锂治疗经前多愁善感症:病例报告。

Rümeysa Ayşe Güllülü, Anıl Muştucu, Cengiz Akkaya
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引用次数: 0

摘要

经前期情感障碍(PDD)的特点是在月经周期的晚黄体期出现精神、身体和认知症状,并在月经后一周消退。对于 PDD,5-羟色胺再摄取抑制剂和联合避孕药是主要的药物治疗方法。如果个人或家族有双相情感障碍(BD)病史,使用抗抑郁药可能会有诱发躁狂发作的风险。双相情感障碍和躁狂症经常同时存在,而且这两种疾病都具有周期性,共同的病因机制(如荷尔蒙变化)也在其中发挥作用。在此,我们介绍了一个没有 BD 但有 BD 家族史的病例,该病例接受了锂单药治疗,并取得了成功。在无法使用一线和二线疗法或对 PDD 患者无反应的情况下,已证明可有效预防一级亲属情绪发作的药物疗法可能是一种可行的解决方案。关键词抗抑郁剂 药物治疗 锂 经前多动障碍 经前综合征
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lithium in the Treatment of Premenstrual Dysphoric Disorder: A Case Report.

Premenstrual dysphoric disorder (PDD) is characterized by mental, physical and cognitive symptoms that occurs in the late luteal phase of the menstrual cycle and regresses in the week following menstruation. In PDD, serotonin reuptake inhibitors and combined contraceptives are the primary pharmacologic treatments. In cases where there is a personal or family history of bipolar disorder (BD), the use of antidepressants may pose a risk of inducing manic episodes. The frequent coexistence of BD and PDD, the fact that both diseases are cyclic in nature and that common mechanisms such as hormonal changes play a role in their aetiologies, suggest that lithium might be efficacious in the treatment of PDD. Here, we present a case who didn't have a BD but a family history of BD and was treated with lithium monotherapy for PDD with a successful outcome. In cases where first- and second-line therapies cannot be used or no response is obtained in PDD patients, pharmacological agents that have demonstrated efficacy in preventing mood episodes among first-degree relatives, may present a viable solution. Keywords: Antidepressive Agents, Drug Therapy, Lithium, Premenstrual Dysphoric Disorder, Premenstrual Syndrome.

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