Journal of pharmaceutical analysis最新文献_第5页

Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity. 姜黄素负载姜源纳米囊泡抗结肠炎活性的配方、表征和评价。

Journal of pharmaceutical analysis Pub Date : 2024-12-01 Epub Date: 2024-05-30 DOI: 10.1016/j.jpha.2024.101014

Shengjie Huang, Min Zhang, Xiaoge Li, Jierong Pei, Zhirong Zhou, Peng Lei, Meng Wang, Peng Zhang, Heshui Yu, Guanwei Fan, Lifeng Han, Haiyang Yu, Yuefei Wang, Miaomiao Jiang

{"title":"Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity.","authors":"Shengjie Huang, Min Zhang, Xiaoge Li, Jierong Pei, Zhirong Zhou, Peng Lei, Meng Wang, Peng Zhang, Heshui Yu, Guanwei Fan, Lifeng Han, Haiyang Yu, Yuefei Wang, Miaomiao Jiang","doi":"10.1016/j.jpha.2024.101014","DOIUrl":"10.1016/j.jpha.2024.101014","url":null,"abstract":"Plant-derived nanovesicles have gained attention given their similarity to mammalian exosomes and advantages such as low cost, sustainability, and tissue targeting. Thus, they hold promise for disease treatment and drug delivery. In this study, we proposed a time-efficient method, PEG 8000 combined with sucrose density gradient centrifugation to prepare ginger-derived nanovesicles (GDNVs). Subsequently, curcumin (CUR) was loaded onto GDNV by ultrasonic incubation. The optimum conditions for ginger-derived nanovesicles loaded with curcumin (CG) were ultrasound time of 3 min, a carrier-to-drug ratio (GDNV:CUR) of 1:1. The study achieved a high loading capacity (94.027% ± 0.094%) and encapsulation efficiency (89.300% ± 0.344%). Finally, the drugs' in vivo distribution and anti-colitis activity were investigated in mice. CG was primarily distributed in the colon after oral administration. Compared to CUR and GDNV, CG was superior in improving disease activity, colon length, liver and spleen coefficients, myeloperoxidase activity, and biochemical factor levels in ulcerative colitis (UC) mice. In addition, CG plays a protective role against UC by modulating serum metabolite levels and gut flora. In summary, our study demonstrated that GDNV can be used for CUR delivery with enhanced therapeutic potential.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 12","pages":"101014"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild photothermal therapy for cancer cell modulation: A transformative approach to regulate cancer cell phenotype and enhance therapeutic outcomes. 轻度光热疗法对癌细胞的调节：一种变革性的方法来调节癌细胞表型和提高治疗效果。

Journal of pharmaceutical analysis Pub Date : 2024-12-01 Epub Date: 2025-01-28 DOI: 10.1016/j.jpha.2025.101185

Jinyuan Liu, Steve Smith, Congzhou Wang

引用次数: 0

Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy. 用于级联扩增光热酶协同治疗的金纳米棒工程纳米凝胶。

Journal of pharmaceutical analysis Pub Date : 2024-12-01 Epub Date: 2024-11-01 DOI: 10.1016/j.jpha.2024.101139

Ling Ding, Xiaoshan Wang, Qing Wu, Xia Wang, Qigang Wang

{"title":"Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy.","authors":"Ling Ding, Xiaoshan Wang, Qing Wu, Xia Wang, Qigang Wang","doi":"10.1016/j.jpha.2024.101139","DOIUrl":"10.1016/j.jpha.2024.101139","url":null,"abstract":"Reactive oxygen species (ROS)-mediated anticancer modalities, which disturb the redox balance of cancer cells through multi-pathway simulations, hold great promise for effective cancer management. Among these, cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability, low toxicity, and high therapeutic efficacy. Herein, we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase (CPO) into gold nanorod (AuNR)-based nanogels (ANGs) for cascade-amplifying photothermal-enzymatic synergistic tumor therapy. Benefiting from photothermal-induced hyperthermia upon near-infrared (NIR) laser exposure, the exogenous ROS (including H2O2) were boosted by the AuNR nanogel owing to the intercellular stress response. This ultimately promoted the efficient enzyme-catalyzed reaction of loaded CPO combined with the rich endogenous H2O2 in tumor cells to significantly elevate intracellular ROS levels above the threshold for improved therapeutic outcomes. Both in vitro and in vivo studies have verified the cascade-amplifying ROS-mediated antitumor effects, providing feasible multimodal synergistic tactics for tumor treatment.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 12","pages":"101139"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sonopharmacology: Regulation of drug activity through ultrasound. 超声药理学：通过超声调节药物活性。

Journal of pharmaceutical analysis Pub Date : 2024-12-01 Epub Date: 2025-01-28 DOI: 10.1016/j.jpha.2025.101186

Wenjing Zhang, Fangyin Song, Zhiyuan Shi, Xin Li, Kuailu Lin

引用次数: 0

Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics. 妇科肿瘤纳米治疗中溶酶体逃逸机制的研究进展。

Journal of pharmaceutical analysis Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1016/j.jpha.2024.101119

Heng Wei, Yingying Hao, Jin Zhang, Yue Qi, Chong Feng, Chen Zhang

{"title":"Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics.","authors":"Heng Wei, Yingying Hao, Jin Zhang, Yue Qi, Chong Feng, Chen Zhang","doi":"10.1016/j.jpha.2024.101119","DOIUrl":"10.1016/j.jpha.2024.101119","url":null,"abstract":"Gynecological cancers present significant treatment challenges due to drug resistance and adverse side effects. This review explores advancements in lysosomal escape mechanisms, essential for enhancing nano-therapeutic efficacy. Strategies such as pH-sensitive linkers and membrane fusion are examined, showcasing their potential to improve therapeutic outcomes in ovarian, cervical, and uterine cancers. We delve into novel materials and strategies developed to bypass the lysosomal barrier, including pH-sensitive linkers, fusogenic lipids, and nanoparticles (NPs) engineered for endosomal disruption. Mechanisms such as the proton sponge effect, where NPs induce osmotic swelling and rupture of the lysosomal membrane, and membrane fusion, which facilitates the release of therapeutic agents directly into the cytoplasm, are explored in detail. These innovations not only promise to improve therapeutic outcomes but also minimize side effects, marking a significant step forward in the treatment of ovarian, cervical, and uterine cancers. By providing a comprehensive analysis of current advancements and their implications for clinical applications, this review sheds light on the potential of lysosomal escape strategies to revolutionize gynecological cancer treatment, setting the stage for future research and development in this vital area.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 12","pages":"101119"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease. 从鼻子到大脑的战略与纳米囊泡系统相结合，用于天然产品的输送：关注阿尔茨海默病的突触可塑性。

Journal of pharmaceutical analysis Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI: 10.1016/j.jpha.2024.101057

Nunzia Maisto, Dalila Mango

{"title":"Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease.","authors":"Nunzia Maisto, Dalila Mango","doi":"10.1016/j.jpha.2024.101057","DOIUrl":"10.1016/j.jpha.2024.101057","url":null,"abstract":"A wide number of natural molecules demonstrated neuroprotective effects on synaptic plasticity defects induced by amyloid-β (Aβ) in ex vivo and in vivo Alzheimer's disease (AD) models, suggesting a possible use in the treatment of this neurodegenerative disorder. However, several compounds, administered parenterally and orally, are unable to reach the brain due to the presence of the blood-brain barrier (BBB) which prevents the passage of external substances, such as proteins, peptides, or phytocompounds, representing a limit to the development of treatment for neurodegenerative diseases, such as AD. The combination of nano vesicular systems, as colloidal systems, and nose to brain (NtB) delivery depicts a new nanotechnological strategy to overtake this limit and to develop new treatment approaches for brain diseases, including the use of natural molecules in combination therapy for AD. Herein, we will provide an updated overview, examining the literature of the last 20 years and using specific keywords that provide evidence on natural products with the ability to restore synaptic plasticity alterations in AD models, and the possible application using safe and non-invasive strategies focusing on nano vesicular systems for NtB delivery.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 12","pages":"101057"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SnoRNAs: The promising targets for anti-tumor therapy. snorna：抗肿瘤治疗的有前景的靶点。

Journal of pharmaceutical analysis Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI: 10.1016/j.jpha.2024.101064

Xiaoyun Hu, Wanlin Cui, Min Liu, Fangxiao Zhang, Yingqi Zhao, Mingrong Zhang, Yuhang Yin, Yalun Li, Ying Che, Xianglong Zhu, Yuxuan Fan, Xiaolan Deng, Minjie Wei, Huizhe Wu

{"title":"SnoRNAs: The promising targets for anti-tumor therapy.","authors":"Xiaoyun Hu, Wanlin Cui, Min Liu, Fangxiao Zhang, Yingqi Zhao, Mingrong Zhang, Yuhang Yin, Yalun Li, Ying Che, Xianglong Zhu, Yuxuan Fan, Xiaolan Deng, Minjie Wei, Huizhe Wu","doi":"10.1016/j.jpha.2024.101064","DOIUrl":"10.1016/j.jpha.2024.101064","url":null,"abstract":"Recently, small nucleolar RNAs (snoRNAs) have transcended the genomic \"noise\" to emerge as pivotal molecular markers due to their essential roles in tumor progression. Substantial evidence indicates a strong association between snoRNAs and critical clinical features such as tumor pathology and drug resistance. Historically, snoRNA research has concentrated on two classical mechanisms: 2'-O-ribose methylation and pseudouridylation. This review specifically summarizes the novel regulatory mechanisms and functional patterns of snoRNAs in tumors, encompassing transcriptional, post-transcriptional, and post-translational regulation. We further discuss the synergistic effect between snoRNA host genes (SNHGs) and snoRNAs in tumor progression. More importantly, snoRNAs extensively contribute to the development of tumor cell resistance as oncogenes or tumor suppressor genes. Accordingly, we provide a comprehensive review of the clinical diagnosis and treatment associated with snoRNAs and explore their significant potential as novel drug targets.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 11","pages":"101064"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI comes to the Nobel Prize and drug discovery. 人工智能获得诺贝尔奖和药物发现。

Journal of pharmaceutical analysis Pub Date : 2024-11-01 Epub Date: 2024-12-21 DOI: 10.1016/j.jpha.2024.101160

Ying Zhou, Yintao Zhang, Zhichao Zhang, Zhimeng Zhou, Feng Zhu

引用次数: 0

Spatial metabolomics reveal metabolic alternations in the injured mice kidneys induced by triclocarban treatment. 空间代谢组学揭示了三氯卡班治疗引起的损伤小鼠肾脏代谢改变。

Journal of pharmaceutical analysis Pub Date : 2024-11-01 Epub Date: 2024-06-26 DOI: 10.1016/j.jpha.2024.101024

Peisi Xie, Jing Chen, Yongjun Xia, Zian Lin, Yu He, Zongwei Cai

{"title":"Spatial metabolomics reveal metabolic alternations in the injured mice kidneys induced by triclocarban treatment.","authors":"Peisi Xie, Jing Chen, Yongjun Xia, Zian Lin, Yu He, Zongwei Cai","doi":"10.1016/j.jpha.2024.101024","DOIUrl":"10.1016/j.jpha.2024.101024","url":null,"abstract":"Triclocarban (TCC) is a common antimicrobial agent that has been widely used in medical care. Given the close association between TCC treatment and metabolic disorders, we assessed whether long-term treatment to TCC at a human-relevant concentration could induce nephrotoxicity by disrupting the metabolic levels in a mouse model. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was applied to investigate the alterations in the spatial distributions and abundances of TCC, endogenous and exogenous metabolites in the kidney after TCC treatment. The results showed that TCC treatment induced the changes in the organ weight, organ coefficient and histopathology of the mouse kidney. MSI data revealed that TCC accumulated in all regions of the kidney, while its five metabolites mainly distributed in the cortex regions. The abundances of 79 biomolecules associated with pathways of leukotriene E4 metabolism, biosynthesis and degradation of glycerophospholipids and glycerolipids, ceramide-to-sphingomyelin signaling were significantly altered in the kidney after TCC treatment. These biomolecules showed distinctive distributions in the kidney and displayed a favorable spatial correlation with the pathological damage. This work offers new insights into the related mechanisms of TCC-induced nephrotocicity and exhibits the potential of MALDI-MSI-based spatial metabolomics as a promising approach for the risk assessment of agents in medical care.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 11","pages":"101024"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression of Ca_V1.2 activation and expression in mast cells ameliorates allergic inflammation diseases. 抑制肥大细胞中CaV1.2的激活和表达可改善变应性炎症疾病。

Journal of pharmaceutical analysis Pub Date : 2024-11-01 Epub Date: 2024-11-14 DOI: 10.1016/j.jpha.2024.101149

Yongjing Zhang, Yingnan Zeng, Haoyun Bai, Wen Zhang, Zhuoyin Xue, Shiling Hu, Shemin Lu, Nan Wang

{"title":"Depression of CaV1.2 activation and expression in mast cells ameliorates allergic inflammation diseases.","authors":"Yongjing Zhang, Yingnan Zeng, Haoyun Bai, Wen Zhang, Zhuoyin Xue, Shiling Hu, Shemin Lu, Nan Wang","doi":"10.1016/j.jpha.2024.101149","DOIUrl":"10.1016/j.jpha.2024.101149","url":null,"abstract":"Allergic inflammation is closely related to the activation of mast cells (MCs), which is regulated by its intracellular Ca2+ level, but the intake and effects of the intracellular Ca2+ remain unclear. The Ca2+ influx is controlled by members of Ca2+ channels, among which calcium voltage-gated channel subunit alpha1 C (CaV1.2) is the most robust. This study aimed to reveal the role and underlying mechanism of MC CaV1.2 in allergic inflammation. We found that CaV1.2 participated in MC activation and allergic inflammation. Nimodipine (Nim), as a strong CaV1.2-specific antagonist, ameliorated allergic inflammation in mice. Further, CaV1.2 activation in MC was triggered by phosphatizing at its Ser1928 through protein kinase C (PKC), which calcium/calmodulin-dependent protein kinase II (CaMKII) catalyzed. Overexpression or knockdown of MC CaV1.2 influenced MC activation. Importantly, CaV1.2 expression in MC had detrimental effects, while its deficiency ameliorated allergic pulmonary inflammation. Results provide novel insights into CaV1.2 function and a potential drug target for controlling allergic inflammation.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"14 11","pages":"101149"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0