The International journal of oral & maxillofacial implants最新文献

{"title":"Effect of Metal Artifacts in Cone-beam Computed Tomography on Accuracy of Implant Placement by Static and Dynamic Computer- Assisted Implant Surgery: An In Vitro Study.","authors":"Chunxu Liu, Shahida Mohd-Said, Xin-Fang Leong, In Meei Tew","doi":"10.11607/jomi.11183","DOIUrl":"https://doi.org/10.11607/jomi.11183","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the impact of metal artifacts in cone-beam computed tomography (CBCT) on the accuracy of static and dynamic computer-assisted implant surgery (CAIS) techniques.</p><p><strong>Materials and methods: </strong>An implant was placed on each of thirty 3D-printed models embedded with Cobalt-Chrome strips to simulate metal artifacts by Porcelain-fused-to-metal (PFM), utilizing these CAIS techniques: radiographic template (RT) (n=10), radiographic markers (RM) (n=10), and dynamic navigation (DN) (n=10). Trueness and precision were analyzed by comparing 3D global deviation and the difference in implant positions at the neck, apex, depth, and angle in initial planned and final placed scans.</p><p><strong>Results: </strong>DN exhibited significantly lower 3D global trueness deviation to RT (p = 0.022) and lower angular deviation compared to both RT (p = 0.003) and RM (p = 0.002). RM showed greater trueness at the implant neck compared to DN (p = 0.005) and better depth trueness than RT (p = 0.001) and DN (p = 0.027). DN demonstrated higher precision in implant angulation than RM (p = 0.011) and RT (p = 0.041).</p><p><strong>Conclusion: </strong>In the presence of metal artifacts, both DN and RM techniques offered greater trueness in specific implant positions compared to RT. However, DN proved to be the most precise method for implant placement.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-29"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implants as Surveyed Crowns for Implant-Assisted Removable Partial Dentures: A Long-Term Case Series Study.","authors":"Shing-Zeng Dung, Shyh-Yuan Lee, Jea-Shen Tsai, I-Shiang Tzeng","doi":"10.11607/jomi.11202","DOIUrl":"https://doi.org/10.11607/jomi.11202","url":null,"abstract":"<p><strong>Purpose: </strong>Long-term data on the use of implants as surveyed crowns for implant-assisted removable partial dentures (IARPDSCs) are limited. This study evaluated the long-term outcomes and assessed the risk factors associated with marginal bone loss (MBL) in IARPDSCs.</p><p><strong>Materials and methods: </strong>A total of 51 implants were placed in 14 partially or fully edentulous patients and restored using IARPDSCs. Implant crowns or bridges served as abutments for the removable partial dentures (RPDs) to enhance their esthetics, comfort, and function. All patients attended regular follow-up appointments every 3-6 months for up to 12.5 years; these visits included professional cleaning and oral hygiene reinforcement. The collected data included patient demographics, treatment modality, arch restoration, Kennedy classification, RPD connection and retention design, opposing dentition, implant characteristics (location, connection type, and diameter), and any complications. The clinical assessments included plaque score, bleeding on probing, probing depth, marginal tissue recession, and keratinized mucosa width. Univariate and multivariate analyses were performed to identify factors influencing the MBL of implants in IARPDSCs.</p><p><strong>Results: </strong>One implant failed during follow-up; thus, the implant survival rate was 98%. All patients were satisfied with their prostheses and reported only minor complications. Univariate analysis showed a significantly higher MBL in maxillary implants than in mandibular implants (P = .045). Multiple regression analysis revealed that bruxism (P = .002) and maxillary implants (P = .013) were significantly associated with a higher MBL. Female sex (P = .051) and anterior implants (P = .058) exhibited a trend toward an association with higher MBL.</p><p><strong>Conclusions: </strong>Within the limitations of this retrospective clinical study, IARPDSCs demonstrated predictable long-term success in carefully selected and well-maintained patients.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-27"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does an Osteoporosis-like Condition Jeopardize the Osseointegration Process around Dental Implants Placed in Animal Models? A Systematic Review.","authors":"Eduardo C Kalil, Khalila C Cotrim, Rafael Siqueira, Vittorio Moraschini, Leonardo P Faverani, João Gabriel G Souza, Jamil A Shibli","doi":"10.11607/jomi.11057","DOIUrl":"https://doi.org/10.11607/jomi.11057","url":null,"abstract":"<p><strong>Introduction: </strong>Knowing that osteoporosis is a metabolic disease that could decrease dental implant success and survival, the purpose of this review was to gather information on the characteristics of implant osseointegration in animal models of induced osteoporosis. By pointing out the role of some factors that could improve the success rate in these situations, this study aimed to enhance the knowledge about this process that can be further translated to clinical designs.</p><p><strong>Methods: </strong>A systematic search in PubMed/Medline, Lilacs, Cochrane Library, Scopus and Web of Science was conducted to identify information between 2002 and 2023 regarding osseointegration of dental implants in animal models of induced osteoporosis. The following search strategy was utilized and adjusted to each database: (((dental implant) AND (Osseointegration)) AND (osteoporosis)) AND/OR (osteoporosis treatment). The inclusion criteria were animal studies in English, involving the placement of an osseointegrated implant in osteoporotic bone, and evaluating bone to implant contact (BIC) %. Exclusion criteria were studies in humans, in vitro studies, procedures involving any kind of bone graft and studies evaluating medication related osteonecrosis of the jaw. A standardized data extraction form was used to record data for each study, covering article title, date, authors, number of animals, purpose of study, type of analysis used by authors, follow-up, type of implant, test and control groups, intervention and conclusions. The risk of bias of the included studies was assessed using the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) Risk of Bias tool.20 Results: A total of 204 articles were found for evaluation and selection. All of the 43 selected studies evaluated the bone-implant contact (BIC) %. Other parameters such as bone to implant mechanical interface, bone area (BA) and bone volume (BV) ratio were also evaluated in some of the studies. There was a tendency for compromised results of implant osseointegration in the presence of osteoporosis. Modification of the implant surface, systemic and local use of anti-resorptive drugs and other substances, showed benefits for the implant success in osteoporotic sites. Still, no consensus among studies on the superiority of systemic medications in improving the process of peri-implant bone repair, was observed.</p><p><strong>Conclusion: </strong>Although it is possible to improve the osseointegration of implants in osteoporotic bone, either by using systemic or local factors, the metabolic bone syndrome caused by osteoporosis can jeopardize the osseointegration of dental implants.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-32"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Evaluation of Peri-Implant Marginal Bone Level of Reduced Diameter Implants by Mixed Model Analysis.","authors":"Paul Henn, Peter Gehrke, Arndt Happe, Jörg Neugebauer","doi":"10.11607/jomi.10574","DOIUrl":"https://doi.org/10.11607/jomi.10574","url":null,"abstract":"<p><strong>Purpose: </strong>The goal of successful implant placement is to maintain a long-term stable marginal peri-implant bone level (MBL). This retrospective study investigated the MBL of reduceddiameter implants (RDI). The implants were analyzed in different indication in the context of various surgical and prosthetic treatment strategies using heterogeneous data from a private practice. Mixed model analysis was used to process the heterogeneous data structure. This method has not been a standard method of data analysis in implantology, and it shows considerable advantages over conventional variance analyses regarding data integration from outpatient practices.</p><p><strong>Method: </strong>123 patients were treated with 326 implants. 247 implants were diameter-reduced, the remaining 79 implants were standard implants (SDI) as patient related controls. The mean observation time was 24.4 months, and the maximum observation time 76.0 months. The peri-implant bone level of the implants was evaluated, while considering the diameter, as well as the time of implant placement, time of loading, extent of augmentation and localization of the implants. The data were evaluated after restructuring using mixed model analysis.</p><p><strong>Result: </strong>No significant difference was found between the use of RDI or SDI in the analyzed indication. Furthermore, no significant difference was found for the implant placement time, loading time, and the use of two-stage augmentations regarding the stability of the peri-implant bone level.</p><p><strong>Conclusion: </strong>Narrow-diameter implants are a sufficient treatment option in horizontally deficient bone conditions. The use of diameterreduced implants in the posterior region shows promising results; 3.5mm diameter implants may be indicated considering the individual patient situation. The use of mixed model analysis for the evaluation of heterogeneous practice data can lead to a significant increase in the number of retrospective studies and data integration from practices, forming a sound basis for evidence-based dentistry.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Occlusal and Axial Thickness on the Fracture Load of Implant-Supported Monolithic Zirconia Crowns.","authors":"Min-Gyung Seo, Kyung-Ho Ko, Yoon-Hyuk Huh, Chan-Jin Park, Lee-Ra Cho","doi":"10.11607/jomi.11086","DOIUrl":"https://doi.org/10.11607/jomi.11086","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the fracture load of monolithic zirconia crowns with implant screw holes, focusing on variations in occlusal and axial thicknesses, and to assess the interaction between these variables.</p><p><strong>Materials and methods: </strong>Six different prostheses were designed using CAD software, varying in occlusal thickness (0.5 mm, 1.0 mm) and axial thickness (0.4 mm, 0.8 mm, 1.2 mm) based on the height and thickness differences of the titanium implant abutment. Twelve specimens per design were created by milling zirconia blocks and titanium abutments. These specimens were cemented with resin and subjected to thermomechanical aging (50 N, 200,000 cycles, 5°C-55°C, 30 seconds dwell time) using a chewing simulator. Static loading was applied using a universal testing machine at a rate of 0.5 mm/min until fracture occurred, and the load value (N) at the moment of the initial fracture was recorded. Fracture pattern and surface analyses were performed. Statistical analyses included two-way analysis of variance, Tukey HSD test, multiple regression analysis, and Fisher's exact test.</p><p><strong>Results: </strong>Both occlusal and axial thicknesses significantly influenced the fracture load (P < .05), with a significant interaction between them (P < .05). An occlusal thickness of 1.0 mm exhibited a significantly higher fracture load compared to 0.5 mm (P < .05). An axial thickness of 1.2 mm showed a significantly higher fracture load compared to 0.4 mm and 0.8 mm (P < .05). The difference in axial thickness between 0.8 mm and 1.2 mm had a more substantial impact on fracture load than the difference in occlusal thickness between 0.5 mm and 1.0 mm (P < .05). Fractographic analysis showed that the thin axial wall exhibited twist hackles without involvement of the crown margin, whereas the thick axial wall exhibited no hackles and a more catastrophic failure involving the crown margin.</p><p><strong>Conclusion: </strong>For monolithic zirconia crowns with implant screw holes, when sufficient occlusal thickness cannot be achieved, an axial thickness of at least 1.2 mm is recommended to ensure higher fracture resistance.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative 3D-Printed Titanium Specimens Favor a Modulation of Inflammation in Dental Pulp Stem Cells During Liposome-Triggered Mineralization.","authors":"Marialucia Gallorini, Alessia Ricci, Serena Pilato, Antonella Fontana, Carlo Mangano, Amelia Cataldi, Susi Zara","doi":"10.11607/jomi.11129","DOIUrl":"https://doi.org/10.11607/jomi.11129","url":null,"abstract":"<p><strong>Purpose: </strong>developing customized titanium specimens, with innovative surfaces, is a suitable strategy to overcome implant failure. Additionally, a faster and efficient osteogenic commitment assists tissue regeneration. To investigate the interplay between inflammation and differentiation upon implantation, Dental Pulp Stem Cells (DPSCs) were cultured on 3D-printed titanium owning an internal open cell form, administering osteogenic factors by a liposomal formulation (LipoMix) compared to traditional delivery of differentiation medium (DM).</p><p><strong>Materials and methods: </strong>osteogenic differentiation was evaluated by western blot, by measuring β1 integrin expression, and by and real-time RT-PCR, by measuring SP7 and Collagen I gene expression; while.angiogenesis was characterized by measuring VEGF secretion levels. Matrix mineralization was assessed by means of Alizarin Red Staining, cell adhesion and inflammation responses through western blot, enzymatic and ELISA assays evaluating Nrf2 expression, catalase activity and Prostaglandin E2 secretion, respectively.</p><p><strong>Results: </strong>LipoMix enhances cell proliferation and adhesion, as revealed by increased integrin β1 expression. Mineralized matrix deposition, SP7 gene expression, Collagen I release and Alkaline Phosphatase activity appear increased in LipoMix condition. Additionally, the redox-sensitive transcription factor Nrf2 is overexpressed at the earliest experimental times, triggering the catalase activity.</p><p><strong>Conclusions: </strong>data reported confirm that internal topography and post-production treatments on titanium surfaces dynamically and positively condition the DPSC progress towards the osteogenic phenotype, moreover, the combination with LipoMix fastens the positive modulation of inflammation under osteogenic conditions. Therefore, the development of customized surfaces along with the administration of differentiating factors enclosed in a liposomal delivery system, could represent a promising and innovative tool in regenerative dentistry.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-31"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Zirconia Thickness, Cement Color, and Titanium Implant Abutment Surface Treatment Type on the Esthetic Outcomes of High-Translucency Monolithic Zirconia.","authors":"Chayanan Sirawuttipong, Mali Palanuwech","doi":"10.11607/jomi.10672","DOIUrl":"10.11607/jomi.10672","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the esthetic outcomes based on the color differences in zirconia (Zr) of varying thickness, resin cement color, and types of titanium (Ti) implant surface treatments.</p><p><strong>Materials and methods: </strong>Overall, 28 high-translucency monolithic zirconia (HTMZ) specimens were arranged into four groups based on Zr thickness: 1.0, 1.5, 2.0, and 2.5 mm (n &#61; 7 per thickness). Each group was tested using two resin cement colors (clear and opaque) in combination with six surface-treated Ti groups (n &#61; 7), including untreated titanium (UT), anodization (AN), 50-μm alumina airborne-particle abrasion followed by AN (SBAN), AN followed by 50-μm alumina airborne-particle abrasion (ANSB), 9.5% hydrofluoric acid followed by AN (HFAN), and AN followed by 9.5% hydrofluoric acid (ANHF). This created a total of 48 experimental groups, including the use of composite resin (n &#61; 7, shade A2D) for four control groups. All specimens were measured using a spectrophotometer and subsequently compared with composite resin (control) with the corresponding Zr thickness to establish color differences. A color difference of < 2.7 was considered clinically acceptable. The data obtained were statistically analyzed using ANOVA and post hoc test (P &#61; .05).</p><p><strong>Results: </strong>Zr thickness, resin cement color, and type of Ti implant surface treatment significantly affected the observed color differences (P < .05). When using 2.5-mm HTMZ with clear resin cement on AN, UT, SBAN, HFAN, and ANSB, the mean color differences were below the clinically acceptable values, and the 95% CIs of color differences were below the clinically acceptable values for AN, UT, and SBAN groups.</p><p><strong>Conclusions: </strong>HTMZ with a minimum thickness of 2.5 mm and clear resin cement on AN, UT, and SBAN groups potentially result in acceptable color matching with 95% CIs.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"765-775"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alveolar Buccal Bone Overbuilding Before Tooth Extraction: A Preclinical Study.","authors":"Takahisa Iida, Michihide Miki, Mauro Ferri, Fernando M Muñoz Guzon, Gianfranco Cesaretti, Daniele Botticelli","doi":"10.11607/jomi.10754","DOIUrl":"10.11607/jomi.10754","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the dimensional changes in the alveolar crest after buccal overbuilding was performed prior to tooth extraction in a dog model.</p><p><strong>Materials and methods: </strong>At the test sites, alveolar crest overbuilding was performed on the buccal aspect of the distal root of the third premolar using xenograft covered with a collagen membrane. No treatment was applied at the control sites. After 3 months, the distal roots of both third premolars were extracted and implants were immediately placed into the alveolus, allowing nonsubmerged healing. After 3 months, biopsy samples were collected.</p><p><strong>Results: </strong>Upon histologic analysis, no statistically significant differences in hard tissue dimensions were found. The buccal bone plate at the test sites presented a tendency for higher resorption compared to the control sites. However, if the contribution of the residue of biomaterial is considered, a higher volumetric gain was registered at the test than at the control sites.</p><p><strong>Conclusions: </strong>The buccal overbuilding performed prior to tooth extraction did not contribute to the preservation of the alveolar crest dimensions after extraction. This could be due to failure to incorporate the graft into the newly formed bone.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"713-722"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing Linear and Angular Deviations After Guided Surgery for Dental Implant Placement: A Preliminary Study.","authors":"Catarina Mendes Fonseca, Patrícia Alexandra Barroso da Fonseca, Margarida Martins Quezada, Tiago Marques, Javier Montero, Dean Morton, André Correia","doi":"10.11607/jomi.10787","DOIUrl":"10.11607/jomi.10787","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the accuracy and precision of prosthetically driven implant placement achieved through static computer-aided implant surgery by analyzing the linear and angular deviations of implants.</p><p><strong>Materials and methods: </strong>A total of 53 implants were included in the study. The implants were positioned using either tooth-supported templates or tooth-and-tissue-supported templates with fixation pins. Two distinct guided surgery approaches were used: pilot drill guided and fully guided. 3D data from the implant planning phase was superimposed with the 3D data from the final implant positions using the 'Treatment Evaluation' tool within coDiagnostiX implant planning software (Straumann). This enabled the automatic calculation of deviations in implant placement accuracy.</p><p><strong>Results: </strong>The average angular deviation observed was 3.90 degrees. For linear deviations, the mean 3D deviation was 1.04 mm at the most coronal point of the implants and 1.56 mm at the implant apex.</p><p><strong>Conclusions: </strong>This research demonstrates the feasibility of a digital workflow for guided implant surgery, offering a promising treatment option. Nonetheless, it is important to note that deviations do occur, particularly in the apical region of the implant. Care should be taken, particularly in cases of limited bone availability.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"738-744"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Antidepressants on Dental Implant Failure: A Systematic Review and Meta-analysis.","authors":"Liza Harutyunyan, Kayla Lieuw, Bryan Yang, Eric Lee, Yu-Ting Yeh, Hsuan-Hung Chen, Guo-Hao Lin","doi":"10.11607/jomi.10798","DOIUrl":"10.11607/jomi.10798","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the risk of dental implant failure for patients with a history of antidepressant use through a systematic review and meta-analysis.</p><p><strong>Materials and methods: </strong>An electronic search was performed up to June 2023 in three databases including PubMed/MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials; data on the comparison of implant failure rate for patients with and without the use of antidepressants were included. Meta-analyses for the risk ratio of implant failure rate at patient level and implant level were performed.</p><p><strong>Results: </strong>Overall, 11 clinical studies were selected for inclusion in this review. The meta-analyses showed a risk ratio of 2.44 (95% CI &#61; 1.75 to 3.39; P < .0001) and 2.44 (95% CI &#61; 1.73 to 3.46; P < .0001) for the implant failure at patient level and implant level, respectively. The comparisons presented a low heterogeneity for the patient-level analysis and a moderate heterogeneity for the implant-level analysis among the pooled studies. Subgroup analyses also revealed that patients who received only selective serotonin reuptake inhibitors (SSRIs) or SSRIs with other types of antidepressants had a higher risk of implant failure than those who were not on any antidepressants.</p><p><strong>Conclusions: </strong>The current review demonstrates that the use of antidepressants such as SSRIs may increase the risk of dental implant failure at both patient level and implant level. Although limited evidence suggests that a certain type of SSRI (sertraline) may have more influence on implant failure than other SSRIs, future studies are needed to confirm this finding.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"665-673"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}