Mojtaba Aghaei, Mohammad Ali JalaliFar, Arshid Yousefi-Avarvand, Seyed Sobhan Bahreiny, Negin Karamali, Zahra Mansouri, Mahdi Amraei, Shaban Alizadeh, Najmaldin Saki, Mohammad-Navid Bastani, Tannaz Sakhavarz, Mohammad Ali Khaksar, Leila Goudarzimehr, Somaieh Mousavei, Ebrahim Babadi
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Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were pooled using a random-effects model to quantify effect sizes. Subgroup analyses and meta-regression were employed to explore heterogeneity sources. Data extracted from 15 studies encompassing 674 patients with ALL demonstrated a significant correlation between elevated VEGF-A levels and unfavorable prognosis (SMD: 0.878; 95% CI: 0.276–1.479; <i>p</i> = 0.004). 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引用次数: 0
摘要
血管内皮生长因子-a （VEGF-A）与其他促血管生成因子联合，在急性淋巴细胞白血病（ALL）的血管生成和发病过程中起关键作用。本荟萃分析旨在评估VEGF-A的诊断价值及其与ALL患者预后的相关性。方法与结果对截至2025年1月的多个数据库进行综合文献检索。采用随机效应模型对95%置信区间（ci）的标准化平均差异（SMDs）进行汇总，以量化效应大小。采用亚组分析和元回归分析探讨异质性来源。从包含674例ALL患者的15项研究中提取的数据显示，VEGF-A水平升高与不良预后之间存在显著相关性（SMD: 0.878; 95% CI: 0.276-1.479; p = 0.004）。值得注意的是，VEGF-A水平的升高在8岁以上的儿科患者中尤为明显（SMD: 0.758; 95% CI: 0.178-1.338; p = 0.010）。结论：VEGF-A表达升高与ALL患者较差的临床预后相关，支持其作为该患者群体诊断和预后生物标志物的实用性。
Update Prognostic Potency of Vascular Endothelial Growth Factor-A in the Acute Lymphoblastic Leukemia Landscape: A Meta-Analysis
Background
Vascular endothelial growth factor-A (VEGF-A), In combination with other pro-angiogenic factors, plays a pivotal role in angiogenesis and the pathogenesis of acute lymphoblastic leukemia (ALL).
Aims
This meta-analysis aims to evaluate the diagnostic value of VEGF-A and its prognostic relevance in the outcome of patients with ALL.
Methods and Results
A comprehensive literature search was conducted up to January 2025 across multiple databases. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were pooled using a random-effects model to quantify effect sizes. Subgroup analyses and meta-regression were employed to explore heterogeneity sources. Data extracted from 15 studies encompassing 674 patients with ALL demonstrated a significant correlation between elevated VEGF-A levels and unfavorable prognosis (SMD: 0.878; 95% CI: 0.276–1.479; p = 0.004). Notably, increased VEGF-A levels were particularly evident in pediatric patients older than 8 years (SMD: 0.758; 95% CI: 0.178–1.338; p = 0.010).
Conclusion
The results indicate that heightened VEGF-A expression is associated with poorer clinical outcomes in ALL, supporting its utility as a diagnostic and prognostic biomarker in this patient population.
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