Cancer reports最新文献

{"title":"Acetyl Salicylic Acid, COX-2 Inhibitors and Other NSAIDs and Breast Cancer Survival in a Finnish Population-Based Cohort","authors":"M. Malin,&nbsp;M. Murto,&nbsp;O. Arponen,&nbsp;A. Jukkola,&nbsp;A. Siltari,&nbsp;M. Artama,&nbsp;K. Visvanathan,&nbsp;T. Murtola","doi":"10.1002/cnr2.70271","DOIUrl":"https://doi.org/10.1002/cnr2.70271","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Non-steroidal anti-inflammatory drugs (NSAIDs), particularly acetylsalicylic acid (ASA), have been associated with reduced breast cancer (BCa) mortality. While overexpression of cyclooxygenase-2 (COX-2) correlates with poorer prognosis in BCa, COX-2 inhibitors (coxibs) have not demonstrated a survival advantage. However, the evidence remains conflicting and limited. We examined associations between BCa mortality and NSAID use in a Finnish population-based cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study cohort, 73 170 women with new BCa diagnosis during 1995–2013 was identified from The Finnish Cancer Registry. Follow-up data including date and the cause of death, NSAID purchases from 1995 to 2015, mammography screening participation and tumor hormone receptor status, were obtained from national registries. NSAID purchases were categorized into NSAIDs overall, ASA, and coxibs. BCa-specific and overall survival by NSAID use were analyzed using Cox proportional hazard regression, adjusted for age, tumor extent, primary treatment, Charlson comorbidity index, hypertension, diabetes, mammography participation, and hormonal therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pre-diagnostic use of NSAIDs (HR 0.78, 95% CI: 0.75–0.81) and coxibs (HR 0.76, 95% CI: 0.71–0.81) was associated with reduced BCa mortality, while ASA showed no association. Post-diagnostic NSAID use was associated with increased BCa mortality (HR 1.27, 95% CI: 1.22–1.33), while ASA use (HR 0.84, 95% CI: 0.73–0.97) showed dose-dependent risk reduction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Post-diagnostic use of ASA is associated with reduced BCa-specific mortality, distinguishing ASA from other NSAIDs. Clinical trials are required to determine the ideal ASA dose, frequency, and duration for treating BCa. Pre-diagnostic use of NSAIDs overall is associated with a slight reduction in BCa mortality without dose dependence. The potential role of pre-diagnostic NSAID use as a prognostic factor in BCa warrants further investigation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Hormone Receptor-Dependent Correlations Between Angiopoietins and VEGF-C in Primary Breast Cancer: Insights Into Lymphangiogenic Biomarkers”","authors":"","doi":"10.1002/cnr2.70252","DOIUrl":"https://doi.org/10.1002/cnr2.70252","url":null,"abstract":"<p>\u0000 <span>V. Montazeri</span>, <span>P. Varshosaz</span>, <span>A. Fakhrjou</span>, and <span>S. Pirouzpanah</span>, “ <span>Hormone Receptor-Dependent Correlations Between Angiopoietins and VEGF-C in Primary Breast Cancer: Insights Into Lymphangiogenic Biomarkers</span>,” <i>Cancer Reports</i> <span>8</span>, no. <span>5</span> (<span>2025</span>): e70101, https://doi.org/10.1002/cnr2.70101.\u0000 </p><p>These changes can be seen in the published version.</p><p>The publisher apologizes for these errors.</p>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"M1 Macrophage-Derived Extracellular Particles Induce Cell Death in MDA-MB-231 Cells","authors":"Parth Desai,&nbsp;Anjali Kumari,&nbsp;Saqer Al Abdullah,&nbsp;Azreen Anwar,&nbsp;Kyle Nowlin,&nbsp;Kristen Dellinger","doi":"10.1002/cnr2.70237","DOIUrl":"https://doi.org/10.1002/cnr2.70237","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Triple-negative breast cancer (TNBC), a leading cause of female mortality worldwide, presents a treatment challenge due to the lack of targeted receptors. Macrophages, recognized for their role in the immune response, provide a promising avenue for cancer research. Given that macrophages secrete extracellular particles (EPs), which have been implicated in biological processes, including intercellular communication and immune modulation, it is hypothesized that EPs derived from macrophages could have potential anticancer effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study examines the effect of M1 macrophage-secreted EPs on TNBC cells to investigate their potential as a therapeutic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>Polarization was induced in RAW 264.7 macrophages and characterized using ELISA, nitrite release, and microscopy. Macrophage-derived EPs were isolated and characterized using nanoparticle tracking analysis, electron microscopy, and western blotting. The influence of EPs on MDA-MB-231 cells, a TNBC model, was assessed using confocal microscopy. Results showed the increasing expression of caspase 3/7 in a time-dependent manner (0, 24, and 48 h). Cell death was observed in TNBC cells with M1 macrophage-derived EPs, while cell proliferation was observed when M2 macrophage-derived EPs interacted with MDA-MB-231 cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, results showed that EPs derived from M1 macrophages could induce cell death in MDA-MB-321 cells, opening up potential options for new treatments in TNBC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Vascular Features Associated With Local Recurrence in Pancreatic Cancer Post-Pancreaticoduodenectomy: A Retrospective Cohort Study","authors":"Ting-Kai Liao,&nbsp;Ying Jui Chao,&nbsp;Wei-Hsun Lu,&nbsp;Ping-Jui Su,&nbsp;Chih-Jung Wang,&nbsp;Yan-Shen Shan","doi":"10.1002/cnr2.70267","DOIUrl":"https://doi.org/10.1002/cnr2.70267","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to analyze the risk factors for local recurrence (LR) following pancreaticoduodenectomy (PD) in pancreatic cancer patients and to identify vascular features associated with this outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pancreatic cancer frequently involves the mesenteric root, particularly the Porto-mesenteric vein (PV-SMV), impacting survival post curative surgery. However, the relationship between vascular structural changes and LR post-operation remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective data collection was conducted at a single tertiary center from December 2010 to March 2021. Clinical characteristics, surgical-pathological factors, and radiological features were compiled.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 203 pancreatic cancer cases undergoing PD were analyzed, with 72 (35.5%) undergoing concurrent PV-SMV resection (VR). Median overall survival post-operation was 22.4 months. LR occurred in 121 patients (60%) at a median time of 8 months postoperatively. Resectable disease exhibited significantly longer local-recurrence free survival compared to borderline resectable/locally advanced pancreatic cancer (BRPC/LAPC) (median 14.5 vs. 7 months, <i>p</i> &lt; 0.001). The most frequent sites of LR were the mesenteric root (37%), superior mesenteric artery (SMA, 21%), and superior mesenteric vein (SMV, 16%), with similar patterns observed in the VR and non-VR groups. BRPC, LAPC, postoperative CA19-9 above normal range, venous thrombosis, and stenosis were associated with LR (HR: 2.1 [95% CI 1.21–3.68], 2.7 [95% CI 1.6–4.71], 1.8 [95% CI 1.21–2.69], 2.0 [95% CI 1.08–3.92], and 1.6 [95% CI 1.0–2.65], respectively), while PV-SMV resection and enlargement of PV-SMV angle were protective factors (HR: 0.4 [95% CI 0.25–0.67] and 0.3 [95% CI 0.19–0.53]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite aggressive treatment strategies including neoadjuvant therapy and radical surgery, LR in pancreatic cancer remains a challenge. This study highlights potential risk factors, recurrence patterns, and associated vascular features for early identification. These findings may guide clinicians in developing more targeted surveillance strategies and inform future research on preventing LR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends of Non-Hodgkin Lymphoma Incidence Among Adults in the United States From 2000 to 2020","authors":"Armin Aslani,&nbsp;Morvarid Najafi,&nbsp;Seyed Ehsan Mousavi,&nbsp;Hanieh Marandi,&nbsp;Zahra Yekta,&nbsp;Seyed Aria Nejadghaderi","doi":"10.1002/cnr2.70269","DOIUrl":"https://doi.org/10.1002/cnr2.70269","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Non-Hodgkin lymphoma (NHL) comprises a broad range of hematologic cancers originating from lymphoid tissues. It ranks among the 10 most frequently diagnosed cancers in the United States (US).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aims to analyze trends in the incidence of adult NHL in the US from 2000 to 2020, considering factors such as age, sex, race/ethnicity, and histological subtypes. Additionally, the impact of the COVID-19 pandemic on these incidence trends was explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>Data from the Surveillance, Epidemiology, and End Results program were utilized to examine the age-standardized incidence rates (ASIR) of NHL. Joinpoint regression modeling was applied to calculate the annual percent change (APC) and the average annual percent change (AAPC) of ASIRs over the period from 2000 to 2020. From 2000 to 2019, a total of 962 535 NHL were reported among all ages in the US. They were mostly B-cell NHL (93.59%), in Non-Hispanic Whites (73.31%), and individuals aged 70–79 (25.94%). The overall ASIRs were 55.58 (55.43, 55.73) for men and 36.00 (35.89, 36.11) for women. There was a notable decline in ASIRs following the onset of the COVID-19 pandemic from 2019 to November 2020, with a percentage change of −10.52% (−11.60, −9.45). The overall AAPC for adult NHL was 0.45% (0.33, 0.62) in men and 0.38% (0.21, 0.57) in women, indicating a minimal yet significant increase.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NHL incidence increased over 2000–2019. These trends in incidence rates exhibited variation across different races, sexes, age groups, and histological subtypes. COVID-19 led to a decrease in NHL incidence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward the Patient Participation Pathway: A Mixed Methods Study of Patients With Cancer and Other Chronic Diseases","authors":"Paloma Casado Durández,&nbsp;Eleuterio A. Sánchez-Romero,&nbsp;Alicia Negrón Fraga,&nbsp;Concepción Rey Benayas,&nbsp;Claudia Ruiz-Huerta García de Viedma,&nbsp;Davinia Medina Ferrer,&nbsp;Ildefonso González Solana,&nbsp;Maria Caballero Nahúm,&nbsp;Mercedes Vinuesa Sebastián,&nbsp;Rosa María de la Salazar Guerra,&nbsp;Nina Cadeau-Comte,&nbsp;Laura Jiménez-Ortega,&nbsp;Juan Nicolás Cuenca-Zaldívar","doi":"10.1002/cnr2.70258","DOIUrl":"https://doi.org/10.1002/cnr2.70258","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Chronic diseases such as breast cancer, colon cancer, chronic obstructive pulmonary disease (COPD), stroke, diabetes, depression, and myocardial infarction remain leading causes of death worldwide, contributing significantly to premature mortality. Understanding psychosocial impact is essential for comprehensive care. This study aimed to explore how patients with different chronic disease profiles experience participation during the chronic phase, using a mixed-methods approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A convergent parallel mixed-methods design was used to integrate qualitative data from focus group discussions and quantitative data from physical performance tests. A total of 117 patients were recruited through clinical referrals and patient associations, using purposive and snowball sampling. Thematic analysis was performed collaboratively to ensure consistency. Statistical analysis (R v4.1.3) examined the coding and sentiment differences across disease profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The sample included 117 patients (mean age = 58.66 years; majority were female). Significant differences in qualitative coding were found between pathologies (<i>p</i> &lt; 0.001), particularly regarding quality of life and emotional experience in COPD and stroke patients compared to others (<i>p</i> &lt; 0.05). Topic modeling identified seven relevant topics, and two main coding clusters emerged: one focused on pain and basic activities, and the other on environment and advanced activities. Positive emotions were predominant (<i>p</i> &lt; 0.001). The thematic analysis revealed three main themes: quality of life, emotional experience, and empowerment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with different chronic conditions experienced disease and unique participation. Patients with breast cancer prioritized pain and daily function, while patients with COPD focused on autonomy in self-management. These findings support the need for individualized disease-specific approaches to promote meaningful patient participation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Androgen Receptor as a Molecular Docking Target for Survival and Response to Metformin-Induced Ferroptosis in Liver Cancer","authors":"Bin Zhang,&nbsp;Zehao Yu,&nbsp;Jinghui Zhang,&nbsp;Yini Xu,&nbsp;Mengna Zhang,&nbsp;Zhiqi Dai,&nbsp;Jiyun Zhu,&nbsp;Siming Zheng","doi":"10.1002/cnr2.70245","DOIUrl":"https://doi.org/10.1002/cnr2.70245","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hepatocellular Carcinoma (HCC) ranks among the most prevalent human cancers and stands as the third most common cause of death related to cancer globally. Current therapies for HCC include surgical resection, local ablation, chemoembolization, liver transplantation, and molecular-targeted therapy. Only a small number of patients are detected in the early stage, and most patients are diagnosed at the time of the middle and late stages, thus losing the opportunity for surgical treatment, which is an essential reason for the high mortality of HCC patients. Initiating cytotoxicity in cancer cells stands as a fundamental approach for tumor treatment, with the majority of research centering on apoptosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Since anti-apoptotic methods often fulfill cancer cells' ability to resist anticancer drugs, research on new induction forms of regulative cell death, such as ferroptosis, is of great clinical value.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>In this study, we employed a combination of in silico molecular docking and in vitro cell validation experiments to identify three ferroptosis suppressor genes, AR, HIF1A, and CA9, as promising components of a survival prognosis model during the metformin-induced ferroptosis process in liver cancer. Further, we discovered that AR could achieve efficient molecular docking with Metformin among these genes. Additionally, cell experiments revealed that Metformin could downregulate the protein expression level of AR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This research has developed a prognostic model for ferroptosis suppressor genes through the analysis of the ferroptosis process induced by metformin in liver cancer. It also screened and validated AR as a potential molecular docking target for metformin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Anaesthesia and Cardiopulmonary Bypass in Paediatric Patients With Abdominal Tumours Invading the Inferior Vena Cava and Right Atrium: A Case Series of a Tertiary Children's Medical Centre in China","authors":"Shangyingying Li,&nbsp;Hongzhen Xu,&nbsp;Jie Li,&nbsp;Ting Zhang,&nbsp;Jie Cui","doi":"10.1002/cnr2.70268","DOIUrl":"https://doi.org/10.1002/cnr2.70268","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Paediatric patients with abdominal tumours associated with tumour thrombus in the inferior vena cava (IVC) and right atrium are relatively rare in clinical practice. Hence, we summarised the management strategies for anaesthesia and cardiopulmonary bypass (CPB) used during surgical treatment for these conditions through multidisciplinary cooperation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We collected the clinical data of paediatric patients who underwent surgery for tumour thrombus removal via CPB from January 2012 to December 2022 because their abdominal tumours had invaded the IVC and right atrium. We explored the strategies used to manage anaesthesia and CPB, assessed the incidence of intraoperative haemorrhage and arterial blood gas analysis, reported the incidence of blood transfusion and described the postoperative outcome and follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of six paediatric patients underwent surgery under CPB to remove the tumour thrombus. Among them, two patients had nephroblastoma, one had renal clear cell carcinoma and three had hepatoblastoma. The average age of the six patients was 25.8 months. The average operation time was 459.8 min, and the average anaesthesia time was 553.1 min. The average CPB time was 150.3 min, and the average aortic block time was 46.1 min. The average hypothermic circulatory arrest time was 20 min. The average quantity infused was as follows: red blood concentrate (RBC): 5.1 units, cryoprecipitate: 3.2 units, fresh frozen plasma (FFP): 200 mL and platelets (PLTs): 4.2 units. The time of extubation ranged from 4 h to 8 days, and the average time spent in the intensive care unit (ICU) was 6.2 days after surgery. No serious complications occurred during the follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The present retrospective study aims to share our clinical experience with the management strategies of anaesthesia and CPB. Steady induction of anaesthesia, intraoperative massive haemorrhage and critical intraoperative situations are the major challenges in anaesthesia management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting Morphological and Functional Dynamics of Non-Tumorigenic and Triple-Negative Breast Cancer Cell Lines Using PCA and t-SNE Analysis","authors":"Yazan A. Almahdi,&nbsp;Eva R. Schwark,&nbsp;Aidan J. Mclaughlin,&nbsp;Besa Xhabija","doi":"10.1002/cnr2.70257","DOIUrl":"https://doi.org/10.1002/cnr2.70257","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Triple-negative breast cancer (TNBC) poses significant challenges due to its aggressive nature and lack of targeted therapies. Understanding the cellular behaviors of TNBC is crucial for developing effective treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aims to compare the morphological characteristics of non-tumorigenic MCF10A and aggressive MDA-MB-231 TNBC cell lines using advanced analytical techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>Advanced techniques such as Principal Component Analysis (PCA), t-Distributed Stochastic Neighbor Embedding (t-SNE), and digital holographic microscopy were utilized. Cellular features such as area, migration, motility, irregularity, and optical thickness were thoroughly analyzed over time. Our results revealed significant morphological differences between the MCF10A and MDA-MB-231 cell lines. Specifically, MDA-MB-231 cells displayed enhanced motility and a smaller, more variable size, attributes that may facilitate their invasive potential. In contrast, MCF10A cells exhibited larger sizes and more regular migration patterns, suggesting stability in structured tissue environments. Additionally, temporal analysis highlighted consistent phenotypic behaviors over time, with MDA-MB-231 cells demonstrating higher optical thickness and irregularity, indicating potential structural complexities associated with malignant transformation. Correlative analysis further confirmed these results by revealing connections between cell size, motility, and optical properties crucial for understanding cell behavior within their microenvironment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The profound differences in cellular dynamics between MCF10A and MDA-MB-231 cell lines underscore the unique adaptive mechanisms of TNBC cells. Our study provides valuable insights into the cellular foundations of TNBC aggressiveness, offering a foundation for future research aimed at understanding the mechanistic underpinnings of TNBC progression and therapeutic targeting.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus on Information Provision for Patients With Early-Stage Colorectal Cancer: A Delphi Study Among Healthcare Practitioners and Patients","authors":"Ilaria Prata,&nbsp;Nina C. A. Vermeer,&nbsp;Koen C. M. J. Peeters,&nbsp;Fabian A. Holman,&nbsp;Elma Meershoek-Klein Kranenbarg,&nbsp;Arwen H. Pieterse","doi":"10.1002/cnr2.70225","DOIUrl":"https://doi.org/10.1002/cnr2.70225","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients with radically endoscopically treated T1 colorectal cancer (CRC) with at least one high-risk histopathological characteristic are presented with the choice between additional surgical resection with lymphadenectomy or intensive surveillance. Healthcare practitioners (HCPs) from various disciplines provide information on the complex trade-offs involved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We aimed to reach consensus on what information patients should be offered at the time of decision making.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We invited HCPs and patients with early-stage (pT1-3N0M0) CRC to participate in a three-round online Delphi study. In the first round, participants were asked to indicate the relevance of 163 items regarding CRC surgery and intensive surveillance, using five-point Likert-type scales. The following rounds only included the items on which no consensus had been reached yet, supplemented with new items that participants had suggested in the previous round(s). Criteria for consensus were defined in advance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty percent (109/341) of the invited participants completed ≥ 50% of items in the first round. After the third round, consensus was reached on 80/154 items regarding colon cancer and 129/179 items regarding rectal cancer; of these, respectively, 40 and 47 items were considered relevant. HCPs tended to consider more frequently occurring complications relevant compared to patients. Patients also considered rare complications relevant but expressed worries about information overload. There was clear consensus on items regarding different types of surgery and recovery expectations, the risk of anastomotic leakage and of receiving a stoma, and the risk of recurrence after both surgery and intensive surveillance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A consensus-based, standardized set of information items was defined in order to facilitate that patients receive complete information in a uniform way. The results of this study aim to support patients and their HCPs to make a well-informed decision between additional surgical resection with lymphadenectomy and intensive surveillance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}