and renal involvement. A diagnosis of systemic sarcoidosis was confirmed via a spleen biopsy. He was treated with infliximab in combination with corticosteroids and a cytotoxic agent.</p><p><strong>Conclusion: </strong>This report emphasizes the importance of diagnosing sarcoidosis based on rare and nonspecific signs and symptoms and treatment choices. Early diagnosis of this disease can lead to more effective treatment and prevent multiple organ involvement. Although there is not any organ-specific treatment for systemic sarcoidosis in children, with just a few reports of effectiveness of infliximab in kidney involvement, we decided to treat our case with infliximab because of corticosteroid and cytotoxic failure. This treatment may show that infliximab plays a key role in treating corticosteroid-resistant sarcoidosis that affects certain organs, like the kidneys, or in reducing the side effects of corticosteroid drugs.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"1828310"},"PeriodicalIF":1.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Thromboembolism in a Patient With Behçet's Disease: A Case Report.","authors":"Elham Kalantari, Mohammad Emami Ardestani","doi":"10.1155/carm/8323943","DOIUrl":"10.1155/carm/8323943","url":null,"abstract":"<p><p>Behçet's disease (BD) is a rare, chronic, and multisystemic vasculitis characterized by recurrent oral and genital ulcers, uveitis, and skin lesions. Although vascular involvement is common in BD, pulmonary manifestations are rare and potentially fatal. Among these, pulmonary thromboembolism (PTE) represents an exceptional event, as deep vein thrombosis (DVT) in BD usually remains adherent to the vessel wall and seldom embolizes to the lungs. We report a 52-year-old male with BD who presented with a four-day history of progressive dyspnea, productive cough, and new-onset hemoptysis. He had been in clinical remission for one year after discontinuing colchicine therapy. On admission, his oxygen saturation was 90% on room air, with inspiratory crackles on auscultation. Laboratory findings revealed leukocytosis, elevated inflammatory markers, and a markedly increased D-dimer level. CT pulmonary angiography demonstrated multiple filling defects in the right main and segmental pulmonary arteries without evidence of pulmonary artery aneurysm (PAA). Anticoagulation with heparin was initiated. However, during hospitalization, the patient developed oral and genital aphthous ulcers, indicating disease relapse. Immunosuppressive therapy with cyclophosphamide and prednisolone led to significant clinical improvement. This case underscores the importance of maintaining a high index of suspicion for PTE in BD and highlights the necessity of distinguishing BD-related thrombosis from conventional embolic events, as management requires a combination of immunosuppressive and anticoagulant therapy to prevent fatal complications.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"8323943"},"PeriodicalIF":1.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Treatment of Saccular Extracranial Carotid Artery Aneurysm.","authors":"Henrique Salles Barbosa, Renata Salles Barbosa, Aline Cristina Pavani, Renata Sydio de Souza, Marina Tambasco Freire Vicente, Mariana Fernandes Carvalho","doi":"10.1155/carm/4459572","DOIUrl":"10.1155/carm/4459572","url":null,"abstract":"<p><p>Extracranial carotid artery aneurysms (ECAAs) are an increase of 50% or more in the diameter of the carotid artery and classified by location. They are rare and most are located in the internal carotid artery or carotid bifurcation. Diagnosis is incidental or by the presentation of a pulsatile neck mass or neurological symptoms. There are no universal recommendations regarding its treatment. Male, 72 years old, with a pulsatile cervical mass on the left. No history of previous trauma. Angioresonance and angiography identified a saccular aneurysm in the carotid bulb, measuring 1 × 0.7 cm. Referred for open surgical treatment, which was performed under general anesthesia and by longitudinal anterior cervicotomy, endoaneurysmorrhaphy, and bovine pericardium patch. There was an uneventful postoperative recovery and hospital discharge on the 3rd postoperative day. ECAAs represent between 0.4% and 1.9% of all peripheral aneurysms. They are more prevalent in men, with an average age at diagnosis of 53 ± 17 years. They can be divided into fusiform or saccular. The most common etiology of ECAA is atherosclerosis (50% of cases). ECAAs can be classified according to Attigah into Types I to V, based on the segment involved. Half of the patients with ECAAs have symptoms at diagnosis. Presentation may include a pulsatile neck mass, cervical discomfort, headache, stroke, or neurological deficits. Although rare, rupture can occur. The indication for correction of ECAAs is based on the risk of cerebral ischemia. Duplex ultrasound is the first option for diagnosis. Angiotomography, angioresonance, and angiography are options as confirmatory examinations. The techniques for repairing ECAAs are endovascular, hybrid or open: stents, embolization, or correction by arterial resection and reconstruction or patch. ECAAs are rare and have potential complications due to cerebral thromboembolism. ECAA repair is possible through open or endovascular techniques.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"4459572"},"PeriodicalIF":1.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Malrotation Through Acute Obstructive Abdomen in an Adolescent From Northeastern Brazil: A Case Report.","authors":"Daniel Vieira de Oliveira, Pedro Melo Toledo Nascimento, Rita de Cassia Almeida Vieira","doi":"10.1155/carm/5628089","DOIUrl":"10.1155/carm/5628089","url":null,"abstract":"<p><p>Intestinal malrotation is a congenital anomaly of the midgut resulting from abnormal embryonic rotation. Although predominantly a neonatal diagnosis, it is an extremely rare, isolated finding in adolescents, often presenting with nonspecific symptoms that lead to diagnostic delays and increased morbidity. We report a 17-year-old male presenting with acute abdominal pain, distension, and vomiting. Diagnosis was established via contrast-enhanced computed tomography (CT), which identified spiral rotation of mesenteric vessels and colonic displacement. The patient initially underwent a laparoscopic Ladd's procedure; however, postoperative complications involving duodenal stenosis and recurrent obstruction required a conversion to a Billroth II gastrojejunostomy with a Braun anastomosis. This case highlights that while the Ladd's procedure remains the surgical standard, the management of malrotation in older patients presents unique challenges compared to neonates. Unlike pediatric cases often associated with other malformations, adolescent presentation is typically isolated and insidious, making contrast-enhanced CT essential for identifying the \"whirlpool sign\" and avoiding misdiagnosis. Furthermore, this report underscores that chronic inflammation or recurrence in adults may demand surgical strategies beyond the standard procedure. In complex scenarios with recurrent obstruction, reconstructive techniques such as the Billroth II gastrojejunostomy with Braun anastomosis or Roux-en-Y gastric bypass are effective alternatives to prevent alkaline gastritis and ensure long-term symptom resolution.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"5628089"},"PeriodicalIF":1.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Chlorhexidine-Induced Oral Allergic Reaction: A Case Report.","authors":"Matteo Zotti, Katia Rupel, Marina Diolosà, Giulia Ottaviani","doi":"10.1155/carm/2841092","DOIUrl":"10.1155/carm/2841092","url":null,"abstract":"<p><p>This case report describes a rare episode of allergic reaction to the topical application of chlorhexidine gel. The patient, following the prescription from her private dentist, presented to the dental emergency unit, referring to the onset of an increasing swelling of the upper lip a few hours after the application of chlorhexidine gel. After the exclusion of a possible infective process starting from the maxillary incisors, the patient was prescribed prednisone and exhibited a quick remission of the swelling. This report aims to emphasize the importance of a correct differential diagnosis to warrant an optimal therapeutic approach to the patient, since swellings of the upper lip could be related to different conditions.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"2841092"},"PeriodicalIF":1.0,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid Web as a Rare Cause of Stroke: A Case Report.","authors":"Jovana Ivanovic, Tamara Svabic Medjedovic, Dragoslav Nestorovic, Ivan Vukasinovic, Vladimir Cvetic, Marko Dragas, Dejana Jovanovic, Predrag Stanarcevic","doi":"10.1155/carm/6341586","DOIUrl":"10.1155/carm/6341586","url":null,"abstract":"<p><p>A carotid web is a rare, focal vascular malformation at the posterior wall of the carotid bulb, which can be associated with acute ischemic stroke, especially in young patients. Also, a carotid web is associated with a high risk of stroke recurrence, despite optimal antithrombotic therapy. Our patient is a 41-year-old, previously healthy female, with a symptomatic carotid web on the right carotid artery, which led to acute embolic ischemic lesions in the right insular and frontal juxtacortical regions. She had recurrent episodes of mild left-sided hemiparesis and dysarthria, with complete spontaneous recovery. Extensive diagnostic procedures did not confirm any other cause of stroke except a symptomatic carotid web. She underwent stent placement, with no new vascular events, a normal neurological examination, and maintaining stent patency 1 year after the stroke onset. A carotid web is an important cause of stroke in young patients, potentially preventable by endovascular stent placement, alongside the best medical treatment.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"6341586"},"PeriodicalIF":1.0,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Diagnosis and Management of Bilateral Plunging Ranula.","authors":"Bo-Wen Liu, Hai-Xiao Zou","doi":"10.1155/carm/8833631","DOIUrl":"10.1155/carm/8833631","url":null,"abstract":"<p><p>Ranula is a benign salivary gland lesion originating from the sublingual salivary gland. This condition is primarily associated with salivary extravasation and retention due to obstruction or injury of the submandibular duct. A plunging ranula represents a rare variant occurring in the neck, submandibular, or submental regions, with bilateral presentations being particularly uncommon. Clinically, due to its lack of specificity, it is easily confused with other cervical lesions. This paper reports a case of a 25-year-old female presenting with bilateral painless submandibular masses. MRI revealed the characteristic bilateral \"drooping tail sign\". Following bilateral sublingual gland and cyst excision, the patient recovered well postoperatively with no immediate complications. At the two-month follow-up, no recurrence was observed, and symptoms were completely resolved. This paper aims to summarize the imaging features of bilateral plunging ranula and enhance clinical capacity for the differential diagnosis of this rare condition.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"8833631"},"PeriodicalIF":1.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthetic Management for Headscarf Pin Tracheobronchial Foreign Body Removal in a Pediatric Patient.","authors":"Amadou Diaw Diop, Faboye Ndoumbe Mathilde Diop, Alpha Diallo, Lijun Chen, Wenqing Zhang","doi":"10.1155/carm/4664553","DOIUrl":"10.1155/carm/4664553","url":null,"abstract":"<p><p>Foreign bodies in the airways are relatively common in preschool- and school-aged children. We report a rare case of the successful removal of a sharp metallic foreign body from the bronchus of a 12-year-old boy under combined inhalational and intravenous anesthesia without tracheal intubation. This report emphasizes the perioperative anesthetic strategies for foreign object removal. The patient presented with sudden-onset choking and hemoptysis. Chest computed tomography revealed a linear metallic foreign body measuring approximately 5 cm long in the left main bronchus. The foreign body was removed via rigid bronchoscopy under deep sedation maintained by a combination of inhalational and intravenous anesthesia while preserving spontaneous respiration. Intraoperative ventilation was controlled intermittently to ensure adequate oxygenation. Based on recent studies, we discuss key anesthetic considerations and risk-mitigation strategies for managing sharp bronchial foreign bodies in pediatric patients. This case highlights the importance of maintaining spontaneous respiration during bronchoscopy and tailoring anesthetic approaches to ensure safe outcomes, despite limited access to advanced airway technologies.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2026 ","pages":"4664553"},"PeriodicalIF":1.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}