The Kaohsiung journal of medical sciences最新文献

Association Between Angiotensin-Converting Enzyme (ACE) Gene Insertion/Deletion (I/D) Polymorphism Genotypes With Brain Volume and Hypertension in Alzheimer's Disease-A Retrospective Study. 血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性基因型与阿尔茨海默病脑容量和高血压的关系——一项回顾性研究

The Kaohsiung journal of medical sciences Pub Date : 2025-05-15 DOI: 10.1002/kjm2.70046

Bin-Tse Lin, Ching-Fang Chien, Ling-Chun Huang, Yuan-Han Yang

{"title":"Association Between Angiotensin-Converting Enzyme (ACE) Gene Insertion/Deletion (I/D) Polymorphism Genotypes With Brain Volume and Hypertension in Alzheimer's Disease-A Retrospective Study.","authors":"Bin-Tse Lin, Ching-Fang Chien, Ling-Chun Huang, Yuan-Han Yang","doi":"10.1002/kjm2.70046","DOIUrl":"https://doi.org/10.1002/kjm2.70046","url":null,"abstract":"This study investigates the role of the ACE I/D polymorphism in Alzheimer's disease (AD) patients, particularly in relation to hypertension and its influence on brain volume. Seventy-seven AD patients, diagnosed based on Aging and Alzheimer's Association criteria, were enrolled from the Kaohsiung Municipal Ta-Tung Hospital Dementia Cohort. ACE I/D genotypes were identified through polymerase chain reaction, and various factors such as age, sex, education, brain volume, and neuropsychological test scores were analyzed. The results indicated that ACE genotypes, presence of apolipoprotein epsilon 4 (APOEε4), and brain volume did not significantly differ between patients with and without hypertension. While age and sex were associated with gray matter volume, cerebrospinal fluid volume correlated with age, sex, and hypertension. Total cranial volume was linked to sex, and the cerebrospinal fluid-to-total intracranial volume ratio was influenced by sex and education. Overall, ACE I/D genotypes and APOEε4 did not have a significant impact on brain volume in AD patients, regardless of hypertension status. Instead, brain atrophy was associated with sex, age, education, and hypertension. These findings suggest that although ACE may not significantly influence brain volume in AD patients, further large-scale studies are needed to clarify its role in AD pathogenesis.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70046"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mantle Cell Lymphoma of the Thyroid: A Rare Cause of Life-Threatening Airway Compromise. 甲状腺套细胞淋巴瘤：危及生命的气道损害的罕见原因。

The Kaohsiung journal of medical sciences Pub Date : 2025-05-15 DOI: 10.1002/kjm2.70048

Kanokwan Kesornpatumanant, Nantawan Numkiatsakul, Narittee Sukswai, Thiti Snabboon

引用次数: 0

Dexmedetomidine Blocks the ERK Pathway by Inhibiting MAP3K8 to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury. 右美托咪定通过抑制MAP3K8阻断ERK通路达到肺缺血再灌注损伤的保护作用

The Kaohsiung journal of medical sciences Pub Date : 2025-05-15 DOI: 10.1002/kjm2.70045

Chun-Huan Hu, Ru Qian, Yong-Bo Wang, Lian-Di Li, Chun-Xing Miao

{"title":"Dexmedetomidine Blocks the ERK Pathway by Inhibiting MAP3K8 to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury.","authors":"Chun-Huan Hu, Ru Qian, Yong-Bo Wang, Lian-Di Li, Chun-Xing Miao","doi":"10.1002/kjm2.70045","DOIUrl":"https://doi.org/10.1002/kjm2.70045","url":null,"abstract":"Lung ischemia/reperfusion injury (LIRI) is a primary contributor to morbidity and mortality following lung transplantation. Dexmedetomidine (DEX) protects the lungs from I/R injury, but the underlying mechanisms remain uncertain. This paper examined the protective effect of DEX in LIRI and elucidated the potential regulation involved. LIRI was induced in mice, followed by the detection of pulmonary arterial pressure, lung compliance, pathological changes, pulmonary vascular permeability, oxidative stress, inflammation, and apoptosis. Mice were infected with overexpression (OE)-mitogen-activated protein kinase kinase kinase 8 (MAP3K8) adenovirus and treated with DEX. MAP3K8 expression was examined in mouse lung tissue and pulmonary microvascular endothelial cells (PMVECs). Cells were infected using OE-MAP3K8 lentivirus and treated with DEX, followed by detection of cell viability and apoptosis, VE-cadherin and α-E-catenin, and pro-inflammatory factors. Rescue experiments were performed by MAP3K8 overexpression and combined extracellular signal-regulated protein kinase (ERK) pathway blocker, PD98059. The results demonstrated that DEX protected mice from LIRI. DEX inhibited MAP3K8 expression. MAP3K8 overexpression increased ERK1/2 phosphorylation and activated the ERK pathway. Upregulation of MAP3K8 impaired the protective effect of DEX in vivo and in vitro, which was reversed by the ERK inhibitor PD98059. Overall, DEX achieved its protective effect against LIRI by inhibiting the MAP3K8-ERK axis.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70045"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LRP8 Regulates Lipid Metabolism to Stimulate Malignant Progression and Cisplatin Resistance in Bladder Cancer. LRP8调节脂质代谢促进膀胱癌恶性进展和顺铂耐药。

The Kaohsiung journal of medical sciences Pub Date : 2025-05-15 DOI: 10.1002/kjm2.70042

Gang-Feng Wu, Zhen-Gang Luo, Ke Gao, Yu Ren, Chong Shen, Xiang-Rong Ying

{"title":"LRP8 Regulates Lipid Metabolism to Stimulate Malignant Progression and Cisplatin Resistance in Bladder Cancer.","authors":"Gang-Feng Wu, Zhen-Gang Luo, Ke Gao, Yu Ren, Chong Shen, Xiang-Rong Ying","doi":"10.1002/kjm2.70042","DOIUrl":"https://doi.org/10.1002/kjm2.70042","url":null,"abstract":"Low-density lipoprotein receptor-related protein 8 (LRP8) is a crucial regulator of lipid metabolism and is implicated in the development and treatment of various cancers. However, its role in bladder cancer (BCa) remains unknown. We analyzed LRP8 expression in BCa using the TCGA database and clinical samples. We manipulated LRP8 expression in tumor cell lines using siRNA or overexpression plasmid transfection. Cell proliferation, migration, invasion, apoptosis, and drug resistance were assessed through CCK-8, transwell, flow cytometry, and IC50 assays. Additionally, a rescue experiment confirmed the association between LRP8 and lipid metabolism. LRP8 was significantly upregulated in BCa tissues and cells. Knockdown of LRP8 reduced tumor cell proliferation, migration, invasion, and increased apoptosis while enhancing cisplatin sensitivity. Overexpression of LRP8 boosted malignant progression and cisplatin resistance in tumor cells. The expression level of LRP8 is positively linked with the expression of lipid metabolism-related genes, phospholipid accumulation, and triglyceride accumulation. Notably, inhibiting lipid metabolism reversed the malignant progression and cisplatin resistance induced by LRP8 overexpression. LRP8 could promote BCa malignant progression and cisplatin resistance through lipid metabolism regulation.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70042"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19-Related Croup With Acute Respiratory Failure. 与covid -19相关的急性呼吸衰竭群体。

The Kaohsiung journal of medical sciences Pub Date : 2025-05-15 DOI: 10.1002/kjm2.70040

Chi-Kai Hsu, Tang-Hsu Hsieh, Yi-Ching Liu, I-Chen Chen

引用次数: 0

Successful Treatment of Osimertinib Resistance in an EGFR-Mutant Lung Cancer Patient With a Rare STRN3-ALK Fusion Using Brigatinib and Osimertinib. 使用布加替尼和奥西替尼成功治疗罕见STRN3-ALK融合的egfr突变肺癌患者的奥西替尼耐药性

The Kaohsiung journal of medical sciences Pub Date : 2025-05-08 DOI: 10.1002/kjm2.70021

Chia-Yu Kuo, Wei-An Lai, Tai-Huang Lee, Chih-Jen Yang

引用次数: 0

Thromboelastography Maximum Amplitude Is a Valuable Biomarker for Early Atherosclerosis in Rheumatoid Arthritis Patients: A Single-Center Cross-Sectional Study. 血栓弹性成像最大振幅是类风湿关节炎患者早期动脉粥样硬化的有价值的生物标志物：一项单中心横断面研究

The Kaohsiung journal of medical sciences Pub Date : 2025-05-08 DOI: 10.1002/kjm2.70043

Qing-Lin Zhang, Qian Xu, Rong Huang, Ming-Zhong Sun, Dong-Mei Jiang, Hui Tao, Hao Jin

{"title":"Thromboelastography Maximum Amplitude Is a Valuable Biomarker for Early Atherosclerosis in Rheumatoid Arthritis Patients: A Single-Center Cross-Sectional Study.","authors":"Qing-Lin Zhang, Qian Xu, Rong Huang, Ming-Zhong Sun, Dong-Mei Jiang, Hui Tao, Hao Jin","doi":"10.1002/kjm2.70043","DOIUrl":"https://doi.org/10.1002/kjm2.70043","url":null,"abstract":"Hypercoagulability contributes to atherosclerosis (AS) progression in individuals suffering from rheumatoid arthritis (RA), and thromboelastography (TEG) is a valuable diagnostic tool. This hospital-based cross-sectional study assessed the clinical efficacy of TEG parameters in detecting hypercoagulability and subclinical AS by purposively sampling 372 RA patients and 105 healthy controls. TEG indices, conventional coagulation markers, and biochemical profiles were assessed. Multivariable logistic modeling and receiver operating characteristic (ROC) analyses were utilized to identify independent risk factors for early AS in patients with RA. Our results indicated that patients with RA experienced a hypercoagulable state in comparison to controls, which was particularly pronounced in RA patients with early AS compared to their non-AS counterparts. Logistic regression analysis revealed that the TEG maximum amplitude (MA) is an independent risk factor for early AS in patients with RA, with an odds ratio of 1.219 and a 95% confidence interval of 1.128-1.317. Additional independent risk factors identified are fibrinogen (FIB), low-density lipoprotein cholesterol (LDL-C), and the adjusted atherogenic index of plasma (aAIP). ROC analysis revealed that MA achieved an area under the curve (AUC) of 0.711 (sensitivity: 71.5%; specificity: 63.5%) for early AS diagnosis. Combining with FIB, LDL-C, and aAIP significantly enhanced diagnostic performance, with an AUC of 0.831 (sensitivity: 77.6%; specificity: 75.3%). These findings highlight MA as a valuable biomarker for early detection of AS in patients with RA. Furthermore, integrating MA with FIB, LDL-C, and aAIP improves diagnostic accuracy, supporting its clinical role in risk stratification and early intervention.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70043"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Angiosarcoma: A Diagnostic and Therapeutic Challenge. 心脏血管肉瘤：诊断和治疗的挑战。

The Kaohsiung journal of medical sciences Pub Date : 2025-05-08 DOI: 10.1002/kjm2.70044

Kang Ying Tan, Yi-Chang Liu

引用次数: 0

Investigating the Impact of hsa_circ_0005255 on Proliferation and Autophagy in Crohn's Disease Intestinal Epithelial Cells Through miR-23a-3p-Mediated NCOA3 Expression. 通过mir -23a-3p介导的NCOA3表达研究hsa_circ_0005255对克罗恩病肠上皮细胞增殖和自噬的影响

The Kaohsiung journal of medical sciences Pub Date : 2025-05-07 DOI: 10.1002/kjm2.70035

Dong Liu, De-Run Kong

{"title":"Investigating the Impact of hsa_circ_0005255 on Proliferation and Autophagy in Crohn's Disease Intestinal Epithelial Cells Through miR-23a-3p-Mediated NCOA3 Expression.","authors":"Dong Liu, De-Run Kong","doi":"10.1002/kjm2.70035","DOIUrl":"https://doi.org/10.1002/kjm2.70035","url":null,"abstract":"Crohn's Disease (CD), an inflammatory bowel disorder, is influenced by genetic, immune, and environmental factors. The present study highlights the pioneering role of circular RNAs (circRNAs) in the etiology of CD, with a specific focus on hsa_circ_0005255 and its regulatory role. Utilizing both bioinformatic and experimental approaches, we exposed the mechanistic and therapeutic significance of hsa_circ_0005255 within the pathophysiological framework of CD. Our findings revealed a significant underexpression of hsa_circ_0005255 in tissue samples from CD patients and in DSS-induced CD mouse models. The overexpression of hsa_circ_0005255 markedly mitigated inflammatory responses, as indicated by decreased serum levels of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6, and reduced histopathological indications of inflammation in colonic tissues. It substantially improved the integrity of the epithelial barrier, evidenced by the upregulation of Zonula Occludens-1 expression and the reduction of apoptosis in colonic epithelial cells. Furthermore, this regulatory effect extended to the enhancement of epithelial cell proliferation and autophagy, characterized by the elevated expression of Ki-67, microtubule-associated protein 1A/1B-light chain 3 II, and Beclin-1, along with the suppression of cleaved caspase-3 and sequestosome 1. Mechanistically, hsa_circ_0005255 functioned as a competitive endogenous RNA, absorbing miR-23a-3p and thereby regulating Nuclear Receptor Coactivator 3. This investigation not only broadens our understanding of the involvement of circRNAs in CD pathogenesis but also identifies hsa_circ_0005255 as a potent biomarker and therapeutic target.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70035"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Clostridioides difficile Infection on Clinical Outcomes in Hospitalized IBD Patients and the Role of Fecal Microbiota Transplantation: A Retrospective Cohort Study. 艰难梭菌感染对IBD住院患者临床结局的影响及粪便菌群移植的作用：一项回顾性队列研究

The Kaohsiung journal of medical sciences Pub Date : 2025-05-01 Epub Date: 2025-03-17 DOI: 10.1002/kjm2.70002

Puo-Hsien Le, Chyi-Liang Chen, Chia-Jung Kuo, Pai-Jui Yeh, Chien-Chang Chen, Yi-Ching Chen, Cheng-Tang Chiu, Hao-Tsai Cheng, Yung-Kuan Tsou, Yu-Bin Pan, Cheng-Hsun Chiu

{"title":"Impact of Clostridioides difficile Infection on Clinical Outcomes in Hospitalized IBD Patients and the Role of Fecal Microbiota Transplantation: A Retrospective Cohort Study.","authors":"Puo-Hsien Le, Chyi-Liang Chen, Chia-Jung Kuo, Pai-Jui Yeh, Chien-Chang Chen, Yi-Ching Chen, Cheng-Tang Chiu, Hao-Tsai Cheng, Yung-Kuan Tsou, Yu-Bin Pan, Cheng-Hsun Chiu","doi":"10.1002/kjm2.70002","DOIUrl":"10.1002/kjm2.70002","url":null,"abstract":"Clostridioides difficile infection (CDI) worsens the prognosis of patients with inflammatory bowel disease (IBD). This retrospective cohort study aimed to evaluate the risk factors, clinical manifestations, and outcomes of CDI in hospitalized patients with IBD, including those with toxin A/B results between April 2007 and April 2021. Patients were classified into the CDI and control groups. Patients with IBD and recurrent or refractory CDI underwent fecal microbiota transplantation (FMT). A total of 144 inpatients with IBD-45 in the CDI group and 99 in the control group-were analyzed. The incidence of CDI in inpatients with IBD was 31%. The Risk factors for CDI included longer IBD duration, biological therapy failure, and biological use. More patients in the CDI group presented with abdominal pain (77.8% vs. 55.6%, p = 0.011). In the antibiotic treatment-only group, the symptom improvement rate was 60.7% (17/28), the microbiological cure rate was 89.3% (25/28), and the overall success rate was 71.4% (20/28). After antibiotic treatment and FMT, 71.4% (10/14) of the patients tested negative for CDI, and 64.3% (9/14) had improved clinical symptoms. CDI led to more hospitalizations (median two times [range 0-12] vs. median one time [range 0-19], p = 0.008), a lower steroid-free remission rate (46.7% vs. 67.7%, p = 0.017), and higher Mayo scores (median 5 points [range 2-12] vs. median 3 points [range 0-12]). Patients who received FMT had fewer hospitalizations and fewer IBD-related complications during follow-up than those who received antibiotics alone. FMT should be considered in patients with IBD with refractory or recurrent CDI to improve clinical outcomes.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70002"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0