The Kaohsiung journal of medical sciences最新文献_第4页

Dexmedetomidine Blocks the ERK Pathway by Inhibiting MAP3K8 to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury. 右美托咪定通过抑制MAP3K8阻断ERK通路达到肺缺血再灌注损伤的保护作用

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-09-01 Epub Date: 2025-05-15 DOI: 10.1002/kjm2.70045

Chun-Huan Hu, Ru Qian, Yong-Bo Wang, Lian-Di Li, Chun-Xing Miao

{"title":"Dexmedetomidine Blocks the ERK Pathway by Inhibiting MAP3K8 to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury.","authors":"Chun-Huan Hu, Ru Qian, Yong-Bo Wang, Lian-Di Li, Chun-Xing Miao","doi":"10.1002/kjm2.70045","DOIUrl":"10.1002/kjm2.70045","url":null,"abstract":"Lung ischemia/reperfusion injury (LIRI) is a primary contributor to morbidity and mortality following lung transplantation. Dexmedetomidine (DEX) protects the lungs from I/R injury, but the underlying mechanisms remain uncertain. This paper examined the protective effect of DEX in LIRI and elucidated the potential regulation involved. LIRI was induced in mice, followed by the detection of pulmonary arterial pressure, lung compliance, pathological changes, pulmonary vascular permeability, oxidative stress, inflammation, and apoptosis. Mice were infected with overexpression (OE)-mitogen-activated protein kinase kinase kinase 8 (MAP3K8) adenovirus and treated with DEX. MAP3K8 expression was examined in mouse lung tissue and pulmonary microvascular endothelial cells (PMVECs). Cells were infected using OE-MAP3K8 lentivirus and treated with DEX, followed by detection of cell viability and apoptosis, VE-cadherin and α-E-catenin, and pro-inflammatory factors. Rescue experiments were performed by MAP3K8 overexpression and combined extracellular signal-regulated protein kinase (ERK) pathway blocker, PD98059. The results demonstrated that DEX protected mice from LIRI. DEX inhibited MAP3K8 expression. MAP3K8 overexpression increased ERK1/2 phosphorylation and activated the ERK pathway. Upregulation of MAP3K8 impaired the protective effect of DEX in vivo and in vitro, which was reversed by the ERK inhibitor PD98059. Overall, DEX achieved its protective effect against LIRI by inhibiting the MAP3K8-ERK axis.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70045"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thromboelastography Maximum Amplitude Is a Valuable Biomarker for Early Atherosclerosis in Rheumatoid Arthritis Patients: A Single-Center Cross-Sectional Study. 血栓弹性成像最大振幅是类风湿关节炎患者早期动脉粥样硬化的有价值的生物标志物：一项单中心横断面研究

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-09-01 Epub Date: 2025-05-08 DOI: 10.1002/kjm2.70043

Qing-Lin Zhang, Qian Xu, Rong Huang, Ming-Zhong Sun, Dong-Mei Jiang, Hui Tao, Hao Jin

{"title":"Thromboelastography Maximum Amplitude Is a Valuable Biomarker for Early Atherosclerosis in Rheumatoid Arthritis Patients: A Single-Center Cross-Sectional Study.","authors":"Qing-Lin Zhang, Qian Xu, Rong Huang, Ming-Zhong Sun, Dong-Mei Jiang, Hui Tao, Hao Jin","doi":"10.1002/kjm2.70043","DOIUrl":"10.1002/kjm2.70043","url":null,"abstract":"Hypercoagulability contributes to atherosclerosis (AS) progression in individuals suffering from rheumatoid arthritis (RA), and thromboelastography (TEG) is a valuable diagnostic tool. This hospital-based cross-sectional study assessed the clinical efficacy of TEG parameters in detecting hypercoagulability and subclinical AS by purposively sampling 372 RA patients and 105 healthy controls. TEG indices, conventional coagulation markers, and biochemical profiles were assessed. Multivariable logistic modeling and receiver operating characteristic (ROC) analyses were utilized to identify independent risk factors for early AS in patients with RA. Our results indicated that patients with RA experienced a hypercoagulable state in comparison to controls, which was particularly pronounced in RA patients with early AS compared to their non-AS counterparts. Logistic regression analysis revealed that the TEG maximum amplitude (MA) is an independent risk factor for early AS in patients with RA, with an odds ratio of 1.219 and a 95% confidence interval of 1.128-1.317. Additional independent risk factors identified are fibrinogen (FIB), low-density lipoprotein cholesterol (LDL-C), and the adjusted atherogenic index of plasma (aAIP). ROC analysis revealed that MA achieved an area under the curve (AUC) of 0.711 (sensitivity: 71.5%; specificity: 63.5%) for early AS diagnosis. Combining with FIB, LDL-C, and aAIP significantly enhanced diagnostic performance, with an AUC of 0.831 (sensitivity: 77.6%; specificity: 75.3%). These findings highlight MA as a valuable biomarker for early detection of AS in patients with RA. Furthermore, integrating MA with FIB, LDL-C, and aAIP improves diagnostic accuracy, supporting its clinical role in risk stratification and early intervention.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70043"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Depth of Invasion in Node-Negative Oral Tongue Cancer Treated With Surgery Alone. 单纯手术治疗淋巴结阴性口腔癌侵袭深度的影响。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-09-01 DOI: 10.1002/kjm2.70102

Po-Wen Hsiao, Yu-Tsai Lin, Hui-Ching Chuang, Chun-Yuan Chao, Chih-Yen Chien, Chao-Hui Yang, Fu-Min Fang, Hui Lu, Ming-Hsien Tsai

{"title":"Impact of Depth of Invasion in Node-Negative Oral Tongue Cancer Treated With Surgery Alone.","authors":"Po-Wen Hsiao, Yu-Tsai Lin, Hui-Ching Chuang, Chun-Yuan Chao, Chih-Yen Chien, Chao-Hui Yang, Fu-Min Fang, Hui Lu, Ming-Hsien Tsai","doi":"10.1002/kjm2.70102","DOIUrl":"https://doi.org/10.1002/kjm2.70102","url":null,"abstract":"Oral tongue squamous cell carcinoma (OTSCC) is an aggressive malignancy and the most common subsite of head and neck cancer among Taiwanese males. This study aimed to evaluate the prognostic significance of depth of invasion (DOI) in patients with node-negative OTSCC treated with radical surgery alone. We retrospectively analyzed 243 patients with node-negative OTSCC who had undergone radical surgery with adequate margins between 2005 and 2017. Each millimeter increase in DOI was significantly associated with a higher hazard of all-cause mortality (ACM) (hazard ratio [HR], 1.07; 95% confidence interval [CI], 1.03-1.111; p < 0.001), cancer-specific mortality (CSM) (HR, 1.087; 95% CI, 1.04-1.136; p < 0.001) and local recurrence (LR) (HR, 1.081; 95% CI, 1.021-1.145; p = 0.008), but not regional recurrence (RR) (HR, 1.042; 95% CI, 0.986-1.102; p = 0.144). In multivariate analysis, DOI remained an independent predictor of ACM, CSM, and LR. A DOI-based nomogram demonstrated improved predictive performance, with a concordance index of 0.700 for overall survival. In conclusion, DOI represents a crucial prognostic factor for ACM, CSM, and LR in patients with node-negative OTSCC treated with surgery alone, highlighting its potential clinical utility for early risk stratification and guidance in decision-making regarding adjuvant therapy or intensified surveillance.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70102"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction. 通过IGF2BP2相互作用hsa_circ_0005654诱导糖尿病足溃疡铁下垂的机制

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-09-01 Epub Date: 2025-06-12 DOI: 10.1002/kjm2.70047

Chun-Meng Li, Xiang-Jian Zheng, Shang-Shang Xie, De-Yong Lin, Zi-Tian Liu

{"title":"Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction.","authors":"Chun-Meng Li, Xiang-Jian Zheng, Shang-Shang Xie, De-Yong Lin, Zi-Tian Liu","doi":"10.1002/kjm2.70047","DOIUrl":"10.1002/kjm2.70047","url":null,"abstract":"This study investigated the molecular mechanism by which hsa_circ_0005654 aggravates diabetic foot ulcers (DFUs) by promoting ferroptosis. A DFU rat model was established, and lentiviral vectors interfering with circ_0005654 and IGF2BP2 expression were injected into DFU rats by tail vein. The successful injection of lentiviral vectors was verified by RT-qPCR. The histopathology of foot ulcer tissues of DFU rats was observed by HE staining. Iron deposition was observed by Perls' Blue staining. Inflammatory factors were detected by ELISA. Protein expression of ferroptosis markers (GPX4 and SLC7A11) was measured by Western blot. The interaction of circ_0005654 with IGF2BP2 was verified by RNA pull-down assay and RIP assay. Iron deposition and inflammatory factor levels were increased in foot ulcer tissues of DFU rats, and wound healing was impaired. Liproxstatin-1, a ferroptosis inhibitor, promoted wound healing in DFU rats by inhibiting ferroptosis and inflammation. circ_0005654 expression was up-regulated. Down-regulating circ_0005654 promoted wound healing in DFU rats by inhibiting ferroptosis and inflammation. circ_0005654 could interact with IGF2BP2, and up-regulating IGF2BP2 attenuated the effects of circ_0005654 down-regulation in DFU rats. circ_0005654 promotes ferroptosis to aggravate DFU by interacting with IGF2BP2.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70047"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19-Related Croup With Acute Respiratory Failure. 与covid -19相关的急性呼吸衰竭群体。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-09-01 Epub Date: 2025-05-15 DOI: 10.1002/kjm2.70040

Chi-Kai Hsu, Tang-Hsu Hsieh, Yi-Ching Liu, I-Chen Chen

引用次数: 0

Mixed Neuroendocrine-Non-Neuroendocrine Tumor of Bile Duct. 胆管混合性神经内分泌-非神经内分泌肿瘤。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-09-01 Epub Date: 2025-05-20 DOI: 10.1002/kjm2.70038

Lian Shen, Wei-Nan Liu, Shuo Qi, Chang-Jun Liu

引用次数: 0

Prognostic Factors Impacting Surgical Resection Outcomes in Elderly Patients With Brain Metastasis. 影响老年脑转移患者手术切除结果的预后因素。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-26 DOI: 10.1002/kjm2.70099

Yu Chang, Heng-Juei Hsu, Chia-En Wong, Junmin Song, Kuo-Chang Huang, Liang-Chao Wang, Chih-Hao Tien, Chih-Yuan Huang, Po-Hsuan Lee, Chi-Chen Huang, Jung-Shun Lee

{"title":"Prognostic Factors Impacting Surgical Resection Outcomes in Elderly Patients With Brain Metastasis.","authors":"Yu Chang, Heng-Juei Hsu, Chia-En Wong, Junmin Song, Kuo-Chang Huang, Liang-Chao Wang, Chih-Hao Tien, Chih-Yuan Huang, Po-Hsuan Lee, Chi-Chen Huang, Jung-Shun Lee","doi":"10.1002/kjm2.70099","DOIUrl":"https://doi.org/10.1002/kjm2.70099","url":null,"abstract":"Brain metastases (BM) among elderly patients with cancer are increasing, and decision-making for treatment is complicated by comorbidities. This study aimed to identify prognostic factors that can help make informed decisions regarding surgical resection in elderly patients with BM. We retrospectively included elderly patients (65 years or older) with newly diagnosed BM who underwent surgery. We conducted survival analyses and Cox regression analyses to identify potential independent predictors of poor survival. A total of 124 elderly patients with BM undergoing surgical resection were enrolled. In the multivariate analysis, male sex (HR: 1.96, 95% CI: 1.22-3.13), ECM (HR: 2.97, 95% CI: 1.82-4.85), BM in eloquent locations (HR: 1.64, 95% CI: 1.02-2.64), KPS deterioration (HR: 1.93, 95% CI: 1.20-3.10), and mFI-5 equal to or greater than 2 (HR: 2.10, 95% CI: 1.12-3.95) were associated with poor overall survival. Conversely, receiving systemic treatment after the diagnosis of BM showed a significant overall survival benefit (HR: 0.45, 95% CI: 0.28-0.70). Elevated SII (HR: 1.99, 95% CI: 1.02-3.90) was significantly associated with poor survival, while elevated PNI (HR: 0.56, 95% CI: 0.33-0.94) indicated better survival. Clinicians should adopt a personalized approach when selecting treatment options for elderly patients with BM, considering BM location, the presence of ECM, comorbidities, and suitability for postoperative systemic treatment. Evaluating preoperative nutritional and inflammatory status and monitoring performance status pre- and postoperatively are needed, as these factors may affect prognosis.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70099"},"PeriodicalIF":3.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sciatic Nerve Stimulation Mitigates Depression-Like Behaviors and Memory Deficits in Stressed Mice. 坐骨神经刺激减轻应激小鼠抑郁样行为和记忆缺陷。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-26 DOI: 10.1002/kjm2.70091

Chih-Hao Tien, Pei-Wen Chen, Ya-Hsin Hsiao, Chia-En Wong, Ming-Tse Wu, Ying-Fei Chen, Kuo-Chang Huang, Po-Hsuan Lee, Kun-Chia Chang, Heng-Juei Hsu, Jung-Shun Lee

{"title":"Sciatic Nerve Stimulation Mitigates Depression-Like Behaviors and Memory Deficits in Stressed Mice.","authors":"Chih-Hao Tien, Pei-Wen Chen, Ya-Hsin Hsiao, Chia-En Wong, Ming-Tse Wu, Ying-Fei Chen, Kuo-Chang Huang, Po-Hsuan Lee, Kun-Chia Chang, Heng-Juei Hsu, Jung-Shun Lee","doi":"10.1002/kjm2.70091","DOIUrl":"https://doi.org/10.1002/kjm2.70091","url":null,"abstract":"Stress causes depression and cognitive decline. With limitations in pharmacotherapy, sciatic nerve stimulation (SNS) offers a promising nondrug alternative. This study aimed to explore the therapeutic efficacy of SNS in mitigating stress-induced depressive behaviors and memory deficits by focusing on astrocytic dysfunction and cellular senescence in the hippocampus. C57BL/6 mice were subjected to the water immersion restraint stress (WIRS) paradigm to induce stress-related behavioral deficits. Behavioral tests assessed locomotion, anxiety, depression-like behavior, and memory. Astrocytic disruption and cellular senescence in the hippocampus were assessed using glial fibrillary acidic protein (GFAP) immunostaining and senescence-associated β-galactosidase (SA-β-gal) staining. SNS at 20 Hz significantly improved cognitive function and reduced depression-like behavior in WIRS-treated mice. It also restored hippocampal GFAP expression and decreased both SA-β-gal-positive cell accumulation and the expression of senescence markers p16 and p21, suggesting an attenuation of cellular senescence. To further explore the link between cellular senescence and SNS-mediated effects, we administered the anti-senescence agent vitamin C to WIRS mice. While vitamin C alleviated stress-induced hippocampal senescence and depressive behavior, it failed to reverse memory deficits or restore GFAP expression, indicating that the benefits of SNS extend beyond its anti-senescent actions. In summary, SNS effectively counteracts the neurobehavioral consequences of chronic stress by targeting astrocytic dysfunction and cellular senescence. These findings support SNS as a promising, nonpharmacological strategy for treating stress-related depression and cognitive decline. Future studies should explore its clinical translation and broader therapeutic potential.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70091"},"PeriodicalIF":3.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1. USP28通过去泛素化和稳定SIRT1促进H1975 NSCLC细胞对奥西替尼的耐药

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-26 DOI: 10.1002/kjm2.70095

Hu-Sen Fan, Xiu-Mei Li, Jia-Qi Gu, Hai-Feng Wang, Zhen-Jiang Zhang

{"title":"USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1.","authors":"Hu-Sen Fan, Xiu-Mei Li, Jia-Qi Gu, Hai-Feng Wang, Zhen-Jiang Zhang","doi":"10.1002/kjm2.70095","DOIUrl":"https://doi.org/10.1002/kjm2.70095","url":null,"abstract":"Osimertinib (OSI) resistance in non-small cell lung cancer (NSCLC) remains a significant challenge. This report explored the precise role of USP28 on OSI resistance in NSCLC and identified a functional downstream effector. OSI-resistant H1975 cells (H1975/OSI) were established by long-term OSI exposure. USP28 and SIRT1 expression levels were analyzed by quantitative PCR, immunoblotting, and immunohistochemistry. Functional assays included cell viability, colony formation, EdU incorporation, apoptosis analysis, and glycolysis assays. The interaction between USP28 and SIRT1 was confirmed by co-immunoprecipitation (Co-IP) assay and SIRT1 protein stability analysis. In vivo validation was performed using H1975/OSI xenograft models. USP28 and SIRT1 were upregulated in H1975/OSI cells and OSI-resistant NSCLC tissues. USP28 overexpression enhanced cell proliferation and glycolysis, suppressed apoptosis, and conferred OSI resistance in H1975 cells, while its depletion exerted opposite effects in H1975/OSI cells. Mechanistically, USP28 stabilized SIRT1 by deubiquitination. SIRT1 knockdown attenuated the effects of USP28 overexpression, while SIRT1 restoration reversed the phenotype alterations upon USP28 depletion. In vivo, USP28 depletion sensitized H1975/OSI xenografts to OSI treatment. Our study indicates that USP28 promotes OSI resistance in NSCLC by deubiquitinating SIRT1. Targeting the USP28/SIRT1 axis may represent a novel therapeutic approach to overcome OSI resistance in EGFR-mutant NSCLC.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70095"},"PeriodicalIF":3.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Baseline Nutritional Status, Psychological Health, Fatigue, and Insomnia on Outcomes of Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer: A Retrospective Cohort Study. 基线营养状况、心理健康、疲劳和失眠对晚期非小细胞肺癌免疫检查点抑制剂治疗结果的影响：一项回顾性队列研究

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-24 DOI: 10.1002/kjm2.70097

Yu-Xuan Zhu, Yuan-Yuan Zhang, Xiu-Juan Jiang

{"title":"Impact of Baseline Nutritional Status, Psychological Health, Fatigue, and Insomnia on Outcomes of Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer: A Retrospective Cohort Study.","authors":"Yu-Xuan Zhu, Yuan-Yuan Zhang, Xiu-Juan Jiang","doi":"10.1002/kjm2.70097","DOIUrl":"https://doi.org/10.1002/kjm2.70097","url":null,"abstract":"This study investigated the impact of pretreatment nutritional status, psychological health, fatigue, and insomnia on outcomes of immune checkpoint inhibitors (ICIs) monotherapy in patients with advanced non-small cell lung cancer (NSCLC). A total of 80 patients with stage IV NSCLC were enrolled. Baseline assessments included the Controlling Nutritional Status (CONUT) score, Herth Hope Index (HHI), Hospital Anxiety and Depression Scale (HADS), Brief Fatigue Inventory (BFI), and Athens Insomnia Scale (AIS). Response to ICImonotherapy, along with progression-free survival (PFS) and overall survival (OS), was evaluated at week eight and through subsequent survival analyses. At week eight, partial response (PR), stable disease (SD), and progressive disease (PD) were observed in 31.8%, 33.0%, and 35.2% of patients, respectively. PD patients had significantly higher pretreatment CONUT scores, greater anxiety and depression, and more severe fatigue and insomnia than PR patients. Low nutritional risk was associated with improved OS and PFS. Higher HHI scores and lower HADS-A/D, BFI, and AIS scores correlated with better survival outcomes. In multivariate analysis, anxiety was independently associated with PFS, and depression and fatigue independently predicted OS. Pretreatment nutritional status, psychological health, fatigue, and insomnia significantly influence immunotherapy response and survival in advanced NSCLC. These findings underscore the clinical importance of comprehensive baseline assessments to identify high-risk patients who may benefit from targeted interventions before initiating immunotherapy. Addressing nutritional deficits, psychological distress, fatigue, and insomnia early could potentially enhance treatment response and improve survival outcomes, offering valuable insights for personalized cancer care strategies.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70097"},"PeriodicalIF":3.1,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0