Journal of pharmaceutical analysis最新文献_第6页

Green analytical chemistry metrics for evaluating the greenness of analytical procedures. 绿色分析化学指标用于评价分析过程的绿色度。

Journal of pharmaceutical analysis Pub Date : 2024-11-01 Epub Date: 2024-05-25 DOI: 10.1016/j.jpha.2024.101013

Lei Yin, Luyao Yu, Yingxia Guo, Chuya Wang, Yuncheng Ge, Xinyue Zheng, Ning Zhang, Jiansong You, Yong Zhang, Meiyun Shi

{"title":"Green analytical chemistry metrics for evaluating the greenness of analytical procedures.","authors":"Lei Yin, Luyao Yu, Yingxia Guo, Chuya Wang, Yuncheng Ge, Xinyue Zheng, Ning Zhang, Jiansong You, Yong Zhang, Meiyun Shi","doi":"10.1016/j.jpha.2024.101013","DOIUrl":"https://doi.org/10.1016/j.jpha.2024.101013","url":null,"abstract":"Green analytical chemistry (GAC) focuses on mitigating the adverse effects of analytical activities on human safety, human health, and environment. In addition to the 12 principles of GAC, proper GAC tools should be developed and employed to assess the greenness of different analytical assays. The 15 widely used GAC metrics, i.e., national environmental methods index (NEMI), advanced NEMI, assessment of green profile (AGP), chloroform-oriented toxicity estimation scale (ChlorTox Scale), Analytical Eco-Scale, Green Certificate Modified Eco-Scale, analytical method greenness score (AMGS), green analytical procedure index (GAPI), ComplexGAPI, red-green-blue (RGB) additive color model, RGB 12 algorithm, analytical greenness calculator (AGREE), AGREE preparation (AGREEprep), HEXAGON, and blue applicability grade index (BAGI), are selected as the typical tools. This article comprehensively presents and elucidates the principles, characteristics, merits, and demerits of 15 widely used GAC tools. This review is helpful for researchers to use the current GAC metrics to assess the environmental sustainability of analytical assays.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 11","pages":"101013"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Small is beautiful" - Examining reliable determination of low-abundant therapeutic antibody glycovariants. “小即是美”-检测低丰度治疗性抗体糖变的可靠测定。

Journal of pharmaceutical analysis Pub Date : 2024-10-01 Epub Date: 2024-04-26 DOI: 10.1016/j.jpha.2024.100982

Katharina Böttinger, Christof Regl, Veronika Schäpertöns, Erdmann Rapp, Therese Wohlschlager, Christian G Huber

{"title":"\"Small is beautiful\" - Examining reliable determination of low-abundant therapeutic antibody glycovariants.","authors":"Katharina Böttinger, Christof Regl, Veronika Schäpertöns, Erdmann Rapp, Therese Wohlschlager, Christian G Huber","doi":"10.1016/j.jpha.2024.100982","DOIUrl":"10.1016/j.jpha.2024.100982","url":null,"abstract":"Glycans associated with biopharmaceutical drugs play crucial roles in drug safety and efficacy, and therefore, their reliable detection and quantification is essential. Our study introduces a multi-level quantification approach for glycosylation analysis in monoclonal antibodies (mAbs), focusing on minor abundant glycovariants. Mass spectrometric data is evaluated mainly employing open-source software tools. Released N-glycan and glycopeptide data form the basis for integrating information across different structural levels up to intact glycoproteins. Comprehensive comparison showed that indeed, variations across structural levels were observed especially for minor abundant species. Utilizing modification finder (MoFi), a tool for annotating mass spectra of intact proteins, we quantify isobaric glycosylation variants at the intact protein level. Our workflow's utility is demonstrated on NISTmAb, rituximab and adalimumab, profiling their minor abundant variants for the first time across diverse structural levels. This study enhances understanding and accessibility in glycosylation analysis, spotlighting minor abundant glycovariants in therapeutic antibodies.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 10","pages":"100982"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of targeted ferroptosis: A new strategy for drug development. 靶向铁下垂的表观遗传调控：药物开发的新策略。

Journal of pharmaceutical analysis Pub Date : 2024-10-01 Epub Date: 2024-05-28 DOI: 10.1016/j.jpha.2024.101012

Shengli Ouyang, Zeyao Zeng, Jieyi He, Lianxiang Luo

{"title":"Epigenetic regulation of targeted ferroptosis: A new strategy for drug development.","authors":"Shengli Ouyang, Zeyao Zeng, Jieyi He, Lianxiang Luo","doi":"10.1016/j.jpha.2024.101012","DOIUrl":"10.1016/j.jpha.2024.101012","url":null,"abstract":"Ferroptosis is a newly discovered form of cell death that is influenced by iron levels and is triggered by cellular metabolism and excessive lipid peroxidation. Epigenetic regulation plays a crucial role in the development and progression of diseases, making it essential to understand these mechanisms in order to identify potential targets for drug development and clinical treatment. The intersection of ferroptosis and epigenetics has opened up new avenues for research in drug development, offering innovative strategies for combating diseases. Recent studies have shown that epigenetic modifications can impact pathways related to ferroptosis, potentially leading to organ dysfunction. Despite the increasing focus on this relationship, the role of epigenetic regulation in drug development remains largely unexplored. This article explores current research on the interplay between epigenetic regulation and ferroptosis, delving into their regulatory mechanisms and discussing the effects of existing epigenetic modification regulators on diseases. Additionally, we highlight ongoing research on epigenetic factors involved in targeting ferroptosis in cancer, providing new insights for the development of cancer treatments.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 10","pages":"101012"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CeFe nanofibrous carbon nanozyme integrated with smartphone for the point-of-care testing of norfloxacin in water. 集成智能手机的CeFe纳米纤维碳纳米酶用于水中诺氟沙星的即时检测。

Journal of pharmaceutical analysis Pub Date : 2024-10-01 Epub Date: 2024-06-26 DOI: 10.1016/j.jpha.2024.101023

Yue Liu, Taimei Cai, Sen Chen, Tao Wen, Hailong Peng

{"title":"CeFe nanofibrous carbon nanozyme integrated with smartphone for the point-of-care testing of norfloxacin in water.","authors":"Yue Liu, Taimei Cai, Sen Chen, Tao Wen, Hailong Peng","doi":"10.1016/j.jpha.2024.101023","DOIUrl":"10.1016/j.jpha.2024.101023","url":null,"abstract":"The overuse of antibiotics has led to the severe contamination of water bodies, posing a considerable hazard to human health. Therefore, the development of an accurate and rapid point-of-care testing (POCT) platform for the quantitative detection of antibiotics is necessary. In this study, Cerium oxide (CeO2) and Ferrosoferric oxide (Fe3O4) nanoparticles were simultaneously encapsulated into N-doped nanofibrous carbon microspheres to form of a novel nanozyme (CeFe-NCMzyme) with a porous structure, high surface area, and N-doped carbon material properties, leading to a considerable enhancement of the peroxidase (POD)-like activity compared with that of the CeO2 or Fe3O4 nanoparticles alone. The POD-like activity of CeFe-NCMzyme can be quenched using L-Cysteine (Cys) and subsequently restored by the addition of a quinolone antibiotic (norfloxacin, NOR). Therefore, CeFe-NCMzyme was used as a colorimetric sensor to detect NOR via an \"On-Off\" model of POD-like activity. The sensor possessed a wide linear range of 0.05-20.0 μM (R 2 = 0.9910) with a detection limit of 35.70 nM. Furthermore, a smartphone-assisted POCT platform with CeFe-NCMzyme was fabricated for quantitative detection of NOR based on RGB analysis. With the use of the POCT platform, a linear range of 0.1-20.0 μM and a detection limit of 54.10 nM were obtained. The spiked recoveries in the water samples were ranged from 97.73% to 102.01%, and the sensor exhibited good accuracy and acceptable reliability. This study provides a portable POCT platform for the on-site and quantitative monitoring of quinolone antibiotics in real samples, particularly in resource-constrained settings.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 10","pages":"101023"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in surface plasmon resonance for analyzing active components in traditional Chinese medicine. 用于分析中药活性成分的表面等离子体共振技术的进展。

Journal of pharmaceutical analysis Pub Date : 2024-10-01 Epub Date: 2024-04-26 DOI: 10.1016/j.jpha.2024.100983

Jing Xie, Xian-Deng Li, Mi Li, Hong-Yan Zhu, Yan Cao, Jian Zhang, A-Jing Xu

引用次数: 0

High-strength antiswelling adhesive achieves both hemostasis and wound healing 高强度消肿粘合剂既能止血又能促进伤口愈合

Journal of pharmaceutical analysis Pub Date : 2024-06-01 DOI: 10.1016/j.jpha.2024.02.009

Xin Zhao, Jinlong Luo, Ying Huang, Lei Mu, Jueying Chen, Zhen Liang, Zhanhai Yin, Dake Chu, Yong Han, Baolin Guo

引用次数: 0

Comparative study of trastuzumab modification analysis using mono/multi-epitope affinity technology with LC-QTOF-MS 利用单/多表位亲和技术与 LC-QTOF-MS 进行曲妥珠单抗修饰分析的比较研究

Journal of pharmaceutical analysis Pub Date : 2024-06-01 DOI: 10.1016/j.jpha.2024.101015

Chen Zuo, Jingwei Zhou, Sumin Bian, Qing Zhang, Yutian Lei, Yuan Shen, Zhiwei Chen, Peijun Ye, Leying Shi, Mao Mu, Jia-Huan Qu, Zhengjin Jiang, Qiqin Wang

引用次数: 0

Rapid Toxicity Characterization of Aconitum Herbal Medicines using Perfusion Nano-electrospray Ionization Mass Spectrometry 利用灌流纳米电喷雾质谱法快速确定乌头类中药的毒性特征

Journal of pharmaceutical analysis Pub Date : 2024-06-01 DOI: 10.1016/j.jpha.2024.101016

Chaofa Wei, Liping Kang, Yaqiu Zhao, Li Zhou, Xiang Li, Shuanglong Wang, Luqi Huang, Zidong Qiu

引用次数: 0

Wheel-shaped polyoxometalates as nanozymes for autophagy-augmented and phototherapy-involved cancer nanotherapy 轮状多氧金属盐作为自噬增强型和光疗参与型癌症纳米疗法的纳米酶

Journal of pharmaceutical analysis Pub Date : 2024-06-01 DOI: 10.1016/j.jpha.2024.101018

Jun Miao, Xiaofeng Fan, Yining Shao, Yalei Zhang, Cailing Chen, Hongrui Tian, Shujun Li, Zhiping Zheng, Xiaoqian Xu

引用次数: 0

Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction between PTBP1 and ACTN4 通过调节 PTBP1 和 ACTN4 之间的蛋白质相互作用，从黄腹角雉茎中提取的萜烯提取物可抑制胃癌细胞肌动蛋白细胞骨架重塑

Journal of pharmaceutical analysis Pub Date : 2024-06-01 DOI: 10.1016/j.jpha.2024.101021

Zewen Chu, Miao Zhu, Yuanyuan Luo, Yaqi Hu, Xinyi Feng, Jiacheng Shen, Haibo Wang, Masataka Sunagawa, Yanqing Liu

引用次数: 0