The Kaohsiung journal of medical sciences最新文献_第10页

Robotic-Assisted Versus Laparoscopic-Assisted Colectomy: Findings on Short-Term Outcomes From A Multi-Institutional Propensity Score-Matched Study. 机器人辅助与腹腔镜辅助结肠切除术：一项多机构倾向评分匹配研究的短期结果。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-01 Epub Date: 2026-01-21 DOI: 10.1002/kjm2.70163

Ching-Wen Huang, Chien-Chih Chen, Jeng-Fu You, Yi-Ho Cheng, Feng-Fan Chiang, Jaw-Yuan Wang

{"title":"Robotic-Assisted Versus Laparoscopic-Assisted Colectomy: Findings on Short-Term Outcomes From A Multi-Institutional Propensity Score-Matched Study.","authors":"Ching-Wen Huang, Chien-Chih Chen, Jeng-Fu You, Yi-Ho Cheng, Feng-Fan Chiang, Jaw-Yuan Wang","doi":"10.1002/kjm2.70163","DOIUrl":"10.1002/kjm2.70163","url":null,"abstract":"The present study compared the short-term outcomes and perioperative complications of robotic-assisted colectomy (RAC) and laparoscopic-assisted colectomy (LAC) in patients with colon cancer. This retrospective study included patients with histologically confirmed colon adenocarcinoma who underwent either RAC or LAC at five medical centers in Taiwan over the period between January 2015 and December 2021. Baseline characteristics, perioperative outcomes, and complications were obtained from operative notes and medical records. A total of 838 patients were included, with 413 undergoing RAC and 425 undergoing LAC. In the original study cohort, right colectomies and sigmoid colectomies were more frequent in the RAC group. In the matched study cohort, the median operative time was significantly longer in the RAC group (p = 0.0065), particularly in the subgroup undergoing left and sigmoid colectomies (p < 0.0001). Conversion rates were similar between the groups (p = 0.0616). Postoperative length of stay was significantly shorter in the RAC group by 1 day (p = 0.0299). Although overall postoperative complications, 30-day mortality, and local recurrence rates were comparable between the groups (all p > 0.05), the patients undergoing right hemicolectomy had a significantly lower complication rate in the RAC group (p = 0.0018). This study is the first multi-institutional propensity score-matched investigation in Taiwan comparing short-term outcomes between RAC and LAC. Our findings suggest that RAC is a safe and feasible alternative to LAC, offering comparable oncological safety with potential advantages such as a reduced length of hospital stay.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70163"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13344327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis. USP7调节TRPV1去泛素化介导软骨细胞下垂，缓解骨关节炎。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-01 Epub Date: 2026-01-09 DOI: 10.1002/kjm2.70162

Jun Li, Ding Chen, Wei-Ye Zhong

{"title":"USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis.","authors":"Jun Li, Ding Chen, Wei-Ye Zhong","doi":"10.1002/kjm2.70162","DOIUrl":"10.1002/kjm2.70162","url":null,"abstract":"Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin-specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry. Safranin O-Fast Green staining detected histopathological changes in OA mice. RT-qPCR and western blotting determined the expression of USP, TRPV1, collagen II, iNOS, MMP13, and MMP3. Primary mouse chondrocytes were treated with IL-1β in vitro to simulate OA. Chondrocyte viability was assessed using the MTT assay. Immunofluorescence staining revealed an increase in reactive oxygen species levels. MDA and Fe2+ levels were measured using appropriate kits. The interaction between USP and TRPV1 was detected using co-immunoprecipitation. An immunoprecipitation assay was used to evaluate TRPV1 ubiquitination. USP7 expression was downregulated in OA mice and IL-1β-stimulated chondrocytes. USP7 overexpression inhibited IL-1β-stimulated ferroptosis and extracellular matrix (ECM) degradation in chondrocytes. USP7, a deubiquitinating enzyme for TRPV1, enhanced TRPV1 stability Reinforced TRPV1 suppressed IL-1β-triggered chondrocyte ferroptosis and ECM degradation. Silencing TRPV1 reversed the effect of USP7 upregulation on IL-1β-induced chondrocyte ferroptosis and OA in OA mice. Therefore, USP7 protects chondrocytes from ferroptosis and ameliorates OA progression by deubiquitinating and upregulating TRPV1, thus providing a new therapeutic target for OA treatment.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70162"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13344328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterogeneity Analyzed by CT-Based Habitat Analysis for Clinical Management of Cancers: A Narrative Review. 以ct为基础的生境分析分析癌症临床管理的异质性：一篇叙述性综述。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-06-25 DOI: 10.1002/kjm2.70257

Yang Zhang, Zhi-Yan Jin, Min-Ying Lydia Su

{"title":"Heterogeneity Analyzed by CT-Based Habitat Analysis for Clinical Management of Cancers: A Narrative Review.","authors":"Yang Zhang, Zhi-Yan Jin, Min-Ying Lydia Su","doi":"10.1002/kjm2.70257","DOIUrl":"10.1002/kjm2.70257","url":null,"abstract":"Tumors are highly heterogeneous, and whole-lesion radiomics analysis is a popular method for extracting texture features that reflect this heterogeneity, which can be used to build models for cancer diagnosis, staging, therapy response evaluation, and prognosis prediction. However, there is no spatial information for understanding which components provide the most critical information. Recently, habitat analysis has gained widespread attention, and it is used to divide a tumor into distinct sub-regions, called habitats, that share common characteristics. CT reveals heterogeneity in attenuation, texture, entropy, and enhancement patterns, which can be used to generate habitats. In the past 2 years, many studies exploring the role of CT habitats have been reported. The divided habitats can be used to build models for the classification of histological or molecular subtypes, the evaluation and prediction of treatment response, and prognostication of progression-free survival or overall survival. This review aims to summarize studies on the application of CT-habitat analysis for cancer management. In addition to clinical applications, various methods for habitat segmentation will be reviewed. Lastly, how spatial information revealed by the habitat can guide tissue biopsy for tissue-level confirmation studies will be described, which is critical for understanding the underlying biology and paving the way for future clinical implementation.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70257"},"PeriodicalIF":3.1,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus. TRIM在系统性红斑狼疮中的表达及其与疾病活动性的关系。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-06-23 DOI: 10.1002/kjm2.70255

Ling-Ying Lu, Ling-Jung Yen, Hui-Ling Hsia, Zi-Xeng Weng, Chi-Hsiang Chung, Paul Wei-Che Hsu, Chih-Wei Chiu, Wu-Chien Chien, Tsung-Hsien Chang

{"title":"TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus.","authors":"Ling-Ying Lu, Ling-Jung Yen, Hui-Ling Hsia, Zi-Xeng Weng, Chi-Hsiang Chung, Paul Wei-Che Hsu, Chih-Wei Chiu, Wu-Chien Chien, Tsung-Hsien Chang","doi":"10.1002/kjm2.70255","DOIUrl":"10.1002/kjm2.70255","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors. The tripartite motif-containing protein (TRIM) family, which regulates immunity, may play a role in SLE. Although TRIM21 is a known autoantigen, the roles of other TRIM family members remain unclear. The present study examined TRIM expression in SLE and evaluated the potential of TRIM proteins as biomarkers. TRIM expression in peripheral blood mononuclear cells was measured using reverse transcription quantitative polymerase chain reaction (PCR) and compared between patients with SLE (n = 33) and healthy controls (n = 20). Associations of TRIM expression with disease activity (active/inactive), renal involvement (nephritis/nonnephritis), clinical manifestations, and laboratory parameters were analyzed. The expression levels of several TRIM genes, specifically TRIM5, TRIM11, TRIM21, and TRIM72, were higher in patients with inactive SLE, nonnephritic disease, or low disease activity than in patients with active disease, nephritic disease, or relapsed SLE and healthy controls. The expression levels of these genes were considerably and negatively associated with clinical symptoms but not laboratory parameters. Hydroxychloroquine users exhibited higher levels of TRIM21 expression than did nonusers. Overall, specific TRIM proteins are inversely correlated with SLE disease activity and clinical phenotypes, which indicates their potential as biomarkers. Hydroxychloroquine may regulate TRIM21 expression. Further investigation into underlying mechanisms and continued TRIM monitoring are necessary to develop new SLE treatments and better assess disease progression.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70255"},"PeriodicalIF":3.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare Cutaneous Metastasis From Esophageal Squamous Cell Carcinoma. 罕见的食管鳞状细胞癌皮肤转移。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-06-22 DOI: 10.1002/kjm2.70249

Sarah Hsin Cheng, Yen-Shuo Huang, Chi-En Hsiao, Hui-Hua Hsiao

引用次数: 0

Rhaponticin Blocks Glycolysis-Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF-1α Activity Inhibition. Rhaponticin阻断糖酵解介导的组蛋白乳酸化，通过抑制HIF-1α活性抑制舌鳞状细胞癌。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-06-18 DOI: 10.1002/kjm2.70254

Yuan Wu, Liang-Liang Yao, Lin Jiang, Zhi-Yi Fang, Jia-Jun Zhu, Yi-Sen Shao, Wen-Juan Wang, Xiao-Wen Wan

{"title":"Rhaponticin Blocks Glycolysis-Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF-1α Activity Inhibition.","authors":"Yuan Wu, Liang-Liang Yao, Lin Jiang, Zhi-Yi Fang, Jia-Jun Zhu, Yi-Sen Shao, Wen-Juan Wang, Xiao-Wen Wan","doi":"10.1002/kjm2.70254","DOIUrl":"10.1002/kjm2.70254","url":null,"abstract":"Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti-tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis involving hypoxia-inducible factor 1α (HIF-1α), glycolysis, and histone H3K18 lactylation (H3K18la). SCC9 and SCC9-CisR cells were treated with Rha alone or in combination with 2-deoxy-D-glucose (2-DG) or sodium lactate (LacNa). The effects of Rha on glycolysis and H3K18la were evaluated by extracellular acidification rate assays, glucose/lactate quantification, and western blotting. Gain- and loss-of-function studies targeting HIF-1α were conducted to determine the mechanistic dependency of Rha-mediated effects. Subcutaneous and liver metastasis xenograft models were established for in vivo validation. Rha significantly suppressed glycolysis, glucose consumption, and lactate production, concomitant with the downregulation of HK2, LDHA, GLUT1, and H3K18la levels. Rha not only mimicked the effects of 2-DG by inhibiting clonogenicity, migration, and invasion and decreasing cisplatin resistance in SCC9 or SCC9-CisR cells but also reversed LacNa-mediated promotion of these parameters, indicating that Rha acts through the glycolysis/lactate pathway. Rha inhibited tumor growth and liver metastasis, enhanced cisplatin sensitivity, and decreased H3K18la levels in mouse models. Mechanistically, Rha inhibited HIF-1α, thereby attenuating glycolytic flux and decreasing lactate-driven H3K18la. Rha inhibits TSCC progression and enhances cisplatin sensitivity by targeting HIF-1α and repressing the glycolysis/lactate/H3K18la axis, suggesting that Rha is a promising candidate for disrupting metabolic/epigenetic crosstalk in TSCC.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70254"},"PeriodicalIF":3.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Retrospective Study on Neonatal Jaundice: Early Risk Stratification Value of DAT-FAT Serological Profiles Confirmed by AET. 新生儿黄疸的回顾性研究：AET证实的DAT-FAT血清学特征的早期危险分层价值。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-06-17 DOI: 10.1002/kjm2.70253

Tian-Ge Wu, Yan-Feng Zhang, Zhong-Jun Shen, Yao Li, Ning Xu, Xiao-Yi Liu, Li-Yan Zhao, Ming-Hao Shi

{"title":"A Retrospective Study on Neonatal Jaundice: Early Risk Stratification Value of DAT-FAT Serological Profiles Confirmed by AET.","authors":"Tian-Ge Wu, Yan-Feng Zhang, Zhong-Jun Shen, Yao Li, Ning Xu, Xiao-Yi Liu, Li-Yan Zhao, Ming-Hao Shi","doi":"10.1002/kjm2.70253","DOIUrl":"10.1002/kjm2.70253","url":null,"abstract":"This retrospective study aimed to explore the value of DAT-FAT serological profiles confirmed by AET in classifying neonatal jaundice, evaluating its severity, and guiding clinical management. A total of 915 jaundiced newborns (584 pathological, 331 physiological) admitted from July 2018 to August 2021 were included. Univariate and multivariate logistic regression analyses were conducted to identify risk factors. To assess predictive ability for jaundice type and early risk stratification of jaundice severity, the 426 patients with ABO incompatibility were stratified into subgroups based on the results of the DAT-FAT-AET serological panel. Maternal pregnancy count, gestational weeks, direct bilirubin at admission, and ABO incompatibility were identified as independent predictors of jaundice type (p < 0.05). Those who tested triple-positive in the DAT-FAT-AET serological panel (Group 2) had the highest predictive value for pathological jaundice (area under the curve, 0.920 [0.788-0.994]), indicating the maximum severity of pathological jaundice (p < 0.01). AET serves as the definitive criterion for confirming ABO-incompatible jaundice, while DAT-FAT profiles enable early risk stratification of severity. Subgrouping by AET-confirmed DAT-FAT serology helps assess etiology and severity in ABO-incompatible neonatal jaundice, supporting clinical early risk stratification.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70253"},"PeriodicalIF":3.1,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Triglyceride-Glucose Index and in-Hospital Intensive Care Unit Readmission in Ischemic Stroke Patients: A Retrospective Analysis Based on the MIMIC-IV Database. 缺血性脑卒中患者甘油三酯-葡萄糖指数与住院重症监护病房再入院的关系：基于MIMIC-IV数据库的回顾性分析

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-06-16 DOI: 10.1002/kjm2.70250

Di Zhang, Ying-Lun Chen, Jian Zhang, Xiang-Jun Hu

{"title":"Association Between Triglyceride-Glucose Index and in-Hospital Intensive Care Unit Readmission in Ischemic Stroke Patients: A Retrospective Analysis Based on the MIMIC-IV Database.","authors":"Di Zhang, Ying-Lun Chen, Jian Zhang, Xiang-Jun Hu","doi":"10.1002/kjm2.70250","DOIUrl":"10.1002/kjm2.70250","url":null,"abstract":"This retrospective cohort study utilized the Medical Information Mart for Intensive Care database to investigate the association between the triglyceride-glucose (TyG) index and in-hospital intensive care unit (ICU) readmission in patients with ischemic stroke (IS). Among 2929 patients, 24.0% experienced ICU readmission. Logistic regression analysis demonstrated that the continuous TyG index was associated with a 17% higher risk of ICU readmission (odds ratio [OR], 1.17; 95% confidence interval [CI], 1.01-1.36; p = 0.04). Compared with the lowest quartile (Q1), the higher TyG index quartiles showed a progressively increased risk of ICU readmission (Q2: OR, 1.49; 95% CI, 1.13-1.96; Q3: OR, 1.46; 95% CI, 1.10-1.95; Q4: OR, 1.53; 95% CI, 1.14-2.05; P for trend = 0.02). Restricted cubic spline analysis revealed a significant nonlinear relationship (P for nonlinearity = 0.027), with an inflection point at a TyG index value of 9.82 (P for log-likelihood ratio = 0.007). Incorporating the TyG index into conventional models significantly improved the predictive performance for ICU readmission, as evidenced by increases in the area under the curve, net reclassification improvement and integrated discrimination improvement. In conclusion, an elevated TyG index was associated with an increased risk of in-hospital ICU readmission in patients with IS and exhibited a nonlinear dose-response relationship. The TyG index enhanced the predictive accuracy of existing scoring tools, suggesting its potential clinical value for risk stratification and early intervention.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70250"},"PeriodicalIF":3.1,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-Guided Thoracic Paravertebral Block With Liposomal Versus Standard Bupivacaine for Older Patients After Thoracoscopic Surgery. 超声引导下胸腔镜术后老年患者椎旁阻滞与标准布比卡因的对比。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-06-11 DOI: 10.1002/kjm2.70244

Wen-Cheng Shi, Ying-Jie Tang, Yao Wang, Zhong Zheng, Jing He

{"title":"Ultrasound-Guided Thoracic Paravertebral Block With Liposomal Versus Standard Bupivacaine for Older Patients After Thoracoscopic Surgery.","authors":"Wen-Cheng Shi, Ying-Jie Tang, Yao Wang, Zhong Zheng, Jing He","doi":"10.1002/kjm2.70244","DOIUrl":"10.1002/kjm2.70244","url":null,"abstract":"The study aimed to investigate the effect of thoracic paravertebral block (TPVB) with liposomal bupivacaine (LB) before anesthesia induction on postoperative pain, quality of recovery (QoR), and opioid consumption in older patients after video-assisted thoracoscopic surgery (VATS). A total of 116 older patients who were scheduled to undergo VATS were allocated into a SB group (TPVB with standard bupivacaine [SB] before anesthesia induction) and a LB group (TPVB with LB before anesthesia induction). The primary outcome was the Numerical Rating Scale (NRS) scores of patients measured at 6, 12, 24, 36, 48, and 72 h postoperatively. The secondary outcomes were score of the QoR-15 questionnaire at 24 h postoperatively, effective times of patient-controlled intravenous analgesia (PCIA), cumulative sufentanil consumption, first time to request for analgesia, incidence of adverse events, and incidence of postoperative delirium. The LB group had significantly lower NRS scores at 24 and 36 h postoperatively than those in the SB group. The LB group exhibited significantly higher QoR-15 scores at 24 h postoperatively, fewer effective times of PCIA, less cumulative sufentanil consumption from 24 to 72 h postoperatively, and longer time to first request for analgesia than the SB group. The two groups did not differ in incidences of adverse events and postoperative delirium. The study provides evidence that TPVB with LB is effective in alleviating postoperative pain at 24 and 36 h postoperatively, improving QoR, and providing opioid savings for older patients after VATS.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70244"},"PeriodicalIF":3.1,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence of Breast Cancer With Scalp Metastasis. 乳腺癌复发伴头皮转移。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-06-11 DOI: 10.1002/kjm2.70252

Yi-Nan Zhu, Wan-Chen Lu, Zi-Yue Wang, Xu-Yong Lin

引用次数: 0