The Kaohsiung journal of medical sciences最新文献

{"title":"Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells","authors":"Yi‐Ching Liu, Yu‐Hsin Tseng, Yu‐Hsin Kuan, Lin‐Yen Wang, Shang‐En Huang, Siao‐Ping Tsai, Jwu‐Lai Yeh, Jong‐Hau Hsu","doi":"10.1002/kjm2.12835","DOIUrl":"https://doi.org/10.1002/kjm2.12835","url":null,"abstract":"Pulmonary vascular remodeling is a key pathological process of pulmonary arterial hypertension (PAH), characterized by uncontrolled proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). Bortezomib (BTZ) is the first Food and Drug Administration (FDA)‐approved proteasome inhibitor for multiple myeloma treatment. Recently, there is emerging evidence showing its effect on reversing PAH, although its mechanisms are not well understood. In this study, anti‐proliferative and anti‐migratory effects of BTZ on PASMCs were first examined by different inducers such as fetal bovine serum (FBS), angiotensin II (Ang II) and platelet‐derived growth factor (PDGF)‐BB, while potential mechanisms including cellular reactive oxygen species (ROS) and mitochondrial ROS were then investigated; finally, signal transduction of ERK and Akt was examined. Our results showed that BTZ attenuated FBS‐, Ang II‐ and PDGF‐BB‐induced proliferation and migration, with associated decreased cellular ROS production and mitochondrial ROS production. In addition, the phosphorylation of ERK and Akt induced by Ang II and PDGF‐BB was also inhibited by BTZ treatment. This study indicates that BTZ can prevent proliferation and migration of PASMCs, which are possibly mediated by decreased ROS production and down‐regulation of ERK and Akt. Thus, proteasome inhibition can be a novel pharmacological target in the management of PAH.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles of Bifidobacterium longum reverse the acquired carboplatin resistance in ovarian cancer cells via p53 phosphorylation on Ser15","authors":"Yun‐Long Fan, Jia‐Xi Jin, Jun Zhu, Hai‐Bo Ruan, Jin‐Qun Huang","doi":"10.1002/kjm2.12837","DOIUrl":"https://doi.org/10.1002/kjm2.12837","url":null,"abstract":"We previously found that the relative abundance of <jats:italic>Bifidobacterium</jats:italic> was increased after chemotherapy; however, the role of <jats:italic>Bifidobacterium longum</jats:italic> in chemotherapeutic drug resistance in ovarian cancer (OVC) remains unclear. This study aimed to understand the potential effects and mechanism of <jats:italic>B. longum</jats:italic> extracellular vesicles (<jats:italic>B. longum</jats:italic>‐EVs) on carboplatin (CBP) resistance in OVC. Eight normal and 11 ovarian tissues were collected and the expression of <jats:italic>B. longum</jats:italic> genomic DNA and its association with acquired CBP resistance in OVC patients was determined. After isolating EVs by ultracentrifugation from <jats:italic>B. longum</jats:italic> (ATCC 15707), CBP‐resistant A2780 cells were treated with PBS, CBP, <jats:italic>B. longum</jats:italic>‐EVs, or CBP + <jats:italic>B. longum</jats:italic>‐EVs, and subsequently analyzed by CCK‐8, Edu staining, Annexin V/PI double staining, wound healing, and Transwell assays to detect cell viability, proliferation, apoptosis, migration, and invasion, respectively. MRP1, ATP7A, ATP7B, and p53 expression as well as p53 phosphorylation were measured by western blot analysis. S15A mutation of p53 was assessed to examine the potential role of p53 Ser15 phosphorylation in CBP‐resistant OVC. <jats:italic>B. longum</jats:italic> levels were elevated and positively associated with CBP resistance in OVC patients. Only high concentrations of <jats:italic>B. longum</jats:italic>‐EVs attenuated A2780 cell proliferation, apoptosis, migration, and invasion. <jats:italic>B. longum</jats:italic>‐EVs exposure significantly enhanced the sensitivity of CBP‐resistant A2780 cells to CBP and decreased the expression of drug resistance‐related proteins. The effect of <jats:italic>B. longum</jats:italic>‐EVs on reversing CBP resistance was completely inhibited by S15A mutation of p53. <jats:italic>B. longum</jats:italic>‐EVs enhanced the sensitivity of OVC cells to CBP through p53 phosphorylation on Ser15.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140635689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of ASIC3/ERK pathway by paeoniflorin improves intestinal fluid metabolism and visceral sensitivity in slow transit constipated rats","authors":"Yuan Deng, Qiong Zhao, Hong‐Yun Zhou, Zi‐Qi Zhang, Yu Zhan","doi":"10.1002/kjm2.12829","DOIUrl":"https://doi.org/10.1002/kjm2.12829","url":null,"abstract":"Slow transit constipation (STC) is one of the most common gastrointestinal disorders in children and adults worldwide. Paeoniflorin (PF), a monoterpene glycoside compound extracted from the dried root of <jats:italic>Paeonia lactiflora</jats:italic>, has been found to alleviate STC, but the mechanisms of its effect remain unclear. The present study aimed to investigate the effects and mechanisms of PF on intestinal fluid metabolism and visceral sensitization in rats with compound diphenoxylate‐induced STC. Based on the evaluation of the laxative effect, the abdominal withdrawal reflex test, enzyme‐linked immunosorbent assay, quantitative real‐time polymerase chain reaction, western blot, and immunohistochemistry were used to detect the visceral sensitivity, fluid metabolism‐related proteins, and acid‐sensitive ion channel 3/extracellular signal‐regulated kinase (ASIC3/ERK) pathway‐related molecules. PF treatment not only attenuated compound diphenoxylate‐induced constipation symptoms and colonic pathological damage in rats but also ameliorated colonic fluid metabolic disorders and visceral sensitization abnormalities, as manifested by increased colonic goblet cell counts and mucin2 protein expression, decreased aquaporin3 protein expression, improved abdominal withdrawal reflex scores, reduced visceral pain threshold, upregulated serum 5‐hydroxytryptamine, and downregulated vasoactive intestinal peptide levels. Furthermore, PF activated the colonic ASIC3/ERK pathway in STC rats, and ASIC3 inhibition partially counteracted PF's modulatory effects on intestinal fluid and visceral sensation. In conclusion, PF alleviated impaired intestinal fluid metabolism and abnormal visceral sensitization in STC rats and thus relieved their symptoms through activation of the ASIC3/ERK pathway.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140628934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal cancer localization by sagittal computed tomography images and endoscopic measurement","authors":"Jen Yang, Wei‐Lun Chang, Forn‐Chia Lin, Nan‐Tsing Chiu","doi":"10.1002/kjm2.12834","DOIUrl":"https://doi.org/10.1002/kjm2.12834","url":null,"abstract":"","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140616706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive effects of the interactions among cesarean section, birth weight, and preterm birth on the risk of atopic dermatitis in children","authors":"Chih‐Kai Wong, Cheng‐Fang Yen, Yi‐Lung Chen","doi":"10.1002/kjm2.12826","DOIUrl":"https://doi.org/10.1002/kjm2.12826","url":null,"abstract":"","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"202 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140616708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of multi-disciplinary lifestyle modifications in Taiwanese nonalcoholic steatohepatitis patients","authors":"Ming-Lun Yeh, Chia-Yen Dai, Chung-Feng Huang, Shiu-Feng Huang, Pei-Chien Tsai, Po-Yau Hsu, Ching-I Huang, Yu-Ju Wei, Po-Cheng Liang, Ming-Jong Bair, Mei-Hsuan Lee, Zu-Yau Lin, Jee-Fu Huang, Ming-Lung Yu, Wan-Long Chuang","doi":"10.1002/kjm2.12833","DOIUrl":"https://doi.org/10.1002/kjm2.12833","url":null,"abstract":"Lifestyle modification is the standard of care for nonalcoholic fatty liver disease (NAFLD) patients. We aimed to investigate the efficacy of a short-term lifestyle modification program in the disease course of Taiwanese nonalcoholic steatohepatitis (NASH) patients with paired biopsies. All patients received a 6-month, strict multidisciplinary program of lifestyle modifications led by physicians, dieticians, and nursing staff. The histopathological and clinical features were assessed. The endpoints were normalization of transaminase levels, metabolic parameters, a decrease in the NAFLD activity score (NAS) ≥1, and a decrease in the fibrosis stage ≥1. We also aimed to elucidate the predictors associated with disease progression. A total of 37 patients with biopsy-proven NASH were enrolled. The normalization of transaminase levels increased from 0% to 13.5%. There were also significantly increased proportions of patients with normal total cholesterol, triglyceride, and hemoglobin A1c levels. Fifteen (40.5%) patients had an increased NAS ≥1, whereas 10 (27.0%) patients had NAS regression. Twelve (32.4%) patients had increased fibrosis ≥1 stage. Only 2 (5.4%) patients experienced fibrosis regression. A high fasting plasma glucose (FPG) level was associated with NAS progression. Older age and higher transaminase and FPG levels were factors associated with fibrosis progression. Seven (18.9%) patients achieved a body weight reduction &gt;3%, and 4 (57.1%) of them experienced NAS regression. No significant effect of weight reduction on the progression of fibrosis was observed. The short-term lifestyle modification program significantly decreased liver enzymes and metabolic parameters in NASH patients. A more precise or intensive program may be needed for fibrosis improvement.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140592319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful intraoperative radiation therapy for a rapidly recurrent smooth muscle tumor of uncertain malignant potential","authors":"Yu-Hsuan Chung, Peir-In Liang, Feng-Hsiang Tang","doi":"10.1002/kjm2.12831","DOIUrl":"https://doi.org/10.1002/kjm2.12831","url":null,"abstract":"<p>Smooth muscle tumors of uncertain malignant potential (STUMPs) represent a group of rare uterine neoplasms whose morphological features are between those of leiomyoma and leiomyosarcoma.<span>¹</span> STUMP recurrence poses a major challenge because no gold standard for treatment has been established. The present case highlights the effective use of intraoperative radiotherapy (IORT) as a salvage technique in a patient with twice recurrent STUMP, with the treatment resulting in more than 5 years of disease-free survival.</p>\u0000<p>A 46-year-old woman presented with large myoma and compression symptoms and underwent laparoscopic myomectomy. Her pathology report revealed STUMPs requiring laparoscopic hysterectomy. Six months postoperation, the patient visited our outpatient department for dull intermittent right-lower-quadrant abdominal pain. Laboratory data revealed elevated C-reactive protein (58.5 mg/dL) and CA-125 levels (Figure 1A). Transabdominal sonography revealed a right adnexal mass measuring 5.44 × 5.29 cm² with complex echogenicity. Abdominal computed tomography (CT) revealed a large cystic lesion in the right adnexa (Figure 1B). Therefore, laparoscopic surgery was performed, revealing multiple peritoneal nodules, a few bloody ascites, and a lesion on the right fallopian tube. Hence, peritoneal tumor excision, right salpingo-oophorectomy, and ascites collection were performed. Cytological analysis of the ascites revealed no malignant cells. However, histopathological analysis of the peritoneal tumor and right fallopian tube revealed STUMPs (Figure 1C). No subsequent events were observed throughout the patient's outpatient follow-up. However, 7 months postoperation, outpatient sonography revealed left-upper- and right-lower-quadrant abdominal masses with complex echogenicity. Therefore, abdominal CT was performed to confirm STUMP recurrence resulting in ileus (Figure 1D). Midline laparotomic tumor excision with IORT (20 Gy/1 fx) and seromuscular layer repair of the descending colonic wall were performed (Figure 1E). Histopathology again confirmed recurrent STUMPs (Figure 1F). After the operation, the patient regularly received outpatient ultrasound and CT scan follow-up and has remained recurrence-free for more than 7 years.</p>\u0000<figure><picture>\u0000<source media=\"(min-width: 1650px)\" srcset=\"/cms/asset/49d4fc13-71ad-4729-910a-9b2c548d1769/kjm212831-fig-0001-m.jpg\"/><img alt=\"Details are in the caption following the image\" data-lg-src=\"/cms/asset/49d4fc13-71ad-4729-910a-9b2c548d1769/kjm212831-fig-0001-m.jpg\" loading=\"lazy\" src=\"/cms/asset/f27a2f12-0266-489b-8f0b-d3aec7540b70/kjm212831-fig-0001-m.png\" title=\"Details are in the caption following the image\"/></picture><figcaption>\u0000<div><strong>FIGURE 1<span style=\"font-weight:normal\"></span></strong><div>Open in figure viewer<i aria-hidden=\"true\"></i><span>PowerPoint</span></div>\u0000</div>\u0000<div>(A) Serum levels of CA-125 with STUMP recurrence. (B) Large cystic lesion with an","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"165 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140592311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced expression of activity-regulated cytoskeleton-associated protein in the medial prefrontal cortex is involved in working memory performance","authors":"Tsan-Ju Chen, Dean-Chuan Wang, Pei-Chun Liu, Hui-Shan Hung, Tsung-Lin Cheng","doi":"10.1002/kjm2.12832","DOIUrl":"https://doi.org/10.1002/kjm2.12832","url":null,"abstract":"Working memory (WM) is a cognitive function important for guiding the on-going or upcoming behavior. A memory-related protein Arc (activity-regulated cytoskeleton-associated protein) is implicated in long-term memory consolidation. Recent evidence further suggests the involvement of hippocampal Arc in spatial WM. The medial prefrontal cortex (mPFC) is a key brain region mediating WM. However, the role of mPFC Arc in WM is still uncertain. To investigate whether mPFC Arc protein is involved in WM performance, delayed non-match to sample (DNMS) T-maze task was performed in rats with or without blocking new synthesis of mPFC Arc. In DNMS task, a 10-s or 30-s delay between the sample run and the choice run was given to evaluate WM performance. To block new Arc protein synthesis during the DNMS task, Arc antisense oligodeoxynucleotides (ODNs) were injected to the bilateral mPFC. The results show that, in rats without surgery for cannula implantation and subsequent intracerebral injection of ODNs, WM was functioning well during the DNMS task with a delay of 10 s but not 30 s, which was accompanied with a significantly increased level of mPFC Arc protein, indicating a possible link between enhanced Arc protein expression and the performance of WM. After preventing the enhancement of mPFC Arc protein expression with Arc antisense ODNs, rat's WM performance was impaired. These findings support enhanced mPFC Arc protein expression playing a role during WM performance.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140592461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased serum adipokines are associated with sarcopenia in non‐obese women with rheumatoid arthritis","authors":"Tzu‐Jung Fang, Min‐Hsi Chiu, Ming‐Shyan Huang, Chia‐Yen Dai, Yao‐Tsung Yeh, Jeng‐Hsien Yen","doi":"10.1002/kjm2.12823","DOIUrl":"https://doi.org/10.1002/kjm2.12823","url":null,"abstract":"Large cohort studies have disclosed the association between obesity and rheumatoid arthritis (RA) risk. The sarcopenia prevalence in RA patients can be up to 31%. However, there is little information linking adipokines to sarcopenia in RA, so this study aimed to investigate whether adipokines were indeed involved in secondary sarcopenia in RA with a focus on non‐obese females. Sixty‐four female patients and 36 controls were included in this study. The serum adipokine levels (leptin and adiponectin) were determined by ELISA kits. The impacts of adipokines on muscle atrophy and potential autophagy were examined in mouse myoblasts, C2C12, upon treatment with recombinant leptin and adiponectin agonist (AdipoRan). Interestingly, serum adiponectin was significantly increased but the ratio of leptin/adiponectin was dramatically decreased in the RA patients with sarcopenia. After normalization by body mass, serum leptin was positively associated but adiponectin was negatively associated with muscle mass respectively, even after adjustment for fat mass. Treating C2C12 cells with leptin and AdipoRan inhibited proliferation of mature myotube respectively, as did treatment with the serum from RA patients. A combination of low leptin and high AdipoRan greatly decreased myogenin, but instead increased MAFbx and MuRF‐1 as well as increased Beclin 1, Atg5, and LC3β. Taken together, our study reveals that secondary sarcopenia of RA females may be an imbalance of RA‐related, but not obesity‐related, increase in adipokine production; additionally, the reduced leptin/adiponectin ratio could be a better indicator in monitoring sarcopenia in non‐obese RA females. Moreover, adipokine imbalance may promote muscle atrophy through inducing autophagy.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140592309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NTRK3 exhibits a pro‐oncogenic function in upper tract urothelial carcinomas","authors":"Lee‐Moay Lim, Yi‐Chen Lee, Ting‐Wei Lin, Zi‐Xuan Hong, Wei‐Chi Hsu, Hung‐Lung Ke, Daw‐Yang Hwang, Wen‐Yu Chung, Wei‐Ming Li, Hui‐Hui Lin, Hung‐Tien Kuo, A‐Mei Huang","doi":"10.1002/kjm2.12824","DOIUrl":"https://doi.org/10.1002/kjm2.12824","url":null,"abstract":"Neurotrophic receptor tyrosine kinase 3 (NTRK3) has pleiotropic functions: it acts not only as an oncogene in breast and gastric cancers but also as a dependence receptor in tumor suppressor genes in colon cancer and neuroblastomas. However, the role of NTRK3 in upper tract urothelial carcinoma (UTUC) is not well documented. This study investigated the association between NTRK3 expression and outcomes in UTUC patients and validated the results in tests on UTUC cell lines. A total of 118 UTUC cancer tissue samples were examined to evaluate the expression of NTRK3. Survival curves were generated using Kaplan–Meier estimates, and Cox regression models were used for investigating survival outcomes. Higher NTRK3 expression was correlated with worse progression‐free survival, cancer‐specific survival, and overall survival. Moreover, the results of an Ingenuity Pathway Analysis suggested that NTRK3 may interact with the PI3K‐AKT‐mTOR signaling pathway to promote cancer. NTRK3 downregulation in BFTC909 cells through shRNA reduced cellular migration, invasion, and activity in the AKT‐mTOR pathway. Furthermore, the overexpression of NTRK3 in UM‐UC‐14 cells promoted AKT‐mTOR pathway activity, cellular migration, and cell invasion. From these observations, we concluded that NTRK3 may contribute to aggressive behaviors in UTUC by facilitating cell migration and invasion through its interaction with the AKT‐mTOR pathway and the expression of NTRK3 is a potential predictor of clinical outcomes in cases of UTUC.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140592355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}