Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献_第10页

Anterior chamber paracentesis for increased intraocular pressure with intravitreal injections: systematic review and meta-analysis. 前房穿刺术治疗玻璃体内注射升高眼压：系统回顾和荟萃分析。

IF 3.3 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-26 DOI: 10.1016/j.jcjo.2025.06.003

Michele Zaman, Sarah Alowedi, Sanjay Sharma

{"title":"Anterior chamber paracentesis for increased intraocular pressure with intravitreal injections: systematic review and meta-analysis.","authors":"Michele Zaman, Sarah Alowedi, Sanjay Sharma","doi":"10.1016/j.jcjo.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.06.003","url":null,"abstract":"Objective: Intravitreal injections (IVIs) can cause a transient asymptomatic spike in intraocular pressure (IOP), which may cause irreversible damage to the patient's optic nerve. Anterior chamber paracentesis (ACP) is a well-established method to lower IOP. We aim to systematically review the literature, assessing the safety and efficacy of ACP for increased IOP with IVI of antivascular endothelial growth factor medications.Methods: The following databases were used: MEDLINE, EMBASE, and CINAHL. Articles were included if they had human participants and discussed the use of ACP for increased IOP during IVIs. Key terms searched were anterior chamber paracentesis, intravitreal injections, and intraocular pressure.Results: Our search captured 236 articles, and ultimately 13 studies were included in our review. Six studies were included in our meta-analysis of studies that reported the IOP after 30 minutes post-ACP. Ten included studies reported that ACP is a safe and effective procedure that lowers the IOP of patients during the IVI process. The overall pooled effect size is significant for IOP measurements 30 minutes after ACP is -1.54 with a 95% CI of -2.20 to -0.88 mm Hg, 5 minutes after ACP is -2.37 with a 95% CI of -2.77 to -1.97 mm Hg and 2 minutes after ACP is -5.09 with a 95% CI of -8.48 to -1.70 mm Hg.Conclusions: In conclusion, performing an ACP is a safe and effective way to reduce the transient spike in IOP after IVIs. However, this procedure is not without the potential for complications.","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features and outcomes of melanoma involving eyelid and conjunctiva. 眼睑及结膜黑色素瘤的临床特征及预后。

IF 2.8 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-26 DOI: 10.1016/j.jcjo.2025.06.020

Robert A Churchill, Caroline Y Yu, Kenny Y Wang, Boyoung M Kim, Lilly H Wagner, Elizabeth A Bradley, Andrea A Tooley, Lauren A Dalvin

{"title":"Clinical features and outcomes of melanoma involving eyelid and conjunctiva.","authors":"Robert A Churchill, Caroline Y Yu, Kenny Y Wang, Boyoung M Kim, Lilly H Wagner, Elizabeth A Bradley, Andrea A Tooley, Lauren A Dalvin","doi":"10.1016/j.jcjo.2025.06.020","DOIUrl":"10.1016/j.jcjo.2025.06.020","url":null,"abstract":"Objective: We sought to describe the long-term outcomes in patients with melanoma involving the eyelid and conjunctiva.Design: A retrospective cohort study.Participants: Patients with biopsy-confirmed melanoma involving the eyelid and conjunctiva.Methods: We investigated 13 patients from a single academic center with biopsy-confirmed melanoma involving the eyelid and conjunctiva between January 2000 and December 2021. Primary endpoints included local recurrence, metastasis, and death.Results: Presumed origin of melanoma was conjunctiva in 9 patients (69%), eyelid in 3 patients (23%), and indeterminate in 1 patient (8%). Primary treatment was exenteration in 3 patients (23%), full-thickness resection in 3 patients (23%), Mohs micrographic surgery in 4 patients (31%), and nonsurgical treatment in 3 patients (23%). Four patients (31%) underwent secondary exenteration due to tumour recurrence. Local tumour recurrence occurred in 7 patients (54%) after a mean 43 months (5-167) and metastasis in 4 patients (31%) after mean 29 months (16-46). Five patients (38%) died after a mean of 45 months (16-107) after initial melanoma diagnosis. There were 3 (23%) deaths attributable to melanoma; all had undergone exenteration during their treatment course. In the 7 (54%) patients managed with globe-sparing treatment, all had best-corrected visual acuity of 20/60 or better at last follow-up.Conclusions: In this cohort, there was a high rate of local recurrence, metastasis, and death, regardless of whether patients received globe sparing or non-globe sparing treatment.","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-MOG optic neuritis following SARS-CoV-2 vaccination: a case report. SARS-CoV-2疫苗接种后抗mog视神经炎1例报告

IF 3.3 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-26 DOI: 10.1016/j.jcjo.2025.06.018

Logan C Barr, Ryan H Kirkpatrick, Jacob Rullo

引用次数: 0

Renal cell carcinoma metastasis to an eyelid: systemic cancer history imperative when assessing new eyelid lesions. 肾细胞癌转移到眼睑：当评估新的眼睑病变时，系统性癌症病史是必要的。

IF 3.3 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-26 DOI: 10.1016/j.jcjo.2025.06.024

Sina Tangestanipour, Sara Jessica Brade, Lisa Jagan, Vladimir Kratky

引用次数: 0

Relapse of B-cell acute lymphoblastic leukemia revealed by multiple ocular locations. 多眼部位显示的b细胞急性淋巴细胞白血病复发。

IF 3.3 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-25 DOI: 10.1016/j.jcjo.2025.06.012

Lauriana Solecki, Anne Sophie Gauthier, Arnaud Sauer

引用次数: 0

Orbital metastasis at the optic nerve head-globe junction from esophageal cancer. 食管癌视神经头-球交界处的眼眶转移。

IF 3.3 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-25 DOI: 10.1016/j.jcjo.2025.06.023

Patrick Wang, Evan F Sharma, Bryan Luu, Vladimir Kratky

引用次数: 0

Prospective study of blepharoptosis after plaque radiotherapy. 斑块放疗后上睑下垂的前瞻性研究。

IF 2.8 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-25 DOI: 10.1016/j.jcjo.2025.06.026

B Michelle Kim, Darrell Kohli, Aravindh Nirmalan, Gavin W Roddy, Lauren A Dalvin, Andrea A Tooley

{"title":"Prospective study of blepharoptosis after plaque radiotherapy.","authors":"B Michelle Kim, Darrell Kohli, Aravindh Nirmalan, Gavin W Roddy, Lauren A Dalvin, Andrea A Tooley","doi":"10.1016/j.jcjo.2025.06.026","DOIUrl":"10.1016/j.jcjo.2025.06.026","url":null,"abstract":"Objective: To prospectively describe the degree of blepharoptosis among patients who underwent plaque radiotherapy.Design: A single-center prospective cohort study.Participants: Patients who underwent plaque radiotherapy at a single center.Methods: Margin reflex distance 1 (MRD1), palpebral fissure height, eyelid excursion, and exophthalmometry measurements were taken before and after surgery. To determine the impact of surgical manipulation versus radiation exposure, measurements were compared to a separate cohort of 28 patients who underwent filtering glaucoma surgery.Results: There were 24 patients treated with plaque radiotherapy in the study, with a mean age of 61 years at presentation and 70.8% male sex. In involved eyes, mean palpebral fissure height decreased from 8.38 mm preoperatively to 7.25 mm postoperatively (p < 0.01) and mean MRD1 decreased from 3.46 mm to 2.29 mm (p < 0.01). Frequency of ptosis increased from 20.8% preoperatively to 62.5% postoperatively. In a similarly aged cohort of patients undergoing glaucoma filtering surgery, the frequency of ptosis also increased from 32.1% preoperatively to 64.3% postoperatively. The frequency was not different between the plaque and glaucoma groups preoperatively (p = 0.359) or postoperatively (p = 0.894). The degree of ptosis in patients who underwent plaque radiotherapy was similar to patients who underwent glaucoma surgery.Conclusions: Blepharoptosis is a frequent side effect of plaque radiotherapy, with more than half of patients affected after surgery. When compared to similar surgical manipulation for filtering glaucoma surgery, radiation did not appear to be associated with more frequent blepharoptosis. Patients should be advised that blepharoptosis can be a side effect following plaque radiotherapy.","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cenegermin treatment for pediatric neurotrophic keratopathy: a systematic review. genergmin治疗小儿神经营养性角膜病变的系统综述。

IF 3.3 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-25 DOI: 10.1016/j.jcjo.2025.06.021

Daiana R Pur, Fady Sedarous, Asim Ali, Rookaya Mather

{"title":"Cenegermin treatment for pediatric neurotrophic keratopathy: a systematic review.","authors":"Daiana R Pur, Fady Sedarous, Asim Ali, Rookaya Mather","doi":"10.1016/j.jcjo.2025.06.021","DOIUrl":"10.1016/j.jcjo.2025.06.021","url":null,"abstract":"Objective: This systematic review evaluates the efficacy and safety of cenegermin in pediatric neurotrophic keratopathy (NK), assessing treatment outcomes, predictors of efficacy, and adverse effects.Methods: Adhering to PRISMA guidelines, we reviewed studies from Embase, MEDLINE, HealthSTAR, and other databases up to July 28, 2024. Studies were included if they involved pediatric patients (≤18 years) treated with cenegermin for NK. Two reviewers independently screened and extracted data, assessing the risk of bias using Joanna Briggs Institute tools.Results: Of the 20 articles reviewed, 8 case reports or series met inclusion criteria, encompassing 21 pediatric cases (33% female), with an average age of 5.87 ± 3.05 years. Etiologies included congenital conditions, radiotherapy, and infections. Cenegermin was administered as a 0.002% drop 6 times daily for 8 weeks. Treatment was typically initiated after the failure of conventional methods. Improvements in corneal transparency were observed in all cases, with visual acuity improved in 4 out of 6 studies reporting this metric. Factors associated with improvement in corneal transparency were the severity of preexisting corneal scarring and ocular surface instability.Conclusions: Cenegermin is a viable treatment option for pediatric NK, showing efficacy in improving corneal transparency and, to a lesser extent, visual acuity. However, its adoption is constrained by limited pediatric data, cost, and potential side effects. Further research is needed to establish long-term safety and effectiveness, and to optimize treatment protocols for this vulnerable population.","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of cross-reactivity between flaviviruses in a patient with West Nile retinopathy. 西尼罗视网膜病变患者黄病毒交叉反应一例。

IF 3.3 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-25 DOI: 10.1016/j.jcjo.2025.06.019

Natalie S Chen, Isaac I Bogoch, Alexander J Kaplan

引用次数: 0

Prevalence of vernal keratoconjunctivitis in Canada: a cross-sectional survey study. 加拿大春季角膜结膜炎患病率：一项横断面调查研究。

IF 3.3 4区医学

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Pub Date : 2025-07-21 DOI: 10.1016/j.jcjo.2025.06.005

Manokamna Agarwal, Ya-Ping Jin, Larissa Gouvea, Kamiar Mireskandari, Asim Ali

{"title":"Prevalence of vernal keratoconjunctivitis in Canada: a cross-sectional survey study.","authors":"Manokamna Agarwal, Ya-Ping Jin, Larissa Gouvea, Kamiar Mireskandari, Asim Ali","doi":"10.1016/j.jcjo.2025.06.005","DOIUrl":"10.1016/j.jcjo.2025.06.005","url":null,"abstract":"Objective: To estimate the prevalence of vernal keratoconjunctivitis (VKC) in Canada in January 2023.Methods: A total of 1 061 ophthalmologists registered with the Canadian Ophthalmological Society were contacted in January 2023 and offered an online survey on VKC. Eighty (7.5%) responded. The prevalence of VKC in Canada was estimated using 6 distinct hypotheses, each based on different assumptions regarding disease duration and the potential experiences of nonresponding ophthalmologists.Results: On the basis of the 6 different hypotheses, the estimated prevalence (per 10,000) of active VKC in January 2023 ranged between 0.13 (95% confidence interval [CI] 0.12-0.14) to 3.34 (95% CI 3.29-3.40) for the total population of Canada, and 0.61 (95% CI 0.56-0.66) to 16.11 (95% CI 15.84-16.39) for Canadians aged 0-19 years. Building on the most likely hypothesis that the disease duration was 4 years, and assuming on-responding ophthalmologists had seen half of the VKC cases as survey responders, the best estimate of VKC prevalence in Canada was 0.90 (95% CI 0.84-0.96) per 10,000 population and 4.33 (95% CI 4.07-4.61) per 10,000 children and teens. The most common VKC-associated complications were reported to be shield ulcer and steroid-induced ocular hypertension ranging from 0.02 to 0.48 and 0.02 to 0.47 cases per 10,000 inhabitants, respectively, depending on the hypothesis assumed.Conclusions: This national survey reported that the prevalence of VKC per 10,000 population in 2023 ranged from 0.13 to 3.34 for Canadians of all ages and from 0.61 to 16.11 for children and teens. The best estimate was 0.90 per 10,000 population of all ages and 4.33 per 10,000 children and teens.","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0