Circulation reports最新文献_第6页

Factors Associated With Caregiving Appraisal by Caregivers of Patients With Heart Failure　- A Cross-Sectional Study. 心衰患者照护者对照护评价的相关因素-一项横断面研究。

IF 1.1

Circulation reports Pub Date : 2025-06-21 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-24-0109

Miki Hirano, Akiko Okada, Eiko Moriya, Miyuki Tsuchihashi-Makaya

{"title":"Factors Associated With Caregiving Appraisal by Caregivers of Patients With Heart Failure　- A Cross-Sectional Study.","authors":"Miki Hirano, Akiko Okada, Eiko Moriya, Miyuki Tsuchihashi-Makaya","doi":"10.1253/circrep.CR-24-0109","DOIUrl":"10.1253/circrep.CR-24-0109","url":null,"abstract":"Background: Caregiver support is essential for patients with heart failure to receive continued care at home.Methods and results: This cross-sectional study of 60 heart failure patients and their primary caregivers (consent rate 62.5%) examined the relationship between the caregivers' assessment of caregiving using the Caregiver Reaction Assessment Japanese version and the patients' and caregivers' sociodemographic factors, the patients' physical condition, the caregiving activities, and health-related quality of life assessed using Short Form-8. The results indicated that Short Form-8 scores were inversely associated with positive appraisal of caregiving (β=-0.33; P=0.01). The impact on the schedule of daily living was associated with caregivers' mental health (β=-0.28; P=0.04) and the frequency of practical support related to medical treatment (β=0.25; P=0.05). There were associations between the following: impact on health (2.3±0.9) and caregiver employment (β=-0.27; P=0.03); lack of family support (2.2±0.8) and hours of care per day (β=0.25; P=0.05); and impact on finances (2.3±1.2) and functional health literacy (β=0.25; P=0.05).Conclusions: Evaluating caregiving appraisal and related factors among caregivers of patients with heart failure may lead to effective support for caregivers.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"619-626"},"PeriodicalIF":1.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Utility of the Rotational and Orbital Atherectomy System in the Endovascular Therapy of Severely Calcified Femoropopliteal Lesions. 旋转和轨道动脉粥样硬化切除术系统在血管内治疗严重钙化股腘动脉病变中的临床应用。

IF 1.1

Circulation reports Pub Date : 2025-06-20 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0013

Motoki Yasunaga, Osamu Iida, Taku Toyoshima, Daichi Yoshii, Naoya Kurata, Yusuke Ki, Hitoshi Minamiguchi, Yasuhiro Ichibori, Kei Nakamoto, Naoki Mori, Yoshiharu Higuchi

{"title":"Clinical Utility of the Rotational and Orbital Atherectomy System in the Endovascular Therapy of Severely Calcified Femoropopliteal Lesions.","authors":"Motoki Yasunaga, Osamu Iida, Taku Toyoshima, Daichi Yoshii, Naoya Kurata, Yusuke Ki, Hitoshi Minamiguchi, Yasuhiro Ichibori, Kei Nakamoto, Naoki Mori, Yoshiharu Higuchi","doi":"10.1253/circrep.CR-25-0013","DOIUrl":"10.1253/circrep.CR-25-0013","url":null,"abstract":"Background: Endovascular therapy (EVT) for severely calcified femoropopliteal (FP) lesions in patients with peripheral artery disease (PAD) is challenging. This study evaluates the clinical utility of rotational atherectomy and orbital atherectomy in EVT for such lesions.Methods and results: This single-center retrospective study enrolled 62 consecutive patients with symptomatic PAD (71.0% male; median age 76 years; diabetes 71.0%; hemodialysis 30.6%; chronic limb-threatening ischemia 27.4%) due to severely calcified FP lesions (chronic total occlusion 32.3%; average lesion length 150 mm; Peripheral Arterial Calcium Scoring System classification: grade 1, 6.5%; grade 2, 12.9%; grade 3, 22.6%; and grade 4, 54.8%) who underwent EVT with atherectomy systems. The luminal gain was evaluated using angiography and intravascular ultrasound (IVUS). Quantitative vascular analysis showed stenosis diameters of 86.6% (pretreatment), 48.4% (after atherectomy), and 25.5% (after adjunctive balloon angioplasty). IVUS indicated the minimum lumen area increased from 2.0 mm2 to 8.1 mm2 after atherectomy and 17.8 mm2 after angioplasty (P<0.001). Superficial calcium arcs decreased from 195.9° (141.6, 360) to 158.7° (119.9, 211.2; P<0.001). Procedural success was achieved in all patients. Distal embolization occurred in 7 patients. No major adverse events occurred within 30 days.Conclusions: Atherectomy systems significantly increased lumen dimensions in severely calcified FP lesions by removing superficial calcium without increasing the risk of major complications. However, a notable incidence of distal embolism remains unavoidable.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"670-676"},"PeriodicalIF":1.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological Re-Evaluation of Cardiac Sarcoidosis　- A Case-Based Analysis of 14 Post-Mortem Japanese Hearts. 心脏结节病的形态学再评价——以14例日本人死后心脏为例分析。

IF 1.1

Circulation reports Pub Date : 2025-06-20 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0069

Hiromoto Sone, Hitomi Kera, Kinta Hatakeyama, Junko Nakashima, Takafumi Ogawa, Toshiko Onizuka-Yamochi, Hiroshi Suzuki, Hatsue Ishibashi-Ueda, Taka-Aki Matsuyama

{"title":"Morphological Re-Evaluation of Cardiac Sarcoidosis　- A Case-Based Analysis of 14 Post-Mortem Japanese Hearts.","authors":"Hiromoto Sone, Hitomi Kera, Kinta Hatakeyama, Junko Nakashima, Takafumi Ogawa, Toshiko Onizuka-Yamochi, Hiroshi Suzuki, Hatsue Ishibashi-Ueda, Taka-Aki Matsuyama","doi":"10.1253/circrep.CR-25-0069","DOIUrl":"10.1253/circrep.CR-25-0069","url":null,"abstract":"Background: Cardiac sarcoidosis is a major cause of secondary cardiomyopathy leading to lethal arrhythmias and heart failure; however, identifying specific imaging findings of cardiac sarcoidosis remains a major issue. We re-examined the macroscopic morphology of post-mortem hearts to identify and reconfirm crucial findings for the clinical diagnosis of cardiac sarcoidosis.Methods and results: We examined 14 autopsied hearts from patients who were diagnosed with cardiac sarcoidosis from 2002 to 2019 at several medical institutions in Japan. The cases were classified into 2 groups: ante-mortem diagnosis (Group A, n=8), and post-mortem diagnosis (Group B, n=6). Of the 14 hearts, steroids were only administered in Group A. Seven macroscopic features were re-evaluated in all hearts: (1) epicardial irregularity (n=5); (2) fibrosis in the posterior interventricular junction (n=11); (3) ventricular septum wall thinning (n=9); (4) diffuse left ventricular wall thinning (n=4); (5) ventricular aneurysms (n=3); (6) papillary muscle deformities (n=12); and (7) white colored fibrosis (n=8).Conclusions: This study highlights the underreported macroscopic findings of cardiac sarcoidosis. The 7 features highlight the uniqueness of cardiac sarcoidosis, which warrants recognition of this disease as a distinct pathological entity rather than merely a dilated cardiomyopathy-like secondary cardiomyopathy.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"654-660"},"PeriodicalIF":1.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Outcomes Following Percutaneous Coronary Intervention With Rotational Atherectomy for Severely Calcified Lesions. 经皮冠状动脉介入治疗合并动脉粥样硬化旋转切除术治疗严重钙化病变的远期疗效。

Circulation reports Pub Date : 2025-06-17 eCollection Date: 2025-07-10 DOI: 10.1253/circrep.CR-25-0061

Mikako Kise, Takayuki Ishihara, Naoko Higashino, Takuya Tsujimura, Yosuke Hata, Sho Nakao, Masaya Kusuda, Toshiaki Mano

{"title":"Long-Term Outcomes Following Percutaneous Coronary Intervention With Rotational Atherectomy for Severely Calcified Lesions.","authors":"Mikako Kise, Takayuki Ishihara, Naoko Higashino, Takuya Tsujimura, Yosuke Hata, Sho Nakao, Masaya Kusuda, Toshiaki Mano","doi":"10.1253/circrep.CR-25-0061","DOIUrl":"10.1253/circrep.CR-25-0061","url":null,"abstract":"Background: While severe calcification is associated with unfavorable clinical outcomes, rotational atherectomy (RA) has been used for lesion modification of severely calcified lesions. However, long-term outcomes after percutaneous coronary intervention (PCI) with RA have not yet been fully investigated.Methods and results: We enrolled 301 patients with 334 lesions, which were treated using PCI with RA. The primary outcome was target vessel failure (TVF) defined as a composite of cardiac death (CD), target vessel myocardial infarction (MI), and target vessel revascularization (TVR). The secondary outcome was a major adverse cardiac event (MACE), defined as a composite of CD, MI, TVR, and definite stent thrombosis (ST). In addition, the predictors of TVF were evaluated using Cox proportional hazards regression analysis. The mean follow-up duration was 36.6±27.0 months. The cumulative incidence rates of TVF were 20.6%, 29.1%, and 32.5% at 2, 4, and 6 years, respectively. The 6-year cumulative incidence of MACE was 32.9%. The independent predictors of TVF were hemodialysis (hazard ratio 3.22 [95% confidential interval 1.91-5.43]) and diabetes (2.10 [1.24-3.57]).Conclusions: The 6-year TVF rate after RA reached over 30%. Hemodialysis and diabetes significantly impacted the long-term outcome. The strategy of PCI with RA should be carefully selected for severely calcified lesions in patients with hemodialysis and diabetes.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 7","pages":"528-534"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled Nutritional Status Scores and Bleeding Events in Lower Extremity Arterial Disease　- 3-Year Clinical Outcome Study. 控制营养状况评分和下肢动脉疾病出血事件- 3年临床结果研究。

IF 1.1

Circulation reports Pub Date : 2025-06-17 eCollection Date: 2025-08-08 DOI: 10.1253/circrep.CR-25-0076

Takafumi Fujita, Makoto Sugihara, Kaori Mine, Yuta Kato, Tetsuo Hirata, Tadaaki Arimura, Yuhei Shiga, Takashi Kuwano, Shin-Ichiro Miura

{"title":"Controlled Nutritional Status Scores and Bleeding Events in Lower Extremity Arterial Disease　- 3-Year Clinical Outcome Study.","authors":"Takafumi Fujita, Makoto Sugihara, Kaori Mine, Yuta Kato, Tetsuo Hirata, Tadaaki Arimura, Yuhei Shiga, Takashi Kuwano, Shin-Ichiro Miura","doi":"10.1253/circrep.CR-25-0076","DOIUrl":"10.1253/circrep.CR-25-0076","url":null,"abstract":"Background: Malnutrition has been associated with poor prognosis in patients with lower extremity arterial disease (LEAD). Malnutrition can influence adverse bleeding events in patients with coronary artery disease. However, the association between bleeding events and malnutrition in patients with LEAD remains unclear. Therefore, this study evaluated the association between nutritional screening with controlled nutritional status (CONUT) score and bleeding events in patients with LEAD.Methods and results: This single-center retrospective observational study included 297 patients with LEAD who underwent endovascular therapy between January 2016 and December 2021. The high CONUT group was compared with the low CONUT group. The primary outcome was freedom from bleeding events, which was defined as Bleeding Academic Research Consortium type 3 or type 5. The high CONUT group had significantly higher cumulative bleeding events than the low CONUT group (log-rank P value <0.0001). Univariate analysis revealed that patients with a high CONUT score (hazard ratio [HR] 4.48; 95% confidence Interval [CI] 1.92-10.4; P=0.0005), chronic limb-threatening ischemia (HR 5.30; 95% CI 2.07-13.5; P=0.0005), non-ambulatory (HR 3.12; 95% CI 1.11-8.77; P= 0.03), and chronic kidney disease on hemodialysis (HR 4.01; 95% CI 1.72-9.33; P=0.001) had significantly more bleeding events than those with low CONUT scores.Conclusions: A high CONUT score at admission is closely associated with bleeding events in patients with LEAD.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 8","pages":"677-684"},"PeriodicalIF":1.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing Effects of Tafamidis in Controlling Left Ventricular and Left Atrial Strains in Patients With Wild-Type Transthyretin Amyloid Cardiomyopathy. 他法非地对野生型转甲状腺蛋白淀粉样心肌病患者左室和左房负荷的控制效果比较。

Circulation reports Pub Date : 2025-06-14 eCollection Date: 2025-07-10 DOI: 10.1253/circrep.CR-25-0066

Chisa Eguchi, Hiroaki Kawano, Rosy Haruna Nishizawa, Tsuyoshi Yoshimuta, Chikara Ohno, Sanae Kojima, Takako Minami, Daisuke Sato, Masamichi Eguchi, Shinji Okano, Satoshi Ikeda, Mitsuharu Ueda, Koji Maemura

{"title":"Comparing Effects of Tafamidis in Controlling Left Ventricular and Left Atrial Strains in Patients With Wild-Type Transthyretin Amyloid Cardiomyopathy.","authors":"Chisa Eguchi, Hiroaki Kawano, Rosy Haruna Nishizawa, Tsuyoshi Yoshimuta, Chikara Ohno, Sanae Kojima, Takako Minami, Daisuke Sato, Masamichi Eguchi, Shinji Okano, Satoshi Ikeda, Mitsuharu Ueda, Koji Maemura","doi":"10.1253/circrep.CR-25-0066","DOIUrl":"10.1253/circrep.CR-25-0066","url":null,"abstract":"Background: Although tafamidis is used to treat patients with transthyretin amyloid cardiomyopathy (ATTR-CM), its specific effects on cardiac function remain unclear. Thus, this study aimed to investigate the effect of tafamidis on left atrial (LA) and left ventricular (LV) functions using speckle-tracking echocardiography after 1.5 years of treatment in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM).Methods and results: We included 27 patients (mean age, 76 years) with ATTRwt-CM confirmed by biopsy. We analyzed LV and LA strains using 2-dimensional speckle-tracking echocardiography and compared these parameters before and after a 1.5-year follow up between 20 patients with and 7 patients without tafamidis treatment. Echocardiography speckle tracking examination showed no significant changes in global longitudinal strain (GLS) or LA reservoir strain (LASr) in patients with ATTRwt-CM after 1.5 years of tafamidis treatment. However, significant deterioration of GLS (-9.3 [-11, -7.4] to -8.0 [-9, -6.7]; P=0.0381) and LASr (11 [6, 16] to 6 [5, 11]; P=0.0074) were observed in patients with ATTRwt-CM without tafamidis.Conclusions: The LA and LV functions of patients with ATTRwt-CM treated with tafamidis were more favorable than those of untreated patients.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 7","pages":"562-567"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Extracorporeal Cardiopulmonary Resuscitation and Prognosis in the Short and Long Term in Patients With Acute Myocardial Infarction Complicated by Refractory Cardiac Arrest. 急性心肌梗死合并难治性心脏骤停患者体外心肺复苏与短期和长期预后的关系。

IF 1.1

Circulation reports Pub Date : 2025-06-11 eCollection Date: 2025-07-10 DOI: 10.1253/circrep.CR-25-0071

Shumpei Kosugi, Yasunori Ueda, Kuniyasu Ikeoka, Haruya Yamane, Takuya Ohashi, Takashi Iehara, Kazuho Ukai, Taro Takeuchi, Masayuki Nakamura, Tatsuhisa Ozaki, Tsuyoshi Mishima, Haruhiko Abe, Koichi Inoue, Yasushi Matsumura

{"title":"Association Between Extracorporeal Cardiopulmonary Resuscitation and Prognosis in the Short and Long Term in Patients With Acute Myocardial Infarction Complicated by Refractory Cardiac Arrest.","authors":"Shumpei Kosugi, Yasunori Ueda, Kuniyasu Ikeoka, Haruya Yamane, Takuya Ohashi, Takashi Iehara, Kazuho Ukai, Taro Takeuchi, Masayuki Nakamura, Tatsuhisa Ozaki, Tsuyoshi Mishima, Haruhiko Abe, Koichi Inoue, Yasushi Matsumura","doi":"10.1253/circrep.CR-25-0071","DOIUrl":"10.1253/circrep.CR-25-0071","url":null,"abstract":"Background: Although extracorporeal cardiopulmonary resuscitation (ECPR) is expected to improve outcomes in patients with cardiac arrest (CA), its impact on prognosis in acute myocardial infarction (MI) patients complicated by CA remains unclear. This study aimed to investigate the short- and long-term effects of ECPR on prognosis in these patients.Methods and results: This single-center, retrospective study analyzed consecutive MI patients. Patients were classified into 3 groups: CA requiring ECPR (ECPR group); CA achieving return of spontaneous circulation without ECPR (CCPR group); and without CA (non-CA group). The primary endpoint was 30-day mortality, while long-term all-cause mortality, cardiovascular death, and major adverse cardiovascular events were evaluated among discharged patients. Of the 625 patients analyzed, 57 were in the ECPR group, 104 in the CCPR group, and 464 in the non-CA group. Multivariable analysis revealed that the ECPR group had a significantly higher prevalence of 30-day mortality than the CCPR group (adjusted hazard ratio [HR] 3.99; 95% confidence interval [CI] 2.23-7.13) and the non-CA group (HR 43.48; 95% CI 19.70-95.92). However, there were no significant differences in long-term outcomes among the 3 groups.Conclusions: The 30-day mortality was worse in the ECPR group than in the CCPR or non-CA groups. In contrast, the long-term prognosis was comparable among discharged patients, regardless of the presence of CA or the need for ECPR.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 7","pages":"554-561"},"PeriodicalIF":1.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Further Development of Cardiovascular Intensive Care Rehabilitation　- The Required Role of Nurses in Cardiovascular Intensive Care Rehabilitation. 心血管重症康复的进一步发展——护士在心血管重症康复中的作用。

Circulation reports Pub Date : 2025-06-06 eCollection Date: 2025-07-10 DOI: 10.1253/circrep.CR-25-0068

Yuya Tamaki, Kazuki Gushiken, Terumi Hirata, Yoshito Arasaki, Morikuni Wakugawa, Shuichiro Ikemiya, Haruno Nagata

引用次数: 0

Advancing Scientific Cardiac Rehabilitation　- Retrospect and Prospect. 推进心脏康复科学——回顾与展望。

IF 1.1

Circulation reports Pub Date : 2025-06-04 eCollection Date: 2025-07-10 DOI: 10.1253/circrep.CR-25-0065

Yoichi Goto

{"title":"Advancing Scientific Cardiac Rehabilitation　- Retrospect and Prospect.","authors":"Yoichi Goto","doi":"10.1253/circrep.CR-25-0065","DOIUrl":"10.1253/circrep.CR-25-0065","url":null,"abstract":"On the 30th anniversary of the founding of the Japanese Association of Cardiac Rehabilitation in 1995, this article provides an overview of the past and future of cardiac rehabilitation (CR) as science. The development of CR thus far has undoubtedly been supported not only by clinical needs but also by numerous pieces of scientific evidence regarding its effectiveness. In the first part of this article, I aim to scrutinize past evidence on CR scientifically, because all evidence must be critically examined. In the latter part, I will look ahead to the future of CR. Recently, there has been a rapid increase in very elderly frail patients with multiple comorbidities. In the near future, treatment for these patients will not be completed with acute-phase interventions targeting a single organ, and hence, patient outcome goals are expected to shift from improving survival prognosis to improving physical activity capacity and quality of life, indicating a growing need for CR like never before. Given the current rise in patients in the area where evidence is lacking, a new evidence-based CR that is not simply an extension of traditional practices is required. Taking into account the changes in the times, we must steadfastly pursue scientific CR by creating new evidence.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 7","pages":"500-507"},"PeriodicalIF":1.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of Cardiovascular Prognostic Value of Endothelial Function Tests by Repeated Measurements. 通过重复测量内皮功能试验提高心血管预后价值。

IF 1.1

Circulation reports Pub Date : 2025-06-03 eCollection Date: 2025-07-10 DOI: 10.1253/circrep.CR-25-0042

Nobuyuki Masaki, Yuko Higashimura, Bonpei Takase

{"title":"Improvement of Cardiovascular Prognostic Value of Endothelial Function Tests by Repeated Measurements.","authors":"Nobuyuki Masaki, Yuko Higashimura, Bonpei Takase","doi":"10.1253/circrep.CR-25-0042","DOIUrl":"10.1253/circrep.CR-25-0042","url":null,"abstract":"Background: The clinical significance of monitoring endothelial function in predicting cardiovascular events has not yet been fully explored.Methods and results: Patients with diabetes or hypertension were enrolled in this study. Three flow-mediated dilation (FMD) and 2 EndoPAT reactive hyperemia index (RHI) were measured periodically in 3 years at 1.5-year intervals. Patients were followed up for 10 years after the examination period. In the FMD study, 136 patients were classified as those with consistently good endothelial function, as defined by FMD >7% on 3 occasions (n=33), and those without (n=103). In multivariate Cox analysis, patients who maintained high FMD had less thromboembolic major cardiovascular events or angina pectoris (n=24; hazard ratio [HR] 0.216; 95% confidence interval [CI] 0.047-0.985; P=0.048). In the EndoPAT study, 120 patients were classified as those with consistently abnormal endothelial function, as defined by RHI <1.67 on 2 occasions (n=34), and those without (n=86). There were 9 all-cause deaths and 10 hospitalizations for heart failure. Patients with consistent RHI <1.67 had a higher mortality (HR 10.794; 95% CI 1.520-76.629; P=0.017) and incidence of heart failure (HR 5.356; 95% CI 1.301-22.052; P=0.020).Conclusions: Repeated measurements improved the predictive performance and revealed differences between FMD and EndoPAT RHI, which were better at predicting coronary events and heart failure, respectively.","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 7","pages":"568-577"},"PeriodicalIF":1.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0