The Kaohsiung journal of medical sciences最新文献_第10页

Psychological Capital Moderates the Association Between Social Participation and Depressive Symptoms in Taiwanese University Students. 心理资本调节台湾大学生社会参与与抑郁症状的关系。

The Kaohsiung journal of medical sciences Pub Date : 2025-06-20 DOI: 10.1002/kjm2.70072

Yi-Lung Chen, Agata Chudzicka-Czupała, Cheng-Fang Yen

引用次数: 0

Case Report of Long QT Syndrome in a Patient With Syncope. 长QT综合征并发晕厥1例报告。

The Kaohsiung journal of medical sciences Pub Date : 2025-06-17 DOI: 10.1002/kjm2.70065

Chun-Yu Chen, Rui-Xian Wang, Ken-Pen Weng, Shih-Ming Huang

引用次数: 0

Severe Skin Necrosis and Crusting Following Disseminated Herpes in a Kidney Transplant Patient: A Rare and Alarming Case. 肾移植患者播散性疱疹后严重皮肤坏死和结痂：罕见而令人担忧的病例。

The Kaohsiung journal of medical sciences Pub Date : 2025-06-17 DOI: 10.1002/kjm2.70062

Chung-Ting Cheng, Lee-Moay Lim, Hung-Tien Kuo, Yi-Wen Chiu

引用次数: 0

LncRNA SOX21-AS1 Promotes the Progression of Pancreatic Cancer by Sponging miR-9-3p and Upregulating YOD1. LncRNA SOX21-AS1通过海绵化miR-9-3p和上调YOD1促进胰腺癌进展

The Kaohsiung journal of medical sciences Pub Date : 2025-06-17 DOI: 10.1002/kjm2.70054

Han-Bing Xu, Jian-Tao Han, Cheng-Peng Zhang, Bin Jiang

{"title":"LncRNA SOX21-AS1 Promotes the Progression of Pancreatic Cancer by Sponging miR-9-3p and Upregulating YOD1.","authors":"Han-Bing Xu, Jian-Tao Han, Cheng-Peng Zhang, Bin Jiang","doi":"10.1002/kjm2.70054","DOIUrl":"https://doi.org/10.1002/kjm2.70054","url":null,"abstract":"Pancreatic cancer (PC) is a highly aggressive malignancy of the digestive system. Recent studies have indicated that the long noncoding RNA SOX21-AS1 is significantly upregulated in PC tissue samples. This study aims to elucidate the biological role and underlying molecular mechanisms of SOX21-AS1 in PC progression. Quantitative real-time PCR (qRT-PCR) and western blot analyses were employed to assess RNA and protein expression levels, respectively. The subcellular localization of SOX21-AS1 was determined using subcellular fractionation assays. PC cell viability, migratory capacity, and apoptosis were evaluated through CCK-8 assays, wound healing assays, and flow cytometry. Dual-luciferase reporter and RNA pull-down assays were conducted to confirm the interactions between miR-9-3p and either SOX21-AS1 or YOD1. Additionally, a xenograft mouse model was established to investigate the in vivo effects of SOX21-AS1. The findings revealed that SOX21-AS1 is highly expressed in PC tissues and cell lines, with its upregulation correlating with poor patient prognosis. Functional assays demonstrated that knockdown of SOX21-AS1 suppressed PC cell proliferation and migration, induced apoptosis in vitro, and reduced tumor growth in vivo. Mechanistically, SOX21-AS1 competitively interacted with miR-9-3p to upregulate YOD1, consequently activating the TGF-β/Smad signaling pathway. Furthermore, overexpression of YOD1 reversed the tumor-suppressive effects observed after SOX21-AS1 knockdown. In conclusion, SOX21-AS1 promotes PC cell malignancy through the miR-9-3p/YOD1 axis and subsequent activation of TGF-β/Smad signaling.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70054"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Spread Through Air Spaces (STAS) on Recurrence and Surgical Trends in Stage I Non-Small Cell Lung Cancer: A Real-World Cohort Study. 气道扩散（STAS）对I期非小细胞肺癌复发和手术趋势的影响：一项真实世界队列研究

The Kaohsiung journal of medical sciences Pub Date : 2025-06-17 DOI: 10.1002/kjm2.70061

Cheng-Hao Chuang, Yu-Wei Liu, Wei-An Lai, Yi-Wen Shen, Shih-Yu Kao, Yu-Ching Wei, Chu-Chun Chien, Hui-Yang Hung, Jui-Ying Lee, Min-Fang Chao, Jen-Yu Hung, Inn-Wen Chong, Chih-Jen Yang

{"title":"Impact of Spread Through Air Spaces (STAS) on Recurrence and Surgical Trends in Stage I Non-Small Cell Lung Cancer: A Real-World Cohort Study.","authors":"Cheng-Hao Chuang, Yu-Wei Liu, Wei-An Lai, Yi-Wen Shen, Shih-Yu Kao, Yu-Ching Wei, Chu-Chun Chien, Hui-Yang Hung, Jui-Ying Lee, Min-Fang Chao, Jen-Yu Hung, Inn-Wen Chong, Chih-Jen Yang","doi":"10.1002/kjm2.70061","DOIUrl":"https://doi.org/10.1002/kjm2.70061","url":null,"abstract":"Non-small cell lung cancer (NSCLC) is the most common form of lung cancer, which remains a leading cause of cancer mortality worldwide. Early detection, particularly at Stage I, is critical for improving survival outcomes. Low-dose computed tomography (LDCT) has increased the detection of small asymptomatic tumors, resulting in an earlier diagnosis and facilitating less invasive surgical approaches such as segmentectomy and wedge resection, which preserve lung function while offering survival outcomes comparable to lobectomy. However, the risk factors for recurrence in Stage I NSCLC remain poorly understood. This retrospective study analyzed 1077 Stage I NSCLC patients treated at Kaohsiung Medical University Hospital from 2010 to 2022. Data including AJCC 7th and 8th editions staging, surgical interventions, and pathological features were analyzed. The proportion of Stage I cases increased significantly from 9.3% in 2010 to 33.8% in 2017, with Stage IA cases increasing from 12.1% in 2018 to 38.2% in 2022. Concurrently, the lobectomy rate decreased from 75% in 2010 to 43.6% in 2022, with more sublobar resections performed. Kaplan-Meier analysis found no significant differences in recurrence-free survival between lobectomy and sublobar resection with regional lymph node dissection. Cox regression identified spread through air spaces (STAS) as an independent risk factor for recurrence (hazard ratio 2.87, p = 0.006), along with male sex, larger tumor size, and visceral pleural invasion. These findings highlight the role of LDCT in early detection and the importance of tailored treatment strategies, particularly addressing STAS, to optimize recurrence-free survival and improve outcomes of patients with Stage I NSCLC.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70061"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Point-of-Care Model for Hepatitis C Elimination in Remote Islands of Taiwan. 台湾偏远海岛的丙型肝炎即时治疗模式。

The Kaohsiung journal of medical sciences Pub Date : 2025-06-06 DOI: 10.1002/kjm2.70060

Tzu-Chun Lin, Pei-Chien Tsai, Chung-Feng Huang, Ming-Lun Yeh, Yu-Ju Wei, Ming-Yen Hsieh, Ming-Jong Bair, Chia-Yen Dai, Jee-Fu Huang, Ming-Lung Yu, Wan-Long Chuang

{"title":"A Point-of-Care Model for Hepatitis C Elimination in Remote Islands of Taiwan.","authors":"Tzu-Chun Lin, Pei-Chien Tsai, Chung-Feng Huang, Ming-Lun Yeh, Yu-Ju Wei, Ming-Yen Hsieh, Ming-Jong Bair, Chia-Yen Dai, Jee-Fu Huang, Ming-Lung Yu, Wan-Long Chuang","doi":"10.1002/kjm2.70060","DOIUrl":"https://doi.org/10.1002/kjm2.70060","url":null,"abstract":"Timely and efficient diagnosis of hepatitis C virus (HCV) infection remains the effective approach for the subsequent care cascade of HCV treatment. It is of importance in under-resourced areas. The study aimed to assess the feasibility of a point-of-care (POC) model by a rapid diagnostic test and subsequent confirmational HCV RNA test in remote islands where traffic is an additional hurdle for health care. We conducted a mass POC screening program in 3 outlying islands, including Liuqiu (6.8 km2, 12,000 residents), Green (15.1 km2, 4280 residents), and Orchid (48.4 km2, 5230 residents) islands. We used immunochromatography-based finger-tip assays for HCV antibody detection. Serum HCV RNA was measured among patients seropositive for the rapid anti-HCV test. There were 1055, 268, and 276 adult residents receiving rapid tests in Liuqiu, Green, and Orchid, respectively, yielding response rates of 47.0%, 41.1%, and 24.4%, respectively. The prevalence of anti-HCV-positive were 1.3% (n = 14), 1.1% (n = 3), and 0, respectively. Nine (52.9%) of the 17 anti-HCV-positive patients were HCV RNA-negative. The HCV RNA-positive patients then received anti-viral treatment. The average turnaround time for overall POC HCV test results was 11.8 ± 3.2 min, and the sampling time was completed within 10-30 s. Meanwhile, the labor cost of HCV RNA screening was 156.3 USD, which was a 28.6% decrease compared to traditional methods. The study demonstrated the feasibility and effectiveness of the POC model for HCV elimination in remote islands with limited resources.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70060"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Kaohsiung journal of medical sciences Pub Date : 2025-06-06 DOI: 10.1002/kjm2.70057

Yu-Tsun Hsieh, Pier-In Liang, Meng-Hsuan Chiang

引用次数: 0

Dexmedetomidine as a Ropivacaine Adjuvant in a Thoracic Paravertebral Block Combined With an Erector Spinae Plane Block for Improving Early Quality of Recovery After Transapical Transcatheter Aortic Valve Implantation. 右美托咪定作为罗哌卡因佐剂在胸椎旁阻滞联合竖椎平面阻滞中提高经根尖经导管主动脉瓣置入术后早期恢复质量

The Kaohsiung journal of medical sciences Pub Date : 2025-06-06 DOI: 10.1002/kjm2.70058

Gui-Ling Dong, Rong-En Qiu, Chen-Zhan Xu

{"title":"Dexmedetomidine as a Ropivacaine Adjuvant in a Thoracic Paravertebral Block Combined With an Erector Spinae Plane Block for Improving Early Quality of Recovery After Transapical Transcatheter Aortic Valve Implantation.","authors":"Gui-Ling Dong, Rong-En Qiu, Chen-Zhan Xu","doi":"10.1002/kjm2.70058","DOIUrl":"https://doi.org/10.1002/kjm2.70058","url":null,"abstract":"The study aimed to investigate the effectiveness of dexmedetomidine (Dex) as an adjuvant for ropivacaine in a thoracic paravertebral block (TPVB) combined with an erector spinae plane block (ESPB) for improving early quality of recovery and postoperative pain after transapical transcatheter aortic valve implantation (TAVI). A total of 89 patients who were scheduled to undergo transapical TAVI under general anesthesia were allocated into Group RS and Group RD by using a computer-generated random-number list. Group RS (n = 45) received 35 mL of 0.5% ropivacaine with 5 mL of a normal saline mixture in TPVB combined with ESPB and Group RD (n = 44) received 35 mL of 0.5% ropivacaine with 1 μg/kg Dex in 5 mL of normal saline. The RD group exhibited significantly higher global QoR-15 scores with lower visual analog scale (VAS) scores at 12 and 24 h postoperatively than the RS group. The RD group needed fewer press times of PCIA than the RS group. The postoperative sufentanil consumption was significantly less in the RD group than that in the RS group. A longer time to first use of flurbiprofen with less remedial doses of flurbiprofen consumption within 48 h postoperatively was required for the RD group than that for the RS group. The two groups did not differ in the incidence of side effects. The findings of the study suggest that adding Dex to ropivacaine in TPVB combined with ESPB is effective in improving early quality of recovery and alleviating postoperative pain for patients undergoing transapical TAVI under general anesthesia.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70058"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus-Positive Hepatocellular Carcinoma Cells. EP300调节MCM8转录并增强乙型肝炎病毒阳性肝癌细胞的恶性表型

The Kaohsiung journal of medical sciences Pub Date : 2025-06-01 Epub Date: 2025-03-17 DOI: 10.1002/kjm2.70006

Fang Xue, Tian-Feng Sun

{"title":"EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus-Positive Hepatocellular Carcinoma Cells.","authors":"Fang Xue, Tian-Feng Sun","doi":"10.1002/kjm2.70006","DOIUrl":"10.1002/kjm2.70006","url":null,"abstract":"Chronic infection with the hepatitis B virus (HBV) remains one of the primary drivers of the development of hepatocellular carcinoma (HCC), a highly aggressive malignancy with a grim prognosis. This study focused on the role of E1A-binding protein p300 (EP300) in the malignant phenotype of HBV-positive HCC cells and its functional mechanism. Increased EP300 expression was detected in HBV-positive tumor tissues and cells compared to their control counterparts. Silencing EP300 reduced tumorigenic activity, proliferation, viability, migration, invasion, and resistance to apoptosis of HBV-positive cells and reduced the concentrations of HBV infection markers HBsAg and HBeAg. These effects were achieved, at least in part, through downregulation of minichromosome maintenance 8 homologous recombination repair factor (MCM8). MCM8 was identified as a target of EP300 and mediated by acetylation modification. MCM8 was upregulated in HBV-positive tumors and HCC cells while decreasing following EP300 silencing in cells. However, the restoration of MCM8 expression in these cells rescued their malignant properties. In summary, this study suggests a role for EP300-mediated MCM8 upregulation in the malignant properties of HBV-positive HCC.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70006"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smoking and Elevated Preneoadjuvant Chemoradiotherapy Serum Carcinoembryonic Antigen Levels Are Associated With High Tumor Regression Grade and Poor Survival in Patients With Locally Advanced Rectal Cancer. 吸烟和新辅助放化疗前血清癌胚抗原水平升高与局部晚期直肠癌患者肿瘤消退程度高和生存率低相关

The Kaohsiung journal of medical sciences Pub Date : 2025-06-01 Epub Date: 2025-03-13 DOI: 10.1002/kjm2.70008

Jen-Pin Chuang, Hsiang-Lin Tsai, Po-Jung Chen, Ching-Wen Huang, Wei-Chih Su, Tsung-Kun Chang, Yen-Cheng Chen, Ching-Chun Li, Yung-Sung Yeh, Jaw-Yuan Wang

{"title":"Smoking and Elevated Preneoadjuvant Chemoradiotherapy Serum Carcinoembryonic Antigen Levels Are Associated With High Tumor Regression Grade and Poor Survival in Patients With Locally Advanced Rectal Cancer.","authors":"Jen-Pin Chuang, Hsiang-Lin Tsai, Po-Jung Chen, Ching-Wen Huang, Wei-Chih Su, Tsung-Kun Chang, Yen-Cheng Chen, Ching-Chun Li, Yung-Sung Yeh, Jaw-Yuan Wang","doi":"10.1002/kjm2.70008","DOIUrl":"10.1002/kjm2.70008","url":null,"abstract":"Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for patients with locally advanced rectal cancer (LARC). Tumor regression grade (TRG) is an essential prognostic factor in determining treatment efficacy. However, the potential factors influencing TRG in patients with rectal cancer who have received NACRT have not been investigated. We conducted a retrospective analysis of patients with LARC who received NACRT followed by surgical resection. We collected data on the patient characteristics, including age, sex, comorbidities, tumor size, lymph node status, time between NACRT and surgery, and pretreatment carcinoembryonic antigen (CEA) levels. TRG was determined on the basis of a pathological assessment of resected specimens, and overall survival (OS) at 5 years was determined. Univariate and multivariate logistic regression models were employed to evaluate the association between the patient characteristics and TRG. Univariate analysis revealed that smoking and prechemoradiotherapy (pre-CRT) and preoperative CEA levels were significantly associated with TRG. In a multivariate analysis, both smoking and higher pre-CRT CEA levels were identified as significant predictors of a high TRG. The hazard ratios were 2.32 (95% confidence interval [CI]: 1.06-5.07, p = 0.036) for smoking and 3.1 (95% CI: 1.69-5.68, p < 0.001) for higher pre-CRT CEA levels. In Kaplan-Meier analysis, the nonsmoker group exhibited higher OS (p = 0.004). Elevated pre-CRT CEA levels and current smoking status were associated with a more than two fold increase in the risk of a higher TRG after NACRT. Moreover, smoking was a significant risk factor for poor OS in patients with LARC following NACRT.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70008"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0