Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献

{"title":"Serial analysis of macular and circumpapillary structures in glaucomatous eyes with peripapillary retinoschisis","authors":"Jooyoung Yoon,&nbsp;Ji Hong Kim,&nbsp;Yu Jeong Kim,&nbsp;Han Woong Lim,&nbsp;Kyeong Ik Na,&nbsp;Derek S. Welsbie,&nbsp;Won June Lee","doi":"10.1016/j.jcjo.2026.03.020","DOIUrl":"10.1016/j.jcjo.2026.03.020","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effect of peripapillary retinoschisis (PPRS) on circumpapillary and macular retinal thickness and its correlation with longitudinal changes in the visual field.</div></div><div><h3>Methods</h3><div>A wide-field scan using swept-source optical coherence tomography was performed to measure the circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) thickness. The relationship between longitudinal measurements of cpRNFL, mGCIPL thickness, and visual field index (VFI) was assessed using repeated-measures correlation. Pearson correlation analysis was used to evaluate the correlation between the VFI change rate and the change rates of cpRNFL or mGCIPL thickness.</div></div><div><h3>Results</h3><div>A total of 25 eyes were included in the final analysis. The cpRNFL thickness significantly increased with PPRS (<em>P</em> &lt; .001) and decreased after the resolution of PPRS (<em>P</em> &lt; .001), whereas the mGCIPL thickness did not change with PPRS (all <em>P</em> &gt; .05). The longitudinal measurements of cpRNFL thickness did not show a significant correlation with VFI (<em>P</em> = .560), nor did its change rate correlate significantly with the progression rate of VFI (<em>P</em> = .294). In contrast, mGCIPL thickness exhibited a significant correlation with the VFI (<em>P</em> &lt; .001), and its change rate also showed a significant correlation with the progression rate of the VFI (<em>P</em> = .035).</div></div><div><h3>Conclusions</h3><div>The mGCIPL thickness could serve as a reliable marker for assessing progression in glaucomatous eyes with PPRS. Monitoring changes in each parameter across consecutive tests is essential to identifying the most appropriate marker for detecting glaucoma progression, given that structural alterations such as PPRS may occur in glaucomatous eyes.</div></div>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Pages 876-884"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined ab interno canaloplasty using the iTrack microcatheter with phacoemulsification in uveitic glaucoma","authors":"Kate Lim,&nbsp;Nir Shoham-Hazon","doi":"10.1016/j.jcjo.2026.03.024","DOIUrl":"10.1016/j.jcjo.2026.03.024","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Pages 1041-1043"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purtscher-like retinopathy associated with thrombotic microangiopathy after hematopoietic stem cell transplantation","authors":"Felix Innauer,&nbsp;Paul Wintersteller,&nbsp;Jakob Gran,&nbsp;Monja Michelitsch,&nbsp;Gerald Seidel","doi":"10.1016/j.jcjo.2026.03.025","DOIUrl":"10.1016/j.jcjo.2026.03.025","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Pages 1060-1063"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subgaleal hematoma with orbital compartment syndrome and optic neuropathy in hemophilia B","authors":"Tanya Boghosian,&nbsp;Simon S.M. Fung,&nbsp;Dan DeAngelis,&nbsp;Kamiar Mireskandari","doi":"10.1016/j.jcjo.2026.04.008","DOIUrl":"10.1016/j.jcjo.2026.04.008","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Pages 1048-1051"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Abstract","authors":"","doi":"10.1016/j.jcjo.2026.07.016","DOIUrl":"10.1016/j.jcjo.2026.07.016","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Page 1034"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148775646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year post-onset visual acuity trajectories in Japanese Leber hereditary optic neuropathy: a longitudinal analysis by age, sex, and mtDNA mutation","authors":"Yasuyuki Takai,&nbsp;Akiko Yamagami,&nbsp;Mayumi Iwasa,&nbsp;Kenji Inoue,&nbsp;Ryoma Yasumoto,&nbsp;Hitoshi Ishikawa,&nbsp;Masato Wakakura","doi":"10.1016/j.jcjo.2026.02.011","DOIUrl":"10.1016/j.jcjo.2026.02.011","url":null,"abstract":"<div><h3>Objective</h3><div>To compare 5-year visual acuity trajectories in Leber hereditary optic neuropathy (LHON) by age at onset.</div></div><div><h3>Design</h3><div>A retrospective single-center cohort study.</div></div><div><h3>Participants</h3><div>Fifty-seven patients (114 eyes) with genetically confirmed, bilateral-onset LHON.</div></div><div><h3>Methods</h3><div>Serial best-corrected visual acuity (BCVA, logMAR) over 5 years was extracted from medical records. The age at onset was grouped as ≤19, 20–49, or ≥50 years. Sex and primary mutation (m.11778G&gt;A vs m.14484T&gt;C) were also assessed. Longitudinal trajectories were analyzed using linear mixed-effects models. Between-group differences were summarized using ΔlogMAR curves, area under the Δ curve (AUCΔ), and model-based probabilities of achieving logMAR ≤1.0.</div></div><div><h3>Results</h3><div>The median age at onset was 30.0 years (range: 8–69): 15 patients (26%) were ≤19 years old, 31 (54%) were 20–49 years old, and 11 (19%) were ≥50 years old. Relative to the 20–49-year reference group, the ≤19-year group had better visual outcomes over 5 years, with a negative AUCΔ and higher probabilities of achieving logMAR ≤1.0 (70.2% vs 13.6% at 60 months). The ≥50-year group showed poorer vision over time, with a positive AUCΔ and low probabilities of recovery. Differences by sex were small. Eyes with m.14484T&gt;C had more favourable Δ trajectories than those with m.11778G&gt;A, although the estimates were imprecise.</div></div><div><h3>Conclusions</h3><div>In this cohort, onset at ≤19 years was associated with earlier and greater visual recovery, whereas onset at ≥50 years was associated with persistently worse vision. Age at onset is an important modifier of 5-year visual prognosis in bilaterally affected LHON.</div></div>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Pages 901-907"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous treatment of bilateral macular holes using vitrectomy and pneumatic vitreolysis: a novel single-positioning strategy","authors":"Chris Zajner,&nbsp;Alexander Kahjun Soon,&nbsp;Matthew Anderson","doi":"10.1016/j.jcjo.2026.04.009","DOIUrl":"10.1016/j.jcjo.2026.04.009","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Pages 1051-1054"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the risk of ocular inflammation secondary to sarcoidosis between non-Hispanic White population and Black/African American population","authors":"Manisha Reddy,&nbsp;Jessica Randolph","doi":"10.1016/j.jcjo.2026.03.010","DOIUrl":"10.1016/j.jcjo.2026.03.010","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the risk of developing ocular inflammation in the setting of sarcoidosis among non-Hispanic White (NHW) and Black/African American populations (BAA).</div></div><div><h3>Design</h3><div>Retrospective, population-based cohort study</div></div><div><h3>Participants</h3><div>Participants were aged ≥18 years, diagnosed with sarcoidosis in the last 10 years, and divided into 2 cohorts of NHW and BAA descent. Propensity score matching was used to match for age and sex.</div></div><div><h3>Methods</h3><div>Using the TriNetX database, we determined the frequency of anterior uveitis, chorioretinal inflammation (CRI), optic neuritis (ON), and other disorders of the optic disc between the 2 cohorts using <em>International Classification of Diseases, Tenth Revision</em>, codes. Alternatively, the incidence of sarcoidosis was examined in patients diagnosed with ocular inflammation in the last 10 years, with sarcoidosis diagnosis occurring within 3 months after ocular inflammation.</div></div><div><h3>Main Outcome Measures</h3><div>Risk ratio of the incidence of ocular inflammation between NHW and BAA populations, and the odds ratio of being diagnosed with sarcoidosis when presenting with ocular inflammation between NHW and BAA populations.</div></div><div><h3>Results</h3><div>After propensity score matching, each sarcoidosis cohort had 39 604 patients (mean age of 54.6 (± 13.4) years). Incidence of anterior uveitis was 1188 (3%) NHW and 1868 (4.7%) BAA with RR 0.636 (<em>P</em> &lt; .0001, confidence interval [CI] 0.592−0.683). The incidence of CRI was 410 (1.0%) NHW and 309 (0.8%) BAA with RR 1.327 (<em>P</em> = .0002, CI 1.145−1.537). Incidence of ON was 538 (1.4%) NHW and 660 (1.7%) BAA with RR 0.815 (<em>P</em> = .0004, CI 0.728−0.913). Each anterior uveitis cohort had 32 780 patients (mean age 48.4 ± 18.3 years). Sarcoidosis was identified in 507 (1.5%) NHW and 1103 (3.4%) BAA with OR 0.451 (<em>P</em> &lt; .0001, CI 0.406−0.502). Each CRI cohort had 4116 patients (mean age of 49.8 ± 17.7). Sarcoidosis was identified in 77 (1.9%) NHW and 190 (4.6%) BAA with OR 0.394 (<em>P</em> &lt; .0001, CI 0.301−0.515). Each ON cohort had 22971 patients (mean age of 49.2 ± 17.9). Sarcoidosis was identified in 141 (0.6%) NHW and 483 (2.1%) BAA with OR 0.288 (<em>P</em> &lt; .0001, CI 0.238−0.347).</div></div><div><h3>Conclusions</h3><div>In those with sarcoidosis, BAA are at increased risk of developing anterior uveitis and optic neuropathy, while NHW are at increased risk of developing chorioretinal inflammation. BAA patients newly diagnosed with ocular inflammation are more likely to be diagnosed with sarcoidosis compared to their NHW counterparts.</div></div>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Pages 1025-1029"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chorioretinal folds associated with posterior staphyloma only detected with en face OCT","authors":"Marjan Afzali,&nbsp;Alessandro Feo,&nbsp;Shahin Faghihi,&nbsp;David Sarraf","doi":"10.1016/j.jcjo.2026.04.007","DOIUrl":"10.1016/j.jcjo.2026.04.007","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Pages 1044-1046"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does underlying etiology of corneal perforation and thinning affect outcomes after glue application?","authors":"Ryan S. Huang,&nbsp;Manokamna Agarwal,&nbsp;Michael Mimouni,&nbsp;Clara C. Chan","doi":"10.1016/j.jcjo.2026.02.002","DOIUrl":"10.1016/j.jcjo.2026.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the outcomes of cyanoacrylate tissue adhesive (CTA) in the management of corneal perforation and thinning based on underlying etiology.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included eyes undergoing CTA application for corneal perforation or thinning treated at a tertiary care centre. Eligible cases were categorized into infectious, immune-mediated, ocular surface disease, neurotrophic, or trauma-related etiologies. The primary outcomes were the need for repeat CTA applications and progression to penetrating keratoplasty (PK). Kaplan–Meier survival analysis was conducted to evaluate the time to PK. Multivariable logistic regression was performed to examine associations between etiology and outcomes, adjusting for clinical covariates.</div></div><div><h3>Results</h3><div>A total of 174 eyes were included (56.9% male, mean age: 66.1 ± 18.7 years). Over a median follow-up of 12.5 months (interquartile range [IQR]: 4.1–20.2), an average of 1.7 ± 0.8 CTA applications were performed per eye, with neurotrophic cases requiring the highest number (2.0 ± 0.8; <em>p</em> = 0.038). Overall, 58 eyes (33.3%) progressed to PK, most commonly in the neurotrophic group (43.5%; <em>p</em> = 0.019). Trauma cases had the most favourable PK-free survival (log rank <em>p</em> = 0.033). In multivariable regression, trauma was associated with lower odds of requiring multiple CTA applications (odds ratio [OR]: 0.22; 95% CI: 0.07–0.70; <em>p</em> = 0.010) and of progressing to PK (OR: 0.19; 95% CI: 0.05–0.74; <em>p</em> = 0.016), whereas neurotrophic cases were associated with increased odds of PK (OR: 1.65; 95% CI: 1.06–3.80; <em>p</em> = 0.031) compared with infectious cases.</div></div><div><h3>Conclusions</h3><div>Rates of repeat gluing and progression to PK varied by the underlying etiology. Incorporating etiology into prognostication and management decisions may help identify patients at highest risk for early surgical intervention.</div></div>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"61 4","pages":"Pages 826-832"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}