Cancer reports最新文献

{"title":"Update Prognostic Potency of Vascular Endothelial Growth Factor-A in the Acute Lymphoblastic Leukemia Landscape: A Meta-Analysis","authors":"Mojtaba Aghaei,&nbsp;Mohammad Ali JalaliFar,&nbsp;Arshid Yousefi-Avarvand,&nbsp;Seyed Sobhan Bahreiny,&nbsp;Negin Karamali,&nbsp;Zahra Mansouri,&nbsp;Mahdi Amraei,&nbsp;Shaban Alizadeh,&nbsp;Najmaldin Saki,&nbsp;Mohammad-Navid Bastani,&nbsp;Tannaz Sakhavarz,&nbsp;Mohammad Ali Khaksar,&nbsp;Leila Goudarzimehr,&nbsp;Somaieh Mousavei,&nbsp;Ebrahim Babadi","doi":"10.1002/cnr2.70351","DOIUrl":"https://doi.org/10.1002/cnr2.70351","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Vascular endothelial growth factor-A (VEGF-A), In combination with other pro-angiogenic factors, plays a pivotal role in angiogenesis and the pathogenesis of acute lymphoblastic leukemia (ALL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This meta-analysis aims to evaluate the diagnostic value of VEGF-A and its prognostic relevance in the outcome of patients with ALL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted up to January 2025 across multiple databases. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were pooled using a random-effects model to quantify effect sizes. Subgroup analyses and meta-regression were employed to explore heterogeneity sources. Data extracted from 15 studies encompassing 674 patients with ALL demonstrated a significant correlation between elevated VEGF-A levels and unfavorable prognosis (SMD: 0.878; 95% CI: 0.276–1.479; <i>p</i> = 0.004). Notably, increased VEGF-A levels were particularly evident in pediatric patients older than 8 years (SMD: 0.758; 95% CI: 0.178–1.338; <i>p</i> = 0.010).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results indicate that heightened VEGF-A expression is associated with poorer clinical outcomes in ALL, supporting its utility as a diagnostic and prognostic biomarker in this patient population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Site, Surgery, and BMI Binary Classification on Positioning Errors in Radiotherapy for Breast Cancer Patients: A Retrospective Study","authors":"Bao Wan,&nbsp;Fu-Kui Huan,&nbsp;Yan-Dong Ge,&nbsp;Rui-Ao Zhao,&nbsp;Yong-Tai Zheng,&nbsp;Meng Liang,&nbsp;Yan-Xin Zhang,&nbsp;Wei Zhang,&nbsp;Lu Hou,&nbsp;Ye Zhang,&nbsp;Hong-Kai Wang","doi":"10.1002/cnr2.70343","DOIUrl":"https://doi.org/10.1002/cnr2.70343","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To explore whether tumor site, surgery type, and the different body mass index (BMI) of patients with breast cancer affect the positioning error.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective study of 213 patients treated for breast cancer was binarily classified into groups based on the tumor site (left or right), surgery type (modified radical mastectomy, MRM and breast-conserving surgery, BCS) and BMI criterion (24 kg/m²). Positioning errors were obtained by using Cone-beam CT (CBCT) and analyzed to calculate the differences in 6 degrees of freedom. An independent sample <i>t</i>-test for positioning error was performed with a statistically significant level of 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For tumor site, significant differences were observed in the <i>X</i>, <i>Y</i>, <i>R</i>_<i>x</i>, <i>R</i>_<i>y</i>, <i>R</i>_<i>z</i> directions. The <i>t</i>-test shows a significant difference in the <i>X</i> , <i>Y</i> and <i>Z</i> directions for translation errors of different surgery types. In terms of rotational errors, the <i>R</i>_<i>y</i> direction shows that the MRM group has significantly lower errors than the BCS group. Considering the influence of BMI, there is a significant difference in positioning errors only in the <i>Z</i> direction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>For breast cancer patients, the <i>R</i>_<i>z</i> can serve as a reference for identifying positioning errors in other directions. For patients undergoing BCS, more individualized correction strategies during positioning are necessary. For obese patients, optimization measures should be implemented to address vertical positioning errors, considering body shape and size changes during treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70343","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective Assessment of Physical Activity in Breast Cancer Survivors: Associations With Adiposity and Metabolic Parameters of Glucose and Insulin—Insights From NHANES","authors":"Jose J. Cao-Alvira,&nbsp;Emilia F. Luciano,&nbsp;Moira Sauane,&nbsp;Columba de la Parra","doi":"10.1002/cnr2.70339","DOIUrl":"https://doi.org/10.1002/cnr2.70339","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Physical activity (PA) is a modifiable lifestyle factor strongly linked to adiposity and metabolic health. Breast cancer survivors are at a higher risk of obesity-related metabolic complications, negatively impacting prognosis and quality of life. Therefore, updated objective assessments of PA and its effects on metabolic health are critical to improving survivorship care.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To analyze the most recent nationally representative sample of the US population where physical activity was objectively measured to identify associations between PA, adiposity measures, and metabolic health parameters among cancer survivors, specifically breast cancer survivors.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods and Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;NHANES data from 2011 to 2014 is used to examine associations between PA, adiposity measures, and metabolic parameters in women aged 20 and older. PA is objectively measured using accelerometer data. Adiposity is assessed via sagittal abdominal diameter (SAD), waist circumference (WC), and body mass index (BMI), and the metabolic parameters are glucose and insulin. The analysis involved regressing the natural logarithms of SAD, WC, BMI, glucose, and insulin on moderate-to-vigorous and sedentary PA levels. The sample consisted of 4068 participants, including 397 with cancer diagnoses and 118 with breast cancer. Additionally, factors such as ethnicity, education, income, age, energy intake, diabetes, and smoking habits were considered. The associations between adiposity measures and excess daily sedentary PA are stronger for breast cancer survivors compared to all women and cancer survivors, with statistically significant results for SAD. SAD directly assesses visceral fat and is more closely linked to metabolic and cardiovascular risks. While moderate-to-vigorous PA is associated with decreased adiposity for all women, the decrease is less pronounced among cancer survivors. Daily moderate-to-vigorous PA has a significant and negative correlation with glucose and insulin levels, whereas sedentary PA has a positive correlation. The associations of PA with metabolic parameters in breast cancer survivors are similar to those in all women and cancer survivors.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study provides an updated objective assessment of PA in breast cancer survivors using the most recent NHANES survey cycles, where this data was collected. The results confirm rising obesity rates among breast cancer survivors, highlighting the need for ongoing mo","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of the Effectiveness and Cost of Single-Site Robotic Surgery and Single-Site Laparoscopic Surgery in Gynecological Diseases: The Era of Single-Site Robotic Surgery May Have Arrived","authors":"Jian-Zhao Yin,&nbsp;Wei-Feng Gao","doi":"10.1002/cnr2.70327","DOIUrl":"https://doi.org/10.1002/cnr2.70327","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The existing research data cannot fully prove the advantages of single-site Da Vinci robotic surgery (RSS) compared with single-site laparoscopic surgery (LESS) in the treatment of gynecological diseases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate the effectiveness and cost of RSS and LESS in the treatment of gynecological diseases. To provide a theoretical basis for RSS to replace LESS in the treatment of gynecological diseases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods and Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A systematic search of PubMed, EMbase, and Wanfang (万方), three electronic databases for articles published up to December 31st, 2023, was performed by computer. After literature screening, data extraction, and quality evaluation according to inclusion and exclusion criteria, a meta-analysis was performed using RevMan 5.1 software. A total of 16 articles were included, including 14 articles on effectiveness, with 2315 patients, and 2 articles on cost, with 544 patients. Compared with LESS, RSS was associated with a shorter total operative time for malignant tumor surgery (107 patients MD −24.01 min, 95% CI −32.40 to −15.62, &lt;i&gt;p&lt;/i&gt; &lt; 0.00001), less estimated blood loss (107 patients MD −53.60 mL, 95% CI −105.50 to −1.69, &lt;i&gt;p&lt;/i&gt; = 0.04), and there was no significant difference in postoperative hospital days and postoperative complications between the two groups. The subgroup analysis of total operative time was carried out separately according to the time of study publication and different single-point ports and robotic surgical systems. After 2020 and for using commercial single-point ports other than the Da Vinci dedicated single-point port, or using the fourth-generation Da Vinci SP surgical system, there was no significant difference in total operative time between the two groups (1259 patients MD 16.91 min, 95% CI −9.38 to 43.19, &lt;i&gt;p&lt;/i&gt; = 0.21) (354 patients MD 34.13 min, 95% CI −16.75 to 85.01, &lt;i&gt;p&lt;/i&gt; = 0.19) and (645 patients MD 13.79 min, 95% CI −26.85 to 54.43, &lt;i&gt;p&lt;/i&gt; = 0.51, respectively).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The present meta-analysis supports that, compared with LESS, in gynecological malignant tumor surgery, RSS takes shorter total operating time, less estimated blood loss, and has similar efficacy in postoperative hospital days and postoperative complications. However, the total hospital costs of RSS are higher than those of LESS. Therefore, if the cost of RSS can be reduced, RSS is a feasible surgical method for patients undergoing gynecological malignant tumor s","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorectal Cancer Surgical Pathology: Comparative Study in Lebanon Before and After the Economic Collapse","authors":"Georges Ayoub,&nbsp;Rhea Khazen,&nbsp;Elie Berberi,&nbsp;Viviane Trak Smayra","doi":"10.1002/cnr2.70329","DOIUrl":"https://doi.org/10.1002/cnr2.70329","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objectives</h3>\u0000 \u0000 <p>Colorectal cancer (CRC) screening and early detection reduce mortality. Curative treatment is based on surgical resection, and pathological analysis plays a key role in management. In Lebanon, the impact of the COVID-19 pandemic on healthcare has been compounded by an unprecedented socio-economic crisis in 2020. This has deteriorated access to medical care and could have delayed CRC diagnosis and treatment. The study evaluates the impact of the economic collapse on CRC in Lebanon by comparing characteristics of patients operated on in 2020 and 2021 (post-crisis period) to those operated on in 2018 and 2019 (pre-crisis period).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included patients who underwent surgical resection for colorectal adenocarcinoma at a tertiary care center in Lebanon between 01/01/2018 and 12/31/2021. Patients were divided into two groups according to the corresponding period, and the demographic, clinical, and pathological characteristics were compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 169 patients included, 89 (53%) were operated on in the pre-crisis period and 80 (47%) in the post-crisis period. We reported that in the post-crisis period: more patients presented with clinical complications requiring urgent admission (30% vs. 16%), more tumors were classified as T4b (10% vs. 2%), and more tumors presented lymphatic emboli (65% vs. 45%), perineural (51% vs. 22%) and perivascular invasion (40% vs. 19%) (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights the worsening of clinical and pathological indicators of poor prognosis by the current economic crisis, and this could potentially be translated into a reduction of survival.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Complete Remission of Metastatic Endometrial Carcinosarcoma With Radical Surgical Resection and Postoperative Chemotherapy Utilizing Paclitaxel and Carboplatin","authors":"Kambiz Novin,&nbsp;Soroush Shahrokh,&nbsp;Mohadese Shahin,&nbsp;Farzad Taghizadeh-Hesary","doi":"10.1002/cnr2.70346","DOIUrl":"https://doi.org/10.1002/cnr2.70346","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To present a case of metastatic endometrial carcinosarcoma (ECS) with a long-term complete response to chemotherapy using a paclitaxel and carboplatin regimen.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Report</h3>\u0000 \u0000 <p>A 47-year-old premenopausal woman was diagnosed with a large, advanced intrauterine tumor. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Pathological assessment revealed a uterine mass with mesenchymal and epithelial components consistent with ECS, while the right ovarian tumor was identified as serous papillary carcinoma. The patient experienced a prolonged postoperative recovery period lasting 3 months. Staging workup later revealed recurrence of adnexal and pulmonary lesions, indicating metastasis. The patient received 6 cycles of postoperative chemotherapy consisting of paclitaxel and carboplatin, achieving complete remission that has persisted for 3 years since the initial diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This case highlights the efficacy of postoperative chemotherapy using paclitaxel and carboplatin in the successful treatment of metastatic ECS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Alpha-Fetoprotein-Producing Gastric Cancer Presenting With Dysphagia and Multiple Liver Tumors","authors":"Takayuki Hirano,&nbsp;Reina Hoshi,&nbsp;Bin Yamaoka,&nbsp;Kako Ono,&nbsp;Yosuke Watanabe,&nbsp;Shumpei Goto,&nbsp;Takashi Hosokawa,&nbsp;Koji Kanezawa,&nbsp;Katsuyoshi Shimozawa,&nbsp;Ayumu Arakawa,&nbsp;Shuichiro Uehara","doi":"10.1002/cnr2.70348","DOIUrl":"https://doi.org/10.1002/cnr2.70348","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) is resistant to chemotherapy and is associated with poor prognosis. Pediatric gastric cancer has an incidence of 0.02% among gastric cancer patients, with a median survival of 5 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case</h3>\u0000 \u0000 <p>A 13-year-old boy presented with progressive dysphagia for 2 months, accompanied by loss of appetite and significant weight loss. Liver dysfunction and multiple lesions were observed. Laboratory investigations revealed elevated liver enzymes and tumor markers, including AFP, at 24 502 ng/mL. Computed tomography (CT) showed thickening of the gastric cardia and multiple liver lesions. Upper gastrointestinal endoscopy revealed a type 2 tumor in the cardia. Histopathology confirmed adenocarcinoma, and immunohistochemical staining was positive for AFP, establishing a diagnosis of AFPGC with liver metastases (Stage IV). Given the unresectable and HER2-negative nature of the cancer, chemotherapy with TS-1 and cisplatin was initiated, resulting in a temporary reduction in AFP levels and tumor size. However, disease progression was noted after 3 months, requiring a switch in treatment to ramucirumab, paclitaxel, bleomycin, etoposide, cisplatin, or a study drug. Despite these efforts, the patient succumbed to the disease 16 months after initial treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AFPGC in children is extremely rare, with few reported cases. The 16-month survival observed in this case exceeds previously reported durations (8 and 4 months). Systematic evaluation of persistent gastrointestinal symptoms enabled earlier diagnosis. Standard adult gastric cancer treatment protocols appeared more effective than AFP-tumor-specific regimens, suggesting they may be optimal for pediatric AFPGC as well. Early diagnosis through detailed history-taking and prompt endoscopic examinations in children with gastrointestinal symptoms may lead to significantly prolonged survival and improved management in this rare malignancy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Major Dietary Patterns With Breast Cancer Among Iranian Women: A Hospital-Based Case–Control Study","authors":"Hamidreza Razmi,&nbsp;Mohammad Hadi Nikbakht,&nbsp;Paria Jemsi,&nbsp;Sima Jafarirad,&nbsp;Maedeh Raeisi Zadeh,&nbsp;Samira Razzaghi,&nbsp;Ali Veissi,&nbsp;Farnush Bakhshimoghaddam","doi":"10.1002/cnr2.70341","DOIUrl":"https://doi.org/10.1002/cnr2.70341","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Breast cancer is the most commonly diagnosed cancer in women worldwide. Several studies have investigated the relationship between breast cancer and specific foods or nutrients, rather than examining an overall dietary pattern. This study aims to investigate the association between breast cancer and the predominant dietary pattern in Ahvaz city.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This hospital-based case–control study was conducted on 106 women with breast cancer and 107 controls. Dietary intake data were collected using a 147-item food frequency questionnaire. We merged the data on the 147 foods into 20 food groups to identify major dietary patterns. Factor analysis with varimax rotation was then employed to determine the primary dietary patterns. Binary logistic regression was used to assess the association between dietary patterns and breast cancer, with adjustment for potential confounders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three dietary patterns were identified: healthy, western, and traditional. The Western dietary pattern was robustly associated with a higher risk of breast cancer in premenopausal women (OR = 4.22; 95% CI: 1.09, 16.31; <i>p</i> = 0.03) in the adjusted model. However, no association was found between a healthy and traditional pattern and breast cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that the Western dietary pattern is positively associated with breast cancer risk in premenopausal Iranian women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Identification and Treatment of Cancer of Unknown Primary Originating From Gastric Cancer Using Comprehensive Genomic Profiling and Immune Checkpoint Inhibitor Therapy: A Case Report","authors":"Takahiro Sasaki,&nbsp;Sayaka Yuzawa,&nbsp;Hiroki Tanabe,&nbsp;Yusuke Ono,&nbsp;Keitaro Takahashi,&nbsp;Katsuyoshi Ando,&nbsp;Nobuhiro Ueno,&nbsp;Shin Kashima,&nbsp;Kentaro Moriichi,&nbsp;Mishie Tanino,&nbsp;Yusuke Mizukami,&nbsp;Mikihiro Fujiya","doi":"10.1002/cnr2.70338","DOIUrl":"https://doi.org/10.1002/cnr2.70338","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cancer of unknown primary (CUP) is a challenging malignancy characterized by metastatic tumors with an unidentified primary site, even after extensive pathological and radiographic evaluation. Recent advancements in gene expression profiling and comprehensive genomic profiling (CGP) using next-generation sequencing (NGS) have enabled the identification of potential tissue origins, thereby facilitating personalized treatment strategies. Although most cases of CUP present as adenocarcinomas or poorly differentiated tumors, the treatment remains largely empirical, with limited success from molecularly tailored therapies. However, advances in tumor DNA sequencing and targeted therapies hold great promise for enhancing patient outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case</h3>\u0000 \u0000 <p>A 72-year-old woman presented with epigastric pain and was diagnosed with a duodenal tumor and gastric ulceration via esophagogastroduodenoscopy. A histological evaluation revealed poorly differentiated adenocarcinoma in the duodenum, and the immunohistochemistry findings supported a pancreatobiliary origin. An endoscopic ultrasound-guided biopsy confirmed poorly differentiated adenocarcinoma in the duodenum, while a subsequent gastric examination revealed well-differentiated adenocarcinoma, suggesting dual malignancies. The patient underwent neoadjuvant chemotherapy, followed by pancreatoduodenectomy with distal gastrectomy. The CUP was staged as poorly differentiated adenocarcinoma (pStage IVB), while the gastric cancer was staged as well-differentiated adenocarcinoma (pStage IA). Despite adjuvant TS-1 therapy, lymph node metastasis near the superior mesenteric artery continued to progress. CGP revealed high microsatellite instability and a high tumor mutational burden, along with multiple actionable genetic mutations. Pembrolizumab monotherapy was initiated, leading to complete remission, with no recurrence observed at 1 year after treatment cessation. Genetic and immunohistochemical investigations have identified microsatellite instability in both CUP and gastric cancer tissues, suggesting a shared origin. Targeted gene sequencing confirmed common genetic variations, ultimately revealing that the CUP originated from gastric cancer cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights the critical role of CGP in the diagnosis and treatment of CUP. The use of advanced molecular techniques, including NGS, revealed the gastric origin of CUP and identified actionable biomarkers, leading to successful treatment with immune checkpoint inhibitors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer Awareness and Knowledge Among Women at a Municipal Hospital in Ghana: A Cross-Sectional Study","authors":"Richard Ofosuhene,&nbsp;Alfred Effah,&nbsp;Wilfred Sam-Awortwi Jr.,&nbsp;Richmond Adu Boahen Boamah,&nbsp;Patricia Akosah,&nbsp;Christian Obirikorang","doi":"10.1002/cnr2.70347","DOIUrl":"https://doi.org/10.1002/cnr2.70347","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Breast cancer is the most common cancer in women worldwide; early detection improves prognosis while reducing mortality and morbidity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study evaluates awareness, knowledge, and health-seeking behaviors related to breast cancer among women attending Bibiani Municipal Hospital in Ghana, where data on awareness is scarce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>This cross-sectional study involved 160 women attending the Bibiani Municipal Hospital. Validated questionnaires were used to collect data on sociodemographic characteristics, awareness and knowledge of breast cancer, breast self-examination (BSE), and health-seeking behaviors. Categorical variables were presented as frequency and percentages. Logistic regression was used to determine the independent predictors of adequate knowledge of breast cancer. Statistical analysis was performed using SPSS (version 26.0) and GraphPad Prism (version 8.0). <i>p</i> &lt; 0.05 was considered statistically significant. Most participants were within 36–50 years (47.5%) and had no formal education (30.6%). Only 14.4% reported a family history of breast cancer. The majority (87.5%) were aware of breast cancer. However, only about 44% and 46% exhibited adequate knowledge regarding the risk factors, signs, and symptoms of breast cancer. The majority identified obesity (87.5%) and family history (80.6%) of breast cancer as risk factors, while most participants also identified a lump (68.1%) and pain (60%) in the breast as signs and symptoms. Education, employment status, age, and awareness of breast cancer were significantly associated with knowledge of breast cancer (<i>p</i> &lt; 0.05). Only 47.5% were familiar with BSE, and BSE was performed by just 35.5% of participants. The majority (74.4%) indicated they would seek immediate help for a breast lump.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite high awareness of breast cancer, knowledge of its risk factors and the signs and symptoms was lacking, with over half unaware of breast self-examination (BSE). Health education campaigns by women-friendly organizations are crucial to improving awareness of symptoms, risk factors, and BSE in the Bibiani municipality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}