Circulation reports最新文献_第5页

Real-World Clinical Evidence With Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy　- A Contemporary Review. Tafamidis治疗转甲状腺素淀粉样心肌病的临床证据-一项当代综述。

IF 1.1

Circulation reports Pub Date : 2025-07-03 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0092

Yasuhiro Izumiya, Naoto Kuyama, Shinsuke Hanatani, Yasushi Matsuzawa, Hiroki Usuku, Eiichiro Yamamoto, Kenichi Tsujita

{"title":"Real-World Clinical Evidence With Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy　- A Contemporary Review.","authors":"Yasuhiro Izumiya, Naoto Kuyama, Shinsuke Hanatani, Yasushi Matsuzawa, Hiroki Usuku, Eiichiro Yamamoto, Kenichi Tsujita","doi":"10.1253/circrep.CR-25-0092","DOIUrl":"10.1253/circrep.CR-25-0092","url":null,"abstract":"Transthyretin amyloid cardiomyopathy (ATTR-CM) is increasingly recognized as a cause of heart failure with preserved ejection fraction in older adults. Tafamidis, a transthyretin stabilizer, is the first disease-modifying therapy approved for ATTR-CM. Although its efficacy was demonstrated in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT) trial, real-world data are essential to evaluate its effectiveness across broader and more diverse patient populations. This review synthesizes real-world evidence on tafamidis, including patient characteristics, diagnostic and therapeutic delays, and clinical outcomes such as mortality, hospitalization, cardiac biomarker trends, imaging findings, and functional capacity. Compared with clinical trial participants, real-world patients are generally older, often present with more advanced disease, and initiate treatment later in the disease course. Nevertheless, observational studies from Japan and other countries consistently show that tafamidis is associated with improved survival, reduced heart failure hospitalizations, stabilization of cardiac structure and biomarkers, and preservation of physical function - especially when therapy is started early. Accumulating such data will be crucial for optimizing patient care, particularly in the context of future treatment strategies involving emerging agents such as a next-generation oral transthyretin stabilizer and a subcutaneously administered RNA interference therapeutic. This review aims to bridge the gap between clinical trial findings and routine practice, supporting informed decision-making in the management of this progressive and underdiagnosed condition.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"599-603"},"PeriodicalIF":1.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of General Anesthesia on Catheter Stability During Pulmonary Vein Isolation of Atrial Fibrillation. 全麻对房颤肺静脉隔离术中导管稳定性的影响。

IF 1.1

Circulation reports Pub Date : 2025-07-03 eCollection Date: 2025-09-10 DOI: 10.1253/circrep.CR-25-0035

Yuki Shibuya, Takashi Kanda, Hitoshi Minamiguchi, Takashige Sakio, Mikiko Matsumura, Yuma Hamanaka, Naoki Mori, Kei Nakamoto, Yasuhiro Ichibori, Osamu Iida, Takashi Kita, Yoshiharu Higuchi

{"title":"Impact of General Anesthesia on Catheter Stability During Pulmonary Vein Isolation of Atrial Fibrillation.","authors":"Yuki Shibuya, Takashi Kanda, Hitoshi Minamiguchi, Takashige Sakio, Mikiko Matsumura, Yuma Hamanaka, Naoki Mori, Kei Nakamoto, Yasuhiro Ichibori, Osamu Iida, Takashi Kita, Yoshiharu Higuchi","doi":"10.1253/circrep.CR-25-0035","DOIUrl":"10.1253/circrep.CR-25-0035","url":null,"abstract":"Background: The application of radiofrequency ablation for pulmonary vein isolation (PVI) under general anesthesia (GA) has shown a lower recurrence rate of atrial fibrillation (AF) compared with deep sedation (DS). However, the effect of the different anesthesia methodology on catheter stability remains unclear.Methods and results: We enrolled 32 patients (16 in each group) who underwent PVI using radiofrequency ablation with the CARTO system. The contact force (CF) at each ablation point and catheter tip movement distance were analyzed using VISITAGTM. A total of 1,863 points (GA: 964 points, DS: 899 points) were analyzed for the CF, and 1,969 points (GA: 1,000 points, DS: 969 points) were analyzed for the catheter tip movement distance. The GA group demonstrated a significantly higher mean CF (GA: 12.94±5.27 g vs. DS: 11.93±5.11 g; P<0.01), as well as a higher minimum CF (GA: 4.61±3.85 g vs. DS: 3.79±3.98 g, P<0.01), compared with the DS group. Additionally, catheter tip movement distance was significantly shorter in the GA group than in the DS group (GA: 1.65±0.76 mm vs. DS: 2.29±1.10 mm, P<0.01).Conclusions: Catheter ablation under GA ensures better maintenance of adequate CF and catheter stability than DS.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 9","pages":"750-755"},"PeriodicalIF":1.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Epicardial Fat Volume and Coronary Microvascular Dysfunction. 心外膜脂肪容量与冠状动脉微血管功能障碍的关系。

IF 1.1

Circulation reports Pub Date : 2025-07-02 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0073

Tsuyoshi Ito, Atsushi Niwa, Masashi Yokoi, Shuichi Kitada, Yu Kawada, Tatsuya Mizoguchi, Shohei Kikuchi, Sayuri Yamabe, Toshihiko Goto, Yoshihiro Seo

{"title":"Relationship Between Epicardial Fat Volume and Coronary Microvascular Dysfunction.","authors":"Tsuyoshi Ito, Atsushi Niwa, Masashi Yokoi, Shuichi Kitada, Yu Kawada, Tatsuya Mizoguchi, Shohei Kikuchi, Sayuri Yamabe, Toshihiko Goto, Yoshihiro Seo","doi":"10.1253/circrep.CR-25-0073","DOIUrl":"10.1253/circrep.CR-25-0073","url":null,"abstract":"Background: Coronary microvascular dysfunction (CMD) is associated with myocardial ischemia in patients without obstructive coronary artery disease (CAD). Epicardial fat volume (EFV) has been reported to be associated with epicardial CAD and diastolic dysfunction. However, because its impact on CMD remains unclear, we aimed to investigate the relationship between CMD and EFV.Methods and results: This study included 103 patients without obstructive CAD who underwent assessment of CMD and EFV. CMD was defined as either coronary flow reserve (CFR) <2.0 or index of microcirculatory resistance (IMR) ≥25. EFV was quantified using computed tomography and the EFV index was calculated. CMD was identified in 34 (33%) patients. The EFV index was significantly larger in the CMD group than in the non-CMD group (86.1±27.9 vs. 65.8±20.0 cm3/m2; P<0.01). Notably, patients with low CFR (<2.0) and high IMR (≥25) had a larger EFV index (102.1±33.4 cm3/m2). Univariable logistic regression analysis indicated a significant relationship between CMD and the EFV index (odds ratio (OR): 1.04; P<0.01). In the multivariable model, EFV index was significantly associated with CMD (OR: 1.03; P<0.01). The EFV index significantly correlated with CFR (r=-0.39, P<0.01) and IMR (r=0.32, P<0.01).Conclusions: EFV was associated with CMD in patients without obstructive CAD.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"646-653"},"PeriodicalIF":1.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance Evaluation of Large Language Models With Retrieval-Augmented Generation in Cardiology Specialist Examinations in Japan. 基于检索增强生成的大型语言模型在日本心脏病专科检查中的性能评价。

IF 1.1

Circulation reports Pub Date : 2025-07-02 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0094

Hiromasa Hayama, Tu Hao Tran, Jin Kirigaya, Yosuke Katayama, Tomoko Negishi, Koya Ozawa, Kazuaki Negishi

引用次数: 0

Comparison of Long-Term Outcomes Between Second-Generation Single Long Stents and Overlapping Stents for Long-Diffuse Coronary Artery Disease　- Systematic Review and Meta-Analysis. 第二代单一长支架与重叠支架治疗长弥漫性冠状动脉疾病的远期疗效比较——系统回顾和meta分析

IF 1.1

Circulation reports Pub Date : 2025-07-01 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0075

Masaaki Ikehara, Kaoru Hattori, Hiroshi Niinami, Kiyotaka Iwasaki

{"title":"Comparison of Long-Term Outcomes Between Second-Generation Single Long Stents and Overlapping Stents for Long-Diffuse Coronary Artery Disease　- Systematic Review and Meta-Analysis.","authors":"Masaaki Ikehara, Kaoru Hattori, Hiroshi Niinami, Kiyotaka Iwasaki","doi":"10.1253/circrep.CR-25-0075","DOIUrl":"10.1253/circrep.CR-25-0075","url":null,"abstract":"Background: Coronary artery disease (CAD) is becoming increasingly prevalent in aging populations. Long-diffuse CAD (ldCAD), characterized by lesions ≥30 mm, poses significant treatment challenges. This study aimed to evaluate the long-term prognostic differences between single long stents (SLS) and overlapping stents (OLS) in patients with ldCAD using second-generation and later drug-eluting stents (DES).Methods and results: A systematic review and meta-analysis of studies published between 2000 and October 2024 in PubMed, Embase, Web of Science, and the Cochrane Library was conducted. The primary outcome was major adverse cardiovascular events (MACE) over 1 year. The secondary outcomes were cardiac death, target lesion revascularization, target vessel revascularization (TVR), and fatal or non-fatal myocardial infarction (MI). The analysis included 5 studies with 2,756 patients, indicating no significant differences between SLS and OLS regarding MACE and TVR. However, MI incidence was significantly lower with SLS, whereas OLS showed a higher MI incidence, likely due to differences in lesion length rather than the strategy itself. Subanalyses indicated that SLS significantly reduced contrast volume compared with OLS, with a trend toward shorter lesions and stent lengths.Conclusions: Stent overlap has minimal impact on prognosis with newer DES. Despite limitations from non-randomized data, further research is needed to optimize ldCAD treatment strategies and guide clinical practice.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"604-611"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prefectural Survey on Anthracycline-Related Cardiomyopathy at the Start of the Basic Plan to Promote Cancer Control Programs - Phase 4. 促进癌症控制基本计划启动时的地县蒽环类相关心肌病调查-第4阶段。

IF 1.1

Circulation reports Pub Date : 2025-06-28 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-24-0185

Yuji Okura, Naohito Tanabe, Takeshi Kashimura, Takuro Ishiguro, Mayuko Ikarashi, Chizuko Kanbayashi, Koji Kaneko, Eiko Sakata, Keiichi Tsuchida, Akira Kikuchi, Atsushi Ogawa, Masato Moriyama, Hiroshi Tanaka, Takayuki Inomata

{"title":"Prefectural Survey on Anthracycline-Related Cardiomyopathy at the Start of the Basic Plan to Promote Cancer Control Programs - Phase 4.","authors":"Yuji Okura, Naohito Tanabe, Takeshi Kashimura, Takuro Ishiguro, Mayuko Ikarashi, Chizuko Kanbayashi, Koji Kaneko, Eiko Sakata, Keiichi Tsuchida, Akira Kikuchi, Atsushi Ogawa, Masato Moriyama, Hiroshi Tanaka, Takayuki Inomata","doi":"10.1253/circrep.CR-24-0185","DOIUrl":"10.1253/circrep.CR-24-0185","url":null,"abstract":"Background: Collaboration between cardiologists and oncologists was recommended as part of Japan's Basic Plan to Promote Disease Control Programs in 2023. We evaluated the extent of this collaboration regarding anthracycline-related cardiomyopathy (ARCM).Methods and results: Self-administered questionnaires on ARCM were distributed to all cardiologists and leading oncologists in hospitals across the Niigata Prefecture. Overall, 126 cardiologists and 41 leading oncologists from 29 hospitals responded to the survey. Clinical experience with ARCM was reported by 76.2% of cardiologists and 58.5% of leading oncologists (P=0.044). Guideline recommendations for the early detection and treatment of ARCM were known by 89.1% of cardiologists and 87.8% of leading oncologists. Among the 20 hospitals providing chemotherapy, 12 (60%) had matching answers for 'post-event consultation' or 'pre-event consultation' between the cardiology and oncology departments. Regarding 'pre-event consultation', 4 hospitals had consistent responses for the most proactive response, whereas only 1 hospital had consistent responses from both departments for the majority response. The agreement of responses between the 2 departments was significant for the most proactive response (k=0.485; P=0.005), but not for the majority response (k=0.059; P=0.675).Conclusions: The importance of early detection and treatment of ARCM was understood at the individual level; however, increased emphasis on 'pre-event consultation' is necessary to establish an interdepartmental early detection system.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"627-638"},"PeriodicalIF":1.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allogenic Mitochondria and Associated Organelle Complex Treatment Attenuates High-Fat Diet-Induced Adipose Tissue Remodeling. 同种异体线粒体和相关细胞器复合物治疗减轻高脂肪饮食诱导的脂肪组织重塑。

IF 1.1

Circulation reports Pub Date : 2025-06-28 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0045

Tianyu Liu, Yuuki Shimizu, Hisashi Ota, Takumi Hayashi, Haihang Luo, Yiyang Che, Yuimi Matsuoka, Rick C Tsai, Masashi Suganuma, Toyoaki Murohara

{"title":"Allogenic Mitochondria and Associated Organelle Complex Treatment Attenuates High-Fat Diet-Induced Adipose Tissue Remodeling.","authors":"Tianyu Liu, Yuuki Shimizu, Hisashi Ota, Takumi Hayashi, Haihang Luo, Yiyang Che, Yuimi Matsuoka, Rick C Tsai, Masashi Suganuma, Toyoaki Murohara","doi":"10.1253/circrep.CR-25-0045","DOIUrl":"10.1253/circrep.CR-25-0045","url":null,"abstract":"Background: Metabolic diseases such as obesity and type 2 diabetes are on the rise and have become a significant global public health issue. Mitochondrial function and biogenesis in visceral adipose tissue are key factors influencing the development of obesity and related metabolic disorders. In addition, chronic inflammation involving immune cells can lead to obesity-related metabolic disorders. Given these underlying mechanisms, we aimed to test whether the treatment of frozen-thawed isolated mitochondrial preparations (MRC-Q) from cultured cells had a protective effect on adipose tissue inflammation and remodeling in a high-fat diet-induced mouse model.Methods and results: MRC-Q was given intraperitoneally every 2 weeks to the mice in the diet-induced obesity (DIO) model. The results demonstrated that MRC-Q reduced the amount of adipose tissue and the body weight of the DIO mice, reduced blood glucose, and improved glucose tolerance. This process was accompanied by M2 macrophage polarization and suppression of pro-inflammatory responses in the visceral fat of mice. In addition, in vitro experiments indicated that MRC-Q could directly transform macrophages to the M2 phenotype.Conclusions: A novel mitochondrial preparation, MRC-Q, protected against adipose tissue remodeling in DIO mice by promoting M2 macrophage polarization, and inhibiting pro-inflammatory responses in visceral fat.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"661-669"},"PeriodicalIF":1.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Effects of Empagliflozin and Dapagliflozin in Stable Chronic Heart Failure　- A Prospective Crossover Study. 恩格列净和达格列净在稳定型慢性心力衰竭中的比较效果——一项前瞻性交叉研究。

IF 1.1

Circulation reports Pub Date : 2025-06-27 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0085

Ryo Miyake, Toru Kubota, Akihito Ishikita, Soichi Nakashiro, Daisuke Nagatomo, Keiji Oi, Nobuhiro Suematsu

{"title":"Comparative Effects of Empagliflozin and Dapagliflozin in Stable Chronic Heart Failure　- A Prospective Crossover Study.","authors":"Ryo Miyake, Toru Kubota, Akihito Ishikita, Soichi Nakashiro, Daisuke Nagatomo, Keiji Oi, Nobuhiro Suematsu","doi":"10.1253/circrep.CR-25-0085","DOIUrl":"10.1253/circrep.CR-25-0085","url":null,"abstract":"Background: Empagliflozin and dapagliflozin are both approved for the treatment of chronic heart failure (CHF), but their comparative efficacy remains uncertain. Therefore, we aimed to prospectively compare the effects of 10 mg empagliflozin and 10 mg dapagliflozin on NT-proBNP levels and clinical outcomes in patients with stable CHF.Methods and results: In this single-center, open-label, prospective crossover study, 25 patients with stable CHF (age 74.3±11.9 years; 68% male) were enrolled. Patients were initially treated with either empagliflozin (n=6) or dapagliflozin (n=19) for ≥3 months before switching to the alternative agent. Follow-up assessments were conducted 1 month after the switch. Patients then selected their preferred agent and were followed for ≥1year. NT-proBNP levels were significantly higher in patients initially treated with empagliflozin compared to those treated with dapagliflozin (3,334±2,107 vs. 1,101±923 pg/mL, P=0.001). However, NT-proBNP levels did not change significantly in either group following the crossover. During follow-up, 6 patients (24%) were hospitalized for worsening HF, with no significant difference between treatment groups. Notably, NT-proBNP ≥1,453 pg/mL was significantly associated with poorer outcomes (P=0.008).Conclusions: In this crossover study, empagliflozin and dapagliflozin showed comparable effects on NT-proBNP levels and clinical outcomes, supporting their interchangeable use in stable CHF.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"639-645"},"PeriodicalIF":1.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When the Atheromatous Culprit Coronary Plaque Melts Like Snow in the Sun. 当导致动脉粥样硬化的罪魁祸首冠状动脉斑块像阳光下的雪一样融化。

IF 1.1

Circulation reports Pub Date : 2025-06-24 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0049

Benjamin Duband, Nicolas Combaret, Géraud Souteyrand, Pascal Motreff

引用次数: 0

Feature-Tracking Method Can Estimate Right Ventricular Contractile Properties in Rats With Pulmonary Hypertension. 特征跟踪法可以估计肺动脉高压大鼠右心室收缩特性。

IF 1.1

Circulation reports Pub Date : 2025-06-21 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0028

Haruka Sato, Yui Takahashi, Taiki Hasegawa, Yuka Someya, Masami Nishiyama, Ayana Matsumoto, Natsuki Morita, Chiyohiko Shindoh, Hideki Ota, Ryuta Kawashima, Masahito Miura

{"title":"Feature-Tracking Method Can Estimate Right Ventricular Contractile Properties in Rats With Pulmonary Hypertension.","authors":"Haruka Sato, Yui Takahashi, Taiki Hasegawa, Yuka Someya, Masami Nishiyama, Ayana Matsumoto, Natsuki Morita, Chiyohiko Shindoh, Hideki Ota, Ryuta Kawashima, Masahito Miura","doi":"10.1253/circrep.CR-25-0028","DOIUrl":"10.1253/circrep.CR-25-0028","url":null,"abstract":"Background: Right ventricular (RV) function is a prognostic factor in patients with pulmonary arterial hypertension (PAH). Cardiovascular magnetic resonance (CMR) imaging has been used to assess RV function. However, it is not determined whether RV longitudinal strain (LS) with a feature-tracking method can accurately assess RV contractility. In this study, feature-tracking-based RVLS and RV ejection fraction (RVEF) were compared with contractile properties of RV muscle obtained from rat hearts with PAH.Methods and results: Monocrotaline (MCT-rats, n=19) or solvent (Ctr-rats, n=4) was injected subcutaneously into rats. Four weeks after the injection, retrospective electrocardiogram-gated cine magnetic resonance (8 phases/beat) was imaged using a 7-T magnetic resonance imaging (MRI) scanner and RV pressure was measured. Trabeculae were dissected from the RV and electrically stimulated. Force was measured and maximum dF/dt was calculated as a parameter of contractile properties. Compared with Ctr-rats, MCT-rats showed higher systolic RV pressure. RVLS in all MCT-rats was lower than that in Ctr-rats, while RVEF was preserved (>40%) in 8 out of 16 MCT-rats. MCT-rats showed lower developed force and maximum dF/dt than Ctr-rats. Maximum dF/dt was linearly correlated with RVLS. In contrast, whether RVEF was preserved, maximum dF/dt was decreased in MCT-rats.Conclusions: The present study suggests that RVLS with a feature-tracking method can assess RV contractile properties more accurately than RVEF in rats with PAH. It is useful to estimate the RV function based on feature tracking.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"685-691"},"PeriodicalIF":1.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0