The Kaohsiung journal of medical sciences最新文献

Allogeneic Human Bone Marrow-Derived Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Inflammation Suppression and Angiogenesis Promotion: A Preclinical Study. 异体人骨髓间充质干细胞通过抑制炎症和促进血管生成加速糖尿病伤口愈合：一项临床前研究。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-15 DOI: 10.1002/kjm2.70303

Rong-Fu Chen, Keng-Fan Liu, Chia-Chun Lee, Yu-Han Chen, Hsin-Hsin Shen, Yur-Ren Kuo

{"title":"Allogeneic Human Bone Marrow-Derived Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Inflammation Suppression and Angiogenesis Promotion: A Preclinical Study.","authors":"Rong-Fu Chen, Keng-Fan Liu, Chia-Chun Lee, Yu-Han Chen, Hsin-Hsin Shen, Yur-Ren Kuo","doi":"10.1002/kjm2.70303","DOIUrl":"10.1002/kjm2.70303","url":null,"abstract":"Mesenchymal stem cells (MSCs) have been shown to enhance tissue regeneration and wound healing. This preclinical study investigated the therapeutic potential of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) for accelerating diabetic wound healing. Isolated hBM-MSCs were characterized for surface marker expression and differentiation potential. Their migration-promoting effects were evaluated in vitro. For the in vivo study, a dorsal skin defect model was created in streptozotocin (STZ)-induced diabetic rats. Rats received periwound subcutaneous injections of low- or high-dose hBM-MSCs on Days 4 and 7, or freezing fluid as a vehicle control. Wound healing progression was assessed clinically, and tissue biopsies were analyzed using immunohistochemistry to evaluate inflammatory cell infiltration, cellular proliferation, and angiogenesis. hBM-MSCs exhibited the expected surface marker profile and multilineage differentiation potential. In vitro, hBM-MSCs significantly enhanced the migration of human umbilical vein endothelial cells and human foreskin fibroblasts. In vivo, wounds treated with hBM-MSCs showed significantly accelerated healing compared to vehicle-treated controls (p < 0.05). Immunohistochemical analysis revealed reduced inflammatory cell infiltration and increased expression of Ki-67, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and prolyl 4-hydroxylase (P4H) in hBM-MSC-treated wounds. Allogeneic hBM-MSCs significantly promote diabetic wound healing by suppressing inflammation, enhancing cellular proliferation and differentiation, and stimulating angiogenesis. These findings highlight the therapeutic potential of allogeneic hBM-MSCs for treating diabetic wounds, particularly in patients unsuitable for autologous cell therapy.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70303"},"PeriodicalIF":3.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Artificial Intelligence to Predict Dental Crowding in Modern Orthodontic Practice: A Comprehensive Review. 利用人工智能预测牙齿拥挤在现代正畸实践：一个全面的回顾。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-15 DOI: 10.1002/kjm2.70304

Xiwen Xin, Shun-Yu Kan, Tianle Chen, Ching-Chang Ko

{"title":"Harnessing Artificial Intelligence to Predict Dental Crowding in Modern Orthodontic Practice: A Comprehensive Review.","authors":"Xiwen Xin, Shun-Yu Kan, Tianle Chen, Ching-Chang Ko","doi":"10.1002/kjm2.70304","DOIUrl":"10.1002/kjm2.70304","url":null,"abstract":"Dental crowding is fundamental to orthodontic diagnosis and treatment planning, yet what constitutes \"crowding\" remains surprisingly heterogeneous. Space analysis quantifies tooth size-arch length discrepancy, irregularity indices characterize alignment displacement, and clinician-assigned severity reflects broader diagnostic interpretation. This narrative review examines the evolution of crowding assessment from conventional space analysis and digital measurement to two-dimensional artificial intelligence (AI), three-dimensional point-cloud learning, and clinician-aware agentic AI. Digitalization improves efficiency and reproducibility but does not resolve fundamental dependencies on how crowding is defined, anatomically represented, and established as a reference standard. Two-dimensional models enable prediction from readily available images but are constrained by projection and scale, whereas three-dimensional approaches directly learn from dental surface representations and can capture local geometric relationships. In a companion study of 495 arches from 284 patients, PointNet++ achieved an R2 of 0.718 and a mean absolute error (MAE) of 1.54 mm for prediction of crowding. In a separate retrospective demonstration, a bounded Gemini-based Agent incorporating matched record-derived verbal information reduced MAE from 1.951 to 1.437 mm, whereas mismatched information degraded performance. These findings also illustrate that the target construct-the specific clinical feature of crowding that a model is trained to predict-may differ across assessment methods. Together, these findings highlight a fundamental challenge: improving prediction does not resolve ambiguity in the target construct. Future crowding AI should therefore align the target construct, reference standard, and input representation; preserve provenance and uncertainty; integrate complementary clinical information transparently; and route uncertain cases for expert review.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70304"},"PeriodicalIF":3.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly Recurrent Exotropia After Surgery Unmasks an Oculomotor Nerve Meningioma: A Diagnostic Pitfall. 手术后迅速复发的外斜视揭示了动眼神经脑膜瘤：一个诊断陷阱。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-12 DOI: 10.1002/kjm2.70300

Ting-En Chen, Hsiu-Mei Huang, You-Ting Wu, Jung Lo

引用次数: 0

Efficacy of Negative Pressure Suction-Assisted Flexible Ureteroscopy for Upper Urinary Tract Calculi and Construction of a Stone-Free Rate Prediction Model. 负压吸吸辅助输尿管软镜治疗上尿路结石的疗效及结石游离率预测模型的建立。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-12 DOI: 10.1002/kjm2.70299

Ren-Hui Qiu, Ding-Sheng He, Chun-Yu Guo, Li Dong, Guo-Zhang Lin

{"title":"Efficacy of Negative Pressure Suction-Assisted Flexible Ureteroscopy for Upper Urinary Tract Calculi and Construction of a Stone-Free Rate Prediction Model.","authors":"Ren-Hui Qiu, Ding-Sheng He, Chun-Yu Guo, Li Dong, Guo-Zhang Lin","doi":"10.1002/kjm2.70299","DOIUrl":"10.1002/kjm2.70299","url":null,"abstract":"This study retrospectively analyzed 92 patients who underwent negative-pressure suction sheath-assisted flexible ureteroscopic lithotripsy (observation group) and 85 patients who underwent conventional flexible ureteroscopic lithotripsy (control group). Propensity score full matching and weighted analyses were used to balance covariates. Operative time, hospital stay, pain scores, hemoglobin changes, white blood cell counts, neutrophil counts, stone clearance rates, and complications were compared, and predictive models for stone clearance were constructed. The observation group achieved significantly higher stone-free rates at 3 days (69.6% vs. 29.7%, p < 0.001) and 1 month (75.0% vs. 34.2%, p < 0.001) postoperatively. Relative to the control group, the observation group had postoperative white blood cell counts closer to normal values (9.25 ± 3.26 vs. 10.08 ± 3.78, p < 0.05), with a smaller increase from baseline (0.82 ± 4.90 vs. 2.96 ± 5.02, p < 0.05). The neutrophil percentage was also lower (0.73 ± 0.10 vs. 0.77 ± 0.07, p < 0.05), and visual analogue scale pain score was significantly reduced (2.00 ± 0.53 vs. 2.56 ± 0.89, p < 0.001). The predictive models achieved areas under the receiver operating characteristic curve of 0.727 (95% confidence interval: 0.616-0.839) at 3 days and 0.742 (95% confidence interval: 0.630-0.855) at 1 month postoperatively, indicating good discriminatory ability. This study shows that flexible negative-pressure suction sheath-assisted flexible ureteroscopic lithotripsy improves short- and mid-term stone clearance rates in patients with upper urinary tract stones. The models perform well and may facilitate individualized clinical decision-making.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70299"},"PeriodicalIF":3.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the Asthma Burden Attributable to High Body Mass Index in Children Across 204 Countries and Territories, 1990-2021: An Analysis of the 2021 Global Burden of Disease Study. 1990-2021年204个国家和地区儿童高体重指数导致的哮喘负担趋势：对2021年全球疾病负担研究的分析

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-12 DOI: 10.1002/kjm2.70298

Hua Li, Hai-Yan Chen, Dong-Zhi Zheng, Qiu-Yi Liu, Jia-Bing Li

{"title":"Trends in the Asthma Burden Attributable to High Body Mass Index in Children Across 204 Countries and Territories, 1990-2021: An Analysis of the 2021 Global Burden of Disease Study.","authors":"Hua Li, Hai-Yan Chen, Dong-Zhi Zheng, Qiu-Yi Liu, Jia-Bing Li","doi":"10.1002/kjm2.70298","DOIUrl":"10.1002/kjm2.70298","url":null,"abstract":"High body mass index (BMI) has been identified as a significant risk factor for childhood asthma. Given the rising prevalence of childhood obesity, assessing the impact of high BMI on asthma burden trends is imperative. Utilizing Global Burden of Disease (GBD) data, we estimated age-, sex-, geography-, and sociodemographic index (SDI)-stratified asthma-related deaths and disability-adjusted life years (DALYs) attributable to high BMI in children (0-14 years old) (1990-2021). Health inequality was assessed by integrating SDI with the slope index of inequality and the relative concentration index. Bayesian age-period-cohort analysis projected asthma burden trends from 2022 to 2035. From 1990 to 2021, global asthma mortality due to high BMI declined, while DALYs rose. Females had higher mortality rates, whereas males exhibited greater DALY burdens. Mortality burden correlated negatively with SDI, whereas DALYs correlated positively. Cross-national inequality analyses revealed higher mortality burdens in low-SDI countries and elevated DALY burdens in high-SDI regions. Frontier analyses indicated greater mortality reduction potential in low-and low - middle - SDI areas and higher DALY mitigation opportunities in high-SDI settings. Projections suggest a continued decline in asthma mortality but a rising DALY trend from 2022 to 2035. These findings highlight persistent sex- and SDI-related disparities and support targeted strategies to reduce the global burden of childhood asthma attributable to high BMI.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70298"},"PeriodicalIF":3.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olaparib Blocks Oxidative Stress-Dependent NLRP3 Inflammasome in Pediatric Acute Lung Injury by Metabolic Reprogramming via AMPK-Driven Autophagic Flux. 奥拉帕尼通过代谢重编程通过ampk驱动的自噬通量阻断儿童急性肺损伤中氧化应激依赖的NLRP3炎性体。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-09 DOI: 10.1002/kjm2.70275

Fen Gong, Mei-Ling Yu, Zheng-Rong Chen, Mei Li, Xu Sang, Yong-Dong Yan

{"title":"Olaparib Blocks Oxidative Stress-Dependent NLRP3 Inflammasome in Pediatric Acute Lung Injury by Metabolic Reprogramming via AMPK-Driven Autophagic Flux.","authors":"Fen Gong, Mei-Ling Yu, Zheng-Rong Chen, Mei Li, Xu Sang, Yong-Dong Yan","doi":"10.1002/kjm2.70275","DOIUrl":"10.1002/kjm2.70275","url":null,"abstract":"Pediatric acute lung injury (ALI) is a life-threatening syndrome defined by dysregulated pulmonary inflammation and impaired alveolar gas exchange, with limited therapeutic interventions. This study aims to evaluate the therapeutic efficacy and mechanistic basis of Olaparib, a clinically approved PARP inhibitor, using in vitro and in vivo models of pediatric ALI. In LPS/ATP-stimulated THP-1-derived macrophages, Olaparib induced metabolic reprogramming, as indicated by a reduced NAD+/NADH ratio and an elevated AMP/ATP ratio, leading to activation of the AMPK/ULK1 signaling pathway. This activation enhanced autophagic flux, as evidenced by increased LC3-II conversion, p62 degradation, and analysis of the mRFP-GFP-LC3 reporter. Enhanced autophagy was associated with attenuation of oxidative stress, including reductions in mitochondrial and intracellular reactive oxygen species and malondialdehyde levels, and suppression of NLRP3 inflammasome activation, as evidenced by decreased cleaved caspase-1, IL-1β, and IL-18. In a juvenile murine model of LPS-induced ALI, Olaparib administration reduced histopathological lung injury, inflammatory cell infiltration, and pulmonary edema. It also restored alveolar-capillary barrier integrity by upregulating junctional proteins, including ZO-1, claudin-5, and VE-cadherin, and reduced apoptosis. The protective effects of Olaparib on autophagy, oxidative stress, inflammasome activity, and lung tissue repair were attenuated by pharmacological inhibition of AMPK using compound C. In conclusion, these findings demonstrate that Olaparib ameliorates pediatric ALI through AMPK-dependent induction of autophagic flux via metabolic reprogramming, attenuating oxidative stress and inhibiting NLRP3 inflammasome activation. These results support the therapeutic potential of Olaparib in pediatric ALI.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70275"},"PeriodicalIF":3.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Deep Cutaneous Fungal Infection Caused by Cyphellophora Species in a Diabetic Patient. 1例糖尿病患者由黄柏属真菌引起的深部皮肤真菌感染。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-01 Epub Date: 2026-03-16 DOI: 10.1002/kjm2.70204

Yi-Shan Teng, Pei-Lun Sun, Cheng-Che E Lan

引用次数: 0

Protective Effects of Riociguat Against Contrast-Induced Nephropathy: An Experimental and Machine Learning-Based Study in Rats. 瑞西奎特对造影剂肾病的保护作用：一项基于机器学习的大鼠实验研究。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-01 Epub Date: 2026-03-17 DOI: 10.1002/kjm2.70201

Mustafa Begenc Tascanov, Kenan Toprak, Sibel Turedi, İsmail Koyuncu, Zulkif Tanrıverdi, Necip Fazıl Dedeoglu, Halil Fedai, Asuman Bicer, İbrahim Halil Altıparmak, Recep Demirbag, Gencay Sarıısık

{"title":"Protective Effects of Riociguat Against Contrast-Induced Nephropathy: An Experimental and Machine Learning-Based Study in Rats.","authors":"Mustafa Begenc Tascanov, Kenan Toprak, Sibel Turedi, İsmail Koyuncu, Zulkif Tanrıverdi, Necip Fazıl Dedeoglu, Halil Fedai, Asuman Bicer, İbrahim Halil Altıparmak, Recep Demirbag, Gencay Sarıısık","doi":"10.1002/kjm2.70201","DOIUrl":"10.1002/kjm2.70201","url":null,"abstract":"Contrast-induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine-learning-based prediction of renal injury using histopathological, biochemical, and inflammatory markers. Thirty-six female Wistar albino rats were randomized into control, riociguat, CIN model, and CIN + riociguat groups. CIN was induced by iohexol after dehydration, and riociguat was administered orally for 5 days. Renal injury was assessed by histopathological scoring, TUNEL assay, and biochemical parameters including serum creatinine, urea, tumor necrosis factor-alpha, nitric oxide, neutrophil gelatinase-associated lipocalin, and advanced oxidation protein products. Riociguat significantly decreased serum creatinine, urea, apoptotic index, and histopathological injury scores, reduced inflammatory and oxidative stress markers, and increased nitric oxide levels compared with untreated CIN animals (p < 0.05). Machine learning models (Random Forest, CatBoost, AdaBoost, and XGBoost) were applied for exploratory prediction and feature importance analysis. The apoptotic index and nitric oxide were identified as dominant predictors, indicating mechanistic relevance but limited clinical screening utility because these predictors require histological assessment. Overall, riociguat demonstrated significant renoprotective effects through anti-apoptotic, anti-inflammatory, and antioxidative mechanisms, and machine learning provided hypothesis-generating insight rather than a clinically deployable predictive model.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70201"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF-β1/Smads and Activating Nrf2-ARE Signaling in MI Rodent. 早期达格列清和褪黑素治疗通过抑制TGF-β1/Smads和激活Nrf2-ARE信号改善心肌梗死啮齿动物左室纤维化。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-01 Epub Date: 2026-04-02 DOI: 10.1002/kjm2.70205

Jiunn-Jye Sheu, Jui-Ning Yeh, Han-Tan Chai, John Y Chiang, Chi-Ruei Huang, Jun Guo, Hon-Kan Yip

{"title":"Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF-β1/Smads and Activating Nrf2-ARE Signaling in MI Rodent.","authors":"Jiunn-Jye Sheu, Jui-Ning Yeh, Han-Tan Chai, John Y Chiang, Chi-Ruei Huang, Jun Guo, Hon-Kan Yip","doi":"10.1002/kjm2.70205","DOIUrl":"10.1002/kjm2.70205","url":null,"abstract":"This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF-β/Smads signaling, whereas Mel treatment significantly upregulated Nrf2/ARE signaling in ischemia-reperfusion (IR) H9C2 cells (all P< 0.001). Additionally, simultaneously silencing TGF-β and overexpression of Nrf2 in H9C2 cells significantly suppressed fibrotic and upregulated antioxidant signaling (all P< 0.001). Adult male Sprague-Dawley rats were categorized into groups 1 (sham-operated-control)/2 (AMI)/3 (AMI + DAPA)/4 (AMI + Mel)/5 (AMI + DAPA-Mel), and the hearts were harvested by day 28. By day 28 after AMI induction, the LVEF was highest in group 1, lowest in group 2, and significantly higher in group 5 than in groups 3 and 4, but it did not differ between groups 3 and 4, whereas the LV systolic/diastolic dimensions exhibited an opposite pattern of LVEF among the groups (all P< 0.0001). The protein expressions of TGF-β/Smads signaling exhibited an opposite pattern, whereas the protein expressions of Nrf2/ARE signaling displayed an identical pattern of LVEF among the groups (all P< 0.0001). The protein expressions of oxidative-stress/DNA-mitochondria damaged/inflammatory biomarkers and histopathological/anatomical findings demonstrated that the infarct and fibrotic areas/LV-chamber dimensions/cardiomyocyte size exhibited an opposite manner of LVEF among the groups (all P< 0.0001). In conclusion, combined DAPA-Mel therapy was superior to merely one for improving LVEF and inhibiting fibrosis/LV remodeling in AMI rodents.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70205"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Cardiometabolic Risk Factors and Steatotic Liver Disease on Liver-Related Outcomes in Patients With Chronic Hepatitis C After Curative Antiviral Therapy. 慢性丙型肝炎患者抗病毒治疗后心脏代谢危险因素和脂肪变性肝病对肝脏相关预后的影响

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-10-01 Epub Date: 2026-04-22 DOI: 10.1002/kjm2.70214

Chung-Feng Huang, Yi-Hung Lin, Pei-Chien Tsai, Ming-Lun Yeh, Chih-Wen Wang, Tyng-Yuan Jang, Po-Cheng Liang, Yu-Ju Wei, Nai-Jen Hou, Ming-Yen Hsieh, Chao-Kuan Huang, Tzu-Chun Lin, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu

{"title":"Impact of Cardiometabolic Risk Factors and Steatotic Liver Disease on Liver-Related Outcomes in Patients With Chronic Hepatitis C After Curative Antiviral Therapy.","authors":"Chung-Feng Huang, Yi-Hung Lin, Pei-Chien Tsai, Ming-Lun Yeh, Chih-Wen Wang, Tyng-Yuan Jang, Po-Cheng Liang, Yu-Ju Wei, Nai-Jen Hou, Ming-Yen Hsieh, Chao-Kuan Huang, Tzu-Chun Lin, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu","doi":"10.1002/kjm2.70214","DOIUrl":"10.1002/kjm2.70214","url":null,"abstract":"Patients with chronic hepatitis C (CHC) frequently present with steatotic liver disease (SLD) and cardiometabolic risk factors (CMRFs). This study aimed to evaluate the impact of SLD and CMRFs on liver-related outcomes (LROs) in CHC patients after HCV eradication. This study evaluated 21,972 CHC patients who received curative antivirals in Taiwan. LROs included newly developed hepatocellular carcinoma and liver decompensation. During a follow-up period of 71,000 person-years (PYs), 745 (3.4%) patients developed LROs (annual incidence of 1.05%). The annual incidence of LRO (136.2 vs. 80.7 per 10,000 PYs, p < 0.001) was significantly higher in patients without SLD than in those with SLD. Cox regression analysis revealed that SLD was independently associated with a lower risk of LRO (adjusted hazard ratio [aHR]/95% confidence intervals [CI]: 0.85/0.73-0.99, p = 0.038). There was an increased trend toward increased LRO risk in patients with a higher number of CMRFs than in those without CMRFs (aHR/CI: 1.35/1.02-1.78, 1.48/1.11-1.97, and 1.53/1.15-2.05 for 1, 2, and > 3 CMRFs, respectively). Non-SLD patients who carried CMRFs were independently associated with a high risk of LROs compared to SLD patients without any CMRF carriage (aHR/CI: 1.97/1.11-3.50, p = 0.02). We concluded that CMRF burden had a dose-dependent effect on LRO risk in CHC patients after curative antivirals. Non-SLD CHC patients who possessed CMRFs were at a greater risk of LROs.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70214"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0