The Kaohsiung journal of medical sciences最新文献_第9页

Response to Integration of the Comprehensive Physical Examination and Diagnostic Tools in Clinical Cardiology. 综合体格检查与诊断工具在临床心脏病学中的整合反应。

The Kaohsiung journal of medical sciences Pub Date : 2025-07-13 DOI: 10.1002/kjm2.70075

Yu-Shien Kao, Yi-Hsun Chen, I-Chen Wu

引用次数: 0

Dynamics of Cardiometabolic Risk Factors Are Linked to the Risk of Hypertension and Diabetes in MASLD. 心脏代谢危险因素的动态与MASLD患者高血压和糖尿病的风险相关。

The Kaohsiung journal of medical sciences Pub Date : 2025-07-12 DOI: 10.1002/kjm2.70077

Chin-I Shih, Ming-Lun Yeh, Yi-Hung Lin, Ping-Tsung Shih, Kuan-Ta Wu, Meng-Hsuan Hsieh, Jeng-Fu Yang, Yi-Yu Chen, Po-Cheng Liang, Yu-Ju Wei, Pei-Chien Tsai, Ya-Yun Cheng, Ming-Yen Hsieh, Chih-Wen Wang, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Chi-Kung Ho, Wan-Long Chuang, Vincent Wai-Sun Wong, Wei-Ting Chang, Ming-Lung Yu

{"title":"Dynamics of Cardiometabolic Risk Factors Are Linked to the Risk of Hypertension and Diabetes in MASLD.","authors":"Chin-I Shih, Ming-Lun Yeh, Yi-Hung Lin, Ping-Tsung Shih, Kuan-Ta Wu, Meng-Hsuan Hsieh, Jeng-Fu Yang, Yi-Yu Chen, Po-Cheng Liang, Yu-Ju Wei, Pei-Chien Tsai, Ya-Yun Cheng, Ming-Yen Hsieh, Chih-Wen Wang, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Chi-Kung Ho, Wan-Long Chuang, Vincent Wai-Sun Wong, Wei-Ting Chang, Ming-Lung Yu","doi":"10.1002/kjm2.70077","DOIUrl":"https://doi.org/10.1002/kjm2.70077","url":null,"abstract":"This study investigates the impact of cardiometabolic risk factors (CMRF) on the prevalence and incidence of hypertension (HTN) and diabetes mellitus (DM) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) and nonsteatotic liver disease (non-SLD), using both cross-sectional and longitudinal data. A total of 32,569 Taiwanese adults without viral hepatitis or significant alcohol consumption who underwent health checkups from 1999 to 2013 were analyzed cross-sectionally. Among them, 27,109 individuals free of HTN and DM at baseline and within 1 year of enrollment were followed longitudinally. Participants were classified into four groups based on hepatic steatosis assessed by ultrasound and presence of CMRF: healthy control (non-SLD/CMRF-), simple SLD (SLD/CMRF-), non-SLD/CMRF+, and MASLD. MASLD patients exhibited markedly higher annual incidence rates of HTN and DM (19.7 and 6.3 per 1000 person-years) compared to non-SLD individuals (HTN: 9.0; DM: 0.6 per 1000 person-years). The risk of incident HTN and DM increased progressively with the number of CMRF, with adjusted hazard ratios (aHR) ranging from 2.02 to 15.53 for HTN and from 2.92 to 82.38 for DM. Regression of cardiometabolic dysfunction decreased the risk of HTN and/or DM, and vice versa. The presence of CMRF significantly increased the likelihood of developing HTN and DM in both SLD and non-SLD groups, with aHRs up to 7.48 for HTN and 15.38 for DM. In conclusion, MASLD is strongly associated with increased prevalence and incidence of HTN and DM, and the burden and trajectory of CMRF critically modulate these risks.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70077"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GATA1 Transcriptionally Upregulates LMCD1, Promoting Ferroptosis in Sepsis-Associated Acute Kidney Injury Through the Hippo/YAP Pathway. GATA1转录上调LMCD1，通过Hippo/YAP通路促进脓毒症相关急性肾损伤中的铁凋亡。

The Kaohsiung journal of medical sciences Pub Date : 2025-07-12 DOI: 10.1002/kjm2.70071

You-Qi Zhang, Wei-Xia Peng, You-Fu Li, Peng Lu, Hui Liu, Wen-Guang Liu

{"title":"GATA1 Transcriptionally Upregulates LMCD1, Promoting Ferroptosis in Sepsis-Associated Acute Kidney Injury Through the Hippo/YAP Pathway.","authors":"You-Qi Zhang, Wei-Xia Peng, You-Fu Li, Peng Lu, Hui Liu, Wen-Guang Liu","doi":"10.1002/kjm2.70071","DOIUrl":"https://doi.org/10.1002/kjm2.70071","url":null,"abstract":"Sepsis-associated acute kidney injury (SA-AKI) is associated with morbidity and mortality. Ferroptosis is associated with the pathophysiology of SA-AKI. Here, we investigated the role of LIM and cysteine-rich domain 1 (LMCD1) in the regulation of ferroptosis during SA-AKI progression. SA-AKI models were established by CLP and LPS treatments. Hematoxylin and eosin (HE) and (PAS) staining were conducted to examine renal pathological changes. ELISA was used to measure serum creatinine and BUN levels. Lipid ROS levels in cells were examined using flow cytometry. MDA, GSH, SOD, and Fe2+ levels in the cells were measured using appropriate kits. Molecular interactions were analyzed using ChIP, a dual-luciferase reporter gene, and Co-IP assays. GATA1 knockdown inhibits LPS-induced cell injury, oxidative stress, and ferroptosis in HK-2 cells by transcriptionally inhibiting LMCD1 expression. Moreover, LMCD1 activates the Hippo/YAP pathway by promoting CUL3-mediated Nrf2 ubiquitination degradation. LMCD1 knockdown alleviates CLP-induced AKI in mice by inhibiting ferroptosis. Taken together, LMCD1 transcriptionally activated by GATA1 promotes ferroptosis during SA-AKI progression by activating the Hippo/YAP pathway and facilitating CUL3-mediated Nrf2 ubiquitination degradation.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70071"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of KDM5C-Mediated H3K4me3 Demethylation of HOXC-AS3 in the Proliferation of Colorectal Cancer Cells. kdm5c介导的HOXC-AS3 H3K4me3去甲基化在结直肠癌细胞增殖中的作用机制

The Kaohsiung journal of medical sciences Pub Date : 2025-07-08 DOI: 10.1002/kjm2.70068

Hong Li, Da-Min Li, Zhan Wang, Jie Hou

{"title":"Mechanism of KDM5C-Mediated H3K4me3 Demethylation of HOXC-AS3 in the Proliferation of Colorectal Cancer Cells.","authors":"Hong Li, Da-Min Li, Zhan Wang, Jie Hou","doi":"10.1002/kjm2.70068","DOIUrl":"https://doi.org/10.1002/kjm2.70068","url":null,"abstract":"Colorectal cancer (CRC) ranks as the third most prevalent malignancy and the second leading cause of cancer-related mortality worldwide. This study explored the role of lysine-specific histone demethylase 5C (KDM5C) in CRC progression. Expression levels of KDM5C, HOXC-AS3, and discs large MAGUK scaffold protein 4 (DLG4) were evaluated. Following the KDM5C knockdown, cell proliferation assays were conducted. The recruitment of KDM5C and histone H3 lysine 4 tri-methylation (H3K4me3) to the HOXC-AS3 promoter region was investigated. Furthermore, the subcellular distribution of HOXC-AS3 was assessed using nuclear-cytoplasmic fractionation and RNA fluorescence in situ hybridization (RNA-FISH). The interactions between HOXC-AS3, YTH domain-containing protein 1 (YTHDC1), and DLG4 were detected. The stability of DLG4 mRNA was evaluated, and the functional roles of HOXC-AS3 and DLG4 in CRC cells were examined through combined experimental analyses. KDM5C expression was elevated in CRC cells, whereas HOXC-AS3 and DLG4 levels were notably reduced. Silencing KDM5C resulted in suppressed cell proliferation. Mechanistically, KDM5C inhibited HOXC-AS3 expression by demethylating H3K4me3 at its promoter. HOXC-AS3 promoted DLG4 mRNA stability by recruiting the RNA-binding protein YTHDC1. Combined experimental results indicated that overexpression of HOXC-AS3 or DLG4 reduced the inhibitory effect of KDM5C downregulation on CRC cells. In conclusion, KDM5C promotes CRC cell proliferation by demethylating H3K4me3, repressing HOXC-AS3 expression. The reduced HOXC-AS3 levels impair the recruitment of YTHDC1, leading to decreased DLG4 expression.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70068"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rg1 Restores Sirt2/Foxo1 Expression and Alleviates Autism-Like Behaviors in a Valproic Acid Induced Male Mouse Model. 在丙戊酸诱导的雄性小鼠模型中，人参皂苷Rg1恢复Sirt2/Foxo1表达并减轻自闭症样行为

The Kaohsiung journal of medical sciences Pub Date : 2025-07-07 DOI: 10.1002/kjm2.70078

Fan-Xu Song, Qing-Wei Wu, Wei Pan, Li-Jun Liu, Xin Li, Xue Zhou, Zong-Yao Yu, Xin Ning, Lan-Min Guo

{"title":"Ginsenoside Rg1 Restores Sirt2/Foxo1 Expression and Alleviates Autism-Like Behaviors in a Valproic Acid Induced Male Mouse Model.","authors":"Fan-Xu Song, Qing-Wei Wu, Wei Pan, Li-Jun Liu, Xin Li, Xue Zhou, Zong-Yao Yu, Xin Ning, Lan-Min Guo","doi":"10.1002/kjm2.70078","DOIUrl":"https://doi.org/10.1002/kjm2.70078","url":null,"abstract":"This study investigated whether Ginsenoside Rg1 (Rg1) alleviates autism-like behaviors in mice prenatally exposed to valproic acid (VPA) via Sirt2/Foxo1 signaling. Pregnant C57BL/6J mice received a single intraperitoneal injection of VPA (600 mg/kg) on embryonic Day 12.5 to establish an autism model. At 8 weeks of age, male offspring were randomly divided into four groups: Normal, VPA, VPA + Rg1 (5 mg/kg), and VPA + Rg1 (10 mg/kg). Rg1 was administered once daily for 28 days. Behavioral assessments included grooming, rearing, locomotor activity, social interaction, novel object recognition, open field, and marble-burying tests. Molecular assays measured Sirt2/Foxo1 expression, inflammatory cytokines, oxidative stress markers in the hippocampus and prefrontal cortex. Nissl staining was performed to evaluate neuronal integrity in the prefrontal cortex and hippocampus. Rg1 administration significantly ameliorated core autism-like behaviors in VPA-exposed mice, including deficits in social interaction, recognition memory, and anxiety- and compulsive-like behaviors, as well as excessive grooming and marble-burying. VPA reduced Sirt2/Foxo1 expression, increased levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), and malondialdehyde (MDA), and decreased superoxide dismutase (SOD) activity in both brain regions. Rg1 treatment reversed these alterations in a dose-responsive manner, with the 10 mg/kg dose yielding more pronounced behavioral and molecular improvements than the 5 mg/kg dose. Nissl staining revealed significant neuronal loss in VPA-exposed mice, which was partially restored by Rg1 treatment. These findings suggest that Rg1 alleviates VPA-induced behavioral and neuropathological abnormalities, potentially via Sirt2/Foxo1-mediated regulation of neuroinflammation and oxidative stress, and may represent a promising therapeutic strategy for autism spectrum disorder.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70078"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhaponitin Reverses Cisplatin Resistance and Impairs Cancer Stemness Through HIF-1α/MCT4/Wnt Pathway in Tongue Squamous Cell Carcinoma. Rhaponitin通过HIF-1α/MCT4/Wnt通路逆转舌鳞状细胞癌顺铂耐药并损害癌干性

The Kaohsiung journal of medical sciences Pub Date : 2025-07-03 DOI: 10.1002/kjm2.70069

Yuan Wu, Xiao-Wen Wan, Lin Jiang, Wei Wang, Jia-Jun Zhu, Yi-Sen Shao

{"title":"Rhaponitin Reverses Cisplatin Resistance and Impairs Cancer Stemness Through HIF-1α/MCT4/Wnt Pathway in Tongue Squamous Cell Carcinoma.","authors":"Yuan Wu, Xiao-Wen Wan, Lin Jiang, Wei Wang, Jia-Jun Zhu, Yi-Sen Shao","doi":"10.1002/kjm2.70069","DOIUrl":"https://doi.org/10.1002/kjm2.70069","url":null,"abstract":"Rhaponitin (Rha) possesses anti-tumor activity and mediates the transcriptional activity of hypoxia-inducible factor (HIF)-1α that affects cisplatin (Cis) resistance. However, whether Rha can lessen Cis resistance in tongue squamous cell carcinoma (TSCC) by mediating HIF-1α activity is unclear. Cis-resistant SCC9 (SCC9-CisR) cells were treated with Cis, Rha, or Cis plus Rha to explore the effect of Rha on Cis resistance using a cell counting kit-8, flow cytometry, and tumor sphere formation assays. Stemness markers CD44 and SOX2 and HIF-1α mRNA levels were detected by quantitative PCR. The GSE115119 database and plugin iRegulon were employed to select target genes mediated by HIF-1α. Protein levels of HIF-1α, monocarboxylate transporter 4 (MCT4), and the Wnt/β-catenin pathway were measured by western blot. Subcutaneous xenograft models were constructed to explore the efficacy of Rha in combating Cis resistance. Rha repressed the growth and stemness of SCC9-CisR cells in vitro and in vivo. HIF-1α protein levels were markedly elevated in SCC9-CisR cells, yet Rha treatment attenuated the transcriptional activity of HIF-1α but not HIF-1α mRNA levels. Rha plus Cis repressed the viability and stemness of SCC9-CisR cells, but not HIF-1α-knockdown SCC9-CisR cells, compared with Cis alone. Rha-induced stemness inhibition and apoptosis in SCC9-CisR cells were overridden after HIF-1α overexpression. Rha inhibited the Wnt/β-catenin signaling by regulating the HIF-1α/MCT4 axis. In conclusion, Rha reduced cell stemness and enhanced Cis sensitivity in TSCC, which was achieved possibly via suppressing the Wnt/β-catenin signaling through mediation of the HIF-1α/MCT4 axis.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70069"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncRNA PVT1 Facilitates Phenotypic Switching of Vascular Smooth Muscle Cells in Intracranial Aneurysms by Recruiting KDM1A to Reduce H3K9me2 Modification. LncRNA PVT1通过募集KDM1A减少H3K9me2修饰促进颅内动脉瘤血管平滑肌细胞表型转换。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-07-01 Epub Date: 2025-04-28 DOI: 10.1002/kjm2.70025

Yu-Fei Cheng, Wei Sun, Yi-Xia Wang, Jia-Jie Chen, Ya-Sen Cao

{"title":"LncRNA PVT1 Facilitates Phenotypic Switching of Vascular Smooth Muscle Cells in Intracranial Aneurysms by Recruiting KDM1A to Reduce H3K9me2 Modification.","authors":"Yu-Fei Cheng, Wei Sun, Yi-Xia Wang, Jia-Jie Chen, Ya-Sen Cao","doi":"10.1002/kjm2.70025","DOIUrl":"10.1002/kjm2.70025","url":null,"abstract":"This study explores the differential expression of lncRNA PVT1 in intracranial aneurysms (IAs) and its role in the phenotypic switching of vascular smooth muscle cells (VSMCs). PVT1 and ALOX5 expressions in the serum of IA patients and healthy controls were detected by qRT-PCR. The diagnostic efficacy of PVT1 for IA was analyzed using the receiver operating curve (ROC). VSMCs were treated with H2O2 to induce phenotypic switching. PVT1 expression was silenced in VSMCs, followed by the detection of cell viability, inflammatory factors (TNF-α, IL-1β, IL-6), as well as α-SMA, OPN, and MMP2. RIP confirmed the binding between PVT1 and KDM1A. The enrichment of KDM1A and H3K9me2 on ALOX5 promoter was analyzed by ChIP. PVT1 expression in IA patients was significantly elevated, and PVT1 expression was correlated with the size and location of IAs. H2O2 induced VSMCs to transition from contractile cells to synthetic cells, intensified cellular inflammation, and upregulated PVT1 expression. Inhibition of PVT1 repressed VSMC phenotypic switching. PVT1 promoted ALOX5 expression by recruiting KDM1A to reduce H3K9me2 modification. In conclusion, PVT1 is highly expressed in IA patients and has high diagnostic value. PVT1 promotes VSMC phenotypic switching by recruiting KDM1A to reduce H3K9me2 modification and enhance ALOX5 expression.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70025"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction and Validation of a Risk Prediction Model for Early Severe Intraventricular Hemorrhage in Very Low Birth Weight Infants. 极低出生体重儿早期重度脑室内出血风险预测模型的构建与验证。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI: 10.1002/kjm2.70037

Fei Shen, Jie Xu, Hui Rong, Jing Zhang, Yang Yang, Xian-Wen Li

{"title":"Construction and Validation of a Risk Prediction Model for Early Severe Intraventricular Hemorrhage in Very Low Birth Weight Infants.","authors":"Fei Shen, Jie Xu, Hui Rong, Jing Zhang, Yang Yang, Xian-Wen Li","doi":"10.1002/kjm2.70037","DOIUrl":"10.1002/kjm2.70037","url":null,"abstract":"In the past several years, prediction models for severe intraventricular hemorrhage (IVH) in premature infants have emerged. However, few models have considered the importance of predictors related to the clinical course and hemostatic profile in predicting the risk of hemorrhage, such as the FiO2, hematocrit, and platelet count. Moreover, it is noteworthy that most models unreasonably confuse late-onset IVH with early-onset, posing a high risk of bias. The present study was performed to construct a new prediction model for severe IVH. The data for this population-based study came from a children's hospital. After screening by inclusion and exclusion criteria, 1009 very low birth weight infants (VLBWIs) were subsequently recruited in the study and divided into training and validation sets in a ratio of 7:3. Gestational age, Max FiO2, hematokrit on admission < 45%, and platelet count on admission < 100 × 109/L were incorporated into the nomogram chart. The area under the curve (AUC) values demonstrated robust predictive performance, with the training set yielding an AUC of 0.884 (bootstrap-corrected AUC = 0.903) and the validation set achieving an AUC of 0.859. The Delong test showed no statistically significant difference in AUCs between the training set and validation set (p = 0.528). The result of the Hosmer-Lemeshow test showed the model is well calibrated (p = 0.757). The present study identified the predictor model associated with severe IVH during the first 7 days of life, and the nomogram performed soundly, which would be a promising tool for early stratification of the risk for severe IVH in VLBWIs.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70037"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Adding Transversus Abdominis Plane Block on Intravenous Nalbuphine and Dexmedetomidine for Severely Pre-Eclamptic Parturients After Cesarean Delivery. 经腹平面阻滞对剖宫产后重度先兆子痫患者静脉注射纳布啡和右美托咪定的影响。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-07-01 Epub Date: 2025-05-21 DOI: 10.1002/kjm2.70027

Yong Yang, Ya-Ni Zhang

{"title":"Effects of Adding Transversus Abdominis Plane Block on Intravenous Nalbuphine and Dexmedetomidine for Severely Pre-Eclamptic Parturients After Cesarean Delivery.","authors":"Yong Yang, Ya-Ni Zhang","doi":"10.1002/kjm2.70027","DOIUrl":"10.1002/kjm2.70027","url":null,"abstract":"The use of opioids is frequently associated with the occurrence of adverse effects during cesarean delivery, especially for primiparous women with severe preeclampsia, creating a critical need for investigation of alternative analgesic strategies. The study aims to determine the effects of adding transversus abdominis plane block (TAPB) on patient-controlled intravenous analgesia (PCIA) of nalbuphine (Nal) and dexmedetomidine (Dex) on severely pre-eclamptic parturients after cesarean delivery. This is a randomized controlled trial. Severely pre-eclamptic parturients who were scheduled for elective cesarean delivery with spinal anesthesia were randomly assigned into the TAPB group (TAPB combined with PCIA with Nal and Dex; n = 49) and the PCIA group (same block procedures with normal saline followed by PCIA with Nal and Dex; n = 51). Results showed that adding TAPB to PCIA with Nal and Dex significantly lowered visual analog scale (VAS) scores at rest at 2 and 6 h, at mobilization at 2, 6, and 12 h after surgery, reduced press time of PCIA, shortened time for first feeding and out-of-bed movement, enhanced maternal satisfaction with pain control, and lowered plasma levels of cortisone and norepinephrine. The findings of the study suggest that adding TAPB to PCIA with Nal and Dex could enhance acute recovery with fewer stress responses for severely pre-eclamptic parturients after cesarean delivery.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70027"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Radiofrequency Ablation Safety and Efficacy in Primary Hyperparathyroidism: A Single-Center Retrospective Study in Taiwan and Literature Review. 射频消融治疗原发性甲状旁腺功能亢进的安全性和有效性评价：台湾单中心回顾性研究及文献综述。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI: 10.1002/kjm2.70022

Shu-Ting Wu, Wei-Che Lin, Chih-Ying Lee, Cheng-Kang Wang, An-Ni Lin, Yen-Hsiang Chang, Shun-Yu Chi, Chen-Kai Chou

{"title":"Evaluation of Radiofrequency Ablation Safety and Efficacy in Primary Hyperparathyroidism: A Single-Center Retrospective Study in Taiwan and Literature Review.","authors":"Shu-Ting Wu, Wei-Che Lin, Chih-Ying Lee, Cheng-Kang Wang, An-Ni Lin, Yen-Hsiang Chang, Shun-Yu Chi, Chen-Kai Chou","doi":"10.1002/kjm2.70022","DOIUrl":"10.1002/kjm2.70022","url":null,"abstract":"Radiofrequency ablation (RFA) is increasingly recognized as a minimally invasive option for primary hyperparathyroidism (PHPT). This study aimed to evaluate the effectiveness and safety of ultrasound (US)-guided RFA for the treatment of PHPT in Taiwan. We conducted a retrospective study of patients with PHPT who underwent RFA at a single medical center between March 2020 and January 2023. Serum biochemical samples, changes in parathyroid nodule volume, symptomatic scores, and complications were analyzed at follow-up after RFA. The volume reduction ratio (VRR) and treatment response at 1 year were evaluated. Among the 31 patients, 93.55% achieved a complete response with a VRR of 97.48% at 12 months post-RFA. Serum calcium and intact parathyroid hormone (iPTH) levels were significantly lower immediately after treatment than at baseline. However, a difference in phosphorus levels was noted 1 week later, and the alkaline phosphatase (ALP) level was significantly decreased after 3 months (p < 0.05). Transient hoarseness occurred in three patients and resolved spontaneously within 6 months. US-guided RFA is effective and safe for treating PHPT, with a satisfactory VRR and treatment response. This approach could be an alternative to surgery for ineligible patients.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70022"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0