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Comparison of Discriminative Ability of Bleeding Risk Criteria and Scores for Predicting Short- and Mid-Term Major Bleeding Events in Patients Undergoing Percutaneous Coronary Intervention 比较出血风险标准和评分在预测经皮冠状动脉介入治疗患者短期和中期重大出血事件方面的判别能力
Circulation reports Pub Date : 2023-12-15 DOI: 10.1253/circrep.cr-23-0087
H. Shimono, Akihiro Tokushige, D. Kanda, Ayaka Ohno, R. Arikawa, H. Chaen, Hideki Okui, N. Oketani, Mitsuru Ohishi
{"title":"Comparison of Discriminative Ability of Bleeding Risk Criteria and Scores for Predicting Short- and Mid-Term Major Bleeding Events in Patients Undergoing Percutaneous Coronary Intervention","authors":"H. Shimono, Akihiro Tokushige, D. Kanda, Ayaka Ohno, R. Arikawa, H. Chaen, Hideki Okui, N. Oketani, Mitsuru Ohishi","doi":"10.1253/circrep.cr-23-0087","DOIUrl":"https://doi.org/10.1253/circrep.cr-23-0087","url":null,"abstract":"","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"12 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139001104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periprocedural Thrombogenicity Change Is Associated With Subclinical Leaflet Thrombosis Progression in Patients Undergoing Transcatheter Aortic Valve Implantation. 经导管主动脉瓣植入术患者围手术期血栓形成变化与亚临床瓣叶血栓形成进展有关
Circulation reports Pub Date : 2023-11-30 eCollection Date: 2023-12-08 DOI: 10.1253/circrep.CR-23-0092
Naoto Kuyama, Koichi Kaikita, Masanobu Ishii, Noriaki Tabata, Seitaro Oda, Yasuhiro Otsuka, Koichi Egashira, Yuichiro Shirahama, Shinsuke Hanatani, Seiji Takashio, Yasushi Matsuzawa, Eiichiro Yamamoto, Toshinori Hirai, Kenichi Tsujita
{"title":"Periprocedural Thrombogenicity Change Is Associated With Subclinical Leaflet Thrombosis Progression in Patients Undergoing Transcatheter Aortic Valve Implantation.","authors":"Naoto Kuyama, Koichi Kaikita, Masanobu Ishii, Noriaki Tabata, Seitaro Oda, Yasuhiro Otsuka, Koichi Egashira, Yuichiro Shirahama, Shinsuke Hanatani, Seiji Takashio, Yasushi Matsuzawa, Eiichiro Yamamoto, Toshinori Hirai, Kenichi Tsujita","doi":"10.1253/circrep.CR-23-0092","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0092","url":null,"abstract":"<p><p><b><i>Background:</i></b> Subclinical leaflet thrombosis occasionally occurs after transcatheter aortic valve implantation (TAVI), but its exact etiology and relationship with thrombogenicity remain unknown. <b><i>Methods and Results:</i></b> This study enrolled 35 patients who underwent TAVI. Thrombogenicity was evaluated using a total thrombus-formation analysis system (T-TAS) to compute the thrombus-formation area under the curve (PL<sub>18</sub>-AUC<sub>10</sub> and AR<sub>10</sub>-AUC<sub>30</sub>). Periprocedural thrombogenic parameters including T-TAS were investigated at pre-TAVI, 2 days, 7 days, and 3 months post-TAVI. Hypoattenuated leaflet thickening (HALT) and maximum leaflet thickness (MLT) were evaluated using contrast-enhanced computed tomography 7 days and 3 months post-TAVI. The associations between thrombogenicity and HALT or MLT were assessed. T-TAS parameters consistently decreased at 2 and 7 days post-TAVI, followed by improvement at 3 months. HALT was detected in 20% and 17% of patients at 7 days and 3 months, respectively, post-TAVI. The median MLT value was 1.60 mm at 7 days and 3 months post-TAVI. A significant positive correlation was observed between the decrease in the AR<sub>10</sub>-AUC<sub>30</sub> and MLT at 7 days post-TAVI. Univariate linear regression analysis revealed a decrease in the AR<sub>10</sub>-AUC<sub>30</sub> and an increase in the D-dimer level as a significant predictor of MLT deterioration. <b><i>Conclusions:</i></b> The findings suggested that a transient decrease in thrombogenicity following TAVI predicts leaflet thrombosis, implying that monitoring thrombogenicity may be useful for predicting progression of leaflet thrombosis.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 12","pages":"450-458"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10700031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravascular Lithotripsy for Vessel Preparation in Calcified Coronary Arteries Prior to Stent Placement - Japanese Disrupt CAD IV Study 2-Year Results. 血管内碎石术用于钙化冠状动脉支架置入前的血管准备--日本 Disrupt CAD IV 研究两年结果。
Circulation reports Pub Date : 2023-11-29 eCollection Date: 2023-12-08 DOI: 10.1253/circrep.CR-23-0082
Shigeru Saito, Seiji Yamazaki, Akihiko Takahashi, Atsuo Namiki, Tomohiro Kawasaki, Satoru Otsuji, Shigeru Nakamura, Yoshisato Shibata
{"title":"Intravascular Lithotripsy for Vessel Preparation in Calcified Coronary Arteries Prior to Stent Placement - Japanese Disrupt CAD IV Study 2-Year Results.","authors":"Shigeru Saito, Seiji Yamazaki, Akihiko Takahashi, Atsuo Namiki, Tomohiro Kawasaki, Satoru Otsuji, Shigeru Nakamura, Yoshisato Shibata","doi":"10.1253/circrep.CR-23-0082","DOIUrl":"10.1253/circrep.CR-23-0082","url":null,"abstract":"<p><p><b><i>Background:</i></b> Intravascular lithotripsy (IVL) delivers acoustic pressure waves to modify calcification to enhance vessel compliance and optimize stent deployment. The Disrupt CAD IV study enrolled patients with severe coronary artery calcification. The primary safety (30-day major adverse coronary events [MACE], 6.3%) and effectiveness (procedural success, 93.8%) endpoints were achieved. The present analysis evaluated the 2-year outcomes of the study. <b><i>Methods and Results:</i></b> Disrupt CAD IV (NCT04151628) was a prospective, single-arm, multicenter study designed for regulatory approval of the Shockwave Coronary C<sup>2</sup> IVL system in Japan. Angiographic outcomes were analyzed by an independent core laboratory and adverse events were adjudicated by a Clinical Events Committee. Kaplan-Meier analysis was performed for MACE (composite of cardiac death, MI or target-vessel revascularization [TVR]), target lesion failure (TLF: composite of cardiac death, TV-MI, and target lesion revascularization [TLR]), and stent thrombosis (ST). At 2 years, 62 subjects had completed follow-up. MACE occurred in 12.6% (cardiac death 0.0%, MI 6.3%, TVR 7.9%) and TLF occurred in 7.8% of patients, with both rates driven by non-Q-wave MI events (6.3%). TLR was 3.2%; no ST occurred through 2 years. <b><i>Conclusions:</i></b> Treatment with IVL in patients with severely calcified coronary lesions was associated with low rates of MACE, TLR, and ST at 2 years, demonstrating continued durable safety and effectiveness of coronary IVL in a Japanese population.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 12","pages":"437-441"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10700032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Heart Failure Smartphone Application That Nudges Patients/Physicians Toward Optimal Medical Therapy - Development and Usability Study. 可引导患者/医生采用最佳医疗疗法的心力衰竭智能手机应用程序--开发与可用性研究。
Circulation reports Pub Date : 2023-11-29 eCollection Date: 2023-12-08 DOI: 10.1253/circrep.CR-23-0088
Kosuke Hayashi, Kenta Hachiya, Keisuke Yonezu, Naoyuki Otani, Kenichi Furuya, Iori Miura, Takashi Tomoe, Takushi Sugiyama, Yasuaki Wada, Naohiko Takahashi, Naoto Uemura
{"title":"A Heart Failure Smartphone Application That Nudges Patients/Physicians Toward Optimal Medical Therapy - Development and Usability Study.","authors":"Kosuke Hayashi, Kenta Hachiya, Keisuke Yonezu, Naoyuki Otani, Kenichi Furuya, Iori Miura, Takashi Tomoe, Takushi Sugiyama, Yasuaki Wada, Naohiko Takahashi, Naoto Uemura","doi":"10.1253/circrep.CR-23-0088","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0088","url":null,"abstract":"<p><p><b><i>Background:</i></b> The low implementation rate of guideline-directed medical therapy for heart failure (HF) remains a problem worldwide. To address this issue, we hypothesized that a smartphone application (app) based on behavioral economics that nudges physicians and patients towards optimal medical therapy would be a scalable approach. <b><i>Methods and Results:</i></b> The app prototype was developed, and its usability was tested with 5 HF patients in the outpatient setting. Adherence to the app was outstanding, with a high usability rating from the patients. <b><i>Conclusions:</i></b> It appears feasible to further study our app in a larger cohort to evaluate its efficacy.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 12","pages":"459-462"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10700029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative Evaluation of Mitral Valve Calcification Using Electrocardiography-Gated 4-Dimensional Computed Tomography for Safer MitraClip Procedure. 利用心电图门控四维计算机断层扫描术前评估二尖瓣钙化以提高 MitraClip 手术的安全性
Circulation reports Pub Date : 2023-11-28 eCollection Date: 2023-12-08 DOI: 10.1253/circrep.CR-23-0089
Akiko Masumoto, Hiroyuki Yamamoto, Nobuyuki Takahashi, Tetsuari Onishi, Tomofumi Takaya
{"title":"Preoperative Evaluation of Mitral Valve Calcification Using Electrocardiography-Gated 4-Dimensional Computed Tomography for Safer MitraClip Procedure.","authors":"Akiko Masumoto, Hiroyuki Yamamoto, Nobuyuki Takahashi, Tetsuari Onishi, Tomofumi Takaya","doi":"10.1253/circrep.CR-23-0089","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0089","url":null,"abstract":"","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 12","pages":"463-464"},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10700030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telehealth Follow-up Using a Real-Time Electrocardiogram Device Improves Electrocardiogram Monitoring Duration and Patient Satisfaction After Catheter Ablation. 使用实时心电图设备的远程健康随访提高了导管消融后心电图监测时间和患者满意度。
Circulation reports Pub Date : 2023-10-28 eCollection Date: 2023-11-10 DOI: 10.1253/circrep.CR-23-0083
Mitsuru Takami, Koji Fukuzawa, Kunihiko Kiuchi, Hiroyuki Takahara, Kimitake Imamura, Toshihiro Nakamura, Yusuke Sonoda, Kazutaka Nakasone, Kyoko Yamamoto, Yuya Suzuki, Kenichi Tani, Hidehiro Iwai, Yusuke Nakanishi, Mitsuhiko Shoda, Atsushi Murakami, Shogo Yonehara, Ken-Ichi Hirata
{"title":"Telehealth Follow-up Using a Real-Time Electrocardiogram Device Improves Electrocardiogram Monitoring Duration and Patient Satisfaction After Catheter Ablation.","authors":"Mitsuru Takami, Koji Fukuzawa, Kunihiko Kiuchi, Hiroyuki Takahara, Kimitake Imamura, Toshihiro Nakamura, Yusuke Sonoda, Kazutaka Nakasone, Kyoko Yamamoto, Yuya Suzuki, Kenichi Tani, Hidehiro Iwai, Yusuke Nakanishi, Mitsuhiko Shoda, Atsushi Murakami, Shogo Yonehara, Ken-Ichi Hirata","doi":"10.1253/circrep.CR-23-0083","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0083","url":null,"abstract":"<p><p><b><i>Background:</i></b> There is a strong demand for remote monitoring systems to gather health data. This study investigated the safety, usefulness, and patient satisfaction in outpatient care using telehealth with real-time electrocardiogram (ECG) monitoring after catheter ablation. <b><i>Methods and Results:</i></b> In all, 38 patients who underwent catheter ablation were followed up using telehealth. At the 3- and 6-month follow-up, a self-fitted Duranta ECG monitoring device was sent to the patient's home before the online consultation. Patients attached the devices themselves, and the doctors viewed the patients by video chat and performed real-time ECG monitoring. The frequency of hospital visits and the ECG monitoring duration were compared with conventional in-person follow-up data (n=102). The completion rate for telehealth follow-up was 32 of 38 patients (84%). The number of hospital visits during the 6 months was significantly lower with telehealth follow-up than with conventional follow-up (median [interquartile range] 1 [1-1] vs. 5 [3-5]; P<0.0001). However, the ECG monitoring duration was approximately 4-fold longer for the telehealth follow-up (median [interquartile range] 89 [64-117] vs. 24 [0.1-24] h; P<0.0001). No major adverse events were observed during the telehealth follow-up. Patient surveys showed high satisfaction with telehealth follow-up due to reduced hospital visits. <b><i>Conclusions:</i></b> A combination of telehealth follow-up with real-time ECG monitoring increased the ECG monitoring duration and patient satisfaction without any adverse events.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 11","pages":"415-423"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Octogenarians and Nonagenarians in a Contemporary Cardiac Care Unit - Insights From 2,242 Patients Admitted Between 2019 and 2021. 当代心脏护理部门80多岁和90多岁老人的结局——来自2019年至2021年期间入院的2242名患者的见解
Circulation reports Pub Date : 2023-10-18 eCollection Date: 2023-11-10 DOI: 10.1253/circrep.CR-23-0078
Ryosuke Higuchi, Mamoru Nanasato, Yuko Furuichi, Yumiko Hosoya, Go Haraguchi, Morimasa Takayama, Mitsuaki Isobe
{"title":"Outcomes of Octogenarians and Nonagenarians in a Contemporary Cardiac Care Unit - Insights From 2,242 Patients Admitted Between 2019 and 2021.","authors":"Ryosuke Higuchi, Mamoru Nanasato, Yuko Furuichi, Yumiko Hosoya, Go Haraguchi, Morimasa Takayama, Mitsuaki Isobe","doi":"10.1253/circrep.CR-23-0078","DOIUrl":"10.1253/circrep.CR-23-0078","url":null,"abstract":"<p><p><b><i>Background:</i></b> The number of octo- and nonagenarians admitted to cardiac care units (CCUs) has been increasing in the context of an aging society; however, clinical details and outcomes for these patients are scarce. <b><i>Methods and Results:</i></b> Data from 2,242 consecutive patients admitted to the CCU between 2019 and 2021 (age <80 years, 1,390 [62%]; octogenarians, 655 [29%]; nonagenarians, 197 [8.7%]) were reviewed using the in-hospital database for the Tokyo CCU Network. The primary cause of admission was acute coronary syndrome in younger patients and octogenarians (58% and 49%, respectively) and acute heart failure (AHF) in nonagenarians (42%). The proportions of females, underweight, hypertension, atrial fibrillation, myocardial infarction, stroke, previous heart failure, anemia, and malnutrition were higher among octo- and nonagenarians than among younger patients. In-hospital and 1-year mortality rates were greater in octo- and nonagenarians (younger vs. octogenarian vs. nonagenarian, 2.0% vs. 3.8% vs. 5.6% and 4.1% vs. 11.9% vs. 19.0%, respectively). Multivariate analysis revealed that 1-year mortality was associated with octo-/nonagenarian status (odds ratio [OR] 2.24 and 2.64), AHF (OR 2.88), body mass index (OR per 1-kg/m<sup>2</sup> 0.91), and albumin concentration (OR per 1-g/dL 0.27). <b><i>Conclusions:</i></b> Approximately 40% of patients admitted to the CCU were octo- or nonagenarians, and being an octo- or nonagenarian, having AHF, a lower body mass index, and lower albumin concentrations were associated with 1-year mortality after CCU admission.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 11","pages":"430-436"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normal Values of Echocardiographic Right Ventricular Size and Systolic Function Measurements in a Healthy Japanese Population - Subanalysis of the WASE Study. 日本健康人群超声心动图右心室大小和收缩功能测量正常值- WASE研究的亚分析
Circulation reports Pub Date : 2023-10-18 eCollection Date: 2023-11-10 DOI: 10.1253/circrep.CR-23-0076
Naoko Sawada, Koki Nakanishi, Tomoko Nakao, Tatsuya Miyoshi, Masaaki Takeuchi, Federico M Asch, Roberto M Lang, Masao Daimon
{"title":"Normal Values of Echocardiographic Right Ventricular Size and Systolic Function Measurements in a Healthy Japanese Population - Subanalysis of the WASE Study.","authors":"Naoko Sawada, Koki Nakanishi, Tomoko Nakao, Tatsuya Miyoshi, Masaaki Takeuchi, Federico M Asch, Roberto M Lang, Masao Daimon","doi":"10.1253/circrep.CR-23-0076","DOIUrl":"10.1253/circrep.CR-23-0076","url":null,"abstract":"<p><p><b><i>Background:</i></b> Although accurate assessment of right ventricular (RV) morphology and function is clinically important, data regarding reference values for echocardiographic measurements of the right ventricle in the Japanese population are limited. <b><i>Methods and Results:</i></b> The World Alliance Society of Echocardiography (WASE) Normal Values Study was conducted to examine normal echocardiographic values in 15 countries. Using the WASE study database, we analyzed 2-dimensional echocardiographic parameters of RV size and systolic function in 192 healthy Japanese individuals and compared them with those obtained from 153 healthy American individuals. In the Japanese population, the absolute values of RV dimensions were smaller for women than men, although the difference disappeared after the data were adjusted for body surface area. RV dimensions, RV length and RV area were smaller in the elderly, but age did not affect RV systolic function. The absolute value, but not the adjusted value, of RV size tended to be smaller in Japanese than American individuals for both sexes. For men, RV systolic function parameters were lower in the Japanese population. This trend was not seen in women. <b><i>Conclusions:</i></b> The present study identified normal reference values for RV size and systolic function in a healthy Japanese population. Sex, age, and race had a significant impact on RV size; however, this trend was weak for RV systolic function.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 11","pages":"424-429"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Common Antihypertensives in the Growth of Abdominal Aortic Aneurysm at the Presurgical Stage. 常用抗高血压药物在术前腹主动脉瘤生长中的作用。
Circulation reports Pub Date : 2023-10-17 eCollection Date: 2023-11-10 DOI: 10.1253/circrep.CR-23-0071
Toko Mitsui, Yasuko K Bando, Akihiro Hirakawa, Kenji Furusawa, Ryota Morimoto, Eiji Taguchi, Akira Kimura, Haruo Kamiya, Naomichi Nishikimi, Kimihiro Komori, Kazuhiro Nishigami, Toyoaki Murohara
{"title":"Role of Common Antihypertensives in the Growth of Abdominal Aortic Aneurysm at the Presurgical Stage.","authors":"Toko Mitsui, Yasuko K Bando, Akihiro Hirakawa, Kenji Furusawa, Ryota Morimoto, Eiji Taguchi, Akira Kimura, Haruo Kamiya, Naomichi Nishikimi, Kimihiro Komori, Kazuhiro Nishigami, Toyoaki Murohara","doi":"10.1253/circrep.CR-23-0071","DOIUrl":"10.1253/circrep.CR-23-0071","url":null,"abstract":"<p><p><b><i>Background:</i></b> Whether drug therapy slows the growth of abdominal aortic aneurysms (AAAs) in the Japanese population remains unknown. <b><i>Methods and Results:</i></b> In a multicenter prospective open-label study, patients with AAA at the presurgical stage (mean [±SD] AAA diameter 3.27±0.58 cm) were randomly assigned to treatment with candesartan (CAN; n=67) or amlodipine (AML; n=64) considering confounding factors (statin use, smoking, age, sex, renal function), with effects of blood pressure control minimized setting a target control level. The primary endpoint was percentage change in AAA diameter over 24 months. Secondary endpoints were changes in circulating biomarkers (high-sensitivity C-reactive protein [hs-CRP], malondialdehyde-low-density lipoprotein, tissue-specific inhibitor of metalloproteinase-1, matrix metalloproteinase [MMP] 2, MMP9, transforming growth factor-β1, plasma renin activity [PRA], angiotensin II, aldosterone). At 24 months, percentage changes in AAA diameter were comparable between the CAN and AML groups (8.4% [95% CI 6.23-10.59%] and 6.5% [95% CI 3.65-9.43%], respectively; P=0.23]. In subanalyses, AML attenuated AAA growth in patients with comorbid chronic kidney disease (CKD; P=0.04) or systolic blood pressure (SBP) <130 mmHg (P=0.003). AML exhibited a definite trend for slowing AAA growth exclusively in never-smokers (P=0.06). Among circulating surrogate candidates for AAA growth, PRA (P=0.02) and hs-CRP (P=0.001) were lower in the AML group. <b><i>Conclusions:</i></b> AML may prevent AAA growth in patients with CKD or lower SBP, associated with a decline in PRA and circulating hs-CRP.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 11","pages":"405-414"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On-Site Intravascular Ultrasound-Guided Stenting for Bifurcation Lesions With Angiographically Difficulty in Separation. 血管内超声引导支架治疗难以分离的分叉病变。
Circulation reports Pub Date : 2023-09-28 eCollection Date: 2023-10-10 DOI: 10.1253/circrep.CR-23-0075
Mayuka Masuda, Hiroyuki Yamamoto, Akiko Masumoto, Tomofumi Takaya
{"title":"On-Site Intravascular Ultrasound-Guided Stenting for Bifurcation Lesions With Angiographically Difficulty in Separation.","authors":"Mayuka Masuda,&nbsp;Hiroyuki Yamamoto,&nbsp;Akiko Masumoto,&nbsp;Tomofumi Takaya","doi":"10.1253/circrep.CR-23-0075","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0075","url":null,"abstract":"","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"5 10","pages":"403-404"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/4e/circrep-5-403.PMC10561995.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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