Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献

{"title":"Association of changes in optical coherence tomography metrics with changes in refractive error in patients with neovascular age-related macular degeneration in the CATT.","authors":"Matthew R Starr, Eric A Lovett, Rachel Israilevich, Jason Hsu, Peiying Hua, Jiayan Huang, Maureen G Maguire, Daniel F Martin, Gui-Shuang Ying, Ajay E Kuriyan","doi":"10.1016/j.jcjo.2025.05.016","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.016","url":null,"abstract":"<p><strong>Objective: </strong>Assess the change in refractive error (RE) in patients receiving anti-vascular endothelial growth factor (VEGF) therapy for exudative age-related macular degeneration.</p><p><strong>Methods: </strong>Post hoc analysis of data from the Comparison of AMD Treatments Trials (CATT). Associations between spherical equivalent (SphE) change and optical coherence tomography (OCT) metrics were evaluated using correlation coefficients (r) and regression analyses stratified by baseline lens status.</p><p><strong>Results: </strong>Analysis included 1 171 patients with OCT fluid in the study eye at baseline. The mean (± SD) of SphE shifted toward myopia in study eyes from 0.62 ± 1.63 diopters (D) at baseline to 0.50 ± 1.61 D at 2 years (p < 0.0001). Phakic study eyes had larger myopic shifts than pseudophakic eyes at 2 years (-0.19 ± 0.97 D vs -0.06 ± 0.90 D; p = 0.03). In phakic study eyes, the RE change was significantly correlated with change in subretinal thickness (Spearman r = 0.21; p < 0.0001), subretinal tissue complex (r = 0.12; p = 0.01), and total thickness (r = 0.36; p < 0.0001). A myopic shift greater than 1.0 D occurred in 74 (7.0%) and 104 (10.2%) study eyes at years 1 and 2, respectively.</p><p><strong>Conclusion: </strong>Among CATT participants, the RE of study eyes shifted toward myopia at 2 years with phakic eyes having larger shifts. OCT metric changes were weakly correlated with changes in RE, suggesting that drying of the macula with anti-VEGF therapy may have a minor impact on RE. Still, 10% of patients may develop a 1 D myopic shift at 2 years, typically in those with more baseline fluid. Patients with neovascular AMD may be able to update their spectacles, even if macular edema is present, as the change in RE is negligible when drying the macula.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benchmarking test-retest variability in microperimetry for intermediate age-related macular degeneration using MP-3 and MAIA.","authors":"Jakob Schweighofer, Klaudia Birner, Hamza Mohamed, Johannes Schrittwieser, Hrvoje Bogunovic, Gregor S Reiter, Ursula Schmidt-Erfurth","doi":"10.1016/j.jcjo.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.002","url":null,"abstract":"<p><strong>Objective: </strong>Microperimetry (MP) has emerged as a clinical functional endpoint in nonexudative age-related macular degeneration (AMD). In this study, we aim to provide reference values for test-retest outcomes on two MP devices in intermediate AMD (iAMD).</p><p><strong>Design: </strong>Prospective, cross-sectional study.</p><p><strong>Participants: </strong>3 600 stimuli from 20 eyes in 20 subjects.</p><p><strong>Methods: </strong>Patients diagnosed with iAMD underwent consecutive testing on MP-3 (NIKED, Gamagori, Japan) and MAIA (CenterVue Icare, Padova, Italy). The obtained point-wise sensitivity (PWS) measurements were superimposed with optical coherence tomography (OCT) (Spectralis, Heildelberg Engineering) acquired. Hyperreflective foci (HRF), drusen volume, ellipsoid zone (EZ)-thickness and outer nuclear layer (ONL)-thickness were quantified with deep-learning algorithms. Subretinal drusenoid deposits (SDD) were manually annotated. We assessed test-retest repeatability at the location of these biomarkers using Bland-Altmann coefficients of repeatability. Furthermore, interdevice correlation, fixation stabilities, and examination durations were evaluated.</p><p><strong>Results: </strong>Comparable overall point-wise retest variances were detected for MP-3 (±4.54 dB) and MAIA (±5.24 dB). SDDs led to significantly worse repeatability in the MAIA device (p = 0.03). Drusen, HRF, EZ-thickness, and ONL thickness had no significant impact on test-retest variance. A good intradevice correlation (MP-3: 0.869 [0.851 - 0.886] MAIA 0.848 [0.827 - 0.867]), and a good mean interdevice correlation (0.841 [0.819 - 0.861]) was observed.</p><p><strong>Conclusions: </strong>Intradevice and interdevice repeatability for MP examinations with MP-3 and MAIA in patients with iAMD can be considered as good. Biomarkers except for SDD show no significant impact in repeatability in both devices. This supports MP as a reliable functional endpoint in clinical trials in iAMD.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral retinal hemorrhage following epidural blood patch.","authors":"Patrick Wang, Pear Ferreria","doi":"10.1016/j.jcjo.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.008","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute annular outer retinopathy: initial insights into clinical course variations with multimodal imaging.","authors":"Chunli Chen, Yizhe Cheng, Haiying Zhou, Yongpeng Zhang, Xiaoyan Peng","doi":"10.1016/j.jcjo.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.011","url":null,"abstract":"<p><strong>Objective: </strong>To describe the clinical course and provide initial imaging perspectives in acute annular outer retinopathy (AAOR) by reviewing multimodal imaging (MMI) findings.</p><p><strong>Design: </strong>Observational case series study.</p><p><strong>Participants: </strong>Nine patients (12 eyes) with AAOR.</p><p><strong>Methods: </strong>Review clinical charts and MMI findings.</p><p><strong>Main outcome measures: </strong>Clinical medical records and multimodal imaging features via fundus photographs, optical coherence tomography (OCT), fundus autofluorescence (AF) and OCT angiography (OCTA), as applicable.</p><p><strong>Results: </strong>Twelve eyes of nine patients (18-39 years) were identified. The clinical course was subdivided acutely progressive stage (APS), stationary stage (SS) and atrophic stage (AS) (1-3 weeks, 3 weeks to 3 months and >3 months, respectively). During APS, advancement of peripapillary annular band was noted in all eyes, accompanied by absent ellipsoid zone, increased choroidal thickness (ChT) and thinned outer nuclear layer (ONL) within the affected area. During SS, annular band disappeared in the photograph with improved ONL. During AS, affected area became depigmented with scattered pigmentation, exhibiting hyper-AF or mixed AF. Other manifestations included retinal atrophy and decreased ChT. OCTA revealed an enlarged foveal avascular zone in each stage, especially in AS. Seven eyes of 5 patients showed no macular involvement with best corrected visual acuity (BCVA) of 20/20, while 5 eyes of 5 patients showed macular involvement with poorer BCVA of HM-20/400 at the last visit.</p><p><strong>Conclusions: </strong>AAOR mostly occurs in young individuals with unilateral involvement, especially in those with mild to moderate myopia. The observed variations in the clinical course of AAOR, documented through MMI, aid in the prompt recognition and understanding of this rare entity.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in medico-legal cases against Canadian ophthalmologists: a 10-year retrospective review (2013-2022).","authors":"Derek M Waldner, Gary Garber, Anne Steen, P J Finestone, Richard Liu, Donna Perron, Qian Yang, Anna MacIntyre, Natalie Gagné, Tricia Savoy, Kevin Warrian, Alex Ragan","doi":"10.1016/j.jcjo.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.003","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating drug-induced optic nerve hypoplasia and septo-optic dysplasia from the FDA adverse events database.","authors":"Ayesh Ali, Jamal O Azhari, Ryan Gise, Omar Solyman, Paul Phillips, Abdelrahman M Elhusseiny","doi":"10.1016/j.jcjo.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.005","url":null,"abstract":"<p><strong>Objective: </strong>To identify potential teratogenic medication associated with optic nerve hypoplasia (ONH) and/or septo-optic dysplasia (SOD), by screening the Food and Drug Administration Adverse Events Reporting System (FAERS) database.</p><p><strong>Design: </strong>Retrospective pharmacovigilance study using disproportionality signal detection methods.</p><p><strong>Participants: </strong>Adverse event reports submitted to FAERS between Q1 2004 and Q3 2024. Reports were included if ONH or SOD was listed as an adverse event and drug exposure occurred in utero.</p><p><strong>Methods: </strong>A qualitative assessment evaluated patient demographics, and a disproportionality analysis covered pharmacovigilance signal detection and drug-event reporting frequencies. Pharmacovigilance algorithms that were applied to determine the statistical significance of signals included the proportional reporting ratio (PRR), chi-squared with Yates' correction (χ²), reporting odds ratio (ROR), empirical Bayes geometric mean (EBGM), and information component (IC).</p><p><strong>Results: </strong>A total of 103 adverse event reports for ONH and/or SOD were identified. The 75 cases reporting prenatal medication exposure were included. Twenty-three reports were of male patients, 13 reports of female patients, and 39 of unspecified gender. Thirty drugs were implicated as primary suspect drugs. Diazepam was the most reported primary suspect medication (n = 15; 20%) followed by methadone and citalopram (n = 8; 11%). The disproportionality analysis showed a positive signal with one medication: diazepam (n = 15; PRR = 82.24; χ² = 1008.66, ROR 95% CI: 102.55 [56.75-185.33], EBGM [EBGM05]: 48.45 [28.16], IC [IC05]: 4.46 [3.67]).</p><p><strong>Conclusions: </strong>A possible association was found between prenatal diazepam exposure and ONH/SOD. Further investigation is required to confirm this relationship and drug safety profiles.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative corneal safety of mitomycin C, 5-fluorouracil, and interferon α-2b: a population-based pharmacovigilance analysis.","authors":"Ryan S Huang, Andrew Mihalache, Michael Balas, Marko M Popovic, Clara C Chan","doi":"10.1016/j.jcjo.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.010","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bisphosphonate-induced orbital inflammation.","authors":"Michael T Kryshtalskyj, Mahraz Parvand, Carson D Schell, Karim G Punja","doi":"10.1016/j.jcjo.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.007","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular lens opacification due to calcium deposition after glaucoma filtration device placement.","authors":"Pratima R Vishwakarma, Rushil H Ambani, Anna M Stagner, Roberto Pineda","doi":"10.1016/j.jcjo.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.012","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superior oblique myokymia associated with pituitary gland tumour.","authors":"Dylan T Sherrill, Logan Wiedemann, Nafiseh Hashemi","doi":"10.1016/j.jcjo.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.05.013","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}