Circulation reports最新文献

{"title":"Landiolol-Induced Severe Vasospastic Angina Leading to Total Coronary Occlusion During Coronary Computed Tomography Angiography.","authors":"Takuya Shimizu, Daisuke Hachinohe, Yoshifumi Kashima, Tsutomu Fujita, Shoichi Kuramitsu","doi":"10.1253/circrep.CR-25-0016","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0016","url":null,"abstract":"","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 5","pages":"391-392"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of Predictive Models for Cardiovascular Mortality by Machine Learning Approaches in Patients Who Underwent Transcatheter Aortic Valve Implantation.","authors":"Shunsaku Otomo, Itaru Hosaka, Marenao Tanaka, Naoto Murakami, Nobuaki Kokubu, Atsuko Muranaka, Ryo Nishikawa, Naoki Hachiro, Ryota Kawamura, Jun Nakata, Nobutaka Nagano, Yukinori Akiyama, Tatsuya Sato, Yutaka Iba, Toshiyuki Yano, Nobuyoshi Kawaharada, Masato Furuhashi","doi":"10.1253/circrep.CR-24-0182","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0182","url":null,"abstract":"<p><strong>Background: </strong>Prognostic models for cardiovascular death, but not all-cause death, after transcatheter aortic valve implantation (TAVI) have not been established yet.</p><p><strong>Methods and results: </strong>In 252 patients with aortic stenosis (AS) who underwent TAVI (men/women 83/169; mean age 85 years), we explored predictive models by machine learning for cardiovascular death using 62 candidates. During the follow-up period (mean 1,135 days), 13 (5.2%) patients died of cardiovascular disease. The least absolute shrinkage and selection operator (LASSO) feature selection identified 8 features as important candidates, including old myocardial infarction, triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio, Society of Thoracic Surgeons predicted risk of mortality score (STS-PROM), pulse rate, left atrium volume index, stroke volume index, estimated glomerular filtration rate, and albumin. Cox regression analyses with adjustment for age and sex showed that old myocardial infarction, high levels of TG/HDL-C, STS-PROM, and pulse rate, as well as low levels of glomerular filtration rate and albumin, were independent risk factors for cardiovascular death. Models of logistic regression (LR) and random survival forest (RSF) using the LASSO-selected features, except for STS-PROM, significantly improved predictive abilities for cardiovascular death compared with LR analysis using STS-PROM alone.</p><p><strong>Conclusions: </strong>Machine learning models of prediction for cardiovascular death of LR and RSF using the LASSO-selected features are superior to a LR model using STS-PROM alone in patients with severe AS who underwent TAVI.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 4","pages":"293-302"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health and Cardiovascular Disease　- A Scoping Review of Assessment Methods, Risk Factors, and Prognosis.","authors":"Masato Ogawa, Masatsugu Okamura, Takuma Yagi, Kenichiro Maekawa, Kota Amakasu, Tatsuro Inoue, Seimi Satomi-Kobayashi, Megumi Katayama, Yumi Muraki, Masaya Akashi","doi":"10.1253/circrep.CR-24-0187","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0187","url":null,"abstract":"<p><p>Oral frailty, which encompasses decline in oral health and function with aging, has broader health implications. However, its specific role in individuals with cardiovascular disease (CVD) remains poorly understood. In this scoping review we investigated the prevalence, assessment tools, and potential intervention strategies for oral frailty in patients with CVD. We used the Population, Concept, and Context framework as follows: Population: Patients with CVD; Concept: Existing literature on oral frailty in the context of CVD; Context: Not restricted. Extracted data were synthesized qualitatively. From an initial pool of 3,199 studies, 70 were included in the final analysis, with a cumulative sample size of 891,450 individuals. Among the assessment tools for oral frailty, the number of teeth was the most commonly used measure in 39 studies, followed by the Decayed, Missing, Filled Index. Of the studies, 5 studies indicated that coronary artery disease and diabetes are risk factors for oral frailty, and 8 identified poor oral health as a predictor of cardiac events. However, no study clearly defined oral frailty in the context of CVD. Additionally, only 2 studies explored the relationship between oral health and physical frailty. This results of this review underscore the lack of a standardized definition for oral frailty in CVD. Although associations between oral health and prognosis were observed, further research is needed to clarify the definitions and explore causal relationships.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 4","pages":"223-230"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Guideline-Directed Medical Therapy for Acute Heart Failure With Reduced Ejection Fraction in Frail Elderly Patients With Malnutrition.","authors":"Yoshimitsu Takaoka, Mahbubur Rahman, Taku Asano, Yasufumi Kijima, Jiro Aoki","doi":"10.1253/circrep.CR-25-0003","DOIUrl":"https://doi.org/10.1253/circrep.CR-25-0003","url":null,"abstract":"<p><strong>Background: </strong>The appropriateness of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) in malnourished elderly patients is unclear. This study aims to assess the effects of GDMT on acute heart failure (AHF) with reduced ejection fraction in this specific population using the Geriatric Nutritional Risk Index (GNRI).</p><p><strong>Methods and results: </strong>We retrospectively collected data of patients aged >75 years who were admitted to St. Luke's International Hospital for AHF with reduced ejection fraction from 2011 to 2022. Malnutrition was defined as a GNRI score <92. GDMT was defined as the prescription of 3 or more of the medications for HFrEF at the time of discharge. Among 467 patients, 345 (73.9%) had malnutrition. In the low GNRI group, GDMT was associated with a lower all-cause mortality at 1 year (HR 0.46; 95% CI 0.24-0.89; P=0.021), but not in heart failure (HF) readmission (HR 0.83; 95% CI 0.55-1.25; P=0.364) at 1 year after discharge. In the high GNRI group, GDMT was not significantly associated with these outcomes (all-cause mortality: HR 0.59; 95% CI 0.12-3.06; P=0.534; HF readmission: HR 0.55; 95% CI 0.29-1.05; P=0.069).</p><p><strong>Conclusions: </strong>Implementation of GDMT in AHF with reduced ejection fraction may enhance prognosis, even among elderly patients with malnutrition.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 4","pages":"267-274"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine-Learning-Based Prediction of Exercise Intolerance of Patients With Heart Failure Using Pragmatic Submaximal Exercise Parameters.","authors":"Taishi Kato, Hidetsugu Asanoi, Tomohito Ohtani, Yasushi Sakata","doi":"10.1253/circrep.CR-24-0135","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0135","url":null,"abstract":"<p><strong>Background: </strong>Low peak oxygen uptake (V̇O₂), especially ≤14 mL/min/kg, is a strong indicator of poor prognosis in patients with heart failure (HF). However, measuring this parameter is sometimes difficult if the maximal workload is not reached. This study developed a predictive classification model for low peak V̇O₂ in HF patients using machine learning (ML).</p><p><strong>Methods and results: </strong>We retrospectively analyzed the data for 343 patients with chronic HF and left ventricular ejection fraction <50% who underwent a symptom-limited cardiopulmonary exercise test and extracted 33 variables from their laboratory, echocardiographic, and exercise data up to the submaximal workload. The dataset was randomly divided into training and testing datasets in a 4 : 1 ratio. ML methods, including an exhaustive search for predictor selection, were used, and a support vector machine algorithm was applied for model optimization. We identified 5 important predictors: age, B-type natriuretic peptide, left ventricular end-diastolic diameter, V̇O₂ at rest, and V̇O₂ at respiratory exchange ratio of 1.00. Using these 5 predictors, an optimized predictive model was validated on the testing dataset, yielding an accuracy of 85%, F1 score of 0.81, and area under the receiver operating curve of 0.94 (95% confidence interval: 0.89-1.00).</p><p><strong>Conclusions: </strong>Using readily available parameters, ML methods can enable accurate prediction of low peak V̇O₂ in patients with HF.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 4","pages":"257-266"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Determinants of Depression and Anxiety in Patients With Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension.","authors":"Yuzuki Mitsuyama, Ayumi Goda, Kaori Takeuchi, Hanako Kikuchi, Takumi Inami, Kyoko Soejima, Takashi Kohno","doi":"10.1253/circrep.CR-24-0113","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0113","url":null,"abstract":"<p><strong>Background: </strong>Depression and anxiety screening has not been adequately examined in patients with pulmonary hypertension (PH). We assessed depression and anxiety prevalence and their determinants in pulmonary arterial hypertension (PAH) and chronic thromboembolic PH (CTEPH).</p><p><strong>Methods and results: </strong>This cross-sectional study included 234 patients with PH (age 57 [42-68] years; 75% female; PAH/CTEPH/other: 103/126/5). Overall, 24% and 26% of patients had depression (Hospital Anxiety and Depression Scale [HADS]-depression score ≥8) and anxiety (HADS-anxiety score ≥8) respectively. Depression and anxiety prevalence was 18% and 19% in PAH and 27% and 30% in CTEPH, respectively. Among patients with PAH, depression was significantly associated with higher mean right atrial pressure (odds ratio [OR] 1.17; 95% confidence interval [CI] 1.03-1.32; P=0.013), higher pulmonary vascular resistance (OR 1.08; 95% CI 1.01-1.16; P=0.034), lower arterial oxygen saturation (OR 0.89; 95% CI 0.80-0.98; P=0.021), pulmonary artery oxygen saturation (OR 0.93; 95% CI 0.87-0.99; P=0.020), and reduced use of phosphodiesterase-5 inhibitor (OR 0.30; 95% CI 0.11-0.86; P=0.025). In CTEPH, depression was significantly associated with the presence of a psychiatric disorder (OR 4.71; 95% CI 1.24-17.90; P=0.023). Anxiety was not significantly associated with any of the aforementioned parameters in PAH and CTEPH.</p><p><strong>Conclusions: </strong>Predicting depression and anxiety based on disease severity and hemodynamics was challenging, making individual assessments and approaches crucial.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 4","pages":"285-292"},"PeriodicalIF":0.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caseous Calcification of the Mitral Annulus With Multiple Embolic Strokes.","authors":"Chie Ryou, Makoto Kanazawa, Jun-Ichiro Nishi, Hiroshi Yasunaga, Hideki Tashiro","doi":"10.1253/circrep.CR-24-0188","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0188","url":null,"abstract":"","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 4","pages":"313-314"},"PeriodicalIF":0.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Effects of Coronavirus Disease 2019 (COVID-19) on First Medical Contact to Reperfusion Time in Urban ST-Segment Elevation Myocardial Infarction Patients and Advantage of Prehospital Electrocardiography.","authors":"Kunio Yufu, Tsuyoshi Shimomura, Kyoko Kawano, Hiroki Sato, Keisuke Yonezu, Ichitaro Abe, Shotaro Saito, Hidekazu Kondo, Akira Fukui, Hidefumi Akioka, Tetsuji Shinohara, Yasushi Teshima, Teruo Sakamoto, Ryuzo Abe, Naohiko Takahashi","doi":"10.1253/circrep.CR-24-0174","DOIUrl":"https://doi.org/10.1253/circrep.CR-24-0174","url":null,"abstract":"<p><strong>Background: </strong>We have previously reported the advantages of a prehospital 12-lead electrocardiography system (P-ECG) for ST-segment elevation myocardial infarction (STEMI) patients (<i>Circ Rep</i> 2019; <i>Circ J</i> 2022, 2023). Since 2020 with Coronavirus disease 2019 (COVID-19), the patient transport situation has changed dramatically. We investigated how patient transport was changed by COVID-19. The effect of prehospital electrocardiography (ECG) was also evaluated.</p><p><strong>Methods and results: </strong>Recent urban STEMI patients who received primary percutaneous coronary intervention (PCI) using P-ECG were assigned to a P-ECG group (n=87; age 69±14 years), and comparable urban STEMI patients not using P-ECG were assigned to a Conventional group (n=87; age 71±13 years). The pre-COVID-19 period is defined as the period before the pandemic began, and the COVID-19 period is the time thereafter. In the Conventional group, first medical contact (FMC)-to-reperfusion time (110±45 vs. 90±31 min; P=0.025) and door-to-reperfusion time (89±41 vs. 70±29 min; P=0.015) in the COVID-19 period were significantly longer than in the pre-COVID-19 period. However, in the P-ECG group, there was no difference in FMC-to-reperfusion time and door-to-reperfusion time between the 2 periods. In the Conventional group, Killip class (2.0±1.3 vs. 1.1±0.5; P=0.001) and left ventricular ejection fraction (49±12 vs. 57±9.0%; P=0.002) were significantly poorer in the COVID-19 period than in the pre-COVID-19 period. However, in the P-ECG group, there was no significant difference between the 2 periods.</p><p><strong>Conclusions: </strong>During the COVID-19 pandemic, P-ECG might have provided advantages for patient transport and outcomes in urban STEMI patients.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 4","pages":"239-246"},"PeriodicalIF":0.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Is Social Reintegration Support for Patients With Left Ventricular Assist Device Necessary?","authors":"Tomoko Inoue, Naoya Sakanaka, Misato Ota, Takahisa Noma, Yoichi Yamashita, Taiko Horii, Tetsuo Minamino","doi":"10.1253/circrep.CR-25-0004","DOIUrl":"10.1253/circrep.CR-25-0004","url":null,"abstract":"<p><p>Left ventricular assist devices (LVADs) serve as critical life-sustaining therapy for patients with end-stage heart failure awaiting heart transplantation, significantly improving survival rates and enabling social reintegration. However, many patients with LVAD face multiple challenges in their daily lives and social reintegration, such as anxiety about the device, low societal awareness, and economic and psychological burdens. In Japan, where prolonged waiting periods for heart transplants are inevitable, these challenges further exacerbate the economic and psychological burdens on both patients and caregivers. We present the case of a patient with an LVAD who expressed the desire to return to employment after receiving psychological counseling, and discuss the specific outcomes and challenges of employment support. A multidisciplinary team, including physicians, psychologists, and employment specialists, developed an individualized support plan. This led to successful steps toward social reintegration, which was accomplished in collaboration with the workplace. This case highlights the importance of early intervention during the heart transplant waiting period, specifically the LVAD implantation period, along with continuous psychological, economic, and employment support to improve quality of life post-transplant. Establishing a coordinated support system that involves healthcare providers, employers, and local communities is crucial for the successful social reintegration of patients with an LVAD. Specific measures, such as regular mental health counseling and flexible employment arrangements, are essential to achieving this goal.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 3","pages":"147-153"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Events During Treatment With Xanthine Oxidoreductase Inhibitors in Patients With Gout and Hyperuricemia in Japan　- A JMDC Claims Database Study.","authors":"Kazuomi Kario, Seigo Akari, Hiroshi Kanegae","doi":"10.1253/circrep.CR-24-0178","DOIUrl":"10.1253/circrep.CR-24-0178","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown an increased risk of cardiovascular events during treatment with febuxostat vs. allopurinol, but comparative data with another xanthine oxidoreductase inhibitor (XORi), topiroxostat, are lacking. In this retrospective study we compared the incidence of cardiovascular/renal events in Japanese patients with newly diagnosed hyperuricemia and/or gout treated with allopurinol, febuxostat or topiroxostat.</p><p><strong>Methods and results: </strong>Data came from the JMDC Claims Database from September 2013-September 2019. Participants (n=24,112, age ≥20 years, ≥93% male) were diagnosed with hyperuricemia and/or gout and prescribed XORi treatment in the same month or the following month. Using a Poisson regression model, the adjusted risk (rate ratio [RR]; 95% confidence interval [CI]) of major adverse cardiovascular events was slightly lower with topiroxostat vs. allopurinol (0.63; 0.28-1.41) and febuxostat (0.64; 0.31-1.30). Adjusted risks (RR [95% CI]) for events during treatment with topiroxostat vs. febuxostat and allopurinol were 0.22 [0.10-0.48] and 0.26 [0.11-0.63], respectively, for heart failure, 0.43 [0.27-0.67] and 0.51 [0.31-0.86], respectively, for total cardiovascular events, and 0.46 [0.30-0.69] and 0.62 [0.39-0.98], respectively, for total cardiovascular + renal events. Adjusted risks of atrial fibrillation, heart failure, dialysis, total cardiovascular events, and total cardiovascular + renal events were significantly higher with febuxostat vs. allopurinol.</p><p><strong>Conclusions: </strong>Topiroxostat may provide a better tolerated option for the treatment of hyperuricemia and/or gout in Japanese patients with respect to cardiovascular events.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 3","pages":"183-190"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}