The Kaohsiung journal of medical sciences最新文献_第8页

Determinants of Early Renal Function Recovery After TIPS in Patients With Portal Hypertension. 门静脉高压患者TIPS后早期肾功能恢复的决定因素。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-29 DOI: 10.1002/kjm2.70268

Meng Jia, Yang Luo, Zhao-Yang Tan, Xiao-Ling Zhou, Xi-You Zhang, Jing-Ying Sun, Ye Du

{"title":"Determinants of Early Renal Function Recovery After TIPS in Patients With Portal Hypertension.","authors":"Meng Jia, Yang Luo, Zhao-Yang Tan, Xiao-Ling Zhou, Xi-You Zhang, Jing-Ying Sun, Ye Du","doi":"10.1002/kjm2.70268","DOIUrl":"10.1002/kjm2.70268","url":null,"abstract":"Renal dysfunction frequently occurs in patients with portal hypertension and is linked to unfavorable clinical outcomes. Transjugular intrahepatic portosystemic shunt (TIPS) has the potential to enhance renal perfusion through portal decompression; however, factors predicting early improvement in renal function remain insufficiently defined. This retrospective, single-center study analyzed 188 consecutive patients with portal hypertension who underwent TIPS. Patients receiving renal replacement therapy or with baseline eGFR < 15 mL/min/1.73 m2 were excluded. The primary endpoint was early renal function improvement, defined as a > 10% reduction in serum creatinine within 7 days. Early renal function improvement was observed in 27.7% of the cohort. Lower baseline eGFR was independently associated with higher probability of improvement (adjusted OR: 0.980, 95% CI: 0.966-0.993; p = 0.004). Neither pre- nor post-TIPS portal venous pressure nor the magnitude of pressure reduction was significantly associated with renal response. Restricted cubic spline analysis indicated a linear inverse relationship between baseline eGFR and improvement probability. The multivariable model demonstrated modest discriminative ability (AUC 0.666). Baseline renal function was associated with early post-TIPS early renal function improvement, whereas intra-procedural portal pressure parameters were not predictive. These findings suggest that early renal function improvement following TIPS may predominantly reflect reversible functional impairment rather than established structural kidney injury.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70268"},"PeriodicalIF":3.1,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13417660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FOXC1: A Key Transcription Factor of VSMC-Derived Foam Cell Formation in Atherosclerotic Plaque Instability. FOXC1：动脉粥样硬化斑块不稳定中vsmc衍生泡沫细胞形成的关键转录因子。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-20 DOI: 10.1002/kjm2.70269

Ling-Lin Qian, Xue-Ling Li, Li-Hong Wang, Wei Yang, Yu Jiang

{"title":"FOXC1: A Key Transcription Factor of VSMC-Derived Foam Cell Formation in Atherosclerotic Plaque Instability.","authors":"Ling-Lin Qian, Xue-Ling Li, Li-Hong Wang, Wei Yang, Yu Jiang","doi":"10.1002/kjm2.70269","DOIUrl":"10.1002/kjm2.70269","url":null,"abstract":"The instability of atherosclerotic plaques, particularly intraplaque hemorrhage (IPH), drives life-threatening cardiovascular events, a process in which vascular smooth muscle cell (VSMC)-derived foam cells play a significant role. We aim to identify key biomarkers associated with VSMC-derived foam cells and IPH by analyzing data from human IPH datasets and VSMC-derived foam cell datasets (GSE163154, GSE68021, GSE28829, and GSE43292). Weighted gene co-expression network analysis (WGCNA), differential expression analysis, and machine learning algorithms (LASSO and SVM-RFE) were employed to identify hub genes. The identified genes were validated in independent datasets and in experimental models, including oxidized low-density lipoprotein-stimulated VSMCs and atherosclerotic aortic tissues of high-fat diet-fed ApoE-/- mice. Transcription factor (TF) prediction and dual-luciferase reporter assays were performed to explore upstream regulatory mechanisms. We identified CD68 and CYBA as key hub genes significantly upregulated in both VSMC-derived foam cells and unstable atherosclerotic plaques, with high diagnostic accuracy (AUC > 0.9) by ROC analysis. Experimental validation confirmed their upregulated expression. FOXC1 was identified as a common upstream transcription factor regulating both CD68 and CYBA. FOXC1 protein levels were elevated in VSMC-derived foam cells, and dual-luciferase assays confirmed its direct activation of CD68 and CYBA promoters. FOXC1 overexpression promoted CD68 and CYBA expression and enhanced lipid accumulation in VSMCs, while FOXC1 knockdown exerted opposite effects. Immune infiltration analysis revealed significant correlations between these hub genes and immune cell populations in unstable plaques. This study identifies FOXC1 as a key TF regulating CD68 and CYBA expression, thereby promoting VSMC-derived foam cell formation and plaque instability.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70269"},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma and Synovial Fluid VEGF-A and Neuropilin-1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization-Related Features, and Disease Burden. 膝关节骨性关节炎的血浆和滑液VEGF-A和Neuropilin-1：与放射学严重程度、疼痛敏感相关特征和疾病负担的关系

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-15 DOI: 10.1002/kjm2.70262

Cheng-Ju Tan

{"title":"Plasma and Synovial Fluid VEGF-A and Neuropilin-1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization-Related Features, and Disease Burden.","authors":"Cheng-Ju Tan","doi":"10.1002/kjm2.70262","DOIUrl":"10.1002/kjm2.70262","url":null,"abstract":"This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF-A) and neuropilin-1 (NRP1) levels with radiographic severity, pain sensitization-related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF-A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (Kellgren-Lawrence [KL] grade 2, n = 40; grade 3, n = 52; grade 4, n = 28) and 53 healthy controls, while synovial fluid VEGF-A and NRP1 were assessed in the KOA group. Pain sensitization-related features and disease burden were evaluated using the Central Sensitization Inventory (CSI), pressure pain threshold (PPT), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and visual analog scale (VAS). Plasma VEGF-A and NRP1 levels were elevated in KOA patients versus healthy controls and increased with KL grade, while synovial fluid VEGF-A and NRP1 rose with radiographic severity. Synovial fluid VEGF-A showed stronger discriminatory performance for radiographic severity than synovial fluid NRP1. After the Benjamini-Hochberg FDR correction, plasma and synovial fluid VEGF-A/NRP1 remained associated with VAS, WOMAC, CSI-defined symptom burden, and local PPT in the overall KOA cohort. Multivariable regression adjusted for KL grade, age, sex, BMI, and symptom duration showed that synovial fluid VEGF-A had the strongest independent associations with clinical outcomes. Bootstrap-validated combined ROC models, particularly those incorporating VEGF-A, showed good discriminatory performance for KOA status and severity stratification. These findings suggest that the VEGF-A-NRP1 axis, particularly synovial fluid VEGF-A, may serve as a biomarker framework for KOA severity assessment and symptom-related phenotyping.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70262"},"PeriodicalIF":3.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiopulmonary Exercise Testing (CPET) Guided Sub-Anaerobic Threshold Rehabilitation in MELAS Syndrome: A Case Report. 心肺运动试验（CPET）引导MELAS综合征亚无氧阈康复一例报告。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-15 DOI: 10.1002/kjm2.70266

Yu-Lien Tsai, Kun-Yuan Cheng, Yen-Sen Lu, Ko-Long Lin

引用次数: 0

Effects of Extracorporeal Shock Wave Therapy on Tendon Integrity, Biomechanical Strength, Matrix Remodeling, Inflammation, Angiogenesis, and Tenogenic Differentiation in Rotator Cuff Injury. 体外冲击波治疗对肩袖损伤肌腱完整性、生物力学强度、基质重塑、炎症、血管生成和肌腱分化的影响。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-14 DOI: 10.1002/kjm2.70260

Hua Wang, Fei Wu, Jia-Qing Miao

{"title":"Effects of Extracorporeal Shock Wave Therapy on Tendon Integrity, Biomechanical Strength, Matrix Remodeling, Inflammation, Angiogenesis, and Tenogenic Differentiation in Rotator Cuff Injury.","authors":"Hua Wang, Fei Wu, Jia-Qing Miao","doi":"10.1002/kjm2.70260","DOIUrl":"10.1002/kjm2.70260","url":null,"abstract":"Extracorporeal shock wave therapy (ESWT) improves tendon-bone healing after rotator cuff injury (RCI), but its underlying cellular mechanisms remain unknown. This study aimed to explore the therapeutic effects of ESWT on RCI, with a particular focus on endothelial cells and tenocytes. The RCI model was established in rabbits by rotator cuff tear surgery, followed by ESWT intervention. Histological evaluation, blood perfusion analysis, biomechanical testing, and assessment of inflammation and extracellular matrix (ECM) degradation were performed in RCI-treated rabbits at week (W) 2, W4, and W8. For the in vitro experiments, human umbilical vein endothelial cells (HUVECs) and human tenocytes were treated with ESWT. ESWT reduced Bonar scores, increased the fibrocartilage area and collagen-positive area, and enhanced blood perfusion and biomechanical strength at most time points in RCI rabbits (all p < 0.05). Moreover, ESWT reduced inflammation and ECM degradation, as reflected by reduced tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 and decreased matrix metalloproteinase (MMP)-1 and MMP-9 at most time points in RCI rabbits (all p < 0.05). In HUVECs, ESWT increased proliferation, invasion, branch points, MMP-2, MMP-9, vascular endothelial growth factor A (VEGFA), and fibroblast growth factor 2 (FGF2) (all p < 0.05). In tenocytes, ESWT increased proliferation, collagen I, thrombospondin-4 (TSP4), VEGFA, FGF2, tenomodulin (TNMD), and scleraxis (SCX) (all p < 0.05). ESWT improves tendon integrity, blood perfusion, and biomechanical strength while reducing inflammation and ECM degradation after RCI, possibly via enhanced angiogenic activity in endothelial cells and maintenance of the tenogenic phenotype in tenocytes.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70260"},"PeriodicalIF":3.1,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148439478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiometabolic Biomarkers for Disease Severity Prediction in Metabolic Dysfunction-Associated Steatotic Liver Disease. 代谢功能障碍相关脂肪肝疾病严重程度预测的心脏代谢生物标志物

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-13 DOI: 10.1002/kjm2.70261

Jee-Fu Huang, Chi-Yi Chen, Ming-Jong Bair, Tzu-Chun Lin, Ming-Lun Yeh, Pei-Chien Tsai, Yu-Ju Wei, Chih-Wen Wang, Po-Chen Liang, Ming-Yen Hsieh, Mei-Hsuan Lee, Chia-Yen Dai, Chung-Feng Huang, Ming-Lung Yu, Wan-Long Chuang

{"title":"Cardiometabolic Biomarkers for Disease Severity Prediction in Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Jee-Fu Huang, Chi-Yi Chen, Ming-Jong Bair, Tzu-Chun Lin, Ming-Lun Yeh, Pei-Chien Tsai, Yu-Ju Wei, Chih-Wen Wang, Po-Chen Liang, Ming-Yen Hsieh, Mei-Hsuan Lee, Chia-Yen Dai, Chung-Feng Huang, Ming-Lung Yu, Wan-Long Chuang","doi":"10.1002/kjm2.70261","DOIUrl":"10.1002/kjm2.70261","url":null,"abstract":"The impacts of cardiometabolic risk factors (CMRFs) and the biomarkers on disease severity in metabolic dysfunction-associated steatotic liver disease (MASLD) remain elusive. Accordingly, a multicenter study by recruiting MASLD patients from a nationwide registry database was conducted with a total of 2882 MASLD patients (54.1% males, mean age = 55.6 ± 13.9 years, mean body mass index [BMI] = 28.1 ± 4.9 kg/m2) being recruited. The proportions of patients carrying CMRFs of overweight/obesity, hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol level, and diabetes/prediabetes were 91.2%, 74.5%, 54.8%, 59.6%, and 74.5%, respectively. There was a significant linear trend between significant fibrosis and CMRFs (5.1%, 27%, and 54.6% in patients with one CMRF, 3 CMRFs, and ≥ 4 CMRFs, respectively, p = 0.009). The adjusted odds ratios (aOR) with 95% confidence intervals (CIs) for advanced fibrosis in patients of hemoglobin A1c (HbA1c) 5.7%-6.5%, 6.5%-8.0%, and > 8.0% were 1.02 (95% CI = 0.68-1.53, p = 0.93), 1.83 (95% CI = 1.16-2.88, p = 0.01), and 2.78 (95% CI = 1.45-5.34, p = 0.002), respectively. The significant risk factors for advanced fibrosis in MASLD were age > 60 years (aOR = 12.08, 95% CI = 6.23-23.46, p < 0.001), elevated transaminase level (aOR = 1.06, 95% CI = 1.05-1.09, p < 0.001), and diabetes (aOR = 1.51, 95% CI = 1.02-2.26, p = 0.04). In conclusion, there was a significant linear association between advanced fibrosis and the items of CMRFs. The HbA1c level could serve as a predictive biomarker for advanced fibrosis in MASLD with the implication that diabetes control is mandatory for patients with MASLD.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70261"},"PeriodicalIF":3.1,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148439417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Comments on: Guillain-Barre Syndrome With Cytomegalovirus Infection After Allogeneic Hematopoietic Stem Cell Transplantation. 对异基因造血干细胞移植后格林-巴利综合征合并巨细胞病毒感染评论的回应。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-13 DOI: 10.1002/kjm2.70263

Chin-Mu Hsu, Yong-Jia Chen, Ju-Jung Hou, Hui-Hua Hsiao

引用次数: 0

Before Guillain-Barre Syndrome Is Attributed to a CMV Infection, the Diagnosis Must Be Confirmed and Other Causes Must Be Ruled Out. 在将格林-巴利综合征归因于巨细胞病毒感染之前，必须确认诊断并排除其他原因。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-08 DOI: 10.1002/kjm2.70264

Josef Finsterer

引用次数: 0

Liposomal Bupivacaine Versus Ropivacaine in Combined Thoracic Paravertebral Block and Serratus Anterior Plane Block for Thoracoscopic Surgery: A Randomized Controlled Trial. 布比卡因脂质体与罗哌卡因联合胸腔镜手术椎旁阻滞和锯肌前平面阻滞：一项随机对照试验。

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-07 DOI: 10.1002/kjm2.70258

Lu Jin, Lian Tang

{"title":"Liposomal Bupivacaine Versus Ropivacaine in Combined Thoracic Paravertebral Block and Serratus Anterior Plane Block for Thoracoscopic Surgery: A Randomized Controlled Trial.","authors":"Lu Jin, Lian Tang","doi":"10.1002/kjm2.70258","DOIUrl":"10.1002/kjm2.70258","url":null,"abstract":"The study aimed to compare the use of liposomal bupivacaine (LB) and ropivacaine hydrochloride (RH) in combined thoracic paravertebral block (TPVB) and serratus anterior plane block (SAPB) during video-assisted thoracoscopic surgery (VATS). The primary outcome was cumulative consumption of 72-h morphine milligram equivalent (MME) postoperatively. The secondary outcomes were MME consumption at 0-24 h, 24-48 h, and 48-72 h postoperatively, scores of visual analogue scale (VAS) at 6, 12, 24, 48, and 72 h postoperatively, effective times of patient-controlled intravenous analgesia (PCIA), and first time to request for analgesia. The LB-TPVB-SAPB group (n = 66) exhibited a decrease in total MME consumption within 72 h postoperatively compared to the RH-TPVB-SAPB group (n = 66) [independent t-test: p < 0.0001, Cohen's d = -1.05; mean difference with 95% confidence interval: -14.02 (-18.68 to -9.35)]. Bonferroni multiple comparisons test after repeated-measures ANOVA showed less MME consumption at 0-24 h (p < 0.001) and 24-48 h (p = 0.013) with lower VAS scores at 24 (p < 0.001) and 48 h (p = 0.002) postoperatively in the LB-TPVB-SAPB group than the RH-TPVB-SAPB group. Fewer effective times of PCIA and longer time to first request for analgesia were also observed in the LB-TPVB-SAPB group than the RH-TPVB-SAPB group. In conclusion, this study demonstrates LB in combined TPVB and SAPB could reduce postoperative opioid consumption compared to RH in this combination after VATS and the absolute change in postoperative opioid consumption exceeds the reported minimal clinically important difference.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70258"},"PeriodicalIF":3.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactive Roles of Metabolic Dysfunction-Associated Steatotic Liver Disease and Nutritional Status in the Prognosis of Patients With Hepatocellular Carcinoma After Surgical Resection. 代谢功能障碍相关脂肪变性肝病和营养状况在肝细胞癌术后预后中的相互作用

IF 3.1

The Kaohsiung journal of medical sciences Pub Date : 2026-07-03 DOI: 10.1002/kjm2.70256

Chun-Ting Ho, Chien-An Liu, Chia-Jung Ho, Yi-Chen Lin, Shin-Yu Tsai, Hao-Jan Lei, Shu-Cheng Chou, Yi-Hsiang Huang, Ming-Chih Hou, Jaw-Ching Wu, Chien-Wei Su

{"title":"Interactive Roles of Metabolic Dysfunction-Associated Steatotic Liver Disease and Nutritional Status in the Prognosis of Patients With Hepatocellular Carcinoma After Surgical Resection.","authors":"Chun-Ting Ho, Chien-An Liu, Chia-Jung Ho, Yi-Chen Lin, Shin-Yu Tsai, Hao-Jan Lei, Shu-Cheng Chou, Yi-Hsiang Huang, Ming-Chih Hou, Jaw-Ching Wu, Chien-Wei Su","doi":"10.1002/kjm2.70256","DOIUrl":"10.1002/kjm2.70256","url":null,"abstract":"The prognostic effect of concurrent metabolic dysfunction-associated steatotic liver disease (MASLD) on outcomes for hepatocellular carcinoma (HCC) patients remains unclear. The Prognostic Nutritional Index (PNI) reflects nutritional and inflammatory status and is a well-known prognostic factor. We therefore aimed to evaluate and compare the prognostic role of PNI in patients with HCC with and without concurrent MASLD undergoing curative surgical resection. In our retrospective study, 991 patients undergoing curative HCC resection were stratified according to MASLD status and pre-operative PNI (cut-off: 45). Overall survival (OS) and recurrence-free survival (RFS) were analyzed using Kaplan-Meier methods and Cox proportional hazards models. Further subgroup analysis was performed according to their concurrent viral hepatitis status. High PNI was identified as an independent protective factor against poor OS for the entire cohort (hazard ratio [HR]: 0.65; 95% confidence interval [CI]: 0.49-0.87, p = 0.004). The Kaplan-Meier analysis showed that the high-PNI/MASLD group had the best OS, while the low-PNI/no-MASLD group had the worst. Subgroup analysis indicated that high PNI was an independent protective factor for OS only in the no-MASLD group (HR: 0.59, p = 0.003) but not the MASLD group (HR: 0.94, p = 0.793). Its prognostic effect was more significant in HCC patients without concurrent MASLD or with chronic hepatitis B. To conclude, a better nutritional status, assessed by PNI, is a valuable prognostic marker for patients with HCC. Its protective effect on OS is significantly pronounced in patients without concurrent MASLD, indicating that MASLD status modifies the prognostic utility of PNI.","PeriodicalId":94244,"journal":{"name":"The Kaohsiung journal of medical sciences","volume":" ","pages":"e70256"},"PeriodicalIF":3.1,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0