Cancer reports最新文献

{"title":"Custom Hydroxyapatite-Coated Stem Collar With Extracortical Plate Provides Excellent Long-Term Results Against Aseptic Loosening in Revision, Including Short-Segment, Endoprosthetic Tumour Reconstruction","authors":"Patrick Qi Wang,&nbsp;Kwok Chuen Wong","doi":"10.1002/cnr2.70254","DOIUrl":"https://doi.org/10.1002/cnr2.70254","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Aseptic loosening from endoprosthetic reconstructions following bone tumour resection is a major issue, especially in the revision/multiple revisions settings. The objective was to present long-term outcomes of revision limb salvage surgery using a custom hydroxyapatite-coated stem collar with an extracortical plate at the bone-implant junction specifically designed to prevent aseptic loosening.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifteen (15) patients with an initial extremity bone tumour resection and reconstruction who underwent revision surgery utilizing this implant specification between 2004 and 2016 were included. Multiple prior surgeries and short-segment stem fixation (&lt; 100 mm) were observed in six and nine patients, respectively. Outcomes of interest were rates of aseptic loosening and radiographic evidence of osseointegration along with clinical and functional outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At mean 12-year follow-up (range 6.5 to 18), no patient had evidence of radiographic or clinical aseptic loosening. The distal femur location (<i>p</i> = 0.044), endoprosthetic reconstruction as index procedure (<i>p</i> = 0.026), mechanical failure as reason for revision (<i>p</i> = 0.0047) and additional fixation to the extracortical plate (<i>p</i> = 0.041) were associated with higher bone ingrowth scores. All but two patients, who had mild pain only, were pain-free. Joint range of motion (<i>p</i> &lt; 0.0001) and limb-length discrepancy (<i>p</i> = 0.021) significantly improved. The mean Musculoskeletal Tumor Society score was 26.1 (excellent).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrated excellent results in preventing long-term aseptic loosening with this custom implant specification, which is useful particularly for revisions/multiple revisions and short-segment fixation. However, further larger scale and multicentric studies are needed to validate the data to the broader population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncology Specialists' Perceptions and Insights Into Dihydropyrimidine Dehydrogenase Testing in Palestine","authors":"Mohammad Dweib,&nbsp;Hussein Hallak,&nbsp;Hani Hour,&nbsp;Asmahan Alzeer,&nbsp;Raya Fatafta,&nbsp;Leen Albaw","doi":"10.1002/cnr2.70251","DOIUrl":"https://doi.org/10.1002/cnr2.70251","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study evaluated awareness, prevalence, and utilization of dihydropyrimidine dehydrogenase (DPD) testing and pharmacogenomics among oncologists, residents, and clinical pharmacists working in Palestinian hospitals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to assess the knowledge and opinions of HCPsspecializing in oncology in Palestine regarding screening for DPYD testing prior to prescribing FP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional survey was distributed to 106 HCPs across various hospitals in Palestine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A notable deficiency in training and implementation of pharmacogenomics was observed, with over 70% of participants lacking formal training in the field. Although there is high awareness of DPD deficiency and its impact, fewer than 50% of participants screen for DPD deficiency prior to prescribing fluoropyrimidines (FP). Standardization and promotion of DPD testing are low, and guidelines for prescribing FP are lacking, leading to variations in clinical practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings highlight the need for enhanced training, standardized protocols, and increased awareness to improve patient safety and outcomes in cancer treatment in Palestine.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudogenes as Potential Diagnostic, Prognostic and Therapeutic Biomarkers in Colorectal Cancer: A Systematic Review","authors":"Ali Asadzadeh,&nbsp;Alireza Zangooie,&nbsp;Parmida Bagheri,&nbsp;Helia Zangooie,&nbsp;Zahra Salehi","doi":"10.1002/cnr2.70263","DOIUrl":"https://doi.org/10.1002/cnr2.70263","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Colorectal cancer (CRC) is a leading cause of oncologic death worldwide. Elucidating the molecular mechanisms that underpin its pathogenesis is essential for identifying novel therapeutic targets. Pseudogenes have historically been regarded as non-functional genomic vestiges but have gained recognition for their contributory roles in the oncogenesis of CRC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This systematic review aims to comprehensively evaluate the current literature regarding the involvement of pseudogenes in CRC, with a focus on their clinical relevance as diagnostic and prognostic biomarkers and their potential as innovative therapeutic targets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>We conducted a comprehensive literature search following the PRISMA guidelines across PubMed, SCOPUS, and Web of Science databases. Two reviewers independently carried out the screening of studies and extraction of relevant data. Nineteen studies met the inclusion criteria. These studies highlight pseudogenes' emerging role in colorectal cancer, transitioning from being seen as evolutionary remnants to recognized contributors in tumorigenesis. Key pseudogenes like DUXAP8, SUCLG2P2, and SUMO1P3 are linked to crucial CRC processes such as proliferation, migration, invasion, and angiogenesis. The diagnostic and prognostic potential is found in pseudogenes like MYLKP1 (with SNPs rs12490683 and rs12497343) and POU5F1P1 (SNP rs6983267). Additionally, CDCP1, SUCLG2P2, and MT1DP offer prognostic insights, guiding personalized treatment approaches. Pseudogenes such as CTNNAP1, NMRAL2P, and DUXAP8 show therapeutic potential, advocating for further research into their mechanisms to enhance CRC diagnostics and personalized care. The intricate involvement of pseudogenes in CRC pathogenesis underscores their importance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our review illuminates the promise of pseudogenes as biomarkers and therapeutic targets, indicating a significant step toward the integration of pseudogenes in the future paradigm of precision medicine for CRC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatic Analysis of C1GALT1 in Cancer: Insights Into Prognosis, Metastasis and Therapeutic Potential","authors":"Ecem Kalemoglu,&nbsp;Ayse Caner","doi":"10.1002/cnr2.70259","DOIUrl":"https://doi.org/10.1002/cnr2.70259","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study evaluates the expression, regulation, and clinical relevance of C1GALT1, a key enzyme in mucin-type O-glycosylation, across a broad spectrum of human cancers. Aberrant glycosylation is a well-established hallmark of malignancy, contributing to tumor growth, immune evasion, and metastasis. C1GALT1, also known as core 1 β1,3-galactosyltransferase or T-synthase, catalyzes the formation of the core 1 O-glycan structure and requires the chaperone Cosmc for proper folding and activity. While previous studies have implicated C1GALT1 in cancer progression, a systematic pan-cancer analysis exploring its gene expression patterns, epigenetic regulation, immune interactions, and prognostic significance has not been fully elucidated.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aims to computationally investigate C1GALT1 expression, regulation, and clinical relevance across multiple cancers using TCGA datasets to evaluate its potential as a biomarker and therapeutic target.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We conducted a comprehensive bioinformatic analysis of C1GALT1 using publicly available datasets from The Cancer Genome Atlas (TCGA). Gene expression, DNA methylation, and survival analyses were performed, along with correlation analyses between C1GALT1 and proliferation- or metastasis-related genes, Cosmc expression, and immune cell infiltration (specifically, regulatory T-cells [Tregs] and myeloid-derived suppressor cells [MDSCs]), using transcriptomic web platforms.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;C1GALT1 expression was significantly upregulated in gastrointestinal and genitourinary cancers compared to normal tissues, while downregulated in thyroid, breast, and prostate cancers. Elevated expression correlated with reduced overall survival in lung, bladder, liver, and glioma/glioblastoma. DNA methylation analysis showed an inverse correlation between methylation and expression levels in multiple cancer types. C1GALT1 expression positively correlated with Cosmc, proliferation markers (MKI67, PCNA, MCM family, PLK1), and several metastasis-associated genes. Immune profiling revealed context-dependent correlations: C1GALT1 negatively correlated with Tregs and MDSCs in gastrointestinal cancers but positively in lung, breast, and prostate cancers.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our pan-cancer analysis suggests that C1GALT1 is differentially expressed and epig","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying and Preserving Parathyroid Glands During Thyroid Surgery Using Indocyanine Green and a Review of the Literature","authors":"Maziar Motiee-Langroudi,&nbsp;Athena Farahzadi,&nbsp;Mohammad Shirkhoda,&nbsp;Habibollah Mahmoodzadeh,&nbsp;Ramesh Omranipour,&nbsp;Amirmohsen Jalaeefar,&nbsp;Iraj Harirchi","doi":"10.1002/cnr2.70226","DOIUrl":"https://doi.org/10.1002/cnr2.70226","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The research aims to investigate the potential use of near-infrared fluorescence imaging with Indocyanine green (ICG) to detect the parathyroid glands (PGs) during surgery and to evaluate their blood supply. Additionally, a review of existing literature was performed to evaluate the utility of near-infrared imaging with ICG in identifying parathyroid glands and reducing the incidence of postoperative hypoparathyroidism, a common complication associated with this type of surgery.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The study was carried out at the Cancer Institute, Tehran University of Medical Science, from December 2022 to April 2023, with 30 subjects participating in the research. In order to identify the PGs and evaluate their vascularization after resection, the patients were given an injection of 5 mg of Indocyanine green (ICG). To determine the usefulness of this technique, a comprehensive review of existing research was conducted using the PubMed and Cochrane Library electronic databases for relevant studies published up to September 2023. The reference lists within those studies were also examined to capture any further relevant research.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Result&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 30 surgical procedures were carried out, during which the calcium level of the patients was monitored. On the first day post-surgery, calcium levels ranged from 7 to 9.8 mg/dL, with an average of 8.4 mg/dL, and a median (interquartile range) of 8.5 mg/dL (7.87–8.82 mg/dL). On the tenth day post-surgery, the mean calcium level was 8.34 mg/dL, with a median (interquartile range) of 8.2 mg/dL (8–8.6 mg/dL). Out of all the patients, 23.6% had avascular parathyroid glands and underwent auto transplantation. In two patients, the surgical team was only able to identify the parathyroid gland (PG) with the help of Indocyanine green (ICG); for the remaining 28 patients, this technique confirmed the presence of parathyroid tissue. A total of 72 PGs were detected with near-infrared fluorescence imaging (NIRF) imaging. There were no complications during or after surgery due to the use of ICG. This article reported on 34 studies where a total of 1699 procedures were conducted, which included total thyroidectomy, lobectomy, and parathyroidectomy. The average dose of ICG administered was found to be 6.96 mg, with a median (interquartile range) of 7.5 mg/dL (5–10 mg/dL). Our findings showed that ICG successfully helped surgeons locate parathyroid glands in an average of 88.25% of cases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 ","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of TSPO Gene Expression Levels in Colorectal Cancer Tumors: A Paired Sample Study","authors":"Hamidreza Karami Gorji,&nbsp;Mehdi Karimi,&nbsp;Masoud Mortezazadeh,&nbsp;Niyousha Shirsalimi,&nbsp;Sheyda Akhshabi,&nbsp;Alireza Yousefi Ladmakhi,&nbsp;Mehdi Kashani,&nbsp;Seyyed Taher Seyyed Mahmoudi,&nbsp;Abbas Mofidi,&nbsp;Abolhasan Rezaei","doi":"10.1002/cnr2.70256","DOIUrl":"https://doi.org/10.1002/cnr2.70256","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Colorectal cancer (CRC) is the second leading cause of cancer-related deaths. Early detection through screening is crucial for improving treatment outcomes. Advanced stages of CRC are frequently associated with distant metastasis, posing significant challenges to treatment. This study aimed to assess Translocator Protein (TSPO) gene expression as a potential indicator of invasive behavior in CRC patients. It explored its utility as a biomarker for CRC diagnosis and prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this case–control study, 50 samples were collected from 25 patients with CRC who had undergone colectomy. These included 25 colorectal tumor tissues (case) and 25 non-tumor marginal tissues (control). RNA was extracted and assessed for TSPO gene expression using Real-Time Polymerase Chain Reaction (RT-PCR). The data were analyzed using Relative Expression Software Tool (REST) to determine gene expression levels. SPSS version 24 was used for all statistical analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant increase in TSPO gene expression was observed in CRC tumor tissues compared to normal samples (<i>p</i> &lt; 0.001). This elevated expression was significantly associated with tumor grade (<i>p</i> &lt; 0.05), suggesting a link with disease severity. However, no significant differences in TSPO expression were found between tumor and non-tumor groups when analyzed by sex (male vs. female) or age (&lt; 50 vs. &gt; 50 years).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>TSPO gene expression is elevated in colorectal tumor tissues and is significantly associated with tumor grade. These findings suggest a potential role for TSPO in the development and progression of colorectal cancer. Recognizing the relationship between these genes in the differentiation of changes in CRC cells, especially in clinical trials, can be crucial in finding and controlling the mechanisms involved.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Development of Breast Mass With Recurrent Episodes of Hypoglycemia Should Raise Suspicion of Breast Cancer With Insulinoma: A Case Report","authors":"Tingting Liu,&nbsp;Lin Deng,&nbsp;Ruohan Su,&nbsp;Lin Ni,&nbsp;Zhiwei Wang,&nbsp;Wanqiu Xiong,&nbsp;Bing Wang,&nbsp;Sheng Huang","doi":"10.1002/cnr2.70243","DOIUrl":"https://doi.org/10.1002/cnr2.70243","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Breast cancer ranks first in the global incidence rate of malignant tumors in women. Despite the continuous emergence of new treatment methods, it remains a significant threat to the lives and quality of life of patients. Insulinoma, a rare pancreatic neuroendocrine tumor, causes pancreatic beta cells to over-secrete insulin, disrupting the normal physiological feedback mechanism and leading to hyperinsulinemia. Studies have demonstrated that hyperinsulinemia can promote tumor development through various pathways, posing substantial challenges to tumor treatment. However, in previous studies, no successful treatment cases of breast cancer combined with insulinoma have been reported. Therefore, we present a case of metastatic breast cancer co-occurring with insulinoma. The patient presented with a rapidly growing mass in the left breast accompanied by recurrent hypoglycemic symptoms. Following our treatment, the condition was significantly and effectively controlled.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case</h3>\u0000 \u0000 <p>A 57-year-old female with a rapidly enlarging mass in the left breast for over 1 year, currently measuring approximately 11 × 10 × 8 cm, with multiple enlarged and fused lymph nodes palpable in the ipsilateral axilla and bilateral neck. She had a history of recurrent hypoglycemic symptoms for 2 years, confirmed by laboratory tests, imaging examinations, fine needle aspiration biopsy (FNA), as metastatic breast cancer combined with insulinoma. On August 3, 2023, she underwent ultrasound-guided alcohol ablation of the insulinoma and complete neoadjuvant therapy for breast cancer. The hypoglycemic symptoms disappeared and the tumor was rapidly and effectively controlled. Unfortunately, due to economic reasons, the patient refused further surgical treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The unique aspect of this case lies in the rapid growth of a breast mass over a one-year period, accompanied by recurrent episodes of hypoglycemia. Following clinical evaluation, the diagnosis was metastatic breast cancer with concomitant insulinoma. To our knowledge, reports of similar cases are scarce. This case underscores the importance for clinicians to remain vigilant when encountering rapidly progressing cancers, particularly in identifying various factors that may contribute to cancer development. When multiple diseases coexist, it is crucial to recognize the interrelationships between these conditions and to adopt a multidisciplinary approach to treatment, thereby striving to provide the best personalized care for patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction Model for Familial Aggregated HBV-Associated Hepatocellular Carcinoma Based on Serum Biomarkers","authors":"Linmei Zhong,&nbsp;Guole Nie,&nbsp;Qiaoping Wu,&nbsp;Honglong Zhang,&nbsp;Haiping Wang,&nbsp;Jun Yan","doi":"10.1002/cnr2.70253","DOIUrl":"https://doi.org/10.1002/cnr2.70253","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Accurate assessment of the risk of familial aggregated hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) and regular surveillance for these patients at high risk may be valuable to reduce the occurrence and improve the prognosis of HCC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to develop a simple and reliable prediction model for the risk of HCC in these patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>This study analyzed clinical laboratory results from a database of 1285 patients with familial aggregated HBV who attended the First Hospital of Lanzhou University from January 2010 to December 2019. Univariate and multivariate logistic regression (LR) analysis showed that hemoglobin (Hb), neutrophil percentage (NP), total protein (TP), glutamyl transpeptidase (GGT), alglucosidase alfa (AFU), aspartate aminotransferase (AST) to Alanine aminotransferase (ALT) ratio (AAR), and alpha-fetoprotein (AFP) were identified to be independent risk factors for HBV-associated HCC. Prediction models were developed using a multivariate LR model, classification and regression tree, Native Bayes, Bagged tree, AdaBoost, and random forest. We used a multivariate LR model as a benchmark for performance assessment (AUC = 0.737). The results showed that the Native Bayes model had an AUC of 0.749, which was better than that of the other models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Finally, the Native Bayes model demonstrated better predictive performance for HCC, which helped in the clinical decision-making and identification of HCC high-risk groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wernicke Encephalopathy in a Child With Acute Lymphoblastic Leukemia: A Case Report","authors":"Ghazaleh Shakibamaram,&nbsp;Mohammadreza Dolikhani,&nbsp;Farideh Moussavi,&nbsp;Syna Sarraf,&nbsp;Bredsin Benyamin,&nbsp;Soroor Advani","doi":"10.1002/cnr2.70235","DOIUrl":"https://doi.org/10.1002/cnr2.70235","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Wernicke encephalopathy (WE) is a life-threatening neurological disorder caused by thiamine deficiency, commonly associated with alcoholism but also observed in malnourished pediatric cancer patients undergoing intensive chemotherapy. WE remains underdiagnosed in children, with many cases only confirmed postmortem. We report a 6-year-old girl with acute lymphoblastic leukemia (ALL) who developed WE secondary to treatment-resistant nausea and vomiting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case</h3>\u0000 \u0000 <p>The patient presented with acute gait disturbance, ophthalmoparesis, and paraparesis following persistent vomiting and significant weight loss. Initial diagnostic evaluations, including cerebrospinal fluid analysis and neuroimaging, suggested alternative diagnoses such as cerebellitis and Guillain-Barré Syndrome. However, progressive neurological deterioration, the emergence of encephalopathy, and follow-up magnetic resonance imaging (MRI) findings of hyperintense lesions in the periventricular, periaqueductal, and cerebellar regions supported the diagnosis of WE. The overlapping features with other neurological conditions contributed to a delay in recognizing WE and initiating thiamine therapy. Despite initiating high-dose intravenous thiamine, symptom resolution was significant but partial. Unfortunately, the patient later developed lymphomatous meningitis and sepsis and ultimately succumbed to complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights the importance of early clinical recognition of WE in pediatric leukemia patients with prolonged vomiting, as delayed diagnosis can lead to irreversible neurological damage or death. Given the limitations of early neuroimaging findings, clinical suspicion should prompt immediate thiamine supplementation. The report points out the need for heightened awareness of thiamine deficiency in pediatric oncology, emphasizing the role of prophylactic supplementation in high-risk patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Venetoclax and Selinexor in Targeting Hypoxia-Induced Vulnerabilities in Multiple Myeloma","authors":"Seiichi Okabe,&nbsp;Yuya Arai,&nbsp;Yuko Tanaka,&nbsp;Akihiko Gotoh","doi":"10.1002/cnr2.70249","DOIUrl":"https://doi.org/10.1002/cnr2.70249","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Multiple myeloma (MM) is a blood cancer marked by the abnormal clonal growth of plasma cells. Hypoxia plays a critical role in the progression and treatment resistance of MM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study investigates the expression of B-cell/CLL lymphoma 2 (BCL2) family genes. We also investigated the activity of BCL2 and exportin-1 (XPO1) inhibitors and the potential therapeutic synergy of venetoclax and selinexor under hypoxic conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>Analysis of publicly available datasets revealed hypoxia-induced upregulation of <i>BCL2</i> and <i>BCL2-like 11</i> (<i>BCL2L11)</i>, while <i>BCL2-associated agonist of cell death (BAD)</i> expression was suppressed. Venetoclax, a selective BCL2 inhibitor, demonstrated enhanced cytotoxicity and increased caspase-3/7 activity under hypoxic conditions. Selinexor exhibited potent anti-myeloma effects, including dose-dependent reductions in cell viability and increased apoptotic activity. Combining selinexor with venetoclax under hypoxia produced anti-myeloma effects, significantly reducing cell viability, increasing apoptosis, and disrupting the mitochondrial membrane potential. This combination effectively overcame resistance in bortezomib-resistant MM cells and demonstrated efficacy in primary plasma cell leukemia (PCL) samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings highlight the potential of selinexor and venetoclax combination therapy to exploit hypoxia-induced vulnerabilities in MM cells.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}