Journal of pharmaceutical analysis最新文献_第7页

Pharmacomultiomics suggests new off-targets for targeted anti-cancer agents. 药物组学为靶向抗癌药物提供了新的脱靶点。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-06-01 Epub Date: 2026-02-09 DOI: 10.1016/j.jpha.2026.101580

Xuan Linh Mai, Chae-Young Lee, Eunbyul Cho, Sunghyouk Park, Hyuk Nam Kwon

引用次数: 0

Principles and strategies in cold/hot property studies of traditional Chinese medicine: an evolution from traditional theory to modern elucidation. 中医寒热性质研究的原则与策略：从传统理论到现代阐释的演变。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-06-01 Epub Date: 2025-09-22 DOI: 10.1016/j.jpha.2025.101455

Min Zhang, Xin Zhang, Rui Wei, Yi-Nuo Li, Ying Hu, Ya-Dan Zou, Xue Li, Yue-Fei Wang, Wen-Zhi Yang, De-An Guo

{"title":"Principles and strategies in cold/hot property studies of traditional Chinese medicine: an evolution from traditional theory to modern elucidation.","authors":"Min Zhang, Xin Zhang, Rui Wei, Yi-Nuo Li, Ying Hu, Ya-Dan Zou, Xue Li, Yue-Fei Wang, Wen-Zhi Yang, De-An Guo","doi":"10.1016/j.jpha.2025.101455","DOIUrl":"10.1016/j.jpha.2025.101455","url":null,"abstract":"Property of traditional Chinese medicine (TCM) is the core of the basic theories of TCM. Especially, the cold and hot properties are considered as closely related to the clinical medication and have the guiding significance. Driven by the ongoing advances of modern analytical technology, studies on the ancient theory of TCM cold and hot properties are flourishing recently; however, the review focusing on the applied research methods is insufficient. This review, by the bibliometric analysis of 996 associated publications, discloses the methodological evolution in researching the cold and hot properties of TCM from the traditional temperature-based methods (e.g., cold/hot plate differentiating and infrared thermography technologies) to modern elucidation that relies on the material basis-oriented strategies (multi-omics and gut microbiomics). The analytical techniques that are appliable to the in vitro/in vivo characterization of TCM decoction, analysis of effects on endogenous substances, and use of machine learning models for predicting properties, are systematically summarized. In addition, a review on the principles, characteristics, and applications of these analytical methods is conducted, to highlight the important research ideas and key results. It is thus expected to provide valuable reference for the in-depth analysis and better understanding of the theory of TCM properties.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"16 6","pages":"101455"},"PeriodicalIF":8.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13321016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative diabetes mellitus treatment strategies: Mesenchymal stem cell-based therapy and its impact on pro- and anti-inflammatory cytokines modulation. 创新糖尿病治疗策略：间充质干细胞治疗及其对促炎性和抗炎性细胞因子调节的影响。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-06-01 Epub Date: 2025-11-24 DOI: 10.1016/j.jpha.2025.101497

Amin Ullah, Yutao Wu, Rajeev K Singla, Weidong Tian, Bairong Shen

{"title":"Innovative diabetes mellitus treatment strategies: Mesenchymal stem cell-based therapy and its impact on pro- and anti-inflammatory cytokines modulation.","authors":"Amin Ullah, Yutao Wu, Rajeev K Singla, Weidong Tian, Bairong Shen","doi":"10.1016/j.jpha.2025.101497","DOIUrl":"10.1016/j.jpha.2025.101497","url":null,"abstract":"Diabetes mellitus (DM) is a metabolic condition defined by chronic hyperglycemia with serious complications, including retinopathy, neuropathy, cardiopathy, and nephropathy. DM often accelerates inflammatory responses, which traditional treatments frequently fail to control. Chronic inflammation, with an imbalance between pro-inflammatory and anti-inflammatory cytokines, causes pancreatic β-cell failure and tissue damage. Mesenchymal stem cells (MSCs) are emerging as a promising therapy because of their capacity to control immune responses and stimulate tissue repair. Interleukin-1β (IL-1β), IL-17, IL-6, and tumor necrosis factor alpha (TNF-α) have crucial roles in the diabetes-associated inflammatory environment. MSC therapies reduce levels of pro-inflammatory cytokines and increase levels of anti-inflammatory cytokines, such as IL-10, IL-4, IL-13, and transforming growth factor-beta (TGF-β), reducing inflammation and promoting wound healing. Moreover, the dual functions in inflammation and tissue repair of key cytokines, including TGF-β, IL-6, IL-2, IL-33, and IL-8, provide both challenges and opportunities in MSC therapy. This review explores innovative MSC-based therapies for treating DM, focusing on their modulation of pro- and anti-inflammatory cytokines. MSCs may help reduce diabetic complications by restoring the cytokine balance, increasing insulin sensitivity, and protecting organs. However, the unique source of MSCs and the complex cytokine milieu in DM warrant additional research to improve treatment strategies and ensure long-term safety and efficacy. By highlighting the potential of MSCs to improve DM treatment and enhance patient outcomes, this review attempts to provide a thorough understanding of the molecular mechanisms by which MSCs regulate cytokine activity.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"16 6","pages":"101497"},"PeriodicalIF":8.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13315688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Halogenated anthraquinones in breast cancer therapy: Structural modifications targeting VEGF-related angiogenesis pathways. 卤化蒽醌类药物在乳腺癌治疗中的应用：针对vegf相关血管生成途径的结构修饰。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-06-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jpha.2025.101538

Chenyu Zhou, Murni Nazira Sarian, Xiaohui Tong, Rongchun Han, Theebaa Anasamy, Hamizah Shahirah Hamezah

{"title":"Halogenated anthraquinones in breast cancer therapy: Structural modifications targeting VEGF-related angiogenesis pathways.","authors":"Chenyu Zhou, Murni Nazira Sarian, Xiaohui Tong, Rongchun Han, Theebaa Anasamy, Hamizah Shahirah Hamezah","doi":"10.1016/j.jpha.2025.101538","DOIUrl":"10.1016/j.jpha.2025.101538","url":null,"abstract":"Halogenated anthraquinone derivatives have good potential in addressing the major clinical challenges associated with anthracyclines for breast cancer, including high toxicity, low selectivity, and drug resistance issues. By analyzing the structure-activity relationships of these compounds, the review highlights how specific structural modifications may enhance therapeutic efficacy. A comprehensive overview is also provided to categorize breast cancer progression across stages 0 to IV, along with therapeutic approaches for each of the three basic molecular subtypes, with placing particular focus on triple-negative breast cancer. This review details how anthraquinone derivatives modulate the vascular endothelial growth factor (VEGF)-related signaling pathways and regulate the expression of key proteins and chemokines, thereby inhibiting endothelial cell function during tumor angiogenesis, suppressing cancer cell migration and immune evasion in breast cancer. Studies on halogenated anthraquinone derivatives in anticancer applications between 2013 and 2025 are summarized, and the cutting-edge therapeutic strategies that have contributed to the development of anthraquinone derivatives are highlighted. The high approval rate of halogen-containing drugs released by the U.S. Food and Drug Administration in 2024, alongside their promising therapeutic efficacy in oncology, has once again drawn the attention of researchers. Overall, the contributions of halogen substitution to molecular stability, target specificity, and resistance to metabolic degradation highlight the significant potential of halogenated anthraquinone derivatives in the development of novel therapeutics for breast cancer.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"16 6","pages":"101538"},"PeriodicalIF":8.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunocyte senescence: A new perspective on the remodeling of the ovarian cancer microenvironment and therapeutic intervention. 免疫细胞衰老：卵巢癌微环境重塑和治疗干预的新视角。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-06-01 Epub Date: 2025-11-07 DOI: 10.1016/j.jpha.2025.101492

Xiang Li, Xian Li, Sha Ni, Xiaohui Zhang, Bingnan Liu

{"title":"Immunocyte senescence: A new perspective on the remodeling of the ovarian cancer microenvironment and therapeutic intervention.","authors":"Xiang Li, Xian Li, Sha Ni, Xiaohui Zhang, Bingnan Liu","doi":"10.1016/j.jpha.2025.101492","DOIUrl":"10.1016/j.jpha.2025.101492","url":null,"abstract":"Immune cell senescence in ovarian cancer manifests as distinct phenotypic alterations in T cells, natural killer (NK) cells, macrophages, and dendritic cells (DCs), alongside dynamic crosstalk with the tumor microenvironment (TME). This senescence contributes substantially to the high mortality and therapeutic resistance characteristic of ovarian carcinoma. Senescent immune cells develop a senescence-associated secretory phenotype (SASP), secreting pro-tumorigenic cytokines and chemokines that drive regulatory T cell (Treg) expansion, extracellular matrix (ECM) remodeling, and the establishment of an immunosuppressive niche. Key drivers of immunocyte senescence include telomere erosion, epigenetic dysregulation, metabolic stress, DNA damage from chemotherapy, and chronic inflammatory signals. Emerging interventions, such as senolytic agents to selectively eliminate senescent immune cells, senomorphic compounds to attenuate SASP factors, and strategies to reprogram immune effectors, hold promise for restoring antitumor immunity and overcoming resistance to conventional therapies. A deeper understanding of the molecular mechanisms governing immunosenescence will be critical for the rational design of combination regimens and the development of next-generation immunotherapies in ovarian cancer.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"16 6","pages":"101492"},"PeriodicalIF":8.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances and expanding applications of organoid models in unveiling drug ADME profiles. 类器官模型在揭示药物ADME概况中的最新进展和扩展应用。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-06-01 Epub Date: 2026-05-30 DOI: 10.1016/j.jpha.2026.101676

Guolei Zhang, Ruifan Zhang, Zihang Shu, Jing Zhao, Lei Yin, Meiyun Shi, Yanshuo Han

{"title":"Recent advances and expanding applications of organoid models in unveiling drug ADME profiles.","authors":"Guolei Zhang, Ruifan Zhang, Zihang Shu, Jing Zhao, Lei Yin, Meiyun Shi, Yanshuo Han","doi":"10.1016/j.jpha.2026.101676","DOIUrl":"10.1016/j.jpha.2026.101676","url":null,"abstract":"Organoids are three-dimensional (3D) in vitro models generated from stem or progenitor cells that closely replicate the structural and functional complexity of human organs. These systems are emerging as powerful tools in pharmacokinetic research, addressing key limitations of traditional models such as two-dimensional (2D) cell cultures and animal experiments, which are often constrained by physiological mismatch and species-specific differences. This review summarizes recent advances in the development of organoid models, with a focus on hepatic and intestinal systems, and highlights their application in studying drug absorption, distribution, metabolism, and excretion (ADME). We discuss how organoids improve predictions of oral bioavailability, facilitate assessment of drug-drug interactions (DDI), and help interpret interindividual pharmacokinetic variability. Current challenges including incomplete functional maturation, lack of standardization, and limited vascularization are also considered. Finally, we explore future directions involving the integration of organoids with advanced microphysiological systems (such as organ-on-a-chip (OoC)) and artificial intelligence (AI). With ongoing refinement, organoid-based approaches are expected to significantly improve the efficiency of drug development and the accuracy of clinical translation, paving the way for advances in precision pharmacology and personalized medicine.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"16 6","pages":"101676"},"PeriodicalIF":8.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13315687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cuproptosis tracker: Visualizing organelle dynamics with a dual-targeted fluorescent probe. 铜突跟踪器：用双靶荧光探针可视化细胞器动力学。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-06-01 Epub Date: 2025-11-27 DOI: 10.1016/j.jpha.2025.101500

Furao Li, Chunyan Liang, Xifeng Mo, Xiaohuan Xu, Yongbiao Wei, Chunyan Zhou, Ting Meng, Hui Zhang, Fan Yang

{"title":"Cuproptosis tracker: Visualizing organelle dynamics with a dual-targeted fluorescent probe.","authors":"Furao Li, Chunyan Liang, Xifeng Mo, Xiaohuan Xu, Yongbiao Wei, Chunyan Zhou, Ting Meng, Hui Zhang, Fan Yang","doi":"10.1016/j.jpha.2025.101500","DOIUrl":"10.1016/j.jpha.2025.101500","url":null,"abstract":"Cuproptosis often interacts with mitochondrial (Mito) dysfunction and lipid droplets (LDs) metabolism disturbances, thus resulting in programmed cell death, whereas their dynamic interaction lacks a rational analyzing tool. Herein, we show a Mito-LDs dual-targeted fluorescent reporter (MLR) for tracking the Mito-LDs interaction during cuproptosis by dynamic monitoring of intracellular sulfur dioxide (SO2) dynamics. MLR integrates a coumarin-derived SO2-responsive core linked via piperazine to a benzopyronium Mitol anchor, enabling one-step synthesis with exceptional sensitivity (0.34 μM) and rapid response (<10 s). Live-cell imaging demonstrated MLR's SO2-triggered translocation from Mito to LDs during cuproptosis, directly visualizing inter-organelle communication. Dual fluorescence channel imaging associated SO2 fluctuations with Mito-LDs targeting, revealing the interaction between LDs-Mito during Cu2+ and elesclomol (ES) induced apoptosis. In addition to imaging, MLR-based test strips and hydrogels can achieve rapid (<1 min) on-site SO2 detection. As a dual-organelle tracer for cuproptosis, MLR overcomes single-target probe limitations, offering a transformative platform to analyze spatiotemporal organelle dynamics for advancing diagnostic tools development.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"16 6","pages":"101500"},"PeriodicalIF":8.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13352014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148428085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raman spectroscopy combined with multiple technologies for label-free identification of immune cells: An overview. 拉曼光谱结合多种技术用于免疫细胞的无标记鉴定：综述。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-06-01 Epub Date: 2025-10-10 DOI: 10.1016/j.jpha.2025.101468

Chengshun Jiang, Jie Deng, Wanwan Gan, Jiaqi Zou, Tongkai Cai, Hao Yin, Yongbing Cao

引用次数: 0

Pharmacological effects, classification, genetic and molecular studies of different chemotypes essential oil of Perilla frutescens (L.) Britt.: A review. 紫苏精油不同化学型的药理作用、分类、遗传与分子研究布瑞特。一篇评论。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-05-01 Epub Date: 2025-09-17 DOI: 10.1016/j.jpha.2025.101454

Wei Wei, Zhaoyuan Li, Bin Wang, Yang Liu, Yuxuan Sun, Dong Wen, Mei Rong, Pengcheng Huang, Yuwei Guo, Qiuling Wang, Zhihui Gao, Jianhe Wei

引用次数: 0

Metallic nanoparticles in precision medicine for gastrointestinal cancers: Diagnostic and therapeutic advances. 金属纳米颗粒在胃肠道癌症精准医学中的应用：诊断和治疗进展。

IF 8.9

Journal of pharmaceutical analysis Pub Date : 2026-05-01 Epub Date: 2025-12-31 DOI: 10.1016/j.jpha.2025.101544

Xu Han, Ding Ding, Milad Ashrafizadeh, Gautam Sethi, Ziwen Wang, Yuting Zhang

{"title":"Metallic nanoparticles in precision medicine for gastrointestinal cancers: Diagnostic and therapeutic advances.","authors":"Xu Han, Ding Ding, Milad Ashrafizadeh, Gautam Sethi, Ziwen Wang, Yuting Zhang","doi":"10.1016/j.jpha.2025.101544","DOIUrl":"10.1016/j.jpha.2025.101544","url":null,"abstract":"Gastrointestinal cancers (GI) rank among the most common and lethal tumors. The traditional therapies face limitations in the early diagnosis, accurate targeting, and treatment effectiveness. Metallic nanoparticles (MNPs) such as Au, Ag, and iron oxide present various promising opportunities owing to their exceptional physicochemical properties including high surface area-to-volume ratios, tunable surface chemistry, and biological interactions. Therefore, understanding the function and application of MNPs in the treatment of specific cancers and advancing cancer diagnosis can provide valuable clinical insights. This review assesses the capabilities of MNPs in GI cancers, focusing on the drug delivery, imaging, photothermal therapy (PTT), and the enhancement of radiotherapy. The primary findings encompass using gold nanoparticles (AuNPs) for the targeted drug delivery, photothermal-induced tumor ablation, and radiosensitization in colorectal, pancreatic, and gastric cancers. AgNPs can not only enhance chemotherapy and photodynamic therapy (PDT) but also induce apoptosis. Iron oxide nanoparticles (IONPs) aid in magnetic drug targeting, enhance magnetic resonance imaging (MRI) contrast, and enable combined chemo-photothermal therapy. Metal-organic frameworks (MOFs) facilitate drug delivery, multimodal imaging, and combination treatments, including photodynamic and immunotherapy, for colorectal and pancreatic cancers. The review emphasizes the recent advancements in MNP-based theranostic platforms, showcasing their ability to enhance the early detection, overcome drug resistance, and boost the therapeutic index. The obstacles such as off-target effects, scalability and chronic toxicity are addressed, along with methods for enhancing MNP design and its clinical use. This review emphasizes the transformative possibilities of MNPs in tackling the worldwide challenge of GI cancers.","PeriodicalId":94338,"journal":{"name":"Journal of pharmaceutical analysis","volume":"16 5","pages":"101544"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0