Circulation reports最新文献

Combination Therapy With Clarithromycin and Montelukast Suppresses the Progression of Aortic Aneurysms in Mice With Chronic Obstructive Pulmonary Disease. 克拉霉素和孟鲁司特联合治疗可抑制慢性阻塞性肺疾病小鼠主动脉瘤的进展

IF 1.1

Circulation reports Pub Date : 2025-09-11 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0142

Satoshi Yuhara, Yuji Narita, Aika Yamawaki-Ogata, Masato Mutsuga

{"title":"Combination Therapy With Clarithromycin and Montelukast Suppresses the Progression of Aortic Aneurysms in Mice With Chronic Obstructive Pulmonary Disease.","authors":"Satoshi Yuhara, Yuji Narita, Aika Yamawaki-Ogata, Masato Mutsuga","doi":"10.1253/circrep.CR-25-0142","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0142","url":null,"abstract":"Background: Chronic obstructive pulmonary disease (COPD) is a known risk factor for aortic aneurysm (AA) enlargement and rupture. This study investigated the effects of clarithromycin (CAM) and montelukast (Mont), which are medications used to treat COPD, on AA progression in a murine model of COPD.Methods and results: Apolipoprotein E-deficient mice, aged 28-40 weeks, were infused with angiotensin II by osmotic pumps to induce AA formation. Some of them received COPD induction through a single dose of porcine pancreatic elastase via the trachea. Mice were divided into 3 groups: AA (n=16; AA only, treated with saline); AA-C (n=10; AA and COPD, treated with saline); and AA-Cm (n=10; AA and COPD, treated with CAM and Mont). CAM and Mont were administered orally on a daily basis. After 28 days, aortic diameter, elastin content, matrix metalloproteinase (MMP) activity, and inflammatory markers were evaluated. The AA-C group exhibited significantly larger aneurysm diameter than the AA group (2.41 vs. 1.97 mm; P<0.05). Compared with the AA-C group, the AA-Cm group had higher elastin content (46.8 vs. 32.3%; P<0.01), decreased TNF-α level (115.5 vs. 141.0 pg/mL; P<0.05), reduced MMP-9 activity (54.8 vs. 75.4 pg/mL; P<0.01), and lower M1/M2 macrophage ratio.Conclusions: CAM and Mont attenuate AA progression in COPD by reducing inflammation, preserving elastin, and increasing infiltrated M2 macrophages, suggesting they have a therapeutic potential.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"842-851"},"PeriodicalIF":1.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Significance of Cardiac Troponin I Elevation in Detecting Immune Checkpoint Inhibitor-Induced Myocarditis. 心肌肌钙蛋白I升高检测免疫检查点抑制剂诱导的心肌炎的临床意义。

IF 1.1

Circulation reports Pub Date : 2025-09-04 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0127

Masayoshi Oikawa, Fumika Haga, Tetsuya Tani, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takashi Kaneshiro, Akiomi Yoshihisa, Takafumi Ishida, Yasuchika Takeishi

{"title":"Clinical Significance of Cardiac Troponin I Elevation in Detecting Immune Checkpoint Inhibitor-Induced Myocarditis.","authors":"Masayoshi Oikawa, Fumika Haga, Tetsuya Tani, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takashi Kaneshiro, Akiomi Yoshihisa, Takafumi Ishida, Yasuchika Takeishi","doi":"10.1253/circrep.CR-25-0127","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0127","url":null,"abstract":"Background: Immune checkpoint inhibitors (ICIs) enhance T-cell activity against cancer, but can cause immune-related adverse events, including myocarditis, a rare yet potentially fatal complication. Cardiac troponin I (cTnI) is widely used for screening the development of myocarditis, but its efficacy remains uncertain.Methods and results: From January 2016 to June 2024, we conducted a single-center retrospective study of 468 cancer patients receiving ICI therapy. Serum cTnI levels were assessed at baseline, at 1, 3, 6, 9, 12 months, and every 4 months. During the follow-up period, 26 patients (5.6%) exhibited cTnI elevation. This group had a higher prevalence of breast cancer, higher baseline cTnI levels, lower estimated glomerular filtration rates, and a greater proportion of concomitant ipilimumab and nivolumab use. Multivariate analysis revealed that high baseline cTnI levels and concomitant ipilimumab and nivolumab use were independent predictors of cTnI elevation. Of the 26 patients with elevated cTnI, 4 developed myocarditis, requiring steroid therapy, and exhibited a progressive increase in cTnI levels, whereas the remaining 22 patients without myocarditis did not show such an increase.Conclusions: Occasional cTnI elevation occurs during ICI therapy. However, a marked and sustained increase in cTnI levels may be a sign of the development of myocarditis.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"948-955"},"PeriodicalIF":1.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Rehabilitation and Heart Failure With Preserved Ejection Fraction. 保留射血分数的心脏康复和心力衰竭。

IF 1.1

Circulation reports Pub Date : 2025-09-02 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0130

Akihiro Hirashiki, Atsuya Shimizu

{"title":"Cardiac Rehabilitation and Heart Failure With Preserved Ejection Fraction.","authors":"Akihiro Hirashiki, Atsuya Shimizu","doi":"10.1253/circrep.CR-25-0130","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0130","url":null,"abstract":"Heart failure with preserved ejection fraction (HFpEF) is becoming increasingly prevalent in aging societies. A recent multicenter cohort study in Japan demonstrated that cardiac rehabilitation (CR) significantly improves the prognosis of patients with HFpEF and frailty. The 2025 Japanese Heart Failure Guidelines recommend pharmacologic therapies for HFpEF. Recent international trials have led to the adoption of sodium-glucose transporter 2 inhibitors and angiotensin-receptor-neprilysin inhibitors in Japan, supported by evidence showing reduced rates of heart failure readmission. However, it should be noted that the majority of patients enrolled in those trials were in their early 70s. In real-world clinical practice, the number of patients in their 80s and 90s receiving treatment is increasing. This older population is more susceptible to adverse effects such as orthostatic hypotension, hyperkalemia, and urinary tract infections. Polypharmacy further complicates medication management. In such cases, CR plays a vital role in maintaining quality of life and supporting long-term prognosis. Furthermore, HFpEF is frequently accompanied by comorbidities such as atrial fibrillation, hypertension, and ischemic heart disease. It is important to note that elderly patients are also susceptible to additional conditions, including cerebrovascular disease, musculoskeletal disorders and malignancies. A multidisciplinary approach to CR, tailored to these complex health profiles, is essential to prevent the progression of functional decline and frailty.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"837-841"},"PeriodicalIF":1.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Impact of Fibroblast Growth Factor 21 in Patients With Heart Failure. 成纤维细胞生长因子21对心力衰竭患者预后的影响。

IF 1.1

Circulation reports Pub Date : 2025-08-29 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0067

Hiroaki Sunaga, Kuniko Yoshida, Kazuki Kagami, Tomonari Harada, Tsukasa Murakami, Naoki Yuasa, Hiroki Matsui, Keiko Kawai-Kowase, Tatsuya Iso, Tomoyuki Yokoyama, Masahiko Kurabayashi, Hideki Ishii, Masaru Obokata

{"title":"Prognostic Impact of Fibroblast Growth Factor 21 in Patients With Heart Failure.","authors":"Hiroaki Sunaga, Kuniko Yoshida, Kazuki Kagami, Tomonari Harada, Tsukasa Murakami, Naoki Yuasa, Hiroki Matsui, Keiko Kawai-Kowase, Tatsuya Iso, Tomoyuki Yokoyama, Masahiko Kurabayashi, Hideki Ishii, Masaru Obokata","doi":"10.1253/circrep.CR-25-0067","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0067","url":null,"abstract":"Background: Systemic and cardiac metabolic disorders play a key role in patients with heart failure (HF). Fibroblast growth factor 21 (FGF21) is mainly secreted from the liver and has various effects on cardiomyocytes, including protection against oxidative stress, cardiac hypertrophy, and inflammation. However, the pathophysiologic and prognostic impact of FGF21 remains unknown.Methods and results: Serum levels of FGF21 and echocardiography were performed in patients with compensated HF (n=162) and control patients without HF (n=20). Compared with the control patients, those with HF displayed higher FGF21 levels (100 [76-213] vs. 237 [135-575] pg/mL; P=0.0006). There were no or modest correlations of FGF21 levels with clinical variables and echocardiographic parameters. During a median follow up of 12.0 months, there were 56 primary composite endpoints of all-cause death or HF hospitalization in the HF cohort. The highest FGF21 tertile was associated with a 3-fold increased risk of the composite outcome compared with the lowest tertile. After adjusting for age, sex, and the presence of atrial fibrillation, serum FGF21 remained independently associated with the outcome. Adding FGF21 levels to the model based on N-terminal pro B-type natriuretic peptide levels significantly improved the prognostic value (global chi-square 13.07 vs. 8.65; P=0.04).Conclusions: Data from the present study demonstrated the importance of FGF21 as a potential biomarker that may reflect a different pathophysiologic implication from natriuretic peptides.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"922-929"},"PeriodicalIF":1.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Thrombotic and Bleeding Risks With Plaque Morphology. 血栓和出血风险与斑块形态的关系。

IF 1.1

Circulation reports Pub Date : 2025-08-29 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0133

Yoichiro Otaki, Daisuke Kinoshita, Takafumi Mito, Jun Goto, Taku Shikama, Shigehiko Kato, Tetsu Watanabe, Tetsuya Takahashi, Tamon Yamanaka, Tadateru Iwayama, Toshiki Sasaki, Takeshi Niizeki, Shinpei Kadowaki, Koki Omi, Shigeo Sugawara, Hiromasa Hasegawa, Hyuma Daidoji, Akio Fukui, Masafumi Watanabe

{"title":"Associations of Thrombotic and Bleeding Risks With Plaque Morphology.","authors":"Yoichiro Otaki, Daisuke Kinoshita, Takafumi Mito, Jun Goto, Taku Shikama, Shigehiko Kato, Tetsu Watanabe, Tetsuya Takahashi, Tamon Yamanaka, Tadateru Iwayama, Toshiki Sasaki, Takeshi Niizeki, Shinpei Kadowaki, Koki Omi, Shigeo Sugawara, Hiromasa Hasegawa, Hyuma Daidoji, Akio Fukui, Masafumi Watanabe","doi":"10.1253/circrep.CR-25-0133","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0133","url":null,"abstract":"Background: Plaque morphology evaluation using optical coherence tomography (OCT) is vital for planning an optimized strategy for percutaneous coronary intervention (PCI), and an assessment of thrombotic risk (TR) and bleeding risk (BR) is crucial in managing patients who have undergone PCI. We examined the association of TR and BR with plaque morphology in patients with coronary artery disease (CAD).Methods and results: We conducted a multicenter prospective observational study and enrolled 325 patients with CAD who underwent PCI with OCT (median age 70 years, 19% women). The calcium index, which is equivalent to the calcium plaque volume, was assessed using OCT. Nondeformable calcified plaque was defined as a calcium score ≥3, the threshold for necessitating aggressive lesion modification. The TR and BR were evaluated using CREDO-Kyoto risk scores. The calcium index and prevalence of nondeformable calcified plaque increased significantly with increasing TR and BR scores. The TR and BR scores were significantly associated with higher calcium index after adjustment for confounders (TR score: β, 0.757; 95% confidence interval [CI], 0.568-0.946; P<0.001 and BR score: β, 0.623; 95% CI, 0.374-0.871; P<0.001). Both the calcium index and prevalence of nondeformable calcified plaque were highest in patients with both high TR and BR.Conclusions: The TR and BR scores were associated with significant calcification and nondeformable calcified plaques in patients with CAD.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"939-947"},"PeriodicalIF":1.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictivity of Each Readiness-to-Explant Criterion for Successful Venoarterial Extracorporeal Membrane Oxygenation Explantation. 静脉体外膜氧合移植成功的各项移植准备标准的预测性。

IF 1.1

Circulation reports Pub Date : 2025-08-27 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0131

Keiichiro Iwasaki, Kentaro Ejiri, Hironobu Toda, Yoichi Takaya, Satoshi Akagi, Kazufumi Nakamura, Shinsuke Yuasa

{"title":"Predictivity of Each Readiness-to-Explant Criterion for Successful Venoarterial Extracorporeal Membrane Oxygenation Explantation.","authors":"Keiichiro Iwasaki, Kentaro Ejiri, Hironobu Toda, Yoichi Takaya, Satoshi Akagi, Kazufumi Nakamura, Shinsuke Yuasa","doi":"10.1253/circrep.CR-25-0131","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0131","url":null,"abstract":"Background: The use of temporary mechanical circulatory support (tMCS) has revolutionized the management of cardiogenic shock (CS). However, standardized readiness-to-explant criteria for venoarterial extracorporeal membrane oxygenation (VA-ECMO) have not been established.Methods and results: We performed a retrospective analysis of 37 patients with CS who were explanted from VA-ECMO at Okayama University Hospital from December 2018 to May 2024 to evaluate the diagnostic performance of each readiness-to-explant criterion for explant success or failure. Explant success was defined as 30-day survival without re-insertion of MCS. Hemodynamic parameters were assessed at explant, weaning (1.0 to 1.5 L/min), and the off test (5 min). We assessed the predictive performance among parameters in successful or unsuccessful explantation of VA-ECMO using receiver operative characteristic curve analysis. The pulmonary artery catheter (PAC) criteria (pulmonary artery wedge pressure ≤18 mmHg, central venous pressure ≤12 mmHg, and cardiac index ≥2.2 L/min/m2) at the off test showed the highest predictability for successful explantation of VA-ECMO (area under the receiver operating characteristics curve 0.83; 95% confidence interval 0.71-0.96). The sensitivity, specificity, positive predictive value, and negative predictive value of the PAC criteria were 67%, 100%, 100%, and 38%, respectively.Conclusions: Our results suggest that the PAC criteria at the off test may be the most appropriate algorithm for predicting successful explantation of VA-ECMO. Further prospective studies are needed to validate the present findings and to establish standardized VA-ECMO explantation practices.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"896-903"},"PeriodicalIF":1.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alteration in Carotid Arterial Stiffness During Passive Leg Raising May Reflect Vascular Endothelial Function. 被动抬腿时颈动脉硬度的改变可能反映血管内皮功能。

IF 1.1

Circulation reports Pub Date : 2025-08-27 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0047

Kazunori Okada, Masahiro Nakabachi, Yasuhiro Hayashi

{"title":"Alteration in Carotid Arterial Stiffness During Passive Leg Raising May Reflect Vascular Endothelial Function.","authors":"Kazunori Okada, Masahiro Nakabachi, Yasuhiro Hayashi","doi":"10.1253/circrep.CR-25-0047","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0047","url":null,"abstract":"Background: Flow-mediated dilation (FMD) is the established parameter of endothelial function but requires skill and specialized equipment. This study aimed to investigate whether changes in carotid artery ultrasound parameters during passive leg raising (PLR) could reflect FMD values.Methods and results: Thirty-six adult males underwent standard FMD measurement. After 15 min of rest, a carotid artery ultrasound was performed to measure the maximal common carotid artery (CCA) diameter and stiffness parameter β. The PLR maneuver was then performed, and the change in these parameters (∆CCAPLR and ∆βPLR) was calculated. There were 6 participants with decreased FMD value (<4%). While the maximal CCA diameter remained unchanged during PLR (P=0.54), the stiffness parameter β significantly decreased during PLR compared with baseline (P=0.014). Among several carotid artery ultrasound parameters, ∆βPLR correlated most strongly with FMD (r=-0.70; P<0.001). Receiver operating characteristic analysis showed that ∆βPLR predicted decreased FMD with an area under the curve of 0.89, sensitivity of 87%, and specificity of 83% at an optimal cut-off of 4.7%.Conclusions: Change in carotid arterial stiffness parameter β during the PLR maneuver correlated with FMD, suggesting it may serve as an alternative indicator for endothelial function.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"988-994"},"PeriodicalIF":1.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventricular Arrhythmia Risk Stratification Among Patients With Cardiac Resynchronization Therapy Devices. 心脏再同步化治疗装置患者室性心律失常风险分层。

IF 1.1

Circulation reports Pub Date : 2025-08-26 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0115

Nobuhiko Ueda, Kohei Ishibashi, Takashi Noda, Satoshi Oka, Yuichiro Miyazaki, Akinori Wakamiya, Kenzaburo Nakajima, Tsukasa Kamakura, Mitsuru Wada, Yuko Inoue, Koji Miyamoto, Satoshi Nagase, Takeshi Aiba, Hideaki Kanzaki, Chisato Izumi, Teruo Noguchi, Kengo Kusano

{"title":"Ventricular Arrhythmia Risk Stratification Among Patients With Cardiac Resynchronization Therapy Devices.","authors":"Nobuhiko Ueda, Kohei Ishibashi, Takashi Noda, Satoshi Oka, Yuichiro Miyazaki, Akinori Wakamiya, Kenzaburo Nakajima, Tsukasa Kamakura, Mitsuru Wada, Yuko Inoue, Koji Miyamoto, Satoshi Nagase, Takeshi Aiba, Hideaki Kanzaki, Chisato Izumi, Teruo Noguchi, Kengo Kusano","doi":"10.1253/circrep.CR-25-0115","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0115","url":null,"abstract":"Background: Patients with left ventricular (LV) dysfunction have a higher risk of ventricular arrhythmia (VA) compared with those without, and are candidates for implantable cardioverter defibrillator (ICD). Response to cardiac resynchronization therapy (CRT) decreases the risk of VA; however, selection of a suitable CRT device remains challenging.Methods and results: In 678 patients with a CRT/ICD device and LV dysfunction, we investigated 325 CRT and 142 ICD patients for primary prevention. VA was defined as lasting ≥30 s or being treated with an ICD. CRT non-responders were defined as patients without reduced LV end-systolic volume ≥15%. During the follow-up period, 98 (21%) patients had a VA event (CRT 71 [22%] vs. ICD 27 [19%]; P=0.49). The VA risk score was calculated by summing values for non-left bundle branch block, left atrial diameter >45 mm, persistent atrial fibrillation, male sex, LV ejection fraction <25%, and ischemic cardiomyopathy. Our results showed that the VA risk score stratified the risk of VA among CRT patients (P<0.01), but was not significant for ICD patients (P=0.24). Patients with a VA risk score ≥4 (divided by receiver operating characteristic analysis) had a higher risk of VA among CRT patients (log rank P<0.01); however, it was not significant for ICD patients (log rank P=0.71).Conclusions: The VA risk score could be a useful indicator for VA among CRT candidates.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"861-868"},"PeriodicalIF":1.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Utility of Left Ventricular Ejection Fraction in Patients Undergoing Transcatheter Aortic Valve Implantation　- A Systematic Review and Meta-Analysis. 经导管主动脉瓣植入术患者左室射血分数对预后的影响——系统回顾和荟萃分析。

IF 1.1

Circulation reports Pub Date : 2025-08-26 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0126

Yosuke Nabeshima, Tetsuji Kitano, Yoshiko Sakamoto, Masaaki Takeuchi, Koichi Node

{"title":"Prognostic Utility of Left Ventricular Ejection Fraction in Patients Undergoing Transcatheter Aortic Valve Implantation　- A Systematic Review and Meta-Analysis.","authors":"Yosuke Nabeshima, Tetsuji Kitano, Yoshiko Sakamoto, Masaaki Takeuchi, Koichi Node","doi":"10.1253/circrep.CR-25-0126","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0126","url":null,"abstract":"Background: Left ventricular ejection fraction (LVEF) is widely used to assess systolic function and to predict cardiovascular outcomes, but its prognostic role in patients undergoing transcatheter aortic valve implantation (TAVI) remains uncertain.Methods and results: We performed a systematic review and meta-analysis of studies published from 2001 to 2024 that evaluated the association between preprocedural LVEF and post-TAVI outcomes. Eligible studies were identified via PubMed and Scopus, and included those reporting hazard ratios for preprocedural LVEF. A total of 92 studies comprising 98 patient cohorts and 75,085 individuals were included. Random-effects models were used for univariable and multivariable analyses. Subgroup and meta-regression analyses assessed effect modifiers, including ethnicity, LVEF classification, endpoints, and study design. Each 1% decrease in LVEF was associated with an increased risk of adverse events (hazard ratio 1.02, 95% confidence interval: 1.01-1.03), and this association remained significant after adjusting for confounders. Subgroup analyses confirmed the robustness of this association in various settings. In the multivariable meta-regression, studies with lower mean LVEF demonstrated a stronger association between reduced LVEF and adverse outcomes, but this association was attenuated or nonsignificant in cohorts with preserved systolic function. This suggests that the prognostic value of LVEF may depend on the baseline level of ventricular function and is subject to effect modification.Conclusions: Reduced preprocedural LVEF is independently associated with worse prognosis after TAVI. These results highlight the continued importance of LVEF in risk stratification and clinical decision-making in TAVI candidates.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"980-987"},"PeriodicalIF":1.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrocardiographic Prediction of Acute Pulmonary Embolism at Intermediate-High- and High-Risk. 中高、高危人群急性肺栓塞的心电图预测。

IF 1.1

Circulation reports Pub Date : 2025-08-26 eCollection Date: 2025-10-10 DOI: 10.1253/circrep.CR-25-0012

Hiroki Nakayama, Junya Komatsu, Yuki Nishimura, Hiroki Sugane, Hayato Hosoda, Ryu-Ichiro Imai, Yoko Nakaoka, Koji Nishida, Shinji Mito, Shu-Ichi Seki, Toru Kubo, Naohito Yamasaki, Hiroaki Kitaoka, Sho-Ichi Kubokawa, Kazuya Kawai, Naohisa Hamashige, Yoshinori Doi

{"title":"Electrocardiographic Prediction of Acute Pulmonary Embolism at Intermediate-High- and High-Risk.","authors":"Hiroki Nakayama, Junya Komatsu, Yuki Nishimura, Hiroki Sugane, Hayato Hosoda, Ryu-Ichiro Imai, Yoko Nakaoka, Koji Nishida, Shinji Mito, Shu-Ichi Seki, Toru Kubo, Naohito Yamasaki, Hiroaki Kitaoka, Sho-Ichi Kubokawa, Kazuya Kawai, Naohisa Hamashige, Yoshinori Doi","doi":"10.1253/circrep.CR-25-0012","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0012","url":null,"abstract":"Background: Acute pulmonary embolism (PE) is a life-threatening condition, and the diagnosis of acute PE remains difficult.Methods and results: In all, 133 consecutive patients with acute PE (mean [±SD] age 72±17 years, 53 men) were classified into 4 groups based on the severity of PE: high risk (n=12); intermediate-high risk (n=86); intermediate-low risk (n=1); and low risk (n=34). After excluding the 1 patient with intermediate-low-risk PE, clinical characteristics, the high-, intermediate-high-, and low-risk groups were compared: T wave inversion (V1-V3) was seen in 83%, 56%, and 18% of patients, respectively (P<0.001); an S1Q3T3 pattern was seen in 75%, 35%, and 0% of patients, respectively (P<0.001); echocardiographic evidence of right ventricular (RV) dysfunction was seen in 100%, 86%, and 0% of patients, respectively (P<0.001); the median (interquartile range) door-to-treatment time (n=11, 44, and 15, respectively) was 65 (43-116), 116 (78-213), and 183 (104-222) min, respectively (P<0.01); and the in-hospital death rate was 50%, 1%, and 0%, respectively (P<0.001). Multivariate analysis revealed that T wave inversion and an S1Q3T3 pattern were independently associated with intermediate-high- and high-risk acute PE, with adjusted odds ratios (95% confidence intervals) of 5.85 (2.14-15.96; P=0.0006) and 4.31 (1.65-11.27; P=0.0029), respectively.Conclusions: Electrocardiographic evidence of right precordial T wave inversion and an S1Q3T3 pattern, followed by echocardiographic confirmation of RV dysfunction, may help with the early diagnosis of intermediate-high- and high-risk acute PE and thus contribute to improved door-to-treatment times and the prevention of adverse outcomes.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 10","pages":"973-979"},"PeriodicalIF":1.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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