Long-Term Complete Remission of Metastatic Endometrial Carcinosarcoma With Radical Surgical Resection and Postoperative Chemotherapy Utilizing Paclitaxel and Carboplatin

IF 1.9 Q4 ONCOLOGY

Cancer reports Pub Date : 2025-09-09 DOI:10.1002/cnr2.70346

Kambiz Novin, Soroush Shahrokh, Mohadese Shahin, Farzad Taghizadeh-Hesary

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Abstract

Objective

To present a case of metastatic endometrial carcinosarcoma (ECS) with a long-term complete response to chemotherapy using a paclitaxel and carboplatin regimen.

Case Report

A 47-year-old premenopausal woman was diagnosed with a large, advanced intrauterine tumor. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Pathological assessment revealed a uterine mass with mesenchymal and epithelial components consistent with ECS, while the right ovarian tumor was identified as serous papillary carcinoma. The patient experienced a prolonged postoperative recovery period lasting 3 months. Staging workup later revealed recurrence of adnexal and pulmonary lesions, indicating metastasis. The patient received 6 cycles of postoperative chemotherapy consisting of paclitaxel and carboplatin, achieving complete remission that has persisted for 3 years since the initial diagnosis.

Conclusions

This case highlights the efficacy of postoperative chemotherapy using paclitaxel and carboplatin in the successful treatment of metastatic ECS.

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转移性子宫内膜癌肉瘤根治性手术切除和术后紫杉醇和卡铂化疗的长期完全缓解

目的报道一例转移性子宫内膜癌肉瘤（ECS）对紫杉醇加卡铂化疗方案的长期完全缓解。病例报告一个47岁的绝经前妇女被诊断为一个大的，晚期子宫内肿瘤。她接受了全腹子宫切除术和双侧输卵管卵巢切除术。病理检查显示子宫肿块伴间质和上皮成分，与ECS一致，而右侧卵巢肿瘤被确定为浆液性乳头状癌。术后恢复期延长3个月。后来的分期检查显示附件和肺部病变复发，提示转移。患者术后接受紫杉醇加卡铂6个周期的化疗，自初诊以来，完全缓解持续了3年。结论本病例强调了紫杉醇联合卡铂在转移性ECS术后化疗中的疗效。

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