Circulation reports最新文献

{"title":"Limited Impact of High Bleeding Risk Calculation and Peri-Procedural Discussion on Dual-Antiplatelet Therapy Duration and Clinical Outcomes After Percutaneous Coronary Intervention.","authors":"Tomoki Hattori, Ruka Yoshida, Mikito Takefuji, Kenshi Hirayama, Yasuhiro Ogura, Hirohiko Suzuki, Shunsuke Ito, Ryo Ibayashi, Shu Sobue, Tomoaki Nawano, Hideo Oishi, Ryo Watanabe, Monami Ando, Yukihiko Yoshida, Toyoaki Murohara","doi":"10.1253/circrep.CR-26-0135","DOIUrl":"https://doi.org/10.1253/circrep.CR-26-0135","url":null,"abstract":"<p><strong>Background: </strong>The Japanese version of the high bleeding risk (J-HBR) criteria identifies patients with HBR undergoing percutaneous coronary intervention (PCI). We evaluated whether routine J-HBR calculation and peri-procedural discussion on dual-antiplatelet therapy (DAPT) duration were associated with changes in DAPT practice and clinical outcomes.</p><p><strong>Methods and results: </strong>We retrospectively evaluated 793 patients who underwent PCI between August 2019 and August 2021. Routine J-HBR calculation and peri-procedural discussion on DAPT duration were introduced in August 2020, and patients were categorized into post- and pre-J-HBR groups. The median DAPT duration was 174 and 188 days (P=0.47), and guideline-directed DAPT duration was achieved in 62.6% and 56.9%, respectively (P=0.13) in the post- and pre-J-HBR groups. Clinical outcomes did not differ significantly between groups, including net adverse clinical events (hazard ratio [HR], 1.08; 95% confidence interval [CI], 0.77-1.52; P=0.65), major cardiovascular or cerebrovascular events (HR, 0.76; 95% CI, 0.44-1.32; P=0.34), and major bleeding (HR, 1.30; 95% CI, 0.90-1.89; P=0.17). Multivariable Cox proportional hazards analysis showed that routine J-HBR calculation and peri-procedural discussion were not associated with a significant reduction in major bleeding (HR, 0.97; 95% CI, 0.65-1.46; P=0.88).</p><p><strong>Conclusions: </strong>Routine J-HBR calculation and peri-procedural discussion on DAPT duration were not associated with significant changes in overall DAPT duration or clinical outcomes.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1685-1695"},"PeriodicalIF":2.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Therapy for Acute Heart Failure Patients Admitted to the Cardiovascular Intensive Care Unit and Its Impact on the Nutritional Status at Discharge.","authors":"Mayuko Fukuse, Hiroki Nakano, Junya Kamesako, Koichi Kamioka, Jun Yamashita, Yasushi Miyazawa","doi":"10.1253/circrep.CR-25-0212","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0212","url":null,"abstract":"<p><strong>Background: </strong>Nutritional status at discharge is a prognostic factor in acute heart failure (AHF) patients, but its relationship with early-phase nutritional therapy in the cardiovascular intensive care unit (CICU) remains unclear, so we evaluated the effects of HF severity, respiratory management, and nutritional dosage on nutritional status in AHF patients.</p><p><strong>Methods and results: </strong>We retrospectively analyzed 141 of 160 AHF patients admitted to the CICU in 2021, excluding those with acute coronary syndrome, who had died, or had been discharged early. Patients were divided into 3 groups by respiratory support: invasive ventilation (IPPV, n=21), non-invasive ventilation (NPPV, n=36), and other forms of oxygen supplementation (O₂S, n=84). The mean age of the patients was 72±15 years. On day 3, the IPPV group received less nutrition than the O₂S group, but by day 7 there was no significant difference among the groups in the nutritional doses administered. No significant differences in the Geriatric Nutritional Risk Index (GNRI) at discharge were observed among the groups. Multiple regression analysis identified the energy (standardized β=0.210, P=0.029) and protein (standardized β=0.248, P=0.007) doses on day 3 as being correlated with the GNRI at discharge, independent of HF severity or respiratory management.</p><p><strong>Conclusions: </strong>The nutritional dose on day 3, rather than HF severity, respiratory management or the day 7 nutritional dose, may be associated with the GNRI at discharge.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1704-1710"},"PeriodicalIF":2.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide Outcomes and Predictors of Mortality After Left Ventricular Assist Device Implantation in Korea: Insights From the Korean Registry for Mechanically Assisted Circulatory Support.","authors":"Su-Jin Cho, Jihye Kim, Yoon Jung Choi, Sun Hyun Moon, Chisoo Park, Jong Youn Moon, Eung Joong Kim, Young Hwan Park, Keon Hyun Jo, Hyun-Jai Cho, Jong-Chan Youn, Yang Hyun Cho","doi":"10.1253/circrep.CR-26-0201","DOIUrl":"https://doi.org/10.1253/circrep.CR-26-0201","url":null,"abstract":"<p><strong>Background: </strong>Durable left ventricular assist device (LVAD) therapy was introduced in Korea in 2018 within a transplant environment characterized by frequent preoperative extracorporeal membrane oxygenation (ECMO) support. We evaluated nationwide outcomes and predictors of mortality after LVAD implantation.</p><p><strong>Methods and results: </strong>This registry-based cohort study included all durable LVAD implantations performed in Korea between September 2018 and December 2023 using the Korean Mechanically Assisted Circulatory Support registry. The primary outcome was all-cause mortality. Survival was assessed with Kaplan-Meier and competing risk analyses, and predictors were identified using multivariable Cox models. Among 465 patients (median age 62 years; 78% male), 367 underwent bridge-to-transplantation (BTT) and 98 destination therapy (DT). Preoperative ECMO was used in 27.5%. One-year survival was 83.1% overall and higher in BTT than DT (87.4% vs. 69.6%; P<0.001). At 1 year, 59.6% remained on LVAD support, 24.8% underwent transplantation, and 15.6% died. Arrhythmia, bleeding, and infection were the most common complications. In multivariable analysis, age 60-69 years (hazard ratio [HR] 3.80; 95% confidence interval [CI] 1.73-8.31) and preoperative ECMO (HR 2.85; 95% CI 1.76-4.60) independently predicted mortality, whereas treatment strategy did not.</p><p><strong>Conclusions: </strong>In this high-acuity population with frequent preoperative ECMO support, nationwide LVAD outcomes were comparable to international benchmarks. Mortality was more closely associated with preoperative clinical status than with treatment strategy.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1666-1675"},"PeriodicalIF":2.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Diagnosis of Transthyretin Amyloidosis Cardiomyopathy in Japan: Care Pathway Barriers and Opportunities.","authors":"Jin Endo, Toru Kubo, Kota Suzuki, Hiroo Tsubota, Emma Crawford, Yuchen Hsu","doi":"10.1253/circrep.CR-26-0095","DOIUrl":"https://doi.org/10.1253/circrep.CR-26-0095","url":null,"abstract":"<p><strong>Background: </strong>Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is a progressive, underdiagnosed cause of heart failure, particularly among older adults. Despite updated Japanese Circulation Society (JCS) guidelines and advances in imaging and therapies, diagnostic delays and variability persist. Understanding real-world barriers is essential for improving patient outcomes.</p><p><strong>Methods and results: </strong>A mixed-methods approach was used to develop an evidenced care pathway for ATTR-CM in Japan. A literature review of guidelines and epidemiological data informed a draft pathway. Semistructured interviews with 5 cardiologists from JCS-certified and regional hospitals explored perceived deviations from guidelines and barriers to care. Thematic analysis highlighted 5 perceived challenges: variability in physician awareness, particularly outside heart failure subspecialties; the influence of symptom type and entry point on diagnostic delay; fragmented referral pathways; low patient awareness and disengagement due to complex processes; and limited access to and interpretation of diagnostic tests.</p><p><strong>Conclusions: </strong>Removal of the tissue biopsy requirement for diagnosis and treatment prescription is an important step towards less invasive care and broader treatment access. However, challenges remain in ensuring that non-invasive diagnostic methods are widely available and correctly interpreted. The exploratory findings reported here suggest that addressing awareness gaps, referral fragmentation, and variations in diagnostic expertise may help realize the benefits of non-biopsy diagnosis in Japan.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1649-1657"},"PeriodicalIF":2.3,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Implications of Right Bundle Branch Block in the General Population: A Systematic Review and Meta-Analysis.","authors":"Hiroshi Kawakami, Yuimi Jinno, Miyuki Kawakami, Shunsuke Tamaki, Kazuhisa Nishimura, Yan Luo, Osamu Yamaguchi","doi":"10.1253/circrep.CR-26-0228","DOIUrl":"https://doi.org/10.1253/circrep.CR-26-0228","url":null,"abstract":"<p><strong>Background: </strong>Because the prognostic significance of right bundle branch block (RBBB) in the general population remains uncertain, we conducted a systematic review and meta-analysis to evaluate the association of RBBB with clinical outcomes in general population cohorts.</p><p><strong>Methods and results: </strong>We systematically searched major databases for population-based cohort studies reporting associations between RBBB and clinical outcomes. Hazard ratios (HRs) were pooled using a random-effects model. A total of 14 studies were included in the systematic review, of which 5 (all-cause mortality), 4 (cardiovascular mortality), and 2 studies (pacemaker implantation) were included in the meta-analyses. RBBB was associated with a modest increase in all-cause mortality (HR 1.08; 95% confidence interval (CI), 1.01-1.16), although the association was attenuated in the sensitivity analysis excluding the largest-weight study (HR 1.04; 95% CI, 0.87-1.24). No significant association was observed between RBBB and cardiovascular mortality (HR 1.20; 95% CI, 0.90-1.59). RBBB was associated with an increased risk of pacemaker implantation (HR 3.03; 95% CI, 1.70-5.38), although the number of studies was limited.</p><p><strong>Conclusions: </strong>RBBB was associated with a modest and partially unstable increase in all-cause mortality, but no significant association with cardiovascular mortality was observed. RBBB may reflect underlying risk profiles or progressive conduction system abnormalities, rather than serving as a strong independent predictor of mortality.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1590-1600"},"PeriodicalIF":2.3,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impact of In-Hospital Emergency in Patients Admitted for Non-Surgical Intensive Care.","authors":"Kenichi Tani, Akihiro Shirakabe, Masato Matsushita, Shota Shigihara, Tomofumi Sawatani, Masaki Morooka, Masahito Takahashi, Riku Toguchi, Yuto Yata, Keiichiro Otsubo, Nobuaki Kobayashi, Kuniya Asai","doi":"10.1253/circrep.CR-26-0002","DOIUrl":"https://doi.org/10.1253/circrep.CR-26-0002","url":null,"abstract":"<p><strong>Background: </strong>We aimed to elucidate the prognostic impact of in-hospital emergencies among patients who require non-surgical intensive care.</p><p><strong>Methods and results: </strong>In total, 4,483 patients requiring non-surgical intensive care from 2011 to 2021 were included. Patient backgrounds, in-hospital management, and prognoses were compared among 4 groups according to the hospitalization route: walk-ins (group A; n=636); ambulance (group B; n=2,748); helicopter/car-based emergency medical service (group C; n=565); and in-hospital emergencies (group D; n=534). The proportion of patients admitted to the intensive care unit after in-hospital emergencies was 38.0% among those with sepsis and 29.7% among those with other non-cardiovascular diseases. Furthermore, acute heart failure (AHF), sepsis and other non-cardiovascular disease were the most common diseases in patients with in-hospital emergencies (24.3%, 23.2% and 21.5%, respectively). Kaplan-Meier curve analysis revealed that the prognosis (365-day all-cause mortality) was significantly poorer in group D than in the other groups. A multivariable Cox regression model identified group D as an independent predictor of 365-day all-cause mortality (hazard ratio 1.227; 95% confidence interval 1.027-1.467) relative to out-of-hospital admissions, especially in AHF and non-cardiovascular disease.</p><p><strong>Conclusions: </strong>Patients who required non-surgical intensive care after in-hospital emergencies mainly have AHF and non-cardiovascular etiologies such as sepsis. In-hospital emergency was identified as a significant factor associated with a higher 365-day mortality rate. A clinical approach to reduce their mortality is urgently needed.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1620-1630"},"PeriodicalIF":2.3,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in Culprit- and Non-Culprit Lesion-Attributed Revascularization After Acute Myocardial Infarction: Insights From the Mie ACS Registry.","authors":"Akihiro Takasaki, Hiroki Oizumi, Eisuke Maekawa, Tatsuya Akatsuka, Akiyoshi Ikami, Yosuke Kirii, Hiromasa Ito, Hirokazu Shioji, Tomoyuki Fukuma, Yusuke Tanigaito, Masaki Ishiyama, Tairo Kurita, Toshiki Sawai, Jun Masuda, Kaoru Dohi","doi":"10.1253/circrep.CR-26-0214","DOIUrl":"https://doi.org/10.1253/circrep.CR-26-0214","url":null,"abstract":"<p><strong>Background: </strong>Recurrent ischemic events after acute myocardial infarction (AMI) may arise from treated culprit lesions (CLs) or untreated non-CLs (NCLs). However, temporal trends in CL- and NCL-attributed revascularization in contemporary clinical practice remain unclear.</p><p><strong>Methods and results: </strong>We analyzed data from the Mie ACS Registry, a multicenter registry enrolling patients with AMI who underwent primary percutaneous coronary intervention. Patients with previous coronary artery bypass grafting were excluded. The coprimary endpoints were the times to the first CL- and NCL-attributed revascularization over a 2-year follow-up period. Death was treated as a competing event. Temporal trends and predictors were evaluated using competing-risk analyses. Among 6,363 patients, 2,860 were enrolled in 2013-2017 and 3,503 were enrolled in 2018-2022. The cumulative incidence of CL-attributed revascularization was significantly lower in the later era (6.2% vs. 3.5%; P<0.001), whereas NCL-attributed revascularization showed only modest temporal improvement from 2013-2017 to 2018-2022 (6.6% vs. 5.5%, respectively; P=0.091). In multivariable analyses, late-era (2018-2022) enrollment was independently associated with a lower risk of CL-attributed revascularization (subdistribution hazard ratio [sHR] 0.56; 95% confidence interval [CI] 0.44-0.71; P<0.001), whereas multivessel disease was the strongest predictor of NCL-attributed revascularization (sHR 2.31; 95% CI 1.84-2.91; P<0.001).</p><p><strong>Conclusions: </strong>Despite temporal reductions in CL-attributed revascularization, NCL-attributed events remained relatively unchanged. NCLs continue to represent an important source of residual coronary risk after AMI.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1610-1619"},"PeriodicalIF":2.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Prognostic Performance of the CADILLAC Risk Score and C-Reactive Protein/Albumin Ratio in Acute Myocardial Infarction.","authors":"Mitsutoshi Oguri, Soichiro Maeda, Satoya Yoshida, Yuichiro Koyama, Yusuke Fujikawa, Hiroshi Takahashi, Hideki Ishii","doi":"10.1253/circrep.CR-26-0231","DOIUrl":"https://doi.org/10.1253/circrep.CR-26-0231","url":null,"abstract":"<p><strong>Background: </strong>Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality, so accurate early risk stratification is essential for predicting adverse events. We investigated whether combining the Creactive protein/albumin ratio (CAR) with the CADILLAC (Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications) risk score was associated with an increased risk of 1-year major adverse cardiac events (MACE), and assessed its efficacy in the risk stratification of patients with AMI undergoing primary percutaneous coronary intervention (PCI).</p><p><strong>Methods and results: </strong>In total, 554 patients were enrolled. The rate of 1-year MACE was 10.5%. Both the CADILLAC risk category and CAR tertile were independent predictors of 1-year MACE, after adjustment for covariates (hazard ratio [HR] 1.98, 95% confidence interval [CI] 1.34-2.92, P=0.001; HR 1.65, 95% CI 1.14-2.37, P=0.007, respectively). Compared to patients with a low CADILLAC risk score and a low CAR tertile, those with a high CADILLAC risk score and a high CAR tertile had the highest 1-year MACE (adjusted HR 8.13, 95% CI 1.88-35.2, P=0.005). Adding CAR to a model that combined the CADILLAC risk score with the baseline factors significantly improved the prediction of 1-year MACE.</p><p><strong>Conclusions: </strong>Combining the CAR with the CADILLAC risk score significantly contributed to predicting 1-year MACE in patients with AMI undergoing primary PCI.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1676-1684"},"PeriodicalIF":2.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Nutritional Risk on Long-Term Prognosis in Older Patients With Stage B Heart Failure: A PAPRIKA-HF Registry Subanalysis.","authors":"Shohei Hakozaki, Koichiro Matsumura, Shun Morishita, Junko Morimoto, Satoshi Kurose, Kosuke Fujita, Takayuki Kawamura, Eijiro Yagi, Hiroki Matsuzoe, Masafumi Ueno, Yutaka Kimura, Gaku Nakazawa","doi":"10.1253/circrep.CR-26-0047","DOIUrl":"https://doi.org/10.1253/circrep.CR-26-0047","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition is a common geriatric syndrome associated with adverse long-term outcomes in hospitalized patients with heart failure (HF). However, its prognostic impact in outpatients with stage B HF remains unclear.</p><p><strong>Methods and results: </strong>This multicenter, retrospective cohort study was conducted at 4 outpatient cardiology clinics between June 2021 and May 2023. Among 331 outpatients aged ≥65 years with stage B HF, 307 were included in the final analysis. Nutritional status was assessed using the Geriatric Nutritional Risk Index (GNRI). The primary endpoint was a composite of all-cause death or hospitalization for worsening HF during the 2-year follow-up period. The median GNRI was 102.8, and 22% (67/307) of patients were classified into the low-GNRI group (GNRI ≤ 98.0). Kaplan-Meier analysis showed that the low-GNRI group had a significantly higher incidence of the composite endpoint than the high-GNRI group (14.9% vs. 3.8%; log-rank P<0.001). In multivariable Cox proportional hazards models, a low GNRI was independently associated with adverse events (hazard ratio 3.41; 95% confidence interval 1.34-8.69; P=0.01).</p><p><strong>Conclusions: </strong>Low GNRI scores were independently associated with poorer long-term outcomes in older outpatients with stage B HF. Thus, the GNRI may serve as a simple and practical tool for early risk stratification of this population.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1658-1665"},"PeriodicalIF":2.3,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Tafamidis on Left Ventricular Strain in Patients With Wild-Type Transthyretin Cardiac Amyloidosis With and Without Diabetes Mellitus.","authors":"Kojiro Tsurukawa, Hiroaki Kawano, Chisa Eguchi, Rosy Haruna Nishizawa, Tsuyoshi Yoshimuta, Kentaro Furukawa, Takako Minami, Masamichi Eguchi, Satoshi Ikeda, Koji Maemura","doi":"10.1253/circrep.CR-26-0232","DOIUrl":"https://doi.org/10.1253/circrep.CR-26-0232","url":null,"abstract":"<p><strong>Background: </strong>Tafamidis is used in patients with wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), but the effect of diabetes mellitus (DM) on the efficacy of tafamidis is unknown.</p><p><strong>Methods and results: </strong>We included 57 patients (median age, 77 years) with ATTRwt-CA to compare global longitudinal strain (GLS) before and 1 year after treatment with tafamidis in patients with and without DM (Non-DM, 43 patients; DM, 14 patients). GLS was only ameliorated in patients without DM.</p><p><strong>Conclusions: </strong>The change in GLS at 1 year after tafamidis treatment may be different in ATTRwt-CM patients with and without DM.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"8 10","pages":"1761-1764"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}