Circulation reports最新文献_第4页

Sex Differences in Bleeding Risk Associated With Antithrombotic Therapy Following Percutaneous Coronary Intervention. 经皮冠状动脉介入治疗后抗血栓治疗相关出血风险的性别差异。

Circulation reports Pub Date : 2024-03-05 eCollection Date: 2024-04-10 DOI: 10.1253/circrep.CR-24-0015

Yoshimi Numao, Saeko Takahashi, Yoko M Nakao, Emi Tajima, Satsuki Noma, Ayaka Endo, Junko Honye, Yayoi Tsukada

{"title":"Sex Differences in Bleeding Risk Associated With Antithrombotic Therapy Following Percutaneous Coronary Intervention.","authors":"Yoshimi Numao, Saeko Takahashi, Yoko M Nakao, Emi Tajima, Satsuki Noma, Ayaka Endo, Junko Honye, Yayoi Tsukada","doi":"10.1253/circrep.CR-24-0015","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0015","url":null,"abstract":"Background: Antithrombotic therapy is crucial for secondary prevention of cardiovascular disease (CVD), but women with CVD may face increased bleeding complications post-percutaneous coronary intervention (PCI) under antithrombotic therapy. However, women are often underrepresented in clinical trials in this field, so evidence for sex-specific recommendations is lacking. Methods and Results: A search on PubMed was conducted for English-language articles addressing bleeding complications and antithrombotic therapy in women. Despite women potentially showing higher baseline platelet responsiveness than men, the clinical implications remain unclear. Concerning antiplatelet therapy post-PCI, although women have an elevated bleeding risk in the acute phase, no sex differences were observed in the chronic phase. However, women require specific considerations for factors such as age, renal function, and weight when determining the dose and duration of antiplatelet therapy. Regarding anticoagulation post-PCI, direct oral anticoagulants may pose a lower bleeding risk in women compared with warfarin. Concerning triple antithrombotic therapy (TAT) post-PCI for patients with atrial fibrillation, there is a lack of evidence on whether sex differences should be considered in the duration and regimen of TAT. Conclusions: Recent findings on sex differences in post-PCI bleeding complications did not provide enough evidence to recommend specific therapies for women. Further studies are needed to address this gap and recommend optimal antithrombotic therapy post-PCI for women.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11004037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lead-Specific Performance for Atrial Fibrillation Detection in Convolutional Neural Network Models Using Sinus Rhythm Electrocardiography. 使用窦性心律心电图在卷积神经网络模型中检测心房颤动的导联特异性性能。

Circulation reports Pub Date : 2024-02-27 eCollection Date: 2024-03-08 DOI: 10.1253/circrep.CR-23-0068

Shinya Suzuki, Jun Motogi, Takuya Umemoto, Naomi Hirota, Hiroshi Nakai, Wataru Matsuzawa, Tsuneo Takayanagi, Akira Hyodo, Keiichi Satoh, Takuto Arita, Naoharu Yagi, Mikio Kishi, Hiroaki Semba, Hiroto Kano, Shunsuke Matsuno, Yuko Kato, Takayuki Otsuka, Takayuki Hori, Minoru Matsuhama, Mitsuru Iida, Tokuhisa Uejima, Yuji Oikawa, Junji Yajima, Takeshi Yamashita

{"title":"Lead-Specific Performance for Atrial Fibrillation Detection in Convolutional Neural Network Models Using Sinus Rhythm Electrocardiography.","authors":"Shinya Suzuki, Jun Motogi, Takuya Umemoto, Naomi Hirota, Hiroshi Nakai, Wataru Matsuzawa, Tsuneo Takayanagi, Akira Hyodo, Keiichi Satoh, Takuto Arita, Naoharu Yagi, Mikio Kishi, Hiroaki Semba, Hiroto Kano, Shunsuke Matsuno, Yuko Kato, Takayuki Otsuka, Takayuki Hori, Minoru Matsuhama, Mitsuru Iida, Tokuhisa Uejima, Yuji Oikawa, Junji Yajima, Takeshi Yamashita","doi":"10.1253/circrep.CR-23-0068","DOIUrl":"10.1253/circrep.CR-23-0068","url":null,"abstract":"Background: We developed a convolutional neural network (CNN) model to detect atrial fibrillation (AF) using the sinus rhythm ECG (SR-ECG). However, the diagnostic performance of the CNN model based on different ECG leads remains unclear. Methods and Results: In this retrospective analysis of a single-center, prospective cohort study, we identified 616 AF cases and 3,412 SR cases for the modeling dataset among new patients (n=19,170). The modeling dataset included SR-ECGs obtained within 31 days from AF-ECGs in AF cases and SR cases with follow-up ≥1,095 days. We evaluated the CNN model's performance for AF detection using 8-lead (I, II, and V1-6), single-lead, and double-lead ECGs through 5-fold cross-validation. The CNN model achieved an area under the curve (AUC) of 0.872 (95% confidence interval (CI): 0.856-0.888) and an odds ratio of 15.24 (95% CI: 12.42-18.72) for AF detection using the eight-lead ECG. Among the single-lead and double-lead ECGs, the double-lead ECG using leads I and V1 yielded an AUC of 0.871 (95% CI: 0.856-0.886) with an odds ratio of 14.34 (95% CI: 11.64-17.67). Conclusions: We assessed the performance of a CNN model for detecting AF using eight-lead, single-lead, and double-lead SR-ECGs. The model's performance with a double-lead (I, V1) ECG was comparable to that of the 8-lead ECG, suggesting its potential as an alternative for AF screening using SR-ECG.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10920024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mortality After Alcohol Septal Ablation vs. Septal Myectomy in Patients With Obstructive Hypertrophic Cardiomyopathy. 阻塞性肥厚型心肌病患者进行酒精室间隔消融术与室间隔黏膜切除术后的死亡率。

Circulation reports Pub Date : 2024-02-21 eCollection Date: 2024-03-08 DOI: 10.1253/circrep.CR-23-0101

Risako Yasuda, Itsuki Osawa, Tadahiro Goto, Kohei Hasegawa, Michael A Fifer, Albree Tower-Rader, Muredach P Reilly, Mathew S Maurer, Yanling Zhao, Hiroo Takayama, Yuichi J Shimada

{"title":"Mortality After Alcohol Septal Ablation vs. Septal Myectomy in Patients With Obstructive Hypertrophic Cardiomyopathy.","authors":"Risako Yasuda, Itsuki Osawa, Tadahiro Goto, Kohei Hasegawa, Michael A Fifer, Albree Tower-Rader, Muredach P Reilly, Mathew S Maurer, Yanling Zhao, Hiroo Takayama, Yuichi J Shimada","doi":"10.1253/circrep.CR-23-0101","DOIUrl":"10.1253/circrep.CR-23-0101","url":null,"abstract":"Background: Alcohol septal ablation (ASA) and septal myectomy (SM) are 2 options for septal reduction therapy (SRT) to treat medication-resistant symptomatic obstructive hypertrophic cardiomyopathy (HCM). Because differences in mortality rates after these different SRT methods have not been extensively investigated in real-world settings, in this study compared the 1-year mortality rates after ASA and SM using population-based database. Methods and Results: Utilizing New York Statewide Planning and Research Cooperative System (SPARCS) data from 2005 to 2016, we performed a comparative effectiveness study of ASA vs. SM in patients with HCM. The outcome was all-cause death up to 360 days after SRT. We constructed a multivariable logistic regression model and performed sensitivity analysis with propensity score (PS)-matching and inverse probability of treatment weighting (IPTW) methods. We identified 755 patients with HCM who underwent SRT: 348 with ASA and 407 with SM. The multivariable analysis showed that all-cause deaths were significantly fewer in the ASA group at 360 days after SRT (adjusted odds ratio=0.34; 95% confidence interval [CI] 0.13-0.84; P=0.02). The PS-matching and IPTW methods also supported a lower mortality rate in the ASA group at 360 days post-SRT. Conclusions: In this population-based study of patients with HCM who underwent SRT in a real-world setting, the 1-year all-cause mortality rate was significantly lower in patients who underwent ASA compared with SM.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10920015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Effect of Ivabradine in Mitochondrial Cardiomyopathy. 伊伐布雷定对线粒体心肌病的急性作用

Circulation reports Pub Date : 2024-02-21 eCollection Date: 2024-03-08 DOI: 10.1253/circrep.CR-23-0097

Kenta Uno, Naoki Fujimoto, Masaki Ishiyama, Ryuji Okamoto, Kaoru Dohi

引用次数: 0

Detrimental Impact of Comorbid Mental Disorders in Chronic Thromboembolic Pulmonary Hypertension　- A Retrospective Observational Study. 慢性血栓栓塞性肺动脉高压合并精神障碍的不利影响--一项回顾性观察研究。

Circulation reports Pub Date : 2024-02-20 eCollection Date: 2024-03-08 DOI: 10.1253/circrep.CR-23-0074

Takeshi Adachi, Shiro Adachi, Yoshihisa Nakano, Kenichiro Yasuda, Itsumure Nishiyama, Miku Hirose, Toyoaki Murohara

{"title":"Detrimental Impact of Comorbid Mental Disorders in Chronic Thromboembolic Pulmonary Hypertension　- A Retrospective Observational Study.","authors":"Takeshi Adachi, Shiro Adachi, Yoshihisa Nakano, Kenichiro Yasuda, Itsumure Nishiyama, Miku Hirose, Toyoaki Murohara","doi":"10.1253/circrep.CR-23-0074","DOIUrl":"10.1253/circrep.CR-23-0074","url":null,"abstract":"Background: The relationship between the prognosis of patients with both chronic thromboembolic pulmonary hypertension (CTEPH) and a mental disorder (MD) remains unclear. Methods and Results: The study group comprised 157 patients with CTEPH who underwent right heart catheterization and were subdivided into 2 groups according to the presence of MDs: MD and non-MD. The patients with MDs were defined as those who had visited a psychiatrist and were under psychotropic drug treatment. The primary outcome was a composite of all-cause death and worsening of PH. The median follow-up period was 1,164 days. The incidence of the primary composite outcome was higher in the MD group than in the non-MD group (24.0% vs. 6.8%), whereas the all-cause mortality rate was comparable between groups (12.0% vs. 6.1%). The mean pulmonary arterial pressure, cardiac index, and pulmonary vascular resistance at baseline were all similar between groups. The Cox proportional hazards model indicated that MD was an independent risk factor for the primary composite outcome (hazard ratio, 2.990; 95% confidence interval, 1.034-8.642). Conclusions: In the present study, concomitant CTEPH and MD was significantly associated with a poor prognosis and such patients should be carefully followed.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10920025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescribing Patterns and Outcomes of Edoxaban in Atrial Fibrillation Patients From Asia　- One-Year Data From the Global ETNA-AF Program. 亚洲心房颤动患者的埃多沙班处方模式和疗效--来自全球 ETNA-AF 计划的一年期数据。

Circulation reports Pub Date : 2024-02-20 eCollection Date: 2024-03-08 DOI: 10.1253/circrep.CR-23-0098

Jong-Il Choi, Songsak Kiatchoosakun, Panyapat Jiampo, Hung Fat Tse, Yannie Oi Yan Soo, Chun-Chieh Wang, Chang Hoon Lee, Ladislav Pecen, Martin Unverdorben, Raffaele De Caterina, Paulus Kirchhof

{"title":"Prescribing Patterns and Outcomes of Edoxaban in Atrial Fibrillation Patients From Asia　- One-Year Data From the Global ETNA-AF Program.","authors":"Jong-Il Choi, Songsak Kiatchoosakun, Panyapat Jiampo, Hung Fat Tse, Yannie Oi Yan Soo, Chun-Chieh Wang, Chang Hoon Lee, Ladislav Pecen, Martin Unverdorben, Raffaele De Caterina, Paulus Kirchhof","doi":"10.1253/circrep.CR-23-0098","DOIUrl":"10.1253/circrep.CR-23-0098","url":null,"abstract":"Background: This study reports prescribing patterns and the 1-year effectiveness and safety of edoxaban in an Asian cohort of Edoxaban Treatment in routiNe clinical prActice (ETNA)-Atrial Fibrillation (AF) patients. Methods and Results: The Global ETNA-AF program integrates prospective, observational, noninterventional regional studies, collecting data on characteristics and clinical outcomes of patients with AF receiving edoxaban for stroke prevention. Baseline characteristics, medical history, and 1-year clinical event rates were assessed in patients from South Korea, Taiwan, Hong Kong, and Thailand. Clinically relevant events assessed at 12 months included all-cause death, cardiovascular death, ischemic and hemorrhagic stroke, systemic embolic events (SEEs), bleeding, and net clinical outcome (NCO). Overall, 3,359 patients treated with edoxaban 60 or 30 mg once daily completed 1-year follow-up; 70.9% of patients received recommended dosing according to local labels. Baseline mean±standard deviation age was 71.7±9.6 years, CHA2DS2-VASc score was 3.1±1.5, and modified HAS-BLED score was 2.3±1.1. Mean age and sex were similar across countries/regions. The 1-year event rate for all-cause death was 1.8%; major bleeding, 1.3%; ischemic stroke, 1.1%; cardiovascular mortality, 0.7%; hemorrhagic stroke, 0.3%; SEEs, 0%; and NCO, 4.1%; with differences observed between countries/regions and dosing groups. Conclusions: Most Asian patients with AF were prescribed recommended edoxaban dosing in routine care settings. At 1-year follow-up, this analysis supports the effectiveness and safety of edoxaban in these patients.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10920013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air Embolism Increases Myocardial Brightness. 空气栓塞增加心肌亮度

Circulation reports Pub Date : 2024-01-31 eCollection Date: 2024-02-09 DOI: 10.1253/circrep.CR-23-0090

Eriko Matsuda, Kyoko Kurebayashi, Ayako Murota, Kozue Fujimura, Satoru Takita, Kazuya Murata, Kozaburo Seki

引用次数: 0

Sex Differences in 5-Year Outcomes After Deferral of Revascularization Following Physiological Coronary Assessment. 生理冠状动脉评估后推迟血管重建术 5 年疗效的性别差异。

Circulation reports Pub Date : 2024-01-31 eCollection Date: 2024-02-09 DOI: 10.1253/circrep.CR-23-0100

Takayuki Ishihara, Shoichi Kuramitsu, Hitoshi Matsuo, Kazunori Horie, Hiroaki Takashima, Hidenobu Terai, Yuetsu Kikuta, Tatsuya Saigusa, Tomohiro Sakamoto, Nobuhiro Suematsu, Yasutsugu Shiono, Taku Asano, Kenichi Tsujita, Katsuhiko Masamura, Tatsuki Doijiri, Fumitoshi Toyota, Manabu Ogita, Tairo Kurita, Akiko Matsuo, Ken Harada, Kenji Yaginuma, Shinjo Sonoda, Hiroyoshi Yokoi, Nobuhiro Tanaka, Toshiaki Mano

{"title":"Sex Differences in 5-Year Outcomes After Deferral of Revascularization Following Physiological Coronary Assessment.","authors":"Takayuki Ishihara, Shoichi Kuramitsu, Hitoshi Matsuo, Kazunori Horie, Hiroaki Takashima, Hidenobu Terai, Yuetsu Kikuta, Tatsuya Saigusa, Tomohiro Sakamoto, Nobuhiro Suematsu, Yasutsugu Shiono, Taku Asano, Kenichi Tsujita, Katsuhiko Masamura, Tatsuki Doijiri, Fumitoshi Toyota, Manabu Ogita, Tairo Kurita, Akiko Matsuo, Ken Harada, Kenji Yaginuma, Shinjo Sonoda, Hiroyoshi Yokoi, Nobuhiro Tanaka, Toshiaki Mano","doi":"10.1253/circrep.CR-23-0100","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0100","url":null,"abstract":"Background: The relationship between sex differences and long-term outcomes after fractional flow reserve (FFR)- and instantaneous wave-free ratio (iFR)-guided deferral of revascularization has yet to be elucidated. Methods and Results: From the J-CONFIRM registry (long-term outcomes of Japanese patients with deferral of coronary intervention based on FFR in a multicenter registry), this study included 432 lesions from 385 patients (men, 323 lesions in 286 patients; women, 109 lesions in 99 patients) with paired data of FFR and iFR. The primary endpoint was the cumulative 5-year incidence of target vessel failure (TVF), including cardiac death, target vessel-related myocardial infarction, and clinically driven target vessel revascularization. The median FFR value was lower in men than in women (0.85 [0.81, 0.88] vs. 0.87 [0.83, 0.91], P=0.002), but the iFR value was comparable between men and women (0.94 [0.90, 0.98] vs. 0.93 [0.89, 0.98], P=0.26). The frequency of discordance between FFR and iFR was comparable between men and women (19.5% vs. 23.9%, P=0.34), although with different discordance patterns (P=0.036). The cumulative incidence of 5-year TVF did not differ between men and women after adjustment for baseline characteristics (13.9% vs. 6.9%, adjusted hazard ratio 1.82 [95% confidence interval: 0.44-7.56]; P=0.41). Conclusions: Despite sex differences in the results for physiological indexes, the 5-year TVF in deferred lesions did not differ between men and women after adjustment for baseline characteristics.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Content 内容

Circulation reports Pub Date : 2024-01-10 DOI: 10.1253/circrep.cr-6-content1

引用次数: 0

Evaluation of Changes in Coronary Ischemia After Lipid-Lowering Therapy Using Computed Tomography Angiography 使用计算机断层扫描血管造影术评估降脂疗法后冠状动脉缺血的变化

Circulation reports Pub Date : 2023-12-23 DOI: 10.1253/circrep.cr-23-0091

Takahiro Nishihara, M. Nakashima, K. Ichikawa, Toru Miyoshi

引用次数: 0