Turk psikiyatri dergisi = Turkish journal of psychiatry最新文献

{"title":"Prenatal Hormonal Markers in Neurodevelopment: The 2D:4D Digit Ratio in Children with Tic Disorders","authors":"Burçin Şeyda Karaca, Gonca Özyurt","doi":"10.5080/u27834","DOIUrl":"10.5080/u27834","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the association between tic disorders in children and adolescents and the 2D:4D digit ratio (the ratio of index to ring finger lengths), a widely recognized indirect marker of prenatal hormonal exposure. Given the higher prevalence of tic disorders among males, we assessed whether 2D:4D ratios are related to both the presence and severity of tic disorders.</p><p><strong>Methods: </strong>This observational, cross-sectional study included 57 children and adolescents diagnosed with tic disorders according to DSM-5 criteria and 52 age and sex-matched healthy controls. The lengths of the second (2D) and fourth (4D) digits on both hands were measured using digital calipers, and 2D:4D ratios were calculated accordingly. Tic severity was evaluated using the Yale Global Tic Severity Scale (YGTSS). Statistical analyses included group comparisons, correlation analyses, and logistic regression models.</p><p><strong>Results: </strong>The tic disorder group exhibited significantly shorter absolute 2D and 4D finger lengths bilaterally compared to healthy controls. With respect to digit ratios, the right-hand 2D:4D ratio was significantly higher in the tic disorder group compared to controls (p &lt;0.01), while no significant difference was observed for the left-hand 2D:4D ratio. No significant correlations were identified between rightor left-hand 2D:4D ratios and total or subscale scores of the YGTSS. Logistic regression analysis demonstrated that an increase in the righthand 2D:4D ratio was inversely associated with the likelihood of a tic disorder diagnosis, whereas age and sex were not significant contributors to the model.</p><p><strong>Conclusions: </strong>These findings reveal pronounced group differences in absolute finger lengths between children and adolescents with tic disorders and healthy controls; however, 2D:4D ratios were not directly associated with tic severity. The results suggest that the 2D:4D ratio may be more appropriately considered a supportive biological marker reflecting neurodevelopmental vulnerability, rather than a robust or specific clinical indicator for tic disorders.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"67-76"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Anxiety in Patients Undergoing Elective Surgery During a Healthcare Crisis: A Referral Hospital Experience.","authors":"Maria Mermiri, Maria P Ntalouka, Alexandros Brotis, Athanasios Chatzis, Ioanna Vatsiou, Anastasia Michou, Nikoletta Ntalarizou, Georgios Stefanakis, Vasiliki Siafaka, Metaxia Bareka, Eleni Arnaoutoglou","doi":"10.5080/u27606","DOIUrl":"10.5080/u27606","url":null,"abstract":"<p><strong>Objective: </strong>The psychological impact of healthcare crises is undoubted. Anxiety has a strong impact on the perioperative patients&rsquo; well-being and their subsequent postoperative recovery. The aim of this survey was to assess preoperative anxiety and its accentuating factors in patients undergoing surgery during a healthcare crisis.</p><p><strong>Method: </strong>This study is a cross-sectional observational study. All adult patients undergoing elective surgery during December 2021 were assessed for eligibility. We excluded patients with any diagnosed psychiatric comorbidities. Anxiety was recorded using the modified Preoperative Anxiety Scale (mPAS), with permission by the authors [1]. mPAS consists of 4 sections: (i) demographics, (ii) baseline anxiety trait, (iii) anxiety due to general preoperative factors and (iv) anxiety due pandemic-specific factors. We summarized the results using descriptive and inferential statistics.</p><p><strong>Results: </strong>We included 116 patients, (60 males, 51.7% and mean age 60.6&plusmn;15.5 years) who underwent major (27,23.3%), moderate (49,42.3%), and minor (40,34.5%) surgical interventions. Six patients were excluded due psychiatric disorders. Based on American Society of Anaesthesiologists Physical Status (ASA-PS) they were mostly classified as ASA PS II (62,53.4%) and ASA PS III (29,25%). At baseline, of the 110 patients who completed the questionnaire, 30% (n=33) suffered from baseline anxiety according to mPAS. Severity of planned surgery (n=24, 21.8%) represented a major anxiety source, which was statistically significant for patients undergoing major surgery (p=0.026). However, pandemic-related factors were responsible of anxiety in 36 (32.7%) patients. The female gender and the ASA grade were significantly associated with the levels of COVID-19 anxiety.</p><p><strong>Conclusions: </strong>During a healthcare crisis 30% of the patients experienced anxiety before surgery. The preoperative anxiety was further aggravated due to pandemic-related factors.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"95-102"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction for the article titled \"Investigation of the Frequency of Eating Disorders, Factors Associated with Eating Behaviors, and Quality of Life in Individuals with Bipolar Disorder in the Context of Behavioral Inhibition/Activation Systems\".","authors":"Ayşe Köksal","doi":"10.5080/u28011","DOIUrl":"https://doi.org/10.5080/u28011","url":null,"abstract":"<p><p>On behalf of the authors, I would like to state that within the article published with the citation &ldquo;K&ouml;ksal A, Sağlam Aykut D, Sel&ccedil;uk &Ouml;zmen E. (2025) The Frequency of Eating Disorders, Associated Factors, and Quality of Life in Patients with Bipolar Disorder: An Investigation in the Context of Behavioral Inhibition/Activation Systems. Turk Psikiyatri Derg 36:364-373. https://doi.org/10.5080/u27340&rdquo;, we mistakenly state the ethics committee approval number as 24237859-834 and the date as 2019. The correct ethics committee approval information is as follows. The authors apologize for the mistake. The study was approved by the Scientific Research Ethics Committee of Karadeniz Technical University Faculty of Medicine on June 4, 2018, with protocol number 2018/107.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"205"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attachment in Schizophrenia: Its Associations with Theory of Mind, Childhood Trauma and Psychosocial Functioning.","authors":"Berkant Sağir, Bilge Targitay Öztürk, Cansu Aykaç, Köksal Alptekin, Berna Binnur Akdede","doi":"10.5080/u27800","DOIUrl":"10.5080/u27800","url":null,"abstract":"<p><strong>Objective: </strong>Schizophrenia is a chronic psychiatric disorder that arises from the interaction of biopsychosocial factors. Both the disorder itself and psychosocial variables, such as attachment styles and childhood trauma have been associated with impairments in mentalization processes observed in schizophrenia. This study aimed to assess attachment styles in individuals with schizophrenia and explore the associations between insecure attachment, theory of mind, childhood trauma and psychosocial functioning.</p><p><strong>Method: </strong>The study included 45 patients with schizophrenia and 45 healthy controls. Assessments included the Psychosis Attachment Measure (PAM), Dokuz Eyl&uuml;l Theory of Mind Index (DEZİK&Ouml;), Childhood Trauma Questionnaire (CTQ) and Personal and Social Performance Scale (PSP). Positive and Negative Syndrome Scale (PANSS) and Calgary Depression Scale (CDS) were also administered to patients.</p><p><strong>Results: </strong>Patients with schizophrenia exhibited significantly higher levels of childhood trauma and insecure attachment alongside impaired theory of mind and poorer psychosocial functioning compared to controls. In the schizophrenia group, insecure attachment correlated with greater symptom severity, higher trauma burden and lower functioning. A moderate negative correlation was found between insecure attachment and theory of mind. However, childhood trauma did not significantly mediate the relationship between insecure attachment and theory of mind performance.</p><p><strong>Conclusion: </strong>In individuals with schizophrenia, insecure attachment styles are prevalent and are associated with greater symptom severity and poorer psychosocial functioning. Anxious attachment was found to be associated with reduced theory of mind performance; however, no evidence supporting a mediating role of childhood trauma in this relationship was obtained.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"83-94"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationships Between Internalized Stigma, Depression, andHealth-Related Quality of Life in Individuals Living with HIV.","authors":"Muhammet Sevindik, Arzu Altunçekiç Yildirim","doi":"10.5080/u27864","DOIUrl":"10.5080/u27864","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to examine the relationship between internalized stigma (IS) and depression, and treatment adherence and health-related quality of life (HRQL) in people living with HIV.</p><p><strong>Method: </strong>This cross-sectional study included 75 consecutive individuals living with HIV who had been diagnosed at least three months prior and volunteered to participate. Participants completed a sociodemographic data form, the Berger HIV Stigma Scale, the Beck Depression Inventory (BDI), the Modified Morisky Treatment Adherence Scale, and the Short Form-36/HRQL Scale. Relationships between variables were evaluated using correlation analyses. Variables affecting the HRQL subscales were examined using multiple linear regression analyses. Statistical significance was considered achieved when p&lt;0.05.</p><p><strong>Results: </strong>IS showed significant positive correlations with depressive symptoms (p = 0.003), and significant negative correlations with social functioning and pain. The BDI score was found to be significantly and negatively associated with all subscales of HRQL (p &lt; 0.001). In multiple regression analyses, the BDI was identified as a significant predictor of all quality of life subscales (p &le; 0.01), while IS was not a direct significant predictor (p&gt;0.05). Further analysis using the bootstrap method revealed that the relationships between the IS and HRQL subscales were statistically significant, along with the level of depression.</p><p><strong>Conclusion: </strong>This study demonstrated a strong and consistent association between depression levels and HRQL in individuals living with HIV. Although IS was not directly related to quality of life, it showed a significant pattern when considered in conjunction with depression levels. The findings highlight the importance of considering psychological symptoms and stigma experiences in the clinical follow-up of individuals living with HIV.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"161-169"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Peripheral Inflammatory Biomarkers in Trichotillomania.","authors":"Serkan Yazici, Ezgi Sıla Ahi Üstün, Rıfat Serav Ilhan, Meram Can Saka","doi":"10.5080/u27726","DOIUrl":"10.5080/u27726","url":null,"abstract":"<p><strong>Objective: </strong>Immunological factors may play a role in the etiology of trichotillomania (TTM). Peripheral inflammatory markers such as Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), Monocyte-Lymphocyte Ratio (MLR), monocyte to high-density lipoprotein (HDL) ratio (MHR), Systemic Immune-Inflammation Index (SII) have not yet been investigated in TTM. This study aimed to compare TTM with healthy control (HC) in terms of various inflammatory markers such as NLR, PLR, MLR, MHR, SII.</p><p><strong>Method: </strong>The electronic records were examined of patients who were diagnosed with TTM who attended to the outpatient psychiatry clinic between January 2022 and December 2023. 46 TTM and 44 HC were included in the study. Blood samples for 90 participants were examined from electronic records, and NLR, PLR, MLR, and SII values were calculated. Participants with TTM were scored according to disease severity using the Clinical Global Impression&ndash;Severity (CGI-S) scale.</p><p><strong>Results: </strong>NLR, PLR, MLR, MHR, and SII were significantly higher in TTM. No significant correlation was found between CGI-S scores and NLR, PLR, MLR, MHR, and SII values in TTM. According to binary logistic regression analysis, a significant relationship was found between NLR and TTM.</p><p><strong>Conclusion: </strong>TTM group have elevated peripheral inflammatory markers compared with HC group. Findings of the study support the potential inflammatory process in TTM.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Association of Türkiye Mood Disorders Section Depression Treatment Guideline - III: Treatment Approach for Depression Subtypes and Special Groups, Psychotherapies, and Psychosocial Interventions.","authors":"Ömer Aydemir, Fisun Akdeniz, Burcu Özbaran, Ceren Meriç Özgündüz, Hakan Karaş, Halise Devrimci Özgüven, Hazal Yağmur Yilancioğlu, Müge Alkan, Özlem Eker, Ömer Faruk Uygur, Safiye Zeynep Tatli, Simge Uzman Özbek, Şevin Hun Şenol, Vesile Şentürk Cankorur, Yağmur Kir, Aslı Ceren Hinç, Beyza Erdoğan Aktürk, İlkay Keleş Altun, Kaan Keskin, Okan Görkem, Rukiye Tekdemir, Ece Özlem Öztürk, İsmail Buçgün, Deniz Ceylan, Hidayet Ece Arat Çelik, Mehmet Çağdaş Eker, Mete Ercis, Şükrü Alperen Korkmaz, Vesile Altinyazar, Emre Bora","doi":"10.5080/u27872","DOIUrl":"10.5080/u27872","url":null,"abstract":"<p><p>This guideline article comprehensively examines pharmacological approaches and psychosocial interventions for depression subtypes and special patient groups in the treatment of major depressive disorder (MDD), along with their levels of evidence. Among depression subtypes, the approach with the highest level of evidence for psychotic depression is the combination of an antipsychotic with an antidepressant, whereas in atypical depression, despite a lack of new research, monoamine oxidase inhibitors (MAOI) have shown the most prominent efficacy compared to placebo.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"138-160"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Misophonia and Autistic Traits in Parents of Children with and without Autism Spectrum Disorder.","authors":"Fatma Subaşi Turgut, Masum Öztürk, Zehra Akan, Engin Deniz Yilmaz","doi":"10.5080/u27720","DOIUrl":"10.5080/u27720","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare misophonia levels and autistic traits between parents of children diagnosed with autism spectrum disorder (ASD) and parents of typically developing children.</p><p><strong>Methods: </strong>Parents of children diagnosed with ASD who presented to the Child and Adolescent Psychiatry outpatient clinic (n=56) and parents of typically developing children (n=56) were included in the study. The Childhood Autism Rating Scale (CARS) was administered to the children with ASD. All participating parents completed the Autism Spectrum Quotient (AQ) and the Amsterdam Misophonia Scale&ndash; Revised (AMISOS-R).</p><p><strong>Results: </strong>The rate of reporting throat sounds as a misophonic trigger was higher among parents of children with ASD (p=0.004). Weak but significant positive correlations were found across all participants between the AMISOS-R total score and the AQ total score, the attention switching subscale score, and the communication subscale score (r=0.275, p=0.003; r=0.266, p=0.005; r=0.35, p&lt;0.001, respectively). Among parents of children with ASD, the AMISOS-R total score was positively correlated with items 3, 5, and 9 of the CARS (p&lt;0.05).</p><p><strong>Conclusion: </strong>Our findings support potential associations between misophonia and ASD, and suggest that misophonia in parents may be related to certain characteristics in the child, such as sensory processing and emotional regulation.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"20-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal miR-34a/SIRT1 and BDNF Responses Following Adolescent Stress: Differential Effects of Ketamine and Fluoxetine.","authors":"Feyza Dönmez, Gülin Özdamar Ünal, Kuyaş Hekimler Öztürk, Duygu Kumbul, Eltaf Doğan","doi":"10.5080/u27776","DOIUrl":"10.5080/u27776","url":null,"abstract":"<p><strong>Objective: </strong>Early life stress is a well-established risk factor for psychiatric disorders in adulthood; however, the underlying molecular mechanisms remain unclear. This study investigated the effects of chronic unpredictable mild stress (CUMS) starting in adolescence on anxiety- and depression-like behaviors, as well as on hippocampal miR- 34a, SIRT1, BDNF, and NLRP3 levels in rats treated with ketamine or fluoxetine.</p><p><strong>Methods: </strong>A total of 40 Wistar albino rats (4 weeks old) were divided into four groups: Control, CUMS, CUMS + fluoxetine (FLU), and CUMS + ketamine (KETA). Chronic unpredictable mild stress was applied for 6 weeks, while fluoxetine (10 mg/kg, i.p.) and ketamine (10 mg/kg, i.p.) were administered during the last 3 weeks. Behavioral assessments were performed at weeks 3 and 6 using the sucrose preference test (SPT), open field test (OFT), and forced swim test (FST). Hippocampal BDNF protein levels were measured by ELISA, and miR-34a, SIRT1, and NLRP3 gene expression levels were analyzed by RT-PCR.</p><p><strong>Results: </strong>Both fluoxetine and ketamine improved CUMS-induced depression-like behaviors. Chronic unpredictable mild stress decreased hippocampal BDNF levels and increased miR-34a expression. Fluoxetine reversed the increase in miR-34a and elevated SIRT1 expression and BDNF levels. In contrast, although ketamine improved behavioral outcomes, it did not significantly alter hippocampal BDNF or SIRT1 levels and did not reduce miR-34a expression. No significant differences in NLRP3 expression were observed among the groups.</p><p><strong>Conclusion: </strong>Adolescent CUMS induces depression-like behaviors by affecting the hippocampal miR-34a/SIRT1/BDNF axis. While the antidepressant effects of fluoxetine are associated with this axis, ketamine may exert its behavioral effects through different and possibly extra-hippocampal mechanisms. miR-34a may serve as a potential biomarker for depression related to early life stress.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"125-137"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Comorbid Schizophrenia in an Adolescent with Osteogenesis Imperfecta: A Case Report.","authors":"Ayşe Eylül Özel Gümüş, Merve Onat","doi":"10.5080/u27751","DOIUrl":"10.5080/u27751","url":null,"abstract":"<p><p>Osteogenesis imperfecta (OI) is a rare connective tissue disorder characterized by bone fragility, growth retardation, hearing loss, and short stature. Literature on the comorbidity of OI and psychotic disorders is limited. Antipsychotic side effects such as hyperprolactinemia, sedation, and orthostatic hypotension may increase fracture risk, presenting challenges in comorbid cases. Here, we describe a 14-year-old male with OI and schizophrenia. The patient presented with a three-month history of irritability, self-harm, auditory hallucinations, and referential delusions. His history included multiple fractures, leading to OI diagnosis at age 8. He was admitted with acute psychotic disorder and treated with aripiprazole 20 mg/day, resulting in significant symptom improvement. No new bone fractures were observed during one year of follow-up. This case highlights the management of comorbid OI and schizophrenia. Fracture risk is a critical concern in OI patients. Clinicians should carefully select antipsychotics in the presence of psychosis and closely monitor patients to minimize adverse effects. Keywords: Adolescent, antipsychotics, osteogenesis imperfecta, schizophrenia, side effects.</p>","PeriodicalId":94262,"journal":{"name":"Turk psikiyatri dergisi = Turkish journal of psychiatry","volume":"37 ","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}