Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献

{"title":"Posterior capsule rupture during cataract surgery: analysis of visual outcomes and associated risk factors.","authors":"Wenjun Song, Jeremy Y W Hu, Jarryl H J Tsai, Chun Hau Chua, Bryan C H Ang, David Law","doi":"10.1016/j.jcjo.2026.08.011","DOIUrl":"10.1016/j.jcjo.2026.08.011","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate visual outcomes and identify risk factors for poor visual prognosis and dropped nucleus following posterior capsule rupture (PCR) during cataract surgery over a 5-year period in an Asian tertiary institution.</p><p><strong>Design: </strong>A retrospective chart review.</p><p><strong>Participants: </strong>All eyes that were complicated by PCR during cataract surgery at Tan Tock Seng Hospital, Singapore, between January 2016 and December 2020.</p><p><strong>Methods: </strong>Medical records were reviewed for demographics, preoperative, intraoperative, and postoperative data. The primary outcome measures were best-corrected visual acuity (BCVA) ≥20/40 at 3 months (short-term visual outcome) and at final follow-up (long-term visual outcome). Logistic regression identified independent predictors of poor visual outcomes and intraoperative dropped nucleus.</p><p><strong>Results: </strong>Among 31,663 phacoemulsification cataract surgeries performed during the study period, 234 (0.74%) were complicated by PCR. Of 211 eyes with PCR analyzed for vision, 191 (90.5%) achieved BCVA ≥20/40 at 3 months, and 174 (83.3%) maintained this at final follow-up (median 35 months). Predictors of poor final vision included increasing age (odds ratio [OR]: 1.05; 95% confidence interval [CI]: 1.00-1.10; p = 0.042), postoperative complications (OR: 8.17; 95% CI: 3.34-20.56; p < .001), and non-in-the-bag lens status (OR: 3.89; 95% CI: 1.56-9.69; p = 0.003). Dropped nucleus was associated with early PCR (OR: 8.37; 95% CI: 2.39-32.61; p = 0.001) and vitreous loss (OR: 20.66; 95% CI: 3.95-386.89; p = 0.004).</p><p><strong>Conclusions: </strong>Despite PCR, most patients achieved favourable long-term visual outcomes. Poor long-term visual prognosis was associated with older age, postoperative complications, and non-in-the-bag lens status. Early PCR and vitreous loss were key predictors of dropped nucleus.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congestive heart failure and other cardiac adverse events after intravitreal anti-VEGF therapy: a systematic review and meta-analysis.","authors":"Michael Balas, Andrew Mihalache, Aaditeya Jhaveri, Shayaan Kaleem, Marko M Popovic, Peter J Kertes, Rajeev H Muni","doi":"10.1016/j.jcjo.2026.08.033","DOIUrl":"https://doi.org/10.1016/j.jcjo.2026.08.033","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate congestive heart failure (CHF) and other cardiac adverse events (AEs) after intravitreal anti-vascular endothelial growth factor (VEGF) therapy for retinal vascular disease and compare risks across agents.</p><p><strong>Design: </strong>A systematic review and meta-analysis.</p><p><strong>Methods: </strong>Registered review (PROSPERO CRD42022302658) searched Ovid MEDLINE, Embase, and the Cochrane Library from January 2005 to February 2024 for randomized controlled trials (RCTs) of intravitreal anti-VEGF therapy for neovascular age-related macular degeneration, diabetic macular edema, or retinal vein occlusion. Eligible trials compared an anti-VEGF agent with sham or another anti-VEGF agent and reported CHF (primary outcome) or other cardiac AEs (secondary outcomes: arrhythmias, heart failure/cardiomyopathy, inflammatory heart disease, ischemic heart disease, or valvular heart disease). Risk of bias was assessed with RoB 2, certainty with GRADE, and random-effects models generated risk ratios (RRs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Fourteen reports describing 20 trials (11,803 eyes; mean age 71 ± 12 years; 53% female) were included. CHF was uncommon overall: aflibercept 2.0% (84/4172), ranibizumab 2.2% (25/1158), faricimab 2.3% (44/1926), brolucizumab 2.5% (40/1612), and sham 3.8% (20/524). Ranibizumab did not differ from sham for CHF (RR = 1.53, 95% CI 0.46-5.06), whereas aflibercept was associated with higher CHF risk versus sham in 2 trials (RR = 2.08, 95% CI: 1.03-4.23). No significant CHF differences were detected between aflibercept and brolucizumab, faricimab, or ranibizumab. Other cardiac events were similar across agents.</p><p><strong>Conclusions: </strong>CHF and other AEs after intravitreal anti-VEGF therapy were uncommon in RCTs and comparable across agents. The aflibercept-sham CHF signal was based on limited evidence and should be interpreted cautiously.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography and visual field discordance in optic chiasm compression in patients with pituitary adenomas.","authors":"Daehwan Shin, Jeong Hwan Noh, Minchul Kim, Mingui Kong, Ji Eun Song, Yong Woo Lee, Won Jae Kim, So Young Han","doi":"10.1016/j.jcjo.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.jcjo.2026.09.001","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether optical coherence tomography (OCT) structural measurements correlate with visual field (VF) deficits in pituitary adenomas and to determine when OCT abnormalities appear relative to VF defects.</p><p><strong>Methods: </strong>This retrospective study included 95 patients (190 eyes) who underwent magnetic resonance imaging, automated perimetry, and OCT between 2013 and 2023. Patients were classified as compression (n = 67), abutting (n = 15), or noncontact (n = 13). VF index ([VFI], mean deviation [MD], pattern standard deviation [PSD]) and OCT parameters (retinal nerve fibre layer [RNFL] and ganglion cell-inner plexiform layer [GC-IPL]) were compared across groups and by VF defect status.</p><p><strong>Results: </strong>VF differed significantly across groups. The compression group showed worse VFI (mean [SD], 81.36 [27.42] vs 93.86 [12.87] and 95.58 [3.96]; p = .003) and more negative MD (-6.76 [8.46] vs -2.57 [4.23] and -2.77 [2.06] dB; p = .003), with higher PSD (4.85 [4.56] vs 3.12 [3.02] and 2.60 [1.63] dB; p = .01). GC-IPL did not differ across groups (p = .18), although focal thinning was noted. RNFL differed only in the temporal quadrant (p = .038). Correlation analyses revealed weak to moderate associations between VF indices and OCT parameters (r = 0.34-0.69).</p><p><strong>Conclusions: </strong>Chiasmal compression is associated with VF loss, whereas OCT parameters do not consistently change in parallel. When OCT abnormalities are present, they are likely to reflect damage that has already progressed beyond the reversible stage and may serve as a prognostic indicator of limited postoperative visual recovery.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified technique for mucous membrane grafting for lid margin keratinization: improving exposure and hemostasis.","authors":"Angela Y Zhu, Kamiar Mireskandari, Asim Ali","doi":"10.1016/j.jcjo.2026.08.037","DOIUrl":"https://doi.org/10.1016/j.jcjo.2026.08.037","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of conjunctivitis prior to and following the COVID-19 pandemic.","authors":"Tina Felfeli, Yvonne M Buys, Refik Saskin, Sherif El-Defrawy, Ya-Ping Jin","doi":"10.1016/j.jcjo.2026.08.039","DOIUrl":"https://doi.org/10.1016/j.jcjo.2026.08.039","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staged surgical and optical rehabilitation after bilateral corneoscleral melt from hyperacute gonococcal keratoconjunctivitis.","authors":"David Mikhail, Stuti Misty Tanya, Jack Mouhanna, Langis Michaud, Guillermo Rocha","doi":"10.1016/j.jcjo.2026.08.034","DOIUrl":"https://doi.org/10.1016/j.jcjo.2026.08.034","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral NAION with contralateral incipient NAION in severe iron-deficiency anemia: a case series.","authors":"Manlong Xu, Aljeena Rahat Qureshi, Rahul A Sharma, Edsel B Ing, Arun N E Sundaram","doi":"10.1016/j.jcjo.2026.08.009","DOIUrl":"10.1016/j.jcjo.2026.08.009","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal nevus with retinal invasion.","authors":"Antonio Bechara Ghobril, Salaam Botros, Carol L Shields","doi":"10.1016/j.jcjo.2026.08.030","DOIUrl":"https://doi.org/10.1016/j.jcjo.2026.08.030","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Haemophilus influenzae conjunctivitis and corneal scarring in a boy with x-linked agammaglobulinemia: a case report.","authors":"Ameen Alizada, Sanya Ong, Nicola A M Wright, Mary-Magdalene Ugo Dodd","doi":"10.1016/j.jcjo.2026.08.029","DOIUrl":"https://doi.org/10.1016/j.jcjo.2026.08.029","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Isolated mydriasis from ipsilateral internal carotid artery aneurysm.","authors":"Jonathan A Micieli, Edward Margolin","doi":"10.1016/j.jcjo.2026.08.010","DOIUrl":"10.1016/j.jcjo.2026.08.010","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}