The Kaohsiung journal of medical sciences最新文献_第9页

Corneal thickness and endothelial change after use of ocular hypotensive agents. 使用降眼压药物后的角膜厚度和内皮变化。

The Kaohsiung journal of medical sciences Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1002/kjm2.12840

Hung-Yin Lai, Hung-Chi Lai, Ming-Tse Kuo, Yi-Yu Tsai, Ing-Chou Lai

{"title":"Corneal thickness and endothelial change after use of ocular hypotensive agents.","authors":"Hung-Yin Lai, Hung-Chi Lai, Ming-Tse Kuo, Yi-Yu Tsai, Ing-Chou Lai","doi":"10.1002/kjm2.12840","DOIUrl":"10.1002/kjm2.12840","url":null,"abstract":"Corneal transplantation can restore visual function when visual impairment is caused by a corneal disease. However, this treatment is associated with the scarcity of cornea donors. The suitability of corneal donation from patients with glaucoma using ocular hypotensive agents (OHAs) is controversial. This study aimed to elucidate changes in corneal thickness, corneal endothelial cell density, and corneal endothelial cell hexagonality after OHA use in patients with primary open-angle glaucoma. We retrospectively reviewed the data of 53 glaucoma suspect eyes without OHA use and 106 primary open-angle glaucoma eyes under OHA use. All participants underwent corneal parameter assessment using SP-3000P (Topcon Corp., Tokyo, Japan) at the time of diagnosis and the final visit. The OHA dose and timing of use were recorded. The ocular hypotensive agents score (OHAS) was determined based on the number, formula, frequency, and duration of OHA use. Baseline data showed no significant differences between the two groups with and without OHA use. At the final visit, the OHA-treated group showed significantly lower corneal thickness and corneal endothelial cell density than those of the control group. A weak positive correlation between the OHAS and changes in corneal endothelial cell hexagonality was noted. However, no correlation was observed between the OHAS and changes in corneal thickness or endothelial cell density. In conclusion, patients with glaucoma and using OHAs should undergo the corneal structural properties examinations before donation to ensure the quality of donor cornea.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"671-677"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of urinary exosomal microRNA-21 in the early diagnosis and prognosis of bladder cancer. 尿液外泌体 microRNA-21 在膀胱癌早期诊断和预后中的价值。

The Kaohsiung journal of medical sciences Pub Date : 2024-07-01 Epub Date: 2024-05-27 DOI: 10.1002/kjm2.12845

Fu-Kan Yang, Chao Tian, Lin-Xiong Zhou, Tian-Yu Guan, Gui-Liu Chen, Yi-Ying Zheng, Zheng-Guo Cao

{"title":"The value of urinary exosomal microRNA-21 in the early diagnosis and prognosis of bladder cancer.","authors":"Fu-Kan Yang, Chao Tian, Lin-Xiong Zhou, Tian-Yu Guan, Gui-Liu Chen, Yi-Ying Zheng, Zheng-Guo Cao","doi":"10.1002/kjm2.12845","DOIUrl":"10.1002/kjm2.12845","url":null,"abstract":"Bladder cancer (BC) poses high morbidity and mortality, with urinary exosomal microRNA (miR)-21 showing potential value in its diagnosis and prognosis, and we probed its specific role. We prospectively selected 116 BC patients and 116 healthy volunteers as the BC and control groups, respectively. BC urinary exosomal miR-146a-5p, miR-93-5p, miR-663b, miR-21, and miR-4454 relative expression levels were assessed. The correlations between clinical indexes and urinary exosomal miR-21, prognostic value of miR-21, and diagnostic value of the five candidate miRNAs, urine cytology, and miRNA joint diagnostic panel for BC and urinary exosomal miR-21, miR-4454, and urine cytology for Ta-T1 and T2-T4 stage BC were analyzed. Urinary exosomal miR-146a-5p, miR-93-5p, miR-663b, miR-21, and miR-4454 were highly expressed in BC patients. miR-146a-5p, miR-93-5p, miR-663b, miR-21, miR-4454, miRNA combined diagnostic panel, and urine cytology had certain diagnostic value for BC, with miR-21, miR-4454, and miRNA co-diagnostic panel showing the highest diagnostic value. Collectively, urinary exosomal miR-21 was closely related to Tumor-Node-Metastasis staging and grading in BC patients. Urinary exosomal miR-21 had high diagnostic value for BC and Ta-T1 and T2-T4 stage BC, and had high predictive value for BC poor prognosis, providing an effective indicator for the occurrence, development, and prognostic assessment of BC.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"660-670"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141156014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cough syncope: A familiar stranger. 咳嗽晕厥熟悉的陌生人

The Kaohsiung journal of medical sciences Pub Date : 2024-07-01 Epub Date: 2024-05-18 DOI: 10.1002/kjm2.12830

Nan Wang, Qing Zhang, Jia-Fu Wei

引用次数: 0

Smurf1-targeting microRNA-136-5p-modified bone marrow mesenchymal stem cells combined with 3D-printed β-tricalcium phosphate scaffolds strengthen osteogenic activity and alleviate bone defects. Smurf1靶向microRNA-136-5p修饰的骨髓间充质干细胞与三维打印β-磷酸三钙支架相结合，可增强成骨活性并缓解骨缺损。

The Kaohsiung journal of medical sciences Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI: 10.1002/kjm2.12847

Gang Duan, Ya-Fei Lu, Hong-Liang Chen, Zi-Qiang Zhu, Shuo Yang, Yun-Qing Wang, Jian-Qiang Wang, Xing-Hai Jia

{"title":"Smurf1-targeting microRNA-136-5p-modified bone marrow mesenchymal stem cells combined with 3D-printed β-tricalcium phosphate scaffolds strengthen osteogenic activity and alleviate bone defects.","authors":"Gang Duan, Ya-Fei Lu, Hong-Liang Chen, Zi-Qiang Zhu, Shuo Yang, Yun-Qing Wang, Jian-Qiang Wang, Xing-Hai Jia","doi":"10.1002/kjm2.12847","DOIUrl":"10.1002/kjm2.12847","url":null,"abstract":"Suitable biomaterials with seed cells have promising potential to repair bone defects. However, bone marrow mesenchymal stem cells (BMSCs), one of the most common seed cells used in tissue engineering, cannot differentiate efficiently and accurately into functional osteoblasts. In view of this, a new tissue engineering technique combined with BMSCs and scaffolds is a major task for bone defect repair. Lentiviruses interfering with miR-136-5p or Smurf1 expression were transfected into BMSCs. The effects of miR-136-5p or Smurf1 on the osteogenic differentiation (OD) of BMSCs were evaluated by measuring alkaline phosphatase activity and calcium deposition. Then, the targeting relationship between miR-136-5p and Smurf1 was verified by bioinformatics website analysis and dual luciferase reporter assay. Then, a rabbit femoral condyle bone defect model was established. miR-136-5p/BMSCs/β-TCP scaffold was implanted into the defect, and the repair of the bone defect was detected by Micro-CT and HE staining. Elevating miR-136-5p-3p or suppressing Smurf1 could stimulate OD of BMSCs. miR-136-5p negatively regulated Smurf1 expression. Overexpressing Smurf1 reduced the promoting effect of miR-136-5p on the OD of BMSCs. miR-136-5p/BMSCs/β-TCP could strengthen bone density in the defected area and accelerate bone repair. SmurF1-targeting miR-136-5p-modified BMSCs combined with 3D-printed β-TCP scaffolds can strengthen osteogenic activity and alleviate bone defects.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"621-630"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of Atg5 gene in tumorigenesis under autophagy deficiency conditions. 自噬缺乏条件下Atg5基因在肿瘤发生中的作用

The Kaohsiung journal of medical sciences Pub Date : 2024-07-01 Epub Date: 2024-06-03 DOI: 10.1002/kjm2.12853

Hsiao-Sheng Liu, Yin-Ping Wang, Pei-Wen Lin, Man-Ling Chu, Sheng-Hui Lan, Shan-Ying Wu, Ying-Ray Lee, Hong-Yi Chang

{"title":"The role of Atg5 gene in tumorigenesis under autophagy deficiency conditions.","authors":"Hsiao-Sheng Liu, Yin-Ping Wang, Pei-Wen Lin, Man-Ling Chu, Sheng-Hui Lan, Shan-Ying Wu, Ying-Ray Lee, Hong-Yi Chang","doi":"10.1002/kjm2.12853","DOIUrl":"10.1002/kjm2.12853","url":null,"abstract":"Autophagy is a self-recycling machinery to maintain cellular homeostasis by degrading harmful materials in the cell. Autophagy-related gene 5 (Atg5) is required for autophagosome maturation. However, the role of Atg5 in tumorigenesis under autophagy deficient conditions remains unclear. This study focused on the autophagy-independent role of Atg5 and the underlying mechanism in tumorigenesis. We demonstrated that knockout of autophagy-related genes including Atg5, Atg7, Atg9, and p62 in mouse embryonic fibroblast (MEF) cells consistently decreased cell proliferation and motility, implying that autophagy is required to maintain diverse cellular functions. An Atg7 knockout MEF (Atg7-/- MEF) cell line representing deprivation of autophagy function was used to clarify the role of Atg5 transgene in tumorigenesis. We found that Atg5-overexpressed Atg7-/-MEF (clone A) showed increased cell proliferation, colony formation, and migration under autophagy deficient conditions. Accordingly, rescuing the autophagy deficiency of clone A by overexpression of Atg7 gene shifts the role of Atg5 from pro-tumor to anti-tumor status, indicating the dual role of Atg5 in tumorigenesis. Notably, the xenograft mouse model showed that clone A of Atg5-overexpressed Atg7-/- MEF cells induced temporal tumor formation, but could not prolong further tumor growth. Finally, biomechanical analysis disclosed increased Wnt5a secretion and p-JNK expression along with decreased β-catenin expression. In summary, Atg5 functions as a tumor suppressor to protect the cell under normal conditions. In contrast, Atg5 shifts to a pro-tumor status under autophagy deprivation conditions.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"631-641"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141201358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical shear flow regulates the malignancy of colorectal cancer cells. 机械剪切流调节结直肠癌细胞的恶性程度。

The Kaohsiung journal of medical sciences Pub Date : 2024-07-01 Epub Date: 2024-05-17 DOI: 10.1002/kjm2.12844

Yu-Ting Tseng, Ching-Chung Tsai, Ping-Chen Chen, Bo-Yan Lin, Sodio C N Hsu, Shu-Ping Huang, Bin Huang

{"title":"Mechanical shear flow regulates the malignancy of colorectal cancer cells.","authors":"Yu-Ting Tseng, Ching-Chung Tsai, Ping-Chen Chen, Bo-Yan Lin, Sodio C N Hsu, Shu-Ping Huang, Bin Huang","doi":"10.1002/kjm2.12844","DOIUrl":"10.1002/kjm2.12844","url":null,"abstract":"Colorectal cancer (CRC) is notable for its high mortality and high metastatic characteristics. The shear force generated by bloodstream provides mechanical signals regulating multiple responses of cells, including metastatic cancer cells, dispersing in blood vessels. We, therefore, studied the effect of shear flow on circulating CRC cells in the present study. The CRC cell line SW620 was subjected to shear flow of 12.5 dynes/cm2 for 1 and 2 h separately. Resulting elevated caspase-9 and -3 indicated that shear flow initiated the apoptosis of SW620. Enlarged cell size associated with a higher level of cyclin D1 was coincident with the flow cytometric results indicating that the cell cycle was arrested at the G1 phase. An elevated phosphor-eNOSS1177 increased the production of nitric oxide and led to reactive oxygen species-mediated oxidative stress. Shear flow also regulated epithelial-mesenchymal transition (EMT) by increasing E-cadherin and ZO-1 while decreasing Snail and Twist1. The migration and invasion of sheared SW620 were also substantially decreased. Further investigations showed that mitochondrial membrane potential was significantly decreased, whereas mitochondrial mass and ATP production were not changed. In addition to the shear flow of 12.5 dynes/cm2, the expressions of EMT were compared at lower (6.25 dynes/cm2) and at higher (25 dynes/cm2) shear flow. The results showed that lower shear flow increased mesenchymal characteristics and higher shear flow increased epithelial characteristics. Shear flow reduces the malignancy of CRC in their metastatic dispersal that opens up new ways to improve cancer therapies by applying a mechanical shear flow device.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"650-659"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoglobulin A vasculitis: The clinical features and pathophysiology. 免疫球蛋白 A 血管炎：临床特征和病理生理学。

The Kaohsiung journal of medical sciences Pub Date : 2024-07-01 Epub Date: 2024-06-03 DOI: 10.1002/kjm2.12852

Ya-Chiao Hu, Yao-Hsu Yang, Bor-Luen Chiang

引用次数: 0

Revealing potential Rab proteins participate in regulation of secretory autophagy machinery. 揭示 Rab 蛋白参与调节分泌型自噬机制的潜力

The Kaohsiung journal of medical sciences Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1002/kjm2.12848

Pei-Wen Lin, Man-Ling Chu, Yu-Wen Liu, Yu-Cing Chen, Yao-Hsiang Shih, Sheng-Hui Lan, Shang-Ying Wu, I-Ying Kuo, Hong-Yi Chang, Hsiao-Sheng Liu, Ying-Ray Lee

{"title":"Revealing potential Rab proteins participate in regulation of secretory autophagy machinery.","authors":"Pei-Wen Lin, Man-Ling Chu, Yu-Wen Liu, Yu-Cing Chen, Yao-Hsiang Shih, Sheng-Hui Lan, Shang-Ying Wu, I-Ying Kuo, Hong-Yi Chang, Hsiao-Sheng Liu, Ying-Ray Lee","doi":"10.1002/kjm2.12848","DOIUrl":"10.1002/kjm2.12848","url":null,"abstract":"Autophagy can be classified as degradative and secretory based on distinct functions. The small GTPase proteins Rab8a and Rab37 are responsible for secretory autophagy-mediated exocytosis of IL-1β, insulin, and TIMP1 (tissue inhibitor of 54 metalloproteinase 1). Other Rab family members participating in secretory autophagy are poorly understood. Herein, we identified 26 overlapped Rab proteins in purified autophagosomes of mouse pancreatic β-cell \"Min-6\" and human lung cancer cell \"CL1-5-Q89L\" with high secretory autophagy tendency by LC-MS/MS proteomics analysis. Six Rab proteins (Rab8a, Rab11b, Rab27a, Rab35, Rab37, and Rab7a) were detected in autophagosomes of four cell lines, associating them with autophagy-related vesicle trafficking. We used CL1-5-Q89L cell line model to evaluate the levels of Rab proteins colocalization with autophagy LC3 proteins and presence in purified autophagosomes. We found five Rab proteins (Rab8a, Rab11b, Rab27a, Rab35, and Rab37) are highly expressed in the autophagosome compared to the normal control by immunoblotting under active secretion conditions. However, only Rab8a, Rab35, and Rab37 showing high colocalization with LC3 protein by cofocal microscopy. Despite the discrepancy between the image and immunoblotting analysis, our data sustains the speculation that Rab8a, Rab11b, Rab27a, Rab35, and Rab37 are possibly associated with the secretory autophagy machinery. In contrast, Rab7a shows low colocalization with LC3 puncta and low level in the autophagosome, suggesting it regulates different vesicle trafficking machineries. Our findings open a new direction toward exploring the role of Rab proteins in secretory autophagy-related cargo exocytosis and identifying the cargoes and effectors regulated by specific Rab proteins.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"642-649"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

circUQCRC2 promotes asthma progression in children by activating the VEGFA/NF‐κB pathway by targeting miR‐381‐3p circUQCRC2通过靶向miR-381-3p激活血管内皮生长因子/NF-κB通路，促进儿童哮喘进展

The Kaohsiung journal of medical sciences Pub Date : 2024-06-21 DOI: 10.1002/kjm2.12868

Li‐Juan Yang, Shu‐Xiang Sui, Qing‐Hua Zheng, Min Wang

{"title":"circUQCRC2 promotes asthma progression in children by activating the VEGFA/NF‐κB pathway by targeting miR‐381‐3p","authors":"Li‐Juan Yang, Shu‐Xiang Sui, Qing‐Hua Zheng, Min Wang","doi":"10.1002/kjm2.12868","DOIUrl":"https://doi.org/10.1002/kjm2.12868","url":null,"abstract":"This study targeted to explore circUQCRC2's role and mechanism in childhood asthma. A mouse model of ovalbumin‐induced asthma was established to evaluate the effects of circUQCRC2 on childhood asthma in terms of oxidative stress, inflammation, and collagen deposition. The effects of circUQCRC2 on platelet‐derived growth factor‐BB (PDGF‐BB)‐induced smooth muscle cells (SMCs) were evaluated, the downstream mRNA of miRNA and its associated pathways were predicted and validated, and their effects on asthmatic mice were evaluated. circUQCRC2 levels were upregulated in bronchoalveolar lavage fluid of asthmatic mice and PDGF‐BB‐treated SMCs. Depleting circUQCRC2 alleviated tissue damage in asthmatic mice, improved inflammatory levels and oxidative stress in asthmatic mice and PDGF‐BB‐treated SMC, inhibited malignant proliferation and migration of SMCs, and improved airway remodeling. Mechanistically, circUQCRC2 regulated VEGFA expression through miR‐381‐3p and activated the NF‐κB cascade. circUQCRC2 knockdown inactivated the NF‐κB cascade by modulating the miR‐381‐3p/VEGFA axis. Promoting circUQCRC2 stimulates asthma development by activating the miR‐381‐3p/VEGFA/NF‐κB cascade. Therefore, knocking down circUQCRC2 or overexpressing miR‐381‐3p offers a new approach to treating childhood asthma.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative analysis of surgically excised hereditary and sporadic pheochromocytomas: Insights from a single-center experience. 遗传性嗜铬细胞瘤和散发性嗜铬细胞瘤手术切除对比分析：来自单中心经验的启示。

The Kaohsiung journal of medical sciences Pub Date : 2024-06-01 Epub Date: 2024-05-15 DOI: 10.1002/kjm2.12836

Narin Nasiroglu Imga, Muzaffer Serdar Deniz, Belma Ozlem Tural Balsak, Yilmaz Aslan, Altug Tuncel, Dilek Berker

{"title":"A comparative analysis of surgically excised hereditary and sporadic pheochromocytomas: Insights from a single-center experience.","authors":"Narin Nasiroglu Imga, Muzaffer Serdar Deniz, Belma Ozlem Tural Balsak, Yilmaz Aslan, Altug Tuncel, Dilek Berker","doi":"10.1002/kjm2.12836","DOIUrl":"10.1002/kjm2.12836","url":null,"abstract":"Pheochromocytoma is a tumor that usually originating from adrenal medullary chromaffin cells and producing one or more catecholamines, can manifest as hereditary or sporadic. While the majority pheochromocytomas are sporadic, hereditary forms are often associated with genetic syndromes such as von Hippel-Lindau, multiple endocrine neoplasia type 2, and neurofibromatosis type 1. This study aims to analyze data from our series of surgically excited pheochromocytoma patients and compare the characteristics between hereditary and sporadic cases. We retrospectively evaluated 33 diagnosed pheochromocytoma patients, documenting clinical features, surgical complications, and tumor characteristics in both hereditary and sporadic cases. Among the patients, 21% (7 individuals) had hereditary pheochromocytoma, while 79% (26 individuals) had sporadic cases. During diagnosis, hereditary pheochromocytoma patients exhibited a significantly lower mean age compared to the sporadic group (26.4 ± 9.9 years vs. 50.4 ± 14.0 years; p < 0.001). The maximum tumor size was also lower in hereditary cases compared to sporadic cases (p = 0.004). Adrenal tumor localization analysis showed that 63.6% were right-sided, 24.2% were left-sided, and 12.1% were bilateral. Laboratory analysis revealed significantly higher urinary norepinephrine levels in hereditary pheochromocytoma patients (p = 0.021). Our findings suggest that hereditary pheochromocytoma cases are characterized by a younger age at diagnosis, smaller tumor size, and a higher prevalence of multiple bilateral adrenal adenomas. We recommend genetic testing for all pheochromocytoma patients, particularly those with early-onset disease and bilateral adrenal tumors.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"583-588"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140924240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0