{"title":"Real-World Long-Term Effectiveness of Implantable Cardioverter-Defibrillators in Elderly Patients.","authors":"Hikaru Hagiwara, Noritsugu Nagai, Kotomi Otsubo, Sou Sasaki, Hiroyuki Aoyagi, Yasuyuki Chiba, Hirokazu Komoriyama, Yoshiya Kato, Masayuki Takahashi, Yusuke Tokuda, Toshihiro Shimizu, Minoru Sato, Toshiyuki Nagai, Toshihisa Anzai","doi":"10.1253/circrep.CR-24-0131","DOIUrl":"10.1253/circrep.CR-24-0131","url":null,"abstract":"<p><strong>Background: </strong>Because it is unclear whether implantable cardioverter-defibrillators (ICDs) are equally effective in patients of all ages, we investigated the association of age with long-term clinical outcomes of patients who underwent ICD implantation.</p><p><strong>Methods and results: </strong>A total of 416 consecutive patients (mean age: 69 years) from 4 tertiary hospitals who underwent ICD implantation or were upgraded from an existing permanent pacemaker between January 2011 and November 2022 were enrolled and divided into 3 groups based on age: <65 years (n=158), 65-74 years (n=138), and ≥75 years (n=120). We compared the incidence of all-cause death and adverse cardiovascular events, including cardiac death, appropriate ICD therapy, and heart failure hospitalization. During a median follow-up period of 3.2 years (interquartile range: 1.1-5.6 years), 120 patients died. Older patients had a higher cumulative incidence of all-cause death and composite adverse cardiovascular events. The cumulative incidence of cardiac death and appropriate ICD therapies did not differ significantly; however, the incidence of hospitalization for heart failure increased with age. In multivariate analysis, age was independently associated with all-cause death but not composite adverse outcomes.</p><p><strong>Conclusions: </strong>Age had a significant effect on subsequent all-cause death, but not on adverse cardiovascular events in patients with ICDs, suggesting that age should not be the only indication considered for ICD implantation.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 1","pages":"15-24"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cost-Effectiveness of the Self-Care Management System for Heart Failure.","authors":"Eisaku Nakane, Takao Kato, Nozomi Tanaka, Makoto Idouji, Yuki Yamamoto, Wataru Saitou, Toka Hamaguchi, Mariko Yano, Takeshi Harita, Yuhei Yamaji, Hiroki Fukuda, Tetsuya Haruna, Moriaki Inoko","doi":"10.1253/circrep.CR-24-0088","DOIUrl":"10.1253/circrep.CR-24-0088","url":null,"abstract":"<p><strong>Background: </strong>We recently reported that the self-care management system for heart failure (HF) decreased re-hospitalization for HF. In the present study we estimate the cost-effectiveness of this system.</p><p><strong>Methods and results: </strong>We retrospectively enrolled 569 consecutive patients who were admitted for HF treatment at Kitano Hospital. In the present analysis, we sought to compare cardiovascular healthcare costs and the incremental cost-effective ratio (ICER), expressed as the cost per quality-adjusted life-years (QALY) gained, between patients using the self-care management system (n=153) and those not using the system (n=153) after propensity-score matching. To calculate the QALY, we used the New York Heart Association class and the corresponding scores of quality of life in every 3 months. The healthcare costs of cardiovascular disease were ¥129,747,016 in the user group and ¥156,427,032 in the non-user group, where 24 and 43 patients were hospitalized, respectively. The cost of this new system was ¥50,000 in the user group. The total costs were ¥129,797,016 in the user group and ¥156,427,032 in the non-user group. By using the system, the QALY increased from 0.653 to 0.686. The ICER was below 0 and the system was interpreted as cost-effective.</p><p><strong>Conclusions: </strong>Use of the self-care management system is likely to be a cost-effective treatment for HF with the increase in QALY and the decrease in healthcare costs.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Importance of Protein Intake in Hospitalized Elderly Patients With Heart Failure.","authors":"Hiroyo Miyata, Koichiro Matsumura, Toru Takase, Keishiro Sugimoto, Yohei Funauchi, Eijiro Yagi, Ayano Yoshida, Katsumi Kajihara, Takashi Iwanaga, Teruyoshi Amagai, Gaku Nakazawa","doi":"10.1253/circrep.CR-24-0067","DOIUrl":"10.1253/circrep.CR-24-0067","url":null,"abstract":"<p><strong>Background: </strong>The relationship between protein intake and the long-term prognosis of elderly patients with heart failure remains poorly understood. We investigated the association between predischarge protein intake and long-term prognosis in hospitalized elderly patients with heart failure.</p><p><strong>Methods and results: </strong>A single-center, retrospective analysis of hospitalized patients aged ≥65 years with heart failure and reduced ejection fraction was conducted. Protein intake was evaluated by nutritionists based on visual measurements of the percentage of dietary intake obtained for 7 days before discharge by a nurse. A cutoff of 1.2 g/kg/day protein intake was used to compare the incidence of a composite endpoint, including all-cause mortality and heart failure rehospitalization within 1 year. Among the 100 patients (median age 79 years; 47% male), 56% had low protein intake (<1.2 g/kg/day). Patients with low protein intake had a significantly higher rate of composite endpoints than those with high protein intake (50% vs. 20%; log-rank test P=0.03). Multivariable Cox proportional hazards model revealed that low protein intake was independently associated with long-term prognosis with a hazard ratio of 2.73 and a 95% confidence interval of 1.10-6.80 (P=0.03).</p><p><strong>Conclusions: </strong>Low protein intake in the predischarge phase was associated with long-term prognosis in hospitalized elderly patients with heart failure and reduced ejection fraction.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 1","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Circulation reportsPub Date : 2024-11-29eCollection Date: 2025-01-10DOI: 10.1253/circrep.CR-24-0141
Yuichi Saito, Kazuya Tateishi, Yoshio Kobayashi
{"title":"Clinical Review of Cardiogenic Shock After Acute Myocardial Infarction - Revascularization, Mechanical Circulatory Support, and Beyond.","authors":"Yuichi Saito, Kazuya Tateishi, Yoshio Kobayashi","doi":"10.1253/circrep.CR-24-0141","DOIUrl":"10.1253/circrep.CR-24-0141","url":null,"abstract":"<p><p>Owing to recent advances in early reperfusion and pharmacological therapies, the prognosis of patients with acute myocardial infarction (AMI) has considerably improved over the past decades. However, the mortality rate remains high at ~40-50% after AMI when complicated by cardiogenic shock. Although immediate coronary revascularization of the infarct-related artery has been the only evidence-based treatment, temporary mechanical circulatory support with a microaxial flow pump (Impella) has become another therapeutic option supported by randomized trial data in highly selected patients. Here we summarize the latest evidence concerning clinical challenges in patients with AMI and cardiogenic shock.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 1","pages":"6-14"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Significant Stent Protrusion and Deformation Detected Using Transthoracic Echocardiography Following Percutaneous Coronary Intervention of the Left Main Coronary Artery.","authors":"Takumi Osawa, Akinori Sugano, Hidetaka Nishina, Tomoko Ishizu","doi":"10.1253/circrep.CR-24-0129","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0129","url":null,"abstract":"","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 1","pages":"55-56"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Circulation reportsPub Date : 2024-11-20eCollection Date: 2025-01-10DOI: 10.1253/circrep.CR-24-0134
Naoto Miyawaki, Akira Takashima
{"title":"Evidence of Cardiac Rehabilitation for Heart Failure With Reduced Ejection Fraction in Recovery to Maintenance Phase.","authors":"Naoto Miyawaki, Akira Takashima","doi":"10.1253/circrep.CR-24-0134","DOIUrl":"10.1253/circrep.CR-24-0134","url":null,"abstract":"<p><p>Heart failure (HF) with reduced left ventricular ejection fraction (HFrEF) is typically coupled with progressive left ventricular enlargement and detrimental cardiac remodeling. The management of HFrEF is comprehensive and primarily involves pharmacologic treatment using cardioprotective agents. Cardiac rehabilitation (CR) is also strongly recommended as a treatment for HFrEF. The evidence on CR for HFrEF is accumulating. CR improves exercise tolerance, subjective symptoms caused by HF, quality of life, and rehospitalization rates. Furthermore, CR may improve all-cause mortality, although the improvement might not be evident in the short term (<1 year) but could potentially become more apparent over a longer period. In the upcoming era of super-aging and advancements in information and communications technology, CR for HFrEF will also require updating. Further research on exercise therapy will require a comprehensive evaluation of the quality and nature of exercise and whether CR would be conducted in a home-based or remote setting; these studies should include older adults, and the findings have the potential to revolutionize the field of CR.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 1","pages":"4-5"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Circulation reportsPub Date : 2024-11-15eCollection Date: 2024-12-10DOI: 10.1253/circrep.CR-24-0124
Masaya Kurobe, Yosuke Yamanaka, Akihito Uda, Katsuya Mori, Takeshi Akiyama, Ayumi Morishita, Yuta Ishikawa, Louis P Watanabe, Satoshi Ikeda, Koji Maemura
{"title":"Identification of Physician Concerns Regarding Implementation of the Nagasaki Acute Myocardial Infarction Secondary Prevention Clinical Pathway.","authors":"Masaya Kurobe, Yosuke Yamanaka, Akihito Uda, Katsuya Mori, Takeshi Akiyama, Ayumi Morishita, Yuta Ishikawa, Louis P Watanabe, Satoshi Ikeda, Koji Maemura","doi":"10.1253/circrep.CR-24-0124","DOIUrl":"10.1253/circrep.CR-24-0124","url":null,"abstract":"<p><strong>Background: </strong>The Nagasaki Acute Myocardial Infarction Secondary Prevention Clinical Pathway (NASP) is a regional pathway that aims to standardize practices related to the treatment of acute myocardial infarction in order to improve patient prognoses. This study aimed to understand physician backgrounds and concerns regarding implementation of the NASP.</p><p><strong>Methods and results: </strong>This exploratory sequential mixed-methods study was developed around the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework. Following focus group interviews, the web-based, self-administered questionnaire survey with a cross-sectional study design was given to 62 physicians who practiced at acute care hospitals (ACHs), primary care hospitals (PCHs), or outpatient clinics (OCs) in the Nagasaki prefecture. Hayashi's quantitative theory type II analysis was used to assess the quantitative relationship between physician characteristics and their concerns. In addition, physicians were clustered based on the types of concerns they had. Our results demonstrated that specialists in cardiovascular disease held more concerns regarding implementation of the NASP. Furthermore, workload burden was found to be the most common concern among these physicians. Cooperation between physicians at ACHs and physicians at PCHs/OCs was also found to be vital for the NASP.</p><p><strong>Conclusions: </strong>Interventions such as modifications to the NASP operation may assist in alleviating concerns regarding the NASP and allow for the development of tailored interventions and effective expansion of the pathway.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"6 12","pages":"555-563"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Circulation reportsPub Date : 2024-11-14eCollection Date: 2024-12-10DOI: 10.1253/circrep.CR-24-0105
Kohei Nozaki, Nobuaki Hamazaki, Kentaro Kamiya, Kensuke Ueno, Takashi Miki, Yuta Nanri, Ken Ogura, Shota Uchida, Emi Maekawa, Takeru Nabeta, Yuichiro Iida, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Jiichiro Sasaki, Junya Ako
{"title":"Association Between Amount of Physical Activity and Clinical Outcomes After Treatment for Cardiovascular Disease in Cancer Survivors.","authors":"Kohei Nozaki, Nobuaki Hamazaki, Kentaro Kamiya, Kensuke Ueno, Takashi Miki, Yuta Nanri, Ken Ogura, Shota Uchida, Emi Maekawa, Takeru Nabeta, Yuichiro Iida, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Jiichiro Sasaki, Junya Ako","doi":"10.1253/circrep.CR-24-0105","DOIUrl":"10.1253/circrep.CR-24-0105","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to investigate the association between physical activity before the incidence of cardiovascular disease (CVD) and clinical outcomes in cancer survivors.</p><p><strong>Methods and results: </strong>We analyzed 904 cancer survivors (median age [interquartile range] 75 [68-80] years; 297 [32.9%] patients were female) who required hospitalization for treatment of CVD. The amount of physical activity 1 month before the admission was assessed using the 3-question (3Q) assessment tool, and categorized as minimal, low, adequate, and high according to physical activity level. The primary outcome was the composite events of all-cause death and/or rehospitalization for CVD up to 1 year after discharge. The total amount of physical activity was identified in 544 (60.2%) patients in the minimal group, 95 (10.5%) in the low group, 253 (28.0%) in the adequate group, and 12 (1.3%) in the high group. A total of 686 (75.9%) patients completed follow up, with 252 (27.9%) composite events occurring. Even after adjustment for various confounders, higher physical activity was significantly associated with a lower composite event rate (adjusted hazard ratio [95% confidence interval] 0.859 [0.833-0.900]).</p><p><strong>Conclusions: </strong>High physical activity in cancer survivors was associated with a lower composite event rate after treatment for CVD. Assessment of prehospital physical activity using the 3Q score may be useful in their risk stratification.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"6 12","pages":"547-554"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Machine Learning for Evaluating Vulnerable Plaque on Coronary Computed Tomography Using Spectral Imaging.","authors":"Junji Mochizuki, Yoshiki Hata, Takeshi Nakaura, Katsushi Hashimoto, Hiroyuki Uetani, Yasunori Nagayama, Masafumi Kidoh, Yoshinori Funama, Toshinori Hirai","doi":"10.1253/circrep.CR-24-0086","DOIUrl":"10.1253/circrep.CR-24-0086","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine whether spectral imaging with dual-energy computed tomography (CT) can improve diagnostic performance for coronary plaque characterization.</p><p><strong>Methods and results: </strong>We conducted a retrospective analysis of 30 patients with coronary plaques, using coronary CT angiography (dual-layer CT) and intravascular ultrasound (IVUS) studies. Based on IVUS findings, patients were diagnosed with either vulnerable or stable plaques. We computed 7 histogram parameters for plaque CT numbers in 120 kVp images and virtual monochromatic images ranging from 40 to 140 keV at 5-keV intervals. A predictive model was developed using histogram data of optimal energy, plaque volume or stenosis, and a combination of both. The model's performance was evaluated by calculating the area under the receiver operating characteristic curve (AUC) using 5-fold cross-validation. Peak diagnostic performances for each histogram parameter were observed at various energy levels (40-110 keV) in the univariate logistic regression model. The histogram model demonstrated optimal diagnostic performance at 65 keV, with an AUC of 0.81. The combined model, incorporating histogram data and plaque volume, achieved an AUC of 0.85, which was similar to the performance of qualitative CT characteristics (AUC=0.88; P=0.70).</p><p><strong>Conclusions: </strong>Spectral imaging with dual-energy CT can enhance the diagnostic performance of machine learning using CT histograms for coronary plaque characterization.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"6 12","pages":"564-572"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}