Circulation reports最新文献

Anti-Oxidized Low-Density Lipoprotein Antibodies Before and After Intravenous Immunoglobulin Therapy in Kawasaki Disease　- Evidence for a Potentially Protective Role. 静脉注射免疫球蛋白治疗川崎病前后的抗氧化低密度脂蛋白抗体-潜在保护作用的证据

Circulation reports Pub Date : 2025-04-16 eCollection Date: 2025-05-09 DOI: 10.1253/circrep.CR-25-0018

Zenpei Kano, Yumi Mizuno, Kenji Murata, Sagano Onoyama, Takayuki Hoshina, Yasunari Sakai, Junji Kishimoto, Koichi Kusuhara, Toshiro Hara

{"title":"Anti-Oxidized Low-Density Lipoprotein Antibodies Before and After Intravenous Immunoglobulin Therapy in Kawasaki Disease　- Evidence for a Potentially Protective Role.","authors":"Zenpei Kano, Yumi Mizuno, Kenji Murata, Sagano Onoyama, Takayuki Hoshina, Yasunari Sakai, Junji Kishimoto, Koichi Kusuhara, Toshiro Hara","doi":"10.1253/circrep.CR-25-0018","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0018","url":null,"abstract":"Background: The precise pathogenesis of Kawasaki disease (KD) remains unclear, but immune dysregulation involving damage-associated molecular patterns (DAMPs), such as oxidized low-density lipoprotein (LDL) and high mobility group box 1 (HMGB1), has been implicated. We investigated the roles of 2 anti-DAMPs antibodies in KD and their associations with inflammatory and oxidative stress markers.Methods and results: Serum levels of anti-oxidized LDL and anti-HMGB1 antibodies were measured by enzyme-linked immunosorbent assay in patients with KD and in febrile disease controls (DC). Correlations with inflammatory (C-reactive protein [CRP]) and oxidative stress (red blood cell distribution width [RDW]) markers were evaluated. Serum anti-oxidized LDL antibody levels increased significantly after intravenous immunoglobulin (IVIG) therapy in KD patients, suggesting a protective role of anti-oxidized LDL antibodies against vascular inflammation. Conversely, anti-HMGB1 antibody levels showed a decreasing trend post-IVIG. A significant correlation between antibody levels and CRP was observed in DC but not in KD patients. Furthermore, a weak inverse trend between anti-oxidized LDL antibodies and RDW-coefficient of variation was noted in KD patients.Conclusions: This study highlighted the distinct roles of anti-oxidized LDL and anti-HMGB1 antibodies during the acute phase of KD. The increase in anti-oxidized LDL antibodies following IVIG treatment suggests a protective effect, while the transient nature of anti-HMGB1 antibodies warrants further exploration.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"359-364"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rationale and Design of an Exploratory, Randomized, Open-Label, Multicenter Clinical Trial to Investigate the Efficacy of Long-Acting β2-Agonist/Long-Acting Muscarinic Antagonist on Heart Failure Complicated by Chronic Obstructive Pulmonary Disease (COPD-HF Trial). 一项探索性、随机、开放标签、多中心临床试验的基本原理和设计，研究长效β2激动剂/长效毒蕈碱拮抗剂对心力衰竭合并慢性阻塞性肺疾病（COPD-HF试验）的疗效。

Circulation reports Pub Date : 2025-04-12 eCollection Date: 2025-05-09 DOI: 10.1253/circrep.CR-25-0010

Hiroya Hayashi, Shin Ito, Hiroki Fukuda, Makoto Sata, Yukio Abe, Kohei Fujimoto, Daiju Fukuda, Yohei Hanajima, Mutsuo Horii, Noriyuki Ikehara, Moriaki Inoko, Chisato Izumi, Yasuhiro Izumiya, Takafumi Nakayama, Takashi Sozu, Shigeru Toyoda, Masafumi Watanabe, Masashi Yokoi, Masafumi Kitakaze

{"title":"Rationale and Design of an Exploratory, Randomized, Open-Label, Multicenter Clinical Trial to Investigate the Efficacy of Long-Acting β2-Agonist/Long-Acting Muscarinic Antagonist on Heart Failure Complicated by Chronic Obstructive Pulmonary Disease (COPD-HF Trial).","authors":"Hiroya Hayashi, Shin Ito, Hiroki Fukuda, Makoto Sata, Yukio Abe, Kohei Fujimoto, Daiju Fukuda, Yohei Hanajima, Mutsuo Horii, Noriyuki Ikehara, Moriaki Inoko, Chisato Izumi, Yasuhiro Izumiya, Takafumi Nakayama, Takashi Sozu, Shigeru Toyoda, Masafumi Watanabe, Masashi Yokoi, Masafumi Kitakaze","doi":"10.1253/circrep.CR-25-0010","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0010","url":null,"abstract":"Background: Chronic obstructive pulmonary disease (COPD) is one of the most common comorbidities in patients with chronic heart failure (CHF). A growing number of patients are suffering from both COPD and CHF, and these conditions worsen each other. Inhaled bronchodilator therapy with long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) in combination is currently the mainstay of treatment for COPD. However, the effect of LAMA/LABA on HF with COPD remains unknown.Methods and results: The COPD-HF trial is a multicenter, double-arm, open-label, exploratory, investigator-initiated clinical study to investigate the effect of LAMA/LABA on HF in patients suffering from both COPD and CHF. The participants are randomly assigned (1 : 1) to the LAMA/LABA (tiotropium+olodaterol FDC (fixed-dose combination) 5/5 ug) group (once a day, 2 inhalations) or non-pharmacological treatments for COPD as a control group. The planned number of patients to be enrolled in this trial is 54 in total (27 in each group). The participants are followed up for 12 weeks with and without LAMA/LABA. The primary endpoint is the change in plasma B-type natriuretic peptide levels from the baseline to the end of this study (12 weeks).Conclusions: The COPD-HF trial will investigate the efficacy of LAMA/LABA on HF in patients with COPD and CHF.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"383-388"},"PeriodicalIF":0.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Electron Density Maps and Fused Images in Dual-Energy Cardiac Computed Tomography to Facilitate Detection of Late Iodine Enhancement. 在双能心脏计算机断层扫描中使用电子密度图和融合图像来促进晚期碘增强的检测。

Circulation reports Pub Date : 2025-04-11 eCollection Date: 2025-05-09 DOI: 10.1253/circrep.CR-24-0115

Junji Mochizuki, Yoshiki Hata, Takeshi Nakaura, Yasunori Nagayama, Masafumi Kidoh, Hiroyuki Uetani, Kaori Shiraishi, Naoki Kobayashi, Yoshinori Funama, Toshinori Hirai

{"title":"Use of Electron Density Maps and Fused Images in Dual-Energy Cardiac Computed Tomography to Facilitate Detection of Late Iodine Enhancement.","authors":"Junji Mochizuki, Yoshiki Hata, Takeshi Nakaura, Yasunori Nagayama, Masafumi Kidoh, Hiroyuki Uetani, Kaori Shiraishi, Naoki Kobayashi, Yoshinori Funama, Toshinori Hirai","doi":"10.1253/circrep.CR-24-0115","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0115","url":null,"abstract":"Background: This study aimed to optimize the fusion of quantitative maps and morphological images to improve late iodine enhancement (LIE) imaging using cardiac dual-energy computed tomography (DECT).Methods and results: We retrospectively analyzed 15 patients with suspected old myocardial infarction who underwent cardiac DECT. Virtual monochromatic images (VMI) ranging from 40 to 200 keV and quantitative maps (e.g., iodine concentration, effective atomic number, and electron density [(%EDW: percentage relative to the electron density of water)] were generated. The contrast-to-noise ratio (CNR) between LIE areas and the left ventricular (LV) blood pool and normal myocardium was calculated to determine the optimal image fusion for LIE delineation. VMI at 40 keV demonstrated superior CNR between LIE areas and normal myocardium. Electron density was significantly higher in LIE areas [105.5%EDW (interquartile range (IQR): 105.15-105.65)] than in the LV blood pool [104.4%EDW (IQR: 104.3-104.6)] and normal myocardium [104.4%EDW (IQR: 104.2-104.65)] (P<0.001). Iodine concentration and effective atomic number differed significantly between LIE areas and normal myocardium, but did not differ significantly between LIE areas and the LV blood pool. Fusion of 40 keV VMI with electron density maps yielded the highest area under the receiver operating characteristic curve (0.917).Conclusions: Fused images combining 40 keV VMI with electron density maps significantly enhanced the visualization of LIE areas on DECT, offering improved contrast and diagnostic accuracy for the assessment of myocardial territories.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"341-349"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Hemodynamics and Autonomic Function During Exercise Stress Tests in Healthy Volunteers. 经皮耳迷走神经刺激对健康志愿者运动应激试验中血流动力学和自主神经功能的影响。

Circulation reports Pub Date : 2025-04-11 eCollection Date: 2025-05-09 DOI: 10.1253/circrep.CR-24-0136

Yosuke Yoshida, Satoshi Okayama, Daisuke Fujihara, Midori Taniyama, Ayami Yamada, Megumi Fukui, Naoki Doi, Runa Takahashi, Akihiro Tanabe, Shingo Ogaki, Satoharu Hattori, Atsushi Iwai, Michitaka Nakamura, Naofumi Doi, Yoshihiko Saito

{"title":"Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Hemodynamics and Autonomic Function During Exercise Stress Tests in Healthy Volunteers.","authors":"Yosuke Yoshida, Satoshi Okayama, Daisuke Fujihara, Midori Taniyama, Ayami Yamada, Megumi Fukui, Naoki Doi, Runa Takahashi, Akihiro Tanabe, Shingo Ogaki, Satoharu Hattori, Atsushi Iwai, Michitaka Nakamura, Naofumi Doi, Yoshihiko Saito","doi":"10.1253/circrep.CR-24-0136","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0136","url":null,"abstract":"Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is a potential treatment for cardiovascular disease, but data on its effects on physiological function during exercise are lacking. We investigated the effects of taVNS on hemodynamics and autonomic nervous system function during exercise stress tests.Methods and results: Sixteen healthy volunteers underwent exercise stress tests with and without taVNS in this study, with a randomized crossover design and with a washout period of at least 7 days. taVNS was set to a frequency of 100 Hz and maximum current intensity without causing discomfort. Hemodynamics and autonomic nervous system function were evaluated using plethysmography and heart rate (HR) variability, respectively. After exclusion of an outlier, data of 15 participants were analyzed. In tests with taVNS, HR was significantly reduced at maximum exercise (136.0±9.7 vs. 132.0±9.2; P<0.001) and 1 min after exercise (115.0±11.4 vs. 104.0±15.0; P<0.001), with minimal changes in blood pressure. The stroke volume and total peripheral resistance at maximum exercise significantly increased and decreased, respectively. Furthermore, low/high frequency ratio reflecting sympathetic dominance decreased at rest (3.7±2.5 vs. 1.6±1.3; P<0.001) and at maximum exercise (4.5±4.5 vs. 1.2±0.9; P<0.001).Conclusions: taVNS can reduce HR with minimal effect on blood pressure by inducing parasympathetic dominance during exercise stress tests.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"315-322"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population Gap for Chronic Heart Failure Patients Between Randomized Controlled Trials and Japan's Super-Aged Society. 慢性心力衰竭患者在随机对照试验和日本超老龄化社会之间的人口差距。

Circulation reports Pub Date : 2025-04-08 eCollection Date: 2025-05-09 DOI: 10.1253/circrep.CR-25-0002

Jun-Ichi Noiri, Wataru Fujimoto, Makoto Takemoto, Koji Kuroda, Soichiro Yamashita, Junichi Imanishi, Masamichi Iwasaki, Takafumi Todoroki, Masanori Okuda, Manabu Nagao, Akihide Konishi, Masakazu Shinohara, Ryuji Toh, Kunihiro Nishimura, Hidekazu Tanaka

{"title":"Population Gap for Chronic Heart Failure Patients Between Randomized Controlled Trials and Japan's Super-Aged Society.","authors":"Jun-Ichi Noiri, Wataru Fujimoto, Makoto Takemoto, Koji Kuroda, Soichiro Yamashita, Junichi Imanishi, Masamichi Iwasaki, Takafumi Todoroki, Masanori Okuda, Manabu Nagao, Akihide Konishi, Masakazu Shinohara, Ryuji Toh, Kunihiro Nishimura, Hidekazu Tanaka","doi":"10.1253/circrep.CR-25-0002","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0002","url":null,"abstract":"Background: Heart failure (HF) management has been improved by guideline-directed medical therapy (GDMT) based on findings of major randomized controlled trials (RCTs). However, the applicability of these findings to real-world HF populations, especially Japan's current super-aged society, remains uncertain.Methods and results: We analyzed findings for chronic HF patients from the KUNIUMI registry, a prospective observational study conducted on Awaji Island, Japan, representative of a super-aged society (aging rate ≈37%). We determined what percentage of these patients met the inclusion criteria as well as the exclusion criteria of 6 major representative RCTs (PARADIGM-HF, PARAGON-HF, DAPA-HF, DELIVER, EMPEROR-Reduced, EMPEROR-Preserved) and compared the incidence of cardiovascular death and HF hospitalization over 3 years for patients who did and did not meet the exclusion criteria. Of the 1,646 patients from the KUNIUMI registry, 225 were eligible for PARADIGM-HF, DAPA-HF and EMPEROR-Reduced, 554 for PARAGON-HF, and 631 for DELIVER and EMPEROR-Preserved. The exclusion percentages for the overall eligible population were 48.4% (PARADIGM-HF), 36.4% (DAPA-HF), 42.7% (EMPEROR-Reduced), 57.9% (PARAGON-HF), 32.3% (DELIVER), and 31.4% (EMPEROR-Preserved). It should be noted that ineligible patients had a poorer prognosis than eligible patients (P<0.05 for each trial).Conclusions: The population gap between HF patients in major RCTs and the current super-aged society underscores the need for further evidence of GDMT in real-world settings.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"331-340"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil Extracellular Traps Capturing SARS-CoV-2 in the Lung Tissue (Alveoli and Parenchyma) Cause Microthrombi　- A Strategy to Eliminate SARS-CoV-2 From the Circulation as Degraded Fibrin Clots. 捕获肺组织（肺泡和实质）中SARS-CoV-2的中性粒细胞细胞外陷阱导致微血栓——一种以降解纤维蛋白凝块的形式从循环中消除SARS-CoV-2的策略。

Circulation reports Pub Date : 2025-04-04 eCollection Date: 2025-05-09 DOI: 10.1253/circrep.CR-24-0157

Hiroshi Katayama

{"title":"Neutrophil Extracellular Traps Capturing SARS-CoV-2 in the Lung Tissue (Alveoli and Parenchyma) Cause Microthrombi　- A Strategy to Eliminate SARS-CoV-2 From the Circulation as Degraded Fibrin Clots.","authors":"Hiroshi Katayama","doi":"10.1253/circrep.CR-24-0157","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0157","url":null,"abstract":"Background: It has been thought that neutrophil extracellular traps (NETs) and thrombosis exacerbate COVID-19, but, on the other hand, NETs are an important player in innate immunity. The precise roles of NETs and thrombosis in the course of COVID-19 have not been fully elucidated.Methods and results: The roles were investigated in the literature and a new theory was formulated. When neutrophils encounter SARS-CoV-2 in the lung tissue, they undergo NETosis and capture the virus. This capture is triggered by electrostatic interaction between histones in NETs and SARS-CoV-2; histones are highly positively charged, and viruses, including SARS-CoV-2, have a net negative charge under physiological pH. NETs that capture SARS-CoV-2 fall into alveolar capillaries through the collapsed endothelium to spare the lung tissue from the toxicity of NETs. NETs in the microvessels cause microthrombosis; positively charged histones induce the aggregation of negatively charged platelets, which leads to microthrombi. Microthrombi engulfing SARS-CoV-2 are consolidated into fibrin clots, which are eventually degraded by increased fibrinolysis and eliminated from the circulation.Conclusions: This novel theory suggests that NETosis and microthrombosis are phenomena inevitably elicited in COVID-19, and in combination they are a system newly termed \"NETombosis\". Undegraded fibrin clots remaining in the microcirculation may be the cause of the sequelae, because they cause long-lasting circulatory failure in various organs.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"379-382"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Is an Independent Risk Factor for the Development of Ischemic Heart Disease　- A 10-Year Cohort Study. 代谢功能障碍相关脂肪变性肝病（MASLD）是缺血性心脏病发展的独立危险因素——一项10年队列研究

Circulation reports Pub Date : 2025-04-01 eCollection Date: 2025-05-09 DOI: 10.1253/circrep.CR-25-0019

Toshifumi Ogawa, Tatsuya Sato, Marenao Tanaka, Yukinori Akiyama, Kei Nakata, Hidemichi Kouzu, Kazuma Mori, Hiroki Aida, Wataru Kawaharata, Itaru Hosaka, Toru Suzuki, Nagisa Hanawa, Masato Furuhashi

{"title":"Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Is an Independent Risk Factor for the Development of Ischemic Heart Disease　- A 10-Year Cohort Study.","authors":"Toshifumi Ogawa, Tatsuya Sato, Marenao Tanaka, Yukinori Akiyama, Kei Nakata, Hidemichi Kouzu, Kazuma Mori, Hiroki Aida, Wataru Kawaharata, Itaru Hosaka, Toru Suzuki, Nagisa Hanawa, Masato Furuhashi","doi":"10.1253/circrep.CR-25-0019","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0019","url":null,"abstract":"Background: The association of each of the recently classified steatotic liver diseases (SLDs), including metabolic dysfunction-associated SLD (MASLD), MASLD and increased alcohol intake (MetALD), and alcohol-associated liver disease (ALD), with new development of ischemic heart disease (IHD) remains unclear.Methods and results: We investigated the associations of various SLDs with the development of IHD during a 10-year follow-up period in 13,815 Japanese individuals without a history of IHD (men/women 8,933/4,882; mean age 48 years) who underwent annual health checkups including an abdominal ultrasound examination. Among the participants, 4,639 (33.6%) subjects were diagnosed as having SLDs, and the proportions of subjects with MASLD, MetALD and ALD were 25.4%, 4.7% and 1.9%, respectively. During the follow-up period, 1,963 (16.2%; men/women 1,374 [17.2%]/589 [14.2%]) subjects had new development of IHD. Multivariable Cox proportional hazard model analysis after adjustment of age, sex, estimated glomerular filtration rate (eGFR), current smoking habit, diabetes, hypertension and dyslipidemia showed that the adjusted risk for new onset of IHD was significantly higher in subjects with MASLD (hazard ratio 1.20 [95% confidence interval 1.01-1.55]; P=0.042) than in those without SLD. Other SLDs were not selected as independent risk factors for the development of IHD.Conclusions: The presence of MASLD, but not other SLDs, is an independent risk factor for new onset of IHD during a 10-year follow-up period.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"350-358"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Changes in Left Ventricular Myocardial Mechanics After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis. 重度主动脉瓣狭窄经导管主动脉瓣置换术后左室心肌力学的早期变化。

Circulation reports Pub Date : 2025-03-27 eCollection Date: 2025-05-09 DOI: 10.1253/circrep.CR-24-0139

Takeru Ikenaga, Yuta Kato, Yuto Kawahira, Midori Miyazaki, Tetsuo Hirata, Hiromitsu Teratani, Go Kuwahara, Makoto Sugihara, Hideichi Wada, Masahiro Ogawa, Shin-Ichiro Miura

{"title":"Early Changes in Left Ventricular Myocardial Mechanics After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis.","authors":"Takeru Ikenaga, Yuta Kato, Yuto Kawahira, Midori Miyazaki, Tetsuo Hirata, Hiromitsu Teratani, Go Kuwahara, Makoto Sugihara, Hideichi Wada, Masahiro Ogawa, Shin-Ichiro Miura","doi":"10.1253/circrep.CR-24-0139","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0139","url":null,"abstract":"Background: Transcatheter aortic valve replacement (TAVR) improves left ventricular (LV) deformation by aortic stenosis (AS). However, the early effects of TAVR on LV mechanics as assessed by echocardiography have not been fully elucidated.Methods and results: Between 2021 and 2024, we included 81 patients who underwent transfemoral TAVR for severe AS. We used the natural logarithm of B-type natriuretic peptide (lnBNP) 1 week after TAVR as an indicator of the early effects on LV mechanics. To determine the association with echocardiographic parameters (LV ejection fraction [LVEF], global longitudinal strain [GLS], E/e', and Tei index) and postprocedural lnBNP, we used regression models while adjusting for covariates. There were no significant differences in LVEF, GLS or E/e' between before and after TAVR, but the postprocedural Tei index was significantly higher than the preprocedural Tei index (0.40 vs. 0.26, P<0.01). In a univariate linear regression, the preprocedural LVEF (β=-0.28, P=0.01), GLS (β=-0.24, P=0.04), E/e' (β=0.36, P<0.01), and Tei index (β=0.27, P=0.02) correlated with postprocedural lnBNP. Regarding the postprocedural parameters, GLS (β=-0.27, P=0.02) and E/e' (β=0.36, P<0.01) also correlated with postprocedural lnBNP, but the LVEF and Tei index did not. After adjustment for covariates, these correlations remained significant.Conclusions: Preprocedural echocardiographic parameters reflecting LV function correlated with BNP after TAVR, but the utility of postprocedural parameters may depend on preprocedural LV function or perioperative factors.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"365-371"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiogenesis Using Recombinant Basic Fibroblast Growth Factor With Atelocollagen in Normal and Hind Limb Ischemia Models. 重组碱性成纤维细胞生长因子与游离胶原在正常和后肢缺血模型中的血管生成作用。

Circulation reports Pub Date : 2025-03-15 eCollection Date: 2025-05-09 DOI: 10.1253/circrep.CR-25-0011

Atsushi Kotani, Shin Watanabe, Takao Kato, Takayuki Kikuchi, Keiji Toya, Katsuhiko Hori, Noriko Minobe, Kaori Musumi, Yasuko Kimura, Yoji Nagai, Jun Yoshimura, Hirofumi Kawamata, Kenji Yanishi, Satoaki Matoba

{"title":"Angiogenesis Using Recombinant Basic Fibroblast Growth Factor With Atelocollagen in Normal and Hind Limb Ischemia Models.","authors":"Atsushi Kotani, Shin Watanabe, Takao Kato, Takayuki Kikuchi, Keiji Toya, Katsuhiko Hori, Noriko Minobe, Kaori Musumi, Yasuko Kimura, Yoji Nagai, Jun Yoshimura, Hirofumi Kawamata, Kenji Yanishi, Satoaki Matoba","doi":"10.1253/circrep.CR-25-0011","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0011","url":null,"abstract":"Background: Basic fibroblast growth factor (bFGF) is an angiogenic factor with a short half-life. Because recombinant bFGF is in clinical use, we hypothesized that the localization of recombinant bFGF with atelocollagen would have angiogenic effects at the injection site in normal and hind limb ischemic animal models.Methods and results: We administered the recombinant bFGF with atelocollagen intramuscularly to hind limbs in normal rabbits or in a mouse model of femoral artery ligation to explore the pharmacological action for ischemia. We evaluated blood flow in the ischemic/normal limb using laser speckle perfusion imaging and the density of blood vessels by pathological examination. At the administration site in normal rabbits, a significant increase in the number of blood vessels was noted at 14 days post-administration of recombinant bFGF with atelocollagen compared with saline or atelocollagen alone. In mice with femoral artery ligation, blood flow and vessels in the ischemic hind limb increased at 2 weeks after injection and more at 4 weeks after injection, and the effect was most significant in mice administered 100 μg of recombinant bFGF with 3% of atelocollagen.Conclusions: Intramuscular administration of recombinant bFGF with atelocollagen induced angiogenesis between 2 and 4 weeks in both normal and ischemic hind limbs.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"372-378"},"PeriodicalIF":0.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting Diversity in Cardiac Rehabilitation Programs at Community Hospitals. 促进社区医院心脏康复项目的多样性。

Circulation reports Pub Date : 2025-03-15 eCollection Date: 2025-04-10 DOI: 10.1253/circrep.CR-25-0017

Noriko Fukue, Masakazu Miura, Ikki Tokumoto, Yuka Hajima, Sanae Namba, Shinya Kohtoku, Yasuhiro Ikeda

{"title":"Promoting Diversity in Cardiac Rehabilitation Programs at Community Hospitals.","authors":"Noriko Fukue, Masakazu Miura, Ikki Tokumoto, Yuka Hajima, Sanae Namba, Shinya Kohtoku, Yasuhiro Ikeda","doi":"10.1253/circrep.CR-25-0017","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0017","url":null,"abstract":"Background: Although comprehensive cardiac rehabilitation (CR) is an effective treatment for cardiovascular diseases, its implementation in Japan remains insufficient. Following the 2022 Basic Act on Cardiovascular Disease Prevention, each prefecture has established specific targets.Methods and results: We report our experience implementing and managing CR programs across hospitals of different sizes in Yamaguchi Prefecture, Japan, including Tokuyama Medical Association Hospital (initiated in 2019), Mitajiri Hospital (initiated in 2022), and Yamaguchi Prefectural Grand Medical Center. Hospital size and functionality correlated with the diversity and number of healthcare professionals available to provide CR services. In mixed-care hospitals, both inpatient and outpatient CR participants were older compared with acute-care hospitals. Insurance reimbursement calculations and bed-type restrictions affected CR service delivery. The CR team exemplifies interprofessional collaboration in cardiovascular care.Conclusions: Even without all the necessary professional roles, patients can benefit significantly from CR implemented using available resources. Building effective organizations requires embracing diversity and enabling each profession to demonstrate its expertise while ensuring the psychological safety of team members.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 4","pages":"219-222"},"PeriodicalIF":0.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0