Turk psikiyatri dergisi = Turkish journal of psychiatry最新文献

{"title":"Early Maladaptive Schemas and Penetration Cognitions in Genito-Pelvic Pain/Penetration Disorder: A Multicenter Study.","authors":"Sinay Önen, Gülin Özdamar Ünal, Memduha Aydin","doi":"10.5080/u27894","DOIUrl":"10.5080/u27894","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the relationships between early maladaptive schemas, vaginal penetration-related cognitions, and sexual functioning in women diagnosed with Genito- Pelvic Pain/Penetration Disorder (GPPPD), compared with a control group.</p><p><strong>Method: </strong>This cross-sectional, multicenter study included 100 women diagnosed with GPPPD and 120 volunteer women in whom no sexual dysfunction was detected. Participants completed the Structured Clinical Interview for DSM-5 (SCID-5), the Young Schema Questionnaire Short Form-3 (YSQ-SF3), the Vaginal Penetration Cognitions Questionnaire (VPCQ), and the Golombok-Rust Inventory of Sexual Satisfaction (GRISS). Group differences were analyzed using the Mann-Whitney U test, associations were assessed with Spearman correlation analysis, and a multivariable logistic regression analysis was also performed.</p><p><strong>Results: </strong>Compared with the control group, women diagnosed with GPPPD had significantly higher levels of negative vaginal penetration cognitions and early maladaptive schemas, particularly pessimism, approval-seeking, defectiveness, punitiveness, vulnerability to harm, and unrelenting standards (p&lt;0.001). In addition, genital incompatibility cognitions were associated with pessimism and self-sacrifice schemas, whereas catastrophic and pain-related cognitions were associated with the approval-seeking schema. In the logistic regression analysis, unemployment, higher age at marriage, catastrophic and pain-related cognitions, and genital incompatibility cognitions were independently associated with the presence of GPPPD.</p><p><strong>Conclusion: </strong>Women diagnosed with GPPPD were found to have more negative sexual cognitions and more pronounced maladaptive schema patterns. The findings suggest that evaluating negative penetrationrelated cognitions together with early maladaptive schemas may be clinically useful in GPPPD.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"170-179"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Psychiatric Perspective on Bariatric Surgery and Obesity: What Do Psychiatrists Think and Do? A Cross-Sectional Survey Study.","authors":"Yasemin Koçyiğit, Duygu Çap, Şule Biçakci Ay","doi":"10.5080/u27725","DOIUrl":"10.5080/u27725","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the knowledge levels, attitudes, and referral practices of psychiatrists regarding obesity and bariatric surgery.</p><p><strong>Method: </strong>In this descriptive, cross-sectional study, a questionnaire was administered to 169 psychiatrists and 75 psychiatry residents across Turkiye. The questionnaire included sections on demographic characteristics, clinical approaches to obesity, sources of information about bariatric surgery, referral tendencies, psychiatric contraindications, and knowledge regarding the postoperative period. Data were collected through a structured questionnaire created by the researchers and administered online via Google Forms.</p><p><strong>Results: </strong>Most participants were able to define obesity (82.8%) correctly, but a large proportion reported that they do not routinely record patients&rsquo; height and weight in clinical practice (71.3%). It was reported by 78.7% of the participants that they had conducted at least one psychiatric evaluation prior to bariatric surgery, and 69.7% stated that they would refer patients for surgery when appropriate indications were present. Psychotic disorders, substance use disorders, and eating disorders were most frequently considered as contraindications, while anxiety and personality disorders were generally not regarded as contraindications. The level of knowledge regarding the conditions that need to be considered after surgery varied, with predominant lack of knowledge regarding nutritional management. Approximately one-third of the participants reported that they do not have sufficient knowledge about obesity treatment.</p><p><strong>Conclusion: </strong>Although the general attitudes towards bariatric surgery are positive, there were differences in levels of knowledge and some barriers affecting referral to surgery were evident. These findings highlight the need to develop educational programs aimed at enhancing psychiatrists&rsquo; knowledge and skills related to bariatric surgery.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"9-19"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Role of FDG-PET in Dementias Presenting with Language and Behavioral Symptom.","authors":"Ezgi Yetim, Yavuz Ayhan, M Alperen Yildirim, Bilge Volkan-Salanci, Eser Lay Ergün, Gül Yalçin Çakmakli","doi":"10.5080/u27876","DOIUrl":"10.5080/u27876","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the diagnostic contribution of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in neurodegenerative dementias presenting with language-predominant symptoms, with or without accompanying behavioral changes, and to evaluate the correspondence between PET-derived metabolic patterns and cerebrospinal fluid (CSF) biomarkers.</p><p><strong>Methods: </strong>Sixteen patients with language-predominant onset were categorized into two groups: Alzheimer&rsquo;s disease (AD) spectrum (n=8) and the frontotemporal lobar degeneration (FTLD) spectrum (n=8). All participants underwent clinical evaluation, neuropsychological testing, and FDG-PET imaging. Cerebrospinal fluid biomarkers [Amyloid Beta (A&beta;42), total tau, and phosphorylated tau] were analyzed in eligible individuals (n=6). The two groups were compared across demographic, clinical, and neuroimaging parameters.</p><p><strong>Results: </strong>FDG-PET revealed pronounced posterior temporoparietal hypometabolism in AD-spectrum patients, whereas FTLD-spectrum patients demonstrated frontal, insular, and anterior temporal metabolic involvement. Cerebrospinal fluid biomarker profiles consistently supported Alzheimer-type pathology among AD-spectrum cases. In the FTLD group, one patient exhibited borderline-low A&beta;42; however, the corresponding FDG-PET pattern was characteristic of FTLD.</p><p><strong>Conclusion: </strong>FDG-PET demonstrates a supportive role in differentiating AD from FTLD among patients presenting with language-predominant neurodegenerative syndromes. In scenarios where CSF biomarkers are unavailable or yield borderline values, FDG-PET-based metabolic signatures may offer additional guidance and can contribute to strengthening multimodal diagnostic frameworks in geropsychiatry settings.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Visual Integration, Social Cognition, and Symptoms in Schizophrenia: An Eye-Tracking Study.","authors":"Emine Nur Corum, Muammer Corum, Cumhur Tas","doi":"10.5080/u27715","DOIUrl":"10.5080/u27715","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the associations between eye movement patterns, visual contour integration, social cognitive abilities, and symptom severity in individuals diagnosed with schizophrenia.</p><p><strong>Method: </strong>The study included 40 clinically stable patients with schizophrenia. Eye movements were recorded using an eye-tracking system during a free-viewing paradigm. Visual integration was evaluated with the Jittered Orientation Visual Integration (JOVI) task, while social cognition was assessed using the Reading the Mind in the Eyes Test and the Hinting Task. Symptom severity was measured with the PANSS. Data were analyzed using Pearson correlation coefficients and repeated measures analysis of variance.</p><p><strong>Results: </strong>Positive symptom severity was positively correlated with increased fixation counts and faster path velocity in social contexts. Conversely, social cognition was negatively correlated with fixation duration and saccadic velocity during face exploration. Participants exhibited significantly lower fixation counts when viewing socially relevant images. Additionally, shorter saccade length and slower path velocity were observed during face viewing. However, no significant relationship was found between eye movements and contour integration.</p><p><strong>Conclusion: </strong>This study demonstrates that eye movement characteristics in schizophrenia may be significantly associated with social cognition and symptom severity. Although causal inferences cannot be drawn due to the cross-sectional design, the findings help clarify inconsistencies in the literature and partially address gaps regarding eye movement research. Furthermore, the study provides valuable insights for the development of eye movement&ndash;based assessment and intervention approaches in clinical practice.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"30-37"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turkish Adaptation of the Clinical Perfectionism Questionnaire: A Psychometric Evaluation in Clinical and Non-Clinical Samples.","authors":"Yağmur Sever Fidan, Arda Kizilsert, Nazmiye İlayda Dişpinar Usta, Nisa Parlayici Koçak, Sümeyye Yasemin Çalli, Cansu Özçeri, Selin Uslu Alihanoğlu, Enes Okan, Mihriban Albayrak, Ömer Aydemir","doi":"10.5080/u27873","DOIUrl":"10.5080/u27873","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the validity and reliability of the Turkish version of the Clinical Perfectionism Questionnaire (CPQ-TR) in clinical and non-clinical samples.</p><p><strong>Method: </strong>This cross-sectional study included 63 clinical participants (Obsessive&ndash;Compulsive Disorder and Major Depressive Disorder) and 148 non-clinical participants. The scale adaptation was conducted using a translation&ndash;back translation procedure. Confirmatory factor analysis and internal consistency analyses were performed. Convergent and concurrent validity were examined through correlations with the Frost Multidimensional Perfectionism Scale (FMPS), Depression Anxiety Stress Scales&ndash;21 (DASS&ndash;21), and the Yale&ndash;Brown Obsessive Compulsive Scale (Y-BOCS).</p><p><strong>Results: </strong>The internal consistency of the original 12-item CPQ-TR was found to be at a borderline level (Cronbach&rsquo;s &alpha;=0.677); following the removal of Items 2 and 8, the Cronbach&rsquo;s alpha coefficient of the resulting 10-item form increased to 0.76. Confirmatory factor analysis indicated limited support for a unidimensional factor structure. The CPQ-TR showed strong correlations with the FMPS (r=0.593) and moderate correlations with the Y-BOCS and DASS-21 (r=0.30&ndash;0.35). Participants with Obsessive&ndash;Compulsive Disorder had significantly higher CPQ scores compared to those with Major Depressive Disorder (p=0.018) and healthy controls (p &lt;0.001).</p><p><strong>Conclusion: </strong>The findings indicate that the 12-item CPQ-TR demonstrates borderline internal consistency but remains a valid instrument for assessing clinical perfectionism. The 10-item version appears to be a more psychometrically robust option for use in both research and clinical settings.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotherapy Experiences within Multidisciplinary Care for Functional Neurological Symptom Disorder: A Qualitative Study.","authors":"Talat Demirsöz","doi":"10.5080/u27815","DOIUrl":"10.5080/u27815","url":null,"abstract":"<p><strong>Objective: </strong>Functional Neurological Symptom Disorder (FNSD) is a complex neuropsychiatric condition associated with significant disability and shaped by the interaction of biological, psychological, and social processes. Although clinical recognition of FNSD has increased, patients&rsquo; subjective experiences of psychotherapy within multidisciplinary treatment remain insufficiently examined. This study aimed to qualitatively explore psychotherapy experiences of individuals diagnosed with FNSD who received short-term cognitive behavioral therapy (CBT) as part of a multidisciplinary treatment program.</p><p><strong>Method: </strong>Semi-structured online interviews were conducted with 12 patients diagnosed with functional movement disorders who had completed a multidisciplinary inpatient treatment program. Interviews were audio-recorded, transcribed verbatim, and analyzed using thematic analysis to identify recurrent patterns across the narratives.</p><p><strong>Results: </strong>Patients described therapeutic change across four domains: reduced symptom burden, improved emotional regulation, shifts in illness-related perspectives, and increased behavioral engagement in daily functioning. Change was primarily attributed to three domains: (i) the therapeutic relationship and the psychologically safe treatment environment, (ii) individual readiness and active participation in therapy, and (iii) structured cognitive, behavioral, and experiential techniques. Nevertheless, variability in outcomes was evident, as some patients reported persistent symptoms and ongoing emotional challenges.</p><p><strong>Conclusion: </strong>Psychotherapy experiences in FNSD are not limited to symptom reduction. Alongside improvement, multidimensional experiences such as increased self-awareness, changes in how they understand and interpret their experiences, and re-engagement in daily life were also reported. These findings provide clinically meaningful insights into how therapeutic change is experienced within psychotherapy for FNSD and the factors to which this change is attributed by patients.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"38-48"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of the Turkish version of theWender-Reimherr Adult Attention Deficit Disorder Scale.","authors":"Selin Karakaya, İrem Akyol Ertekin, Burçin Çolak, Bedriye Öncü","doi":"10.5080/u27842","DOIUrl":"10.5080/u27842","url":null,"abstract":"<p><strong>Objective: </strong>The primary aim of this study was to evaluate the validity and reliability of the Turkish version of the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS).</p><p><strong>Method: </strong>The study included 146 individuals diagnosed with attentiondeficit/ hyperactivity disorder (ADHD) and 86 healthy controls (ADHD group: age=24.46&plusmn;5.82; control group: age=24.91&plusmn;2.21). In addition to the WRAADDS, the Adult ADD/ADHD DSM-IV-Based Diagnostic and Assessment Scale, the Wender Utah Rating Scale (WURS), and the Hospital Anxiety and Depression Scale (HADS) were administered.</p><p><strong>Results: </strong>The ADHD group showed significantly higher total and subscale scores on the WRAADDS compared to the control group (p &lt;0.001). Confirmatory factor analysis indicated that the original model demonstrated good fit (&chi;&sup2;=34.392, df=13, p=0.001). Under Factor 1, the dimensions of inattention and disorganization were included, whereas hyperactivity/restlessness, temper, affective lability, emotional overreactivity, and impulsivity were included under Factor 2. In the internal consistency analysis, Cronbach&rsquo;s alpha coefficients were 0.97 for Factor 1 and 0.59 for Factor 2, respectively. The WRAADDS total score showed significant positive correlations with the total scores of other ADHD scales (p &lt;0.01). No significant correlations were found between WRAADDS total score and the anxiety or depression subscales of the HADS (p&gt;0.05).</p><p><strong>Conclusion: </strong>The Turkish version of the WRAADDS is a psychometrically valid and reliable instrument that comprehensively assesses adult ADHD.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"103-113"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Persistence, and Severity of 12-month and 30-day DSM-5 Disorders in the Turkish World Mental Health Survey.","authors":"Cengiz Kiliç, Bedirhan Üstün, Özlem Şeyda Uluğ, Sertaç Ak, Mahir Ulusoy, Songül Kamişli, Özge Karadağ, Emine Eren Koçak, Semra Ulusoy Kaymak, Adam Zhang, Michael Y Ni, Shiyi Wu, Ronald C Kessler","doi":"10.5080/u27855","DOIUrl":"10.5080/u27855","url":null,"abstract":"<p><strong>Objective: </strong>No national mental health survey was conducted in T&uuml;rkiye in the last 30 years. We implemented such a survey in a representative sample of 1.790 adults in the Turkish household population using the World Mental Health Initiative Composite International Diagnostic Interview for DSM-5 (CIDI-5). The current report presents data on 12-month and 30-day prevalence, persistence, severity and sociodemographic correlates of disorders in this Turkish World Mental Health (WMH) Survey.</p><p><strong>Methods: </strong>Adults in a nationally representative sample of 4.067 Turkish households were selected for interview in October 2019. Fieldwork ended prematurely on March 17, 2020, due to COVID-19 pandemic travel restrictions. The 1.790 interviews completed as of that date represent a survey cooperation rate of 44.0% and a survey response rate of 25.6%.</p><p><strong>Results: </strong>The 12-month and 30-day prevalences of any DSM-5/CIDI disorder were 23.9% and 18.3%, respectively. Anxiety disorders (17.2%) were the most common class of disorders followed by mood disorders (12.4%). Most profiles were either severe (32.8%) or moderate (43.8%). Anxiety and mood disorders were more common among females than males, while externalizing disorders were more common among males than females. Overall disorder prevalence was associated with being female, younger age and low education.</p><p><strong>Conclusion: </strong>Nearly 1 in 4 Turkish adults meet criteria for one or more common 12-month DSM-5 disorders. These results underscore the need for improved mental health services for vulnerable groups and for longitudinal research to understand the mental health effects of stressors such as the COVID-19 pandemic, forced migration, or the recent earthquakes.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"180-191"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Concept of Social Cognition and the Instruments Used to Assess It.","authors":"Talat Demirsöz","doi":"10.5080/u27988","DOIUrl":"10.5080/u27988","url":null,"abstract":"<p><p>Dear Editor, I read with great interest the article by Ko&ccedil;yiğit and colleagues (2025), titled &ldquo;Psychometric Properties of Turkish Instruments Assessing Social Cognition in Psychiatry and Neurology: A Systematic Review.&rdquo; This systematic review provides a comprehensive review of the social cognition measures available in Turkish for use in psychiatric and neurological conditions and fills an important gap in the literature. In particular, the review highlights the limited number of instruments assessing social perception and the insufficient psychometric evidence available for many existing measures.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"258-259"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clozapine-Induced Myocarditis in Huntington's Disease: Case Report.","authors":"Nur Özgedik Turhan","doi":"10.5080/u27742","DOIUrl":"10.5080/u27742","url":null,"abstract":"<p><p>Huntington&rsquo;s disease (HD) is an autosomal dominant neurodegenerative disease. Its clinical presentation is primarily characterized by motor dysfunction, cognitive decline, and a broad spectrum of neuropsychiatric symptoms. Common psychiatric manifestations of HD include mood and anxiety disorders as well as behavioral and personality changes. Psychosis is relatively rare. Clozapine may be used for HD with psychosis because of its low extrapyramidal side effect profile. However, clozapine administration has been associated with rare but potentially fatal adverse effects, such as agranulocytosis and myocarditis. Clozapine-induced myocarditis is a severe complication that typically emerges within the first weeks of treatment and can lead to cardiovascular collapse if not recognized early. Although cardiac autonomic dysregulation and basal cardiac stress induced by mutant huntingtin (mHTT) protein accumulation are recognized in patients with Huntington&rsquo;s disease (HD), data regarding clozapine toxicity within this specific context remain limited. This case report presents a 51-year-old male patient who developed acute myocarditis during clozapine treatment initiated for psychotic symptoms arising in the context of HD. Following the discontinuation of clozapine, the patient was referred for cardiological monitoring. Throughout this paper, we will discuss the diagnostic process of myocarditis&mdash;a rare but potentially life-threatening complication of clozapine&mdash;and potential contributing factors. This case highlights the vital importance of early cardiac monitoring during clozapine use, particularly in psychiatric conditions accompanied by neurodegenerative processes. Keywords: Case report, chorea, clozapine, Huntington&rsquo;s disease, myocarditis, psychosis.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"49-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}