The Kaohsiung journal of medical sciences最新文献_第5页

Machine Learning-Based Classification of Depression Using Inflammatory Biomarkers in Pancreatic Cancer Patients. 基于机器学习的胰腺癌患者炎症生物标志物抑郁分类。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-24 DOI: 10.1002/kjm2.70094

Yang-Chen Shen, Po I Wu, Cheng-Feng Lin, Chia-Jui Yen, Yan-Shen Shan, Po See Chen

{"title":"Machine Learning-Based Classification of Depression Using Inflammatory Biomarkers in Pancreatic Cancer Patients.","authors":"Yang-Chen Shen, Po I Wu, Cheng-Feng Lin, Chia-Jui Yen, Yan-Shen Shan, Po See Chen","doi":"10.1002/kjm2.70094","DOIUrl":"https://doi.org/10.1002/kjm2.70094","url":null,"abstract":"Inflammation is a common mediator of pancreatic cancer and depression. This study investigated the predictive value and clinical associations of inflammatory markers and depression in cancer patients using machine learning (ML) and statistical modeling. Pancreatic cancer patients (n = 328; mean age, 65 years; majority with stage IV disease) were assessed using the Patient Health Questionnaire-9 (PHQ-9; depression defined as PHQ-9 ≥ 10). Clinically significant depression was present in 35% of subjects at baseline, and the rate declined at follow-up. Four ML models (logistic regression, random forest, support vector machine, and extreme gradient boosting; XGBoost) were trained using routinely collected clinical data and showed comparable performances with moderate but consistent discriminative capacity (AUC: 0.70-0.72). Permutation importance analysis revealed C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and albumin as key predictors of depression. Generalized estimating equations further confirmed that elevated CRP (OR = 1.32, p = 0.001) and NLR (OR = 1.55, p = 0.001) were independently associated with depression. These findings suggest that inflammatory markers can not only help to identify patients at risk for depression but also underscore the linkage between inflammation and depression. ML models incorporating these markers may therefore support early detection and intervention in pancreatic cancer care.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70094"},"PeriodicalIF":3.1,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Adverse Events in Blunt Chest Trauma: A Novel Nomogram Integrating Vitals, Hemogram, and Comorbidities. 预测钝性胸部创伤的不良事件：一种整合生命体征、血象图和合并症的新Nomogram。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-21 DOI: 10.1002/kjm2.70088

Chang-Lun Huang, Hui-Min Hsieh, Chew-Teng Kor, Ming-Chung Chou, Po-Chih Chang, Ting-Wei Chang, Chao-Wen Chen

{"title":"Predicting Adverse Events in Blunt Chest Trauma: A Novel Nomogram Integrating Vitals, Hemogram, and Comorbidities.","authors":"Chang-Lun Huang, Hui-Min Hsieh, Chew-Teng Kor, Ming-Chung Chou, Po-Chih Chang, Ting-Wei Chang, Chao-Wen Chen","doi":"10.1002/kjm2.70088","DOIUrl":"https://doi.org/10.1002/kjm2.70088","url":null,"abstract":"Blunt chest trauma (BCT) is common and frequently associated with adverse complications. Beyond merely impeding regular respiration, adverse events (AEs) such as hemothorax or pneumothorax can hinder the patient's recovery. Herein, we aim to validate potential predictive factors for AEs among adults with BCT who were admitted concurrently through the dataset focusing on the limited information available upon their arrival at the emergency department (ED). Seventeen variables-including patients' demographics, comorbidities, and vital signs/hemogram data upon arrival at the ED-were investigated. A penalized logistic regression model was applied to the derivation cohort and validated in a subgroup using the same dataset (80%:20%). In addition, we employed the least absolute shrinkage and selection operator (LASSO) logistic regression to develop a nomogram, which enhances the accuracy of estimating individual probabilities for AEs after admission for BCT. Our retrospective review encompassed 3,668 adult patients between 2017 and 2021, and the incidence of AEs was 15.6% (572 out of 3,668). Penalized logistic regression was conducted both without and with the hemogram data (Model 1 and Model 2), yielding relatively satisfactory results (R2: 0.271 vs. 0.291; area under the curve: 0.784 vs. 0.797, respectively). Despite the model's relatively high predictive value in the derivation cohort, the validation data still maintained an acceptable accuracy of 0.7456 and 0.7049, respectively. Employing our penalized logistic regression analysis, the recently formulated nomogram exhibited proficiency in predicting AEs following BCT. This effectiveness was achieved by integrating vital signs, hemogram data, and comorbidities recorded upon their arrival at the ED.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70088"},"PeriodicalIF":3.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Diabetic Striatopathy Misdiagnosed as Intracranial Hemorrhage Showing the Importance of Early MRI. 糖尿病纹状体病误诊为颅内出血1例：早期MRI检查的重要性。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-17 DOI: 10.1002/kjm2.70092

Yi-Ming Lu, I-Hsaio Yang, Yoon Bin Chong

引用次数: 0

Impact of Environmental and Seasonal Factors on Spontaneous Pneumomediastinum With and Without Pneumorrhachis. 环境和季节因素对自发性纵隔气肿伴和不伴气肿的影响。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-17 DOI: 10.1002/kjm2.70096

Yu-Wei Liu, Chieh-Ni Kao, Chi-Chang Ho, Shah-Hwa Chou, Pau-Chung Chen, Shu-Hung Huang

{"title":"Impact of Environmental and Seasonal Factors on Spontaneous Pneumomediastinum With and Without Pneumorrhachis.","authors":"Yu-Wei Liu, Chieh-Ni Kao, Chi-Chang Ho, Shah-Hwa Chou, Pau-Chung Chen, Shu-Hung Huang","doi":"10.1002/kjm2.70096","DOIUrl":"https://doi.org/10.1002/kjm2.70096","url":null,"abstract":"Spontaneous pneumomediastinum (SPM) with pneumorrhachis is rare but generally benign and self-limiting. However, the impact of environmental and seasonal factors on SPM remains unclear. This study investigated their association with SPM onset and clinical outcomes. We conducted a 12-year retrospective review of SPM cases, comparing clinical characteristics and outcomes between patients with and without pneumorrhachis. A case-crossover design was used to assess short-term associations between environmental exposures and SPM incidence, analyzed via conditional logistic regression. A total of 70 consecutive patients were identified, with 9 classified as SPM with pneumorrhachis and 61 as SPM without pneumorrhachis. While both groups were predominantly managed with hospitalization, those with pneumorrhachis had longer hospital stays (median: 7 vs. 3 days, p = 0.002) and were more often associated with severe-grade SPM and identifiable triggers (p < 0.001 and p = 0.009, respectively). No significant environmental exposure differences were observed between groups. Seasonally, SPM incidence was significantly higher in autumn and winter (p < 0.001), consistent with elevated air pollutant levels. Linear regression showed that standardized β coefficients for PM2.5 were higher in autumn and winter (β = 1.15 and β = 1.18), indicating a seasonal association between PM2.5 and SPM onset. Despite experiencing more triggers and longer hospitalization, patients with pneumorrhachis had similarly favorable clinical courses. The seasonal clustering of SPM and its association with elevated PM2.5 levels suggest that air pollution may be a contributing factor, warranting further investigation.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70096"},"PeriodicalIF":3.1,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Effects of Insulin Glargine U300 Versus Insulin Degludec U100 on Glycemic Variability, Hypoglycemia, and Diet Evaluated by Continuous Glucose Monitoring in Type 1 Diabetes: A Retrospective Cross-Sectional Study". 修正了“甘精胰岛素U300与葡糖苷胰岛素U100对1型糖尿病患者血糖变异性、低血糖和饮食的影响：一项回顾性横断面研究”。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-13 DOI: 10.1002/kjm2.70090

引用次数: 0

KLF1 Promotes Non-Small Cell Lung Cancer Cell Proliferation and Invasion by Upregulating the LINC02159/DYNC1H1 Pathway. KLF1通过上调LINC02159/DYNC1H1通路促进非小细胞肺癌细胞增殖和侵袭。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-12 DOI: 10.1002/kjm2.70070

Han Yang

{"title":"KLF1 Promotes Non-Small Cell Lung Cancer Cell Proliferation and Invasion by Upregulating the LINC02159/DYNC1H1 Pathway.","authors":"Han Yang","doi":"10.1002/kjm2.70070","DOIUrl":"https://doi.org/10.1002/kjm2.70070","url":null,"abstract":"Non-small cell lung cancer (NSCLC) is a common and fatal malignancy. This study aimed to elucidate the mechanism of Kruppel-like factor (KLF1) in NSCLC progression. Clinical samples were collected, after which the expression levels of KLF1, LINC02159, and dynein cytoplasmic 1 heavy chain 1 (DYNC1H1) in tissues and cells were initially detected, and NSCLC cell proliferation and invasion were measured when KLF1 was up- or downregulated. The binding relationships among KLF1, the LINC02159 promoter, DYNC1H1, and serine and arginine-rich splicing factor 1 (SRSF1) were analyzed. The colocalization of LINC02159 and SRSF1 was verified. DYNC1H1 stability upon actinomycin D treatment was assessed. Combined experiments were designed to confirm the interaction of the LINC02159/DYNC1H1 pathway in NSCLC development. Finally, xenograft tumors were generated in nude mice to validate the mechanism involved. KLF1, LINC02159, and DYNC1H1 were upregulated in NSCLC tissues and cells. KLF1 overexpression promoted NSCLC cell proliferation and invasion, whereas KLF1 knockdown inhibited NSCLC cell proliferation and invasion. Mechanistically, KLF1 transcriptionally activated LINC02159, which could recruit the SRSF1 protein and increase DYNC1H1 mRNA stability in the cytoplasm. Combined experiments revealed that LINC02159 and DYNC1H1 overexpression could counteract the inhibitory effect of KLF1 silencing on NSCLC cell proliferation and invasion. KLF1 silencing inhibited tumor growth in vivo by downregulating the LINC02159DYNC1H1 pathway.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70070"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disease Modification of Pustular Psoriasis by Secukinumab: A 20-Year Follow-Up of Von Zumbusch-Type Generalized Pustular Psoriasis With Evolution Into Annular Pustular Psoriasis-A Case Report. Secukinumab对脓疱性银屑病的疾病改变：Von zumbusch型广泛性脓疱性银屑病演变为环状脓疱性银屑病的20年随访报告

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-12 DOI: 10.1002/kjm2.70083

Yu-Han Alice Hsu, Cheng-Che E Lan, Sheng-Yiao Lin

引用次数: 0

Long-Term Outcomes of Radiofrequency Ablation for Benign Thyroid Nodules of Different Sizes: Implications of Regrowth and New Growth. 射频消融治疗不同大小良性甲状腺结节的长期疗效：再生和新生长的意义。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-11 DOI: 10.1002/kjm2.70089

Chia-Yin Lu, An-Ni Lin, Cheng-Kang Wang, Pi-Ling Chiang, Chen-Kai Chou, Sheng-Dean Luo, Yueh-Sheng Chen, Chih-Ying Lee, Jung-Hwan Baek, Hsiu-Ling Chen, Wei-Che Lin

{"title":"Long-Term Outcomes of Radiofrequency Ablation for Benign Thyroid Nodules of Different Sizes: Implications of Regrowth and New Growth.","authors":"Chia-Yin Lu, An-Ni Lin, Cheng-Kang Wang, Pi-Ling Chiang, Chen-Kai Chou, Sheng-Dean Luo, Yueh-Sheng Chen, Chih-Ying Lee, Jung-Hwan Baek, Hsiu-Ling Chen, Wei-Che Lin","doi":"10.1002/kjm2.70089","DOIUrl":"https://doi.org/10.1002/kjm2.70089","url":null,"abstract":"Radiofrequency ablation is an effective treatment for benign thyroid nodules. Since initial nodule volume may impact the efficacy of radiofrequency ablation, this study evaluated its long-term outcomes across varying nodule sizes, focusing on regrowth, new growth, and clinical management implications. This retrospective study included 160 patients who underwent thyroid radiofrequency ablation for benign thyroid nodules at a Taiwanese tertiary center between July 2016 and April 2018. Patients were classified into three groups based on nodule size: small (< 10 mL), medium (10-30 mL), and large (> 30 mL). Treatment efficacy was assessed over a period of up to 5 years, focusing on volume reduction rate, regrowth, residual volume, and new growth. The initial ablation rate of all benign thyroid nodules was 99.46%. After the 5-year follow-up, the volume reduction rate was 92.96%. The small nodule group demonstrated the highest volume reduction rate. The incidence of increased residual vital volume was 3.57%. The overall regrowth rate was 9.82%, with a mean time to regrowth of 2.8 years. No nodules required retreatment due to regrowth. New growth was observed in 22.32% of patients, with the highest incidence in the large nodule group (34.29%). Radiofrequency ablation is effective in the long-term management of benign thyroid nodules across various sizes, achieving substantial volume reduction rate with minimal complications. For larger nodules, monitoring for new growth warrants increased attention and may serve as a critical parameter indicative of recurrence and the potential need for retreatment.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70089"},"PeriodicalIF":3.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparoscopic Splenectomy for Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma: A RareEpstein-Barr Virus-Associated Splenic Tumor. 腹腔镜下脾切除术治疗炎性假瘤样滤泡树突状细胞肉瘤：一种罕见的eb病毒相关脾肿瘤。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-04 DOI: 10.1002/kjm2.70082

Hsin-Yi Lin, Po-Hsuan Wu, Hui-Gin Chiu, Jia-Yu Chen

引用次数: 0

Major Ozonated Autoheamotherapy Alleviates Skeletal Muscle Ischemia/Reperfusion Injury by Regulating Nrf2/HO-1 Pathway. 臭氧自热疗法通过调控Nrf2/HO-1通路减轻骨骼肌缺血再灌注损伤

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-08-01 Epub Date: 2025-05-23 DOI: 10.1002/kjm2.70039

Hui-Zhuang Guo, Sheng-Long Yu, Han-Wei Chen

{"title":"Major Ozonated Autoheamotherapy Alleviates Skeletal Muscle Ischemia/Reperfusion Injury by Regulating Nrf2/HO-1 Pathway.","authors":"Hui-Zhuang Guo, Sheng-Long Yu, Han-Wei Chen","doi":"10.1002/kjm2.70039","DOIUrl":"10.1002/kjm2.70039","url":null,"abstract":"Skeletal muscle ischaemia/reperfusion (I/R) injury remains a clinically significant condition characterized by muscular dystrophy. Although ozone therapy has shown protective potential against I/R injury in animal models of various organs including skeletal muscle, its precise mechanistic underpinnings require further elucidation. This investigation evaluates the therapeutic potential of major ozonated autohemotherapy (MOAH) for skeletal muscle I/R injury management. Utilizing a rat femoral artery ligation/release model, we demonstrated that MOAH pretreatment substantially alleviated histopathological damage through hematoxylin-eosin/Masson staining analyzes, diminished skeletal muscle apoptosis via terminal deoxynucleotidyl transferase dUTP nick-end labeling and Western blot, and reduced tissue edema as quantified by wet weight ratios. Serum biomarker assessments confirmed decreased creatine kinase and lactate dehydrogenase levels with MOAH administration. In oxygen-glucose deprivation/reoxygenation (OGD/R)-treated L6 myoblast models, ozone pretreatment enhanced cellular proliferation capacity while attenuating apoptosis and mitochondrial dysfunction. Subsequent analyzes revealed ozone's regulatory effects on oxidative stress markers (MDA content, SOD and CAT activity) and inflammatory factors (TNF-α and IL-1β) across both in vivo and in vitro models. Mechanistic evaluations through Western blot and reverse transcription quantitative real-time polymerase chain reaction techniques identified MOAH-induced activation of the Nrf2/HO-1 signaling pathway, with observed abolition of protective efficacy under Nrf2 knockdown conditions. These results collectively establish that MOAH mitigates skeletal muscle I/R injury through Nrf2/HO-1 pathway modulation, providing substantive mechanistic justification for its clinical implementation in I/R injury therapeutics.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70039"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0