症状维度和精神病风险因素与首发精神病患者功能之间的关系:为期六个月的前瞻性研究

Sakine Aktaş, Umut Kırlı
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引用次数: 0

摘要

研究目的本研究旨在评估不同症状维度和精神病风险因素的严重程度与首次发病精神病(FEP)患者在6个月随访期内的整体功能水平之间的关联:方法:在6个月的随访期内,对32名因FEP住院的患者的精神病症状维度(阳性、阴性、抑郁、躁狂、注意力和其他认知能力)、社会人口学特征和环境风险因素(酒精-药物使用、童年创伤、当前生活压力事件)进行了前瞻性评估。采用线性回归或重复测量方差分析法分析了这些变量与这些患者的纵向功能全面评估(GAF)得分之间的关系:结果:阳性、阴性、抑郁和躁狂维度的严重程度均有所降低(p 结论:躁狂症患者的病程稳定,预后良好:结论:FEP 患者的注意力和其他类型的认知功能具有显著的稳定过程和预后价值。对 FEP 患者使用酒精和药物的干预应成为日常实践的一部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between Symptom Dimensions and Psychosis Risk Factors with Functioning in First Episode Psychosis: A Six Months Prospective Study.

Objective: This study aims to assess the associations of the severity of different symptom dimensions and psychosis risk factors with the overall functioning levels in first-episode psychosis (FEP) patients over a 6-month follow-up period.

Method: Psychosis symptom dimensions (positive, negative, depression, mania, attention and other cognitive), sociodemographic characteristics and environmental risk factors (alcohol-substance use, childhood traumas, current stressful life events) were prospectively assessed in 32 patients who were hospitalized for FEP during the six-month follow-up period. The associations of these variables with the longitudinal Global Assessment of Functioning (GAF) scores of these patients were analyzed using linear regression or repeated measures ANOVA.

Results: The severity of positive, negative, depression and mania dimensions reduced (p<0.001) during the follow-up period, while no significant change was found in Stroop interference effect scores (F=0.4, p=0.53). FEP patients with substance or alcohol use had significantly worse functioning during the follow-up period (F=11.2, p=0.001; F=5.3, p=0.02, respectively), and those patients' functioning improved significantly less (F=10.0, p=0.002; F=4.3; p=0.04, respectively). Stroop test performance detected at the first month of the follow-up period significantly predicted the final general functioning scores of the follow-up [Stroop test word reading time (sec): B=-0.58 (-1.13-0.03); color telling speed (sec): B=-0.35 (-0.59-0.1); interference effect: B=-0.28 (-0.57-0.01)].

Conclusion: The stable course and prognostic value of attention and other types of cognitive functioning in FEP patients is remarkable. Interventions for alcohol-substance use in FEP patients should be a part of routine practice.

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