The International journal of oral & maxillofacial implants最新文献

{"title":"Immediate Versus Non-immediate Loading Protocols for Reduced-Diameter Implants Supporting Overdentures: A Systematic Review and Meta-analysis.","authors":"Ying Liu, Fengxiao He, Yaoyu Zhao, Quan Sun, Haibin Xia, Dahong Xia, Yi Bai","doi":"10.11607/jomi.10625","DOIUrl":"10.11607/jomi.10625","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the influence of immediate loading (IL) and non-immediate loading (NIL) protocols on overdentures retained by reduced-diameter implants (≤ 3.5 mm).</p><p><strong>Materials and methods: </strong>Electronic databases including MEDLINE (via PubMed), Embase, and the Cochrane Central Register of Controlled Trials were searched for randomized controlled trials (RCTs) comparing clinical outcomes of immediately loaded and non-immediately loaded reduced-diameter implants supporting overdentures. The risk of bias within and across the studies and the certainty of evidence were assessed by RoB 2.0 and GRADE, respectively. A sensitivity analysis was performed by eliminating studies at high risk of bias and repeating the data synthesis employing the random effects model. Subgroup analyses were conducted based on the implant diameter and the length of follow-up.</p><p><strong>Results: </strong>Overall, six RCTs with 255 patients were included in this systematic review. The meta-analyses found similar implant survival rates between immediately loaded and non-immediately loaded implants in the mini-implant (RR &#61; 0.98; 95% CI &#61; 0.95, 1.01; P &#61; .12) and narrow-diameter implant subgroups (RR &#61; 0.99; 95% CI &#61; 0.94, 1.03; P &#61; .56) as well as in short-term (RR &#61; 0.98; 95% CI &#61; 0.97, 1.00; P &#61; .11) and long-term (RR &#61; 0.97; 95% CI &#61; 0.93, 1.01; P &#61; .09) follow-up subgroups. Additionally, marginal bone loss (MBL) showed no statistically significant difference between the loading protocols in the subgroup of long-term follow-up (MD &#61; 0.03; 95% CI &#61; -0.16, 0.23; P &#61; .74). Three RCTs investigating peri-implant parameters found relatively higher modified plaque index (PI) and probing depth (PD) in reduced-diameter implants under IL.</p><p><strong>Conclusions: </strong>Compared with NIL, the IL protocol can achieve comparable survival rates and MBL in reduced-diameter implants supporting overdentures.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"657-664"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in the Spatial Position of Mini-implants During Distal Movement of the Entire Maxillary Dentition: An Observational CBCT Study.","authors":"A Sumathi Felicita, T N Uma Maheshwari","doi":"10.11607/jomi.10789","DOIUrl":"10.11607/jomi.10789","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the change in the sagittal and vertical position of mini-implants placed in the maxilla during distal movement of the entire maxillary dentition.</p><p><strong>Materials and methods: </strong>Overall, 28 mini-implants (1 placed on each side in 14 patients) were evaluated in healthy patients aged 15 to 25 years old. CBCTs were taken immediately after leveling and aligning prior to distalization (T1) and after 6 months (T2) to evaluate the distal movement of the maxillary teeth and position of the mini-implants. The vertical and sagittal angulation of each mini-implant was measured at T1 and T2. The linear distance between the mini-implant and the alveolar crest, the maxillary sinus, the maxillary second premolar, and the maxillary first permanent molar were measured. The change in angulation and the linear displacement of the miniimplant were evaluated in the vertical and sagittal plane. Wilcoxon signed rank test was performed to determine if there was a statistically significant change in the position of the mini-implant.</p><p><strong>Results: </strong>Vertically, there was a significant change in the linear distance between the mini-implant and the alveolar crest on the right side (P ≤ .006) as well as the miniimplant and the maxillary sinus on the left side (P ≤ .003). Sagittally, there was a statistically significant rotation of the miniimplant occlusally (left side P ≤ .004 and right side P ≤ .002). The head and tip of the mini-implant were displaced toward the maxillary second premolar and away from the maxillary first permanent molar, respectively. There was a significant relative displacement of the mini-implant anteriorly away from the maxillary first permanent molar (left side P ≤ .026 and right side P ≤ .041) and closer to the maxillary second premolar (left side: P ≤ .011 and right side: P ≤ .002).</p><p><strong>Conclusions: </strong>There was a statistically and clinically significant rotation of the mini-implant in the vertical and sagittal direction during distal movement of the entire maxillary arch. The linear displacement of the mini-implant was more pronounced in the sagittal direction than the vertical direction.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"183-192"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Bone Growth into Surgical Bone Defects Grafted with a Novel Cultivated Coral Graft: A Histomorphometric Study in Rabbit Calvarias.","authors":"Haim Tal, Omer Cohen, Fatma Rayyan, Ariel Pokhojaev, Rachel Sarig, Perry Raz, Ilan Beitlitum","doi":"10.11607/jomi.10703","DOIUrl":"10.11607/jomi.10703","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate a new cultivated coral graft (CCG) in an in vivo experimental guided bone regeneration (GBR) procedure.</p><p><strong>Materials and methods: </strong>The calvarias of eight rabbits were surgically exposed, and circular defects 8 mm in diameter were prepared. One defect was filled with CCG particles (experimental group); the contralateral defect (control group) was spontaneously filled by blood clot. All defects were covered with a collagen membrane. Subjects were euthanized after 8 weeks.</p><p><strong>Results: </strong>Histologic observations of the defects showed similar bone growth patterns in both experimental and control osteotomies. In the experimental defects, no traces of coral particles were observed. Histometric analysis showed denser bone in the pristine zone (65%-66%) than in the peripheral zone for both the control (50%) and experimental defects (31%) (P &#61; not significant). The new bone percentage was reduced from the peripheral zone toward the middle and the center of the defect (31%, 32%, and 27%, respectively) as the distance from the peripheral pristine bone borders increased.</p><p><strong>Conclusions: </strong>The existing data supports the complete degradation of CCG as a spacemaintaining scaffold for GBR procedures.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"723-730"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139522038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aseptic Silk Ligatures Induce Bone Resorption Around Titanium Implants: A 12-Week Pilot Study in Rabbits.","authors":"David Reinedahl, Silvia Galli, Tomas Albrektsson, Pentti Tengvall, Ann Wennerberg","doi":"10.11607/jomi.10780","DOIUrl":"10.11607/jomi.10780","url":null,"abstract":"<p><strong>Purpose: </strong>Marginal bone resorption (MBR) around dental implants may sometimes be a self-limiting condition due to balancing immunologic reactions against utilized materials rather than a progressive bacterial infection. Contrary to previous assumptions from ligature-induced experimental peri-implantitis studies, a recent 8-week experiment by the present authors showed that marginal ligatures trigger an inflammatory immune response, resulting in bone resorption around implants in the absence of plaque. The present study aimed to investigate whether this inflammatory/immunologic reaction attenuates or progresses toward implant failure after a longer healing time (12 weeks).</p><p><strong>Materials and methods: </strong>Sterile silk ligatures were placed around the top of titanium (Ti) implants and compressed against the femoral cortical bone plate of six rabbits. A nonligated implant was used as a control. After 12 weeks of submerged healing, ground sections of implants and surrounding tissues were investigated with light microscopy. The marginal soft tissues were also analyzed using selected quantitative polymerase chain reaction (qPCR) markers.</p><p><strong>Results: </strong>Histologically, the ligatures were outlined by immune cells, including multinucleated giant cells (MNGCs), with adjacent fibrous encapsulation and resorbed peripheral bone that contrasted from the osseointegrated nonligated control implants. The difference in expression of qPCR markers was not significant, but > two-fold upregulation of markers CD11b, IL1β, ARG1, NCF1, and CD4 and > twofold downregulation of CD8 indicated a mild, focal inflammatory/immune response against the ligatures compared to controls, with upregulation of M1 and M2 macrophages, neutrophils, and helper T-cells as well as downregulation of killer T cells. Further, the bone formation markers OC and ALPL were > two-fold downregulated (consistent with the lack of osseointegration of the ligatures) compared to control implants.</p><p><strong>Conclusions: </strong>Marginal silk ligatures trigger an inflammatory/immune response and aseptic bone resorption around implants. Compared to the previous 8-week study, the inflammatory reaction against the silk appears to attenuate with time, with only a mild persisting inflammation that may block osseointegration; instead, a fibrous tissue encapsulation-type reaction is maintained. This may explain why traditional ligature experiments have required regular exchange of ligatures for the bone resorption to progress.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"755-764"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis of Dental Implantology Journals From 1991 to 2023.","authors":"Vinayak M Joshi, Eswar Kandaswamy","doi":"10.11607/jomi.10758","DOIUrl":"10.11607/jomi.10758","url":null,"abstract":"<p><strong>Purpose: </strong>Dental implants are an established treatment option for varying edentulous conditions that has grown in popularity since the 1990s. This increased clinical application has shown a parallel increase in implant-related research. The objective of this paper was to perform a comprehensive bibliometric analysis of five dental implantology journals from 1991 to 2023.</p><p><strong>Materials and methods: </strong>A search was done in the Web of Science database between 1991 and 2023 in five journals with a focus on dental implantology: Clinical Oral Implant Research, Clinical Implant Dentistry and Related Research, Implant Dentistry, The International Journal of Oral & Maxillofacial Implants, and International Journal of Oral Implantology. Results marked as a correction, retraction notice, retracted article, meeting abstract, or withdrawn publication were removed from the analysis. The time period analyzed was divided into four time periods, organized by decade: 1991 to 2000, 2001 to 2010, 2011 to 2020, and 2021 to 2023. Additionally, the top 100 cited papers were also exported separately. Authors and countries with most publications were tabulated from the Web of Science database. VOSviewer software was used to create network maps of keywords and title word occurrences for each of the time periods. HistCite software was used to analyze the number of publications and citation counts.</p><p><strong>Results: </strong>Network maps of keywords and title word occurrences suggested an early focus on osseointegration and titanium implants between 1991 and 2000. Publications between 2001 and 2010 saw a focus on in vivo studies, implant surface, and peri-implantitis. Publications from 2011 and later saw a focus on bone regeneration, complications, and zygomatic implants. The USA ranked highest in total number of publications in all analyzed time periods.</p><p><strong>Conclusions: </strong>Within the limitations of the present study, a comprehensive bibliometric analysis from 1990 to 2023 was reported. Trends in keywords and titles of implant publications were identified in these journals, which mirrored the trends seen in clinical practice.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"193-202"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71430728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT May Help Inform Patients in Dental Implantology.","authors":"Elif Çoban, Berkan Altay","doi":"10.11607/jomi.10777","DOIUrl":"10.11607/jomi.10777","url":null,"abstract":"<p><strong>Purpose: </strong>Patients may have high expectations regarding dental implants based on the source of their information, which can lead to challenges in clinical communication. This study aims to evaluate the quality of responses provided by Chat Generative Pretrained Transformer (ChatGPT, OpenAI), an artificial intelligence (AI) program, to patient questions in the field of dental implantology.</p><p><strong>Materials and methods: </strong>This study was prospectively designed as a cross-sectional study. Frequently asked questions by patients about general information on dental implantology (Part 1) and dental implant brands (Part 2) were posed to the ChatGPT program. Responses were independently assessed by oral and maxillofacial surgeons (Group 1; n &#61; 10), periodontologists (Group 2; n &#61; 10), prosthodontists (Group 3; n &#61; 10), and general dentists (Group 4; n &#61; 10) using the Global Quality Scale (GQS, scored from 1 [low quality] to 5 [high quality]).</p><p><strong>Results: </strong>There was a total of 60 questions, with 30 questions in each part. Participants in the study were evenly distributed by gender (50% female, 50% male) with a mean age of 32.6 ± 4.07 years. The mean years of experience were 8.5 ± 3.12 years. There were no significant differences in mean age, gender, and years of experience among the groups (P > .05). The overall mean GQS score was 3.87 ± 0.29. Part 1 had a mean score of 3.9 ± 0.35, and Part 2 had a mean score of 3.85 ± 0.29, with no statistically significant difference (P > .05).</p><p><strong>Conclusions: </strong>The AI platform may contribute to the additional education of patients in the field of dental implantology and aid in understanding treatment procedures. However, it is concerning that ChatGPT may exhibit bias regarding dental implant brands, which could impact patient guidance.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"203-208"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140905209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Immediate, Early, and Delayed Implant Placement in the Esthetic Zone: A Systematic Review and Meta-analysis.","authors":"Emile Riachi, Gintaras Juodzbalys, Daiva Maciuliene","doi":"10.11607/jomi.10731","DOIUrl":"10.11607/jomi.10731","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the impact of implant placement at different time intervals on the esthetic and clinical outcomes in the esthetic zone.</p><p><strong>Materials and methods: </strong>A literature screening was conducted in PubMed (MEDLINE), ScienceDirect, and Cochrane databases. Relevant articles were included according to selection criteria and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data was collected from studies published from 2017 to 2022 in English.</p><p><strong>Results: </strong>Nine articles were included, in which a total of 495 implants were placed; 250 of the implants were immediate, 109 were early, and 136 were delayed. Immediate implant placement (IIP) showed no statistically significant difference in Pink Esthetic Score (PES) compared with delayed implant placement (DIP). IIP showed significantly higher PES in comparison with early implant placement (EIP) (mean difference [MD] &#61; -0.76; 95% CI &#61; -1.50 to -0.02; P &#61; .04). The probing depth (PD) was considerably greater for immediate implants than for delayed implants (MD &#61; -0.62; 95% CI &#61; -1.05 to -0.18; P &#61; .005), and the Plaque Index (PI) was statistically greater for early implants compared with immediate implants (MD &#61; 0.15; 95% CI &#61; 0.11 to 0.19; P < .00001). All other soft tissue outcomes showed equal results. The marginal bone loss (MBL) was statistically higher in early implants compared with immediate implants (MD &#61; 0.09; 95% CI &#61; 0.02 to 0.16; P &#61; .02).</p><p><strong>Conclusions: </strong>IIP had significantly superior PES, MBL, and PI results when compared with EIP. The PD was significantly higher for immediate implants compared with delayed implants. All other outcomes showed no significant difference between the three implant groups. It is important to highlight the limitations of this review such as the small number of studies included and the few reports on esthetic indices.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"157-173"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of a Single Infrapositioned Anterior Ankylosed Tooth or Implant-Supported Restoration on Smile Attractiveness.","authors":"Panagiotis Ntovas, Maria Soundia, Ilias Karveleas, Ourania Ladia, Dennis Tarnow, Efstratios Papazoglou","doi":"10.11607/jomi.10749","DOIUrl":"10.11607/jomi.10749","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the influence of a single infrapositioned ankylosed tooth or implant-supported restoration on smile esthetics.</p><p><strong>Materials and methods: </strong>A series of 48 digitally modified images that simulated varying degrees of infraposition (from 0.25 to 2.0 mm, with a step of 0.25 mm) were created for each maxillary anterior tooth by altering the full-portrait image of a smiling man, adjusted to show medium and high smile lines. For the model with the high smile line, a series of 24 digitally modified images were created that simulated the infraposition of a single anterior tooth with a restored incisal edge. Smile esthetics for each of the images were evaluated by 160 participants (80 dentists and 80 laypersons), and a visual analog scale (VAS) was implemented.</p><p><strong>Results: </strong>For the images with the high smile line, an infraposition of ≥ 0.25 mm in the central incisor region and ≥ 0.5 mm in the region of the lateral incisor or the canine had a negative effect on the perceived smile esthetics for both the dentists and the laypersons. Regarding the medium smile line, an infraposition of ≥ 0.5 mm in the central and lateral incisor region had a negative effect on the perceived smile esthetics for both groups of observers. In the canine area, an infraposition of ≥ 0.5 mm for the dentists and ≥ 0.75 mm for the laypersons also had a negative impact on the smile esthetics.</p><p><strong>Conclusions: </strong>Even a minor infraposition of a single maxillary anterior ankylosed tooth or implant-supported restoration can reduce the perceived attractiveness of the smile. Infraposition in the canine site can be better tolerated in a medium smile line compared to a high smile line. In patients with a high smile line, prosthetic intervention is needed to restore the incisal edge of an infrapositioned tooth without harmonizing the gingival contour; this can be beneficial for the lateral incisor but ineffective for the central incisor and unfavorable for the canine.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"745-754"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cycle of Life.","authors":"Clark M Stanford","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"39 5","pages":"656"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Simvastatin Gel in Enhancing Periimplant Osteoblastic Activity During the Osseointegration Phase Using Bone Scintigraphy: A Prospective Case-Control Double-Blinded Study.","authors":"K S Maheshwaran, Fathima Banu R, Anand Kumar V, Kasim Mohamed","doi":"10.11607/jomi.10741","DOIUrl":"10.11607/jomi.10741","url":null,"abstract":"<p><strong>Purpose: </strong>To estimate the effect of simvastatin gel in the osseointegration of dental implants using bone scintigraphy.</p><p><strong>Materials and methods: </strong>A total of 20 participants with missing mandibular first molars and D2 type bone were assigned equally to two groups. Group A received 1.2% simvastatin and group B received placebo gels during the placement of implants. The participants were subjected to bone scintigraphy to determine the osteoblastic activity at baseline, 30 days, and 90 days after implant placement.</p><p><strong>Results: </strong>Group A had a significant increase in osteoblastic activity between baseline, day 30, and day 90 (P < .05), with a higher mean of 100.06% ± 21.644% on day 30. Group B had a significant increase in osteoblastic activity only between baseline and day 30 and between baseline and day 90 (P < .05). There was no difference between days 30 and 90 (P > .05), with a higher mean of 79.20% ± 18.255% on day 30. A bivariate analysis performed at different time periods revealed a significant difference between groups A and B on day 30.</p><p><strong>Conclusions: </strong>Implants placed with 1.2% simvastatin gel showed enhanced osteoblastic activity in the 4th week after implant placement, indicating that there was a faster rate of osseointegration at an early stage.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"707-712"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}