T. Nakashima, Katsutaka Hashiba, M. Kikuchi, J. Yamaguchi, S. Kojima, H. Hanada, T. Mano, Takeshi Yamamoto, A. Tanaka, K. Matsuo, Naoki Nakayama, Osamu Nomura, T. Matoba, Y. Tahara, H. Nonogi
{"title":"Impact of Prehospital 12-Lead Electrocardiography and Destination Hospital Notification on Mortality in Patients With Chest Pain ― A Systematic Review ―","authors":"T. Nakashima, Katsutaka Hashiba, M. Kikuchi, J. Yamaguchi, S. Kojima, H. Hanada, T. Mano, Takeshi Yamamoto, A. Tanaka, K. Matsuo, Naoki Nakayama, Osamu Nomura, T. Matoba, Y. Tahara, H. Nonogi","doi":"10.1253/circrep.cr-22-0003","DOIUrl":"https://doi.org/10.1253/circrep.cr-22-0003","url":null,"abstract":"Background: To achieve early reperfusion therapy for ST-elevation myocardial infarction (STEMI), proper and prompt patient transportation and activation of the catheterization laboratory are required. We investigated the efficacy of prehospital 12-lead electrocardiogram (ECG) acquisition and destination hospital notification in patients with STEMI. Methods and Results: This is a systematic review of observational studies. We searched the PubMed database from inception to March 2020. Two reviewers independently performed literature selection. The critical outcome was short-term mortality. The important outcome was door-to-balloon (D2B) time. We used the GRADE approach to assess the certainty of the evidence. For the critical outcome, 14 studies with 29,365 patients were included in the meta-analysis. Short-term mortality was significantly lower in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (odds ratio 0.72; 95% confidence interval [CI] 0.61–0.85; P<0.0001). For the important outcome, 10 studies with 2,947 patients were included in the meta-analysis. D2B time was significantly shorter in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (mean difference −26.24; 95% CI −33.46, −19.02; P<0.0001). Conclusions: Prehospital 12-lead ECG acquisition and destination hospital notification is associated with lower short-term mortality and shorter D2B time than no ECG acquisition or no notification among patients with suspected STEMI outside of a hospital.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82550836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Kobayashi, Shunsuke Uetake, Nobuaki Itoh, Y. Miyauchi
{"title":"Successful Catheter Ablation of Atrial Fibrillation in a Patient With an Abnormal Septum in the Left Atrium","authors":"N. Kobayashi, Shunsuke Uetake, Nobuaki Itoh, Y. Miyauchi","doi":"10.1253/circrep.CR-22-0026","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0026","url":null,"abstract":"the LA into 2 parts, a main chamber (MC) and an accessory chamber (AC). In addition, a fenestration was observed in the posteroinferior side of the membrane (Figure A–D). The right and left pulmonary veins (PVs) were connected to the AC and the MC, respectively. The fossa ovalis was A 50-year-old man underwent catheter ablation for symptomatic paroxysmal atrial fibrillation. Preprocedural cardiac computed tomography showed an abnormal septum extending from the interatrial septum to the posterior wall of the left atrium (LA) that divided","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83311094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Saito, Y. Otaki, Tetsu Watanabe, M. Wanezaki, D. Kutsuzawa, S. Kato, H. Tamura, S. Nishiyama, T. Arimoto, Hiroki Takahashi, Y. Ueno, T. Konta, Masafumi Watanabe
{"title":"Effects of Nitric Oxide Synthase 3 Gene Polymorphisms on Cardiovascular Events in a General Japanese Population ― The Yamagata (Takahata) Study ―","authors":"Y. Saito, Y. Otaki, Tetsu Watanabe, M. Wanezaki, D. Kutsuzawa, S. Kato, H. Tamura, S. Nishiyama, T. Arimoto, Hiroki Takahashi, Y. Ueno, T. Konta, Masafumi Watanabe","doi":"10.1253/circrep.cr-21-0159","DOIUrl":"https://doi.org/10.1253/circrep.cr-21-0159","url":null,"abstract":"Background: Single nucleotide polymorphisms (SNPs) in nitric oxide synthase 3 (NOS3) are associated with cardiovascular risk factors. However, it is not clear whether the NOS3 SNP is a genetic risk factor for cardiovascular diseases. Methods and Results: This prospective cohort study included 2,726 subjects aged ≥40 years who participated in a community-based health checkup. We genotyped 639 SNPs, including 2 NOS3 SNPs (rs1799983 and rs1808593). All subjects were monitored prospectively over a median follow-up period of 16.0 years, with the endpoint being cardiovascular events, including cardiovascular death and/or non-fatal myocardial infarction. Kaplan-Meier analysis demonstrated that both rs1799983 GT/TT and rs1808593 GG carriers had a higher risk of the endpoint than non-carriers. Univariate and multivariate Cox proportional hazard regression analyses revealed that both rs1799983 GT/TT and rs1808593 GG were independently associated with cardiovascular events after adjusting for confounding risk factors. The net reclassification index and integrated discrimination index were significantly improved by the addition of NOS3 SNPs as cardiovascular risk factors. Conclusions:NOS3 gene polymorphisms could be genetic risk factors for cardiovascular events in the general Japanese population, and could be used to facilitate the early identification of individuals at high risk of cardiovascular events.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75035077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Ikeda, S. Yachi, M. Takeyama, Y. Nishimoto, I. Tsujino, J. Nakamura, N. Yamamoto, Hiroko Nakata, S. Ikeda, Michihisa Umetsu, S. Aikawa, H. Hayashi, H. Satokawa, Yoshinori Okuno, Eriko Iwata, Yoshito Ogihara, A. Kondo, Takehisa Iwai, N. Yamada, Tomohiro Ogawa, Takao Kobayashi, M. Mo, Y. Yamashita
{"title":"D-Dimer Values and Venous Thromboembolism in Patients With COVID-19 in Japan ― From the CLOT-COVID Study ―","authors":"N. Ikeda, S. Yachi, M. Takeyama, Y. Nishimoto, I. Tsujino, J. Nakamura, N. Yamamoto, Hiroko Nakata, S. Ikeda, Michihisa Umetsu, S. Aikawa, H. Hayashi, H. Satokawa, Yoshinori Okuno, Eriko Iwata, Yoshito Ogihara, A. Kondo, Takehisa Iwai, N. Yamada, Tomohiro Ogawa, Takao Kobayashi, M. Mo, Y. Yamashita","doi":"10.1253/circrep.CR-22-0022","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0022","url":null,"abstract":"Background: To date, there are no large-scale data on the association between D-dimer levels at admission and the occurrence of venous thromboembolism (VTE) in Japanese patients with coronavirus disease 2019 (COVID-19). Methods and Results: The CLOT-COVID study was a retrospective, multicenter cohort study enrolling consecutive hospitalized patients with COVID-19 across 16 centers in Japan from April 2021 to September 2021. Among 2,894 enrolled patients, 2,771 (96%) had D-dimer levels measured at admission. Patients were divided into 3 groups based on tertiles of D-dimer levels at admission (1st tertile, D-dimer ≤0.5 μg/mL, n=949; 2nd tertile, D-dimer 0.51–1.09 μg/mL, n=894; 3rd tertile, D-dimer ≥1.1 μg/mL, n=928). The higher the tertile group, the more severe the COVID-19 status at admission. The incidence of VTE during hospitalization was highest in the 3rd tertile group (1st tertile, 0.3%; 2nd tertile, 0.3%; 3rd tertile, 3.6%; P<0.001). Even after adjusting for confounders in the multivariable logistic regression model, the higher D-dimer levels in the 3rd tertile (≥1.1 μg/mL) were independently associated with a higher risk of VTE during hospitalization (adjusted odds ratio 4.83 [95% confidence interval 1.93–12.11; P<0.001]; reference=1st tertile). Conclusions: Higher D-dimer levels at admission were associated with a higher risk of VTE events during hospitalization in Japanese patients with COVID-19. This could be helpful in determining patient-specific anticoagulation management strategies for COVID-19 in Japan.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86525523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Hirashiki, A. Shimizu, K. Nomoto, M. Kokubo, Noriyuki Suzuki, H. Arai
{"title":"Systematic Review of the Effectiveness of Community Intervention and Health Promotion Programs for the Prevention of Non-Communicable Diseases in Japan and Other East and Southeast Asian Countries","authors":"A. Hirashiki, A. Shimizu, K. Nomoto, M. Kokubo, Noriyuki Suzuki, H. Arai","doi":"10.1253/circrep.cr-21-0165","DOIUrl":"https://doi.org/10.1253/circrep.cr-21-0165","url":null,"abstract":"Background: Non-communicable diseases (NCDs) are the leading cause of death worldwide. However, current evidence regarding the efficacy and cost-effectiveness of community intervention and health promotion programs for NCDs, specifically hypertension, obesity, diabetes, and dyslipidemia, in East and Southeast Asia has not yet been systematically reviewed. We systematically reviewed the literature from East and Southeast Asian countries to answer 2 clinical questions: (1) do health promotion programs for hypertension, obesity, diabetes, and dyslipidemia reduce cardiovascular events and mortality; and (2) are these programs cost-effective? Methods and Results: Electronic literature searches were performed across Medline, Cochrane Library, and Ichushi using key words and relevant subject headings related to randomized controlled trials, comparative studies, quasi-experimental studies, or propensity score matching that met eligibility criteria that were defined for each question. In all, 3,389 records were identified, of which 12 full-text articles were reviewed. Three papers were from Japan, 7 were from China/Hong Kong Special Administrative Region, and 2 were from South Korea. None were from Southeast Asia. Four papers examined the effect of community intervention or health promotion on the incidence of cardiovascular events or mortality. Eight studies examined the cost-effectiveness of interventions. Conclusions: The literature review revealed that community intervention and health promotion programs for the control of NCDs are a cost-effective means of reducing cardiovascular events and mortality in East Asian countries.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84732952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ventricular Sigmoid Septum as a Risk Factor for Anthracycline-Induced Cancer Therapeutics-Related Cardiac Dysfunction in Patients With Malignant Lymphoma.","authors":"Takafumi Nakayama, Yoshiko Oshima, Yasuhiro Shintani, Junki Yamamoto, Masashi Yokoi, Tsuyoshi Ito, Kazuaki Wakami, Shuichi Kitada, Toshihiko Goto, Hiroya Hashimoto, Shigeru Kusumoto, Tomonori Sugiura, Shinsuke Iida, Yoshihiro Seo","doi":"10.1253/circrep.CR-21-0145","DOIUrl":"10.1253/circrep.CR-21-0145","url":null,"abstract":"<p><p><b><i>Background:</i></b> Identifying risk factors for cancer therapeutics-related cardiac dysfunction (CTRCD) is essential for the early detection and prompt initiation of medial therapy for CTRCD. No study has investigated whether the sigmoid septum is a risk factor for anthracycline-induced CTRCD. <b><i>Methods and Results:</i></b> We enrolled 167 patients with malignant lymphoma who received a CHOP-like regimen from January 2008 to December 2017 and underwent both baseline and follow-up echocardiography. Patients with left ventricular ejection fraction (LVEF) ≤50% were excluded. CTRCD was defined as a ≥10% decline in LVEF and LVEF <50% after chemotherapy. The angle between the anterior wall of the aorta and the ventricular septal surface (ASA) was measured to quantify the sigmoid septum. CTRCD was observed in 36 patients (22%). Mean LVEF and global longitudinal strain (GLS) were lower, left ventricular mass index was higher, and ASA was smaller in patients with CTRCD. In a multivariable Cox proportional hazard analysis, GLS (hazard ratio [HR] per 1% decrease 1.20; 95% confidence interval [CI] 1.07-1.35) and ASA (HR per 1° increase 0.97; 95% CI 0.95-0.99) were identified as independent determinants of CTRCD. An integrated discrimination improvement evaluation confirmed the significant incremental value of ASA for developing CTRCD. <b><i>Conclusions:</i></b> Smaller ASA was an independent risk factor and had significant incremental value for CTRCD in patients with malignant lymphoma who received the CHOP-like regimen.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82830294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Kato, Taka-aki Matsuyama, Masaya Fujishiro, Mari Hashimoto, H. Sone, Toshiko Onizuka-Yamochi
{"title":"Local Variation and Age-Related Change in Atrial and Ventricular Myocardial Contiguity at the Atrioventricular Junction in Human Hearts","authors":"Y. Kato, Taka-aki Matsuyama, Masaya Fujishiro, Mari Hashimoto, H. Sone, Toshiko Onizuka-Yamochi","doi":"10.1253/circrep.cr-22-0013","DOIUrl":"https://doi.org/10.1253/circrep.cr-22-0013","url":null,"abstract":"Background: We explored the histologic patterns of and age-related changes in atrial and ventricular myocardial contiguity at the left and right atrioventricular (AV) junction that could be a target site for catheter ablation. Methods and Results: Twenty-three structurally normal adult hearts obtained at autopsy were studied. The 2 AV annuli were divided into 13 clinically recognized portions in which we measured distance between the atrial and ventricular myocardium at the AV junction. Overall, measured distance was less on the right than left side (mean [±SD] 0.74±0.59 vs. 1.15±0.78 mm, respectively), and distance increased gradually with age. The gap was smallest at the anterolateral portion on the right side and posterolateral portion on the left side. Three specific features were noted, namely extension of the ventricular myocardium (coarse trabeculae) towards the atrium on the right side of the AV junction, extension of the atrial myocardium onto the AV valve leaflets, and a collection of small myocardial cells, perhaps including specialized cells, in the right anterolateral portion. No concealed AV muscular connections were found. Conclusions: Contiguity and separation of the myocardium at the AV junction have specific patterns, and myocardial proximity is influenced by age. These histologic features of the AV junction may prove to be informative for catheter ablation of tachyarrhythmias related to the AV junction.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84551416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fumika Aniya, A. Sakima, M. Takakura, K. Shirai, Masumi Shimabukuro, H. Todoriki, K. Okumura, K. Takemura, Noboru Kinjyo, Y. Ohya
{"title":"Effect of Nutrition Education on the Vegetable Intake of Residents in Okinawa","authors":"Fumika Aniya, A. Sakima, M. Takakura, K. Shirai, Masumi Shimabukuro, H. Todoriki, K. Okumura, K. Takemura, Noboru Kinjyo, Y. Ohya","doi":"10.1253/circrep.CR-21-0152","DOIUrl":"https://doi.org/10.1253/circrep.CR-21-0152","url":null,"abstract":"Background: Increasing vegetable intake is recommended for promoting health in communities. This study investigated the effects of nutrition education on vegetable intake and the factors associated with changes in vegetable intake among residents of Okinawa. Methods and Results: Subjects (n=1,345; mean [±SD] age 56.8±14.6 years; 40.5% male) were recruited from among local residents participating in the Yui Kenko Project. Subjects completed the brief-type self-administered diet history questionnaire (BDHQ) and questionnaires on socioeconomic demographics and social capital. Subjects were divided into 2 groups according to residential area, namely south Okinawa (n=679), where local health promotion activities have been undertaken since the early 2000s, and central Okinawa (n=666). Survey results were fed back to each subject, and health lectures were then conducted at local community centers. After 1 year, the BDHQ was repeated to investigate changes in vegetable and nutritional parameters. After the intervention, residents of south Okinawa increased their crude and energy-adjusted vegetable intake (P<0.05), whereas residents of central Okinawa showed decreased vegetable intake (P<0.05). Univariable and multivariable regression models indicated that, in south Okinawa, participation in local health promotion activities and agreement with general trust were positively correlated with changes in energy-adjusted vegetable intake, whereas in central Okinawa no correlations were observed. Conclusions: The status of social capital should be taken into account when implementing initiatives to increase vegetable intake in communities.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87394631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}