The American journal of the medical sciences最新文献_第5页

Bronchobiliary Fistulas.

The American journal of the medical sciences Pub Date : 2025-02-21 DOI: 10.1016/j.amjms.2025.02.010

Carter Edmunds, Jessica Hollingsworth, Brian Kouri, Rishi Pawa, Swati Pawa

引用次数: 0

The utility of inpatient work-up of incidental anemia during hospitalization for an acute medical condition: A retrospective cohort study. 急性疾病住院期间偶然贫血的住院检查的效用：一项回顾性队列研究。

The American journal of the medical sciences Pub Date : 2025-02-15 DOI: 10.1016/j.amjms.2025.02.009

Genady Drozdinsky, Erez Halperin, Shiri Kushnir, Yaron Rudman, Anat Gafter-Gvili

{"title":"The utility of inpatient work-up of incidental anemia during hospitalization for an acute medical condition: A retrospective cohort study.","authors":"Genady Drozdinsky, Erez Halperin, Shiri Kushnir, Yaron Rudman, Anat Gafter-Gvili","doi":"10.1016/j.amjms.2025.02.009","DOIUrl":"10.1016/j.amjms.2025.02.009","url":null,"abstract":"Introduction: The best timing for evaluation of anemia is not well defined and the clinical yield of performing workup during non-anemia-related hospitalization is unclear. We aimed to evaluate the prognostic value of inpatient laboratory anemia evaluation.Methods: This was a retrospective propensity-matched cohort study between the years 2013-2022 in Rabin Medical Center Israel. We included all patients admitted for non-anemia-related reasons and were found to be anemic. Patients were divided into groups based on basic laboratory anemia evaluation. Outcomes were cancer diagnosis, colonoscopy rate, duration of admission, and all-cause mortality. Multivariable analysis with competing risk of death was performed and a p-value of 5 % was considered significant.Results: Following matching, 4,238 patients were included in the evaluation group compared to 7,680 in the no-evaluation group. In-patient laboratory anemia evaluation was associated with gastrointestinal cancer and any cancer diagnosis - HR of 1.53 (95 % CI, 1.15- 2.05) and HR of 1.23 (95 % CI, 1.11-1.37) respectively. The rate of colonoscopy was higher, and anemia prevalence was lower in the evaluation group after 1-year follow-up. Intravenous iron treatment was more prevalent in the evaluation group. The laboratory anemia evaluation prolonged the admission (5 vs 4 days). There was no difference in the all-cause mortality across the 10-year follow-up.Conclusion: Inpatient anemia evaluation with basic laboratory tests was found to be associated with an increase in outpatient gastrointestinal cancer diagnosis and showed clinical and diagnostic advantages. For patients who can benefit from early gastrointestinal cancer diagnosis, admission holds a valid opportunity to initiate the evaluation.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between psoriasis, psoriatic arthritis and gout or hyperuricemia: A systematic review and meta-analysis. 银屑病、银屑病关节炎与痛风或高尿酸血症之间的关系：一项系统综述和荟萃分析。

The American journal of the medical sciences Pub Date : 2025-02-15 DOI: 10.1016/j.amjms.2025.02.006

Zixia Liu, Xieli Ma, Tian Chang, Chuanhui Yao, Mengge Song, Shang Biyue, Fuyuan Zhang, Jiameng Liu, Quan Jiang

{"title":"Associations between psoriasis, psoriatic arthritis and gout or hyperuricemia: A systematic review and meta-analysis.","authors":"Zixia Liu, Xieli Ma, Tian Chang, Chuanhui Yao, Mengge Song, Shang Biyue, Fuyuan Zhang, Jiameng Liu, Quan Jiang","doi":"10.1016/j.amjms.2025.02.006","DOIUrl":"10.1016/j.amjms.2025.02.006","url":null,"abstract":"Background: Uric acid (UA) has been associated with an increased incidence of psoriasis (PsO) and psoriatic arthritis (PsA). Clinical evidence shows that patients with PsO often have elevated serum UA levels, contributing to HUA and gout. This study investigated the bidirectional relationships among hyperuricemia (HUA), gout, PsO, and PsA through a systematic review and meta-analysis.Objectives: To evaluate the associations between PsO, PsA, and the risks of HUA and gout.Materials and methods: PubMed, Embase, CNKI, and Wanfang databases were searched for relevant literature published from databases inception until February 2024.Quality was assessed using the Newcastle-Ottawa Scale (NOS).Results: A total of 8 studies were included. Eligible studies included case-control, cohort, and cross-sectional studies.The meta-analysis showed that patients with PsO had a 2.56-fold higher risk of HUA [OR = 2.56, 95 % CI (1.82-3.59)] while PsA patients had a 3.56-fold higher risk of HUA [OR = 3.56, 95 % CI (2.04-6.20)]. The risk of gout was 4.95 times higher in PsA [OR = 4.95, 95 % CI (2.72-9.01)] and 1.95 times higher in PsO [OR = 1.95, 95 % CI (1.02-3.75)].Conclusion: This study demonstrated an bidirectional relationship between psoriasis, psoriatic arthritis and gout or hyperuricemia, highlighting the need for clinicians to consider these conditions in managing the studied diseases.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and prognosis of sepsis in cancer patients: A multicenter prospective observational study. 癌症患者败血症的流行病学和预后：多中心前瞻性观察研究》。

The American journal of the medical sciences Pub Date : 2025-02-12 DOI: 10.1016/j.amjms.2025.02.008

Zeynep Ture, Gülşen İskender, Mustafa Serhat Şahinoğlu, Ezel Beste Özkara, Ayşe Kaya Kalem, Esma Eryılmaz Eren, Fatma Yekta Ürkmez, Sinan Çetin, Emel Azak, İlknur Erdem, Jordi Rello, Emine Alp

{"title":"Epidemiology and prognosis of sepsis in cancer patients: A multicenter prospective observational study.","authors":"Zeynep Ture, Gülşen İskender, Mustafa Serhat Şahinoğlu, Ezel Beste Özkara, Ayşe Kaya Kalem, Esma Eryılmaz Eren, Fatma Yekta Ürkmez, Sinan Çetin, Emel Azak, İlknur Erdem, Jordi Rello, Emine Alp","doi":"10.1016/j.amjms.2025.02.008","DOIUrl":"10.1016/j.amjms.2025.02.008","url":null,"abstract":"Objectives: To determine the epidemiology and prognosis of sepsis in cancer patients and the influence of sepsis on the mortality of cancer patients.Methods: In this multicenter, prospective, observational study, cancer patients hospitalized without sepsis followed up until discharge or a maximum of 90 days were included. The incidence of sepsis in the follow-up period, risk factors for sepsis, risk factors for 28-day mortality in patients with sepsis and 90-day mortality in the entire group were determined.Results: During the study, 790 cancer patients were included. Sepsis developed in 72 patients (9.1 %) during the follow-up. Older age, hospitalization due to any infection, graft versus host diseases (GVHD), the presence of a urethral catheter, and previous bacterial infection in the last three months were risk factors of sepsis. Among all cancer patients, sepsis was found to be the most important factor influencing 90-day mortality (OR 13.42(1.79-6.83)). Mortality among the sepsis cohort was independently associated with an infection with a carbapenem-resistant bacterium (OR 15.47(1.45-64.17)), appropriateness of empirical treatment (OR 5.02 (0.17-7.61) and having a clinical improvement on the fifth day of the treatment (OR 10.58(0.39-28.25).Conclusions: Sepsis was documented in one out of 11 hospitalized cancer patients and the mortality rate increases 13-fold when sepsis develops. Invasive devices, GVHD, and previous bacterial infections were related to sepsis and antibiotic resistance were the most important driver for mortality. Antimicrobial stewardship, rational use of catheters (if necessary, in accordance with asepsis/antisepsis, short-term use) is important to save lives in cancer patients.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The "Fixed period," the wildfire news, and an unpublished manuscript: Osler's farewell speech revisited in geographical breadth and emotional depth. “固定时期”，野火新闻，和未发表的手稿：奥斯勒的告别演说在地理广度和情感深度重新审视。

The American journal of the medical sciences Pub Date : 2025-02-11 DOI: 10.1016/j.amjms.2025.02.005

Maren Anderson, R Hal Scofield

引用次数: 0

Facial metastasis of Esophageal squamous cell carcinoma. 食管鳞状细胞癌的面部转移

The American journal of the medical sciences Pub Date : 2025-02-10 DOI: 10.1016/j.amjms.2025.02.003

Sen-Ei Shai, Hung-Ju Kuo, Yi-Ling Lai, Chi-Wei Hsieh

引用次数: 0

Therapeutic appraisal in protracted heart failure. 慢性心力衰竭的治疗评价。

The American journal of the medical sciences Pub Date : 2025-01-31 DOI: 10.1016/j.amjms.2025.01.009

Marjorie Flores Chang, Rohan Samson, Amitabh Pandey, Thierry H Le Jemtel

引用次数: 0

Unexpected renal side effects of mRNA COVID-19 vaccines; a single-center experience and short review. mRNA - COVID-19疫苗的意外肾副作用单中心体验和简短回顾。

The American journal of the medical sciences Pub Date : 2025-01-07 DOI: 10.1016/j.amjms.2025.01.002

Ákos Pethő, Deján Dobi, Magdolna Kardos, Karolina Schnabel

{"title":"Unexpected renal side effects of mRNA COVID-19 vaccines; a single-center experience and short review.","authors":"Ákos Pethő, Deján Dobi, Magdolna Kardos, Karolina Schnabel","doi":"10.1016/j.amjms.2025.01.002","DOIUrl":"10.1016/j.amjms.2025.01.002","url":null,"abstract":"Background: In late 2019, the World Health Organization declared Coronavirus disease 2019 a global emergency. Since then, many vaccines have been developed to combat the pandemic. Millions of people have received one of the approved COVID-19 vaccines; unfortunately, some adverse events also have been recorded.Methods: In the local health system, patients could get either mRNA vaccines (either Pfizer-BioNTech or Moderna), adenoviral vector vaccine (AstraZeneca), or the vaccine based on inactivated virus (Sinovac). We investigated what immune-mediated adverse events occurred in our department after the COVID-19 vaccination.Results: We evaluated six patients from our center who received mRNA vaccines and developed suspected immune-mediated adverse events. The immune-mediated adverse events are characterized by de novo or relapsing glomerular diseases and are further confirmed with percutaneous kidney biopsies. During A follow-up of more than two years, remission occurred in five patients, and glomerulonephritis persisted in one of them.Conclusion: Vaccinations are pivotal in effectively protecting and preventing various epidemics. As such, it is essential to maintain a high level of vigilance concerning post-vaccination adverse events. This heightened level of suspicion leads to earlier detection, better understanding, and optimal prevention and management of these events. To this end, developing a specific vaccine/patient risk profile is necessary to categorize the target population selectively.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing paradigms in asthma management. 哮喘管理模式的改变。

The American journal of the medical sciences Pub Date : 2024-12-19 DOI: 10.1016/j.amjms.2024.12.008

Charles E Grogan, Marlee Wadsworth, Gailen D Marshall

{"title":"Changing paradigms in asthma management.","authors":"Charles E Grogan, Marlee Wadsworth, Gailen D Marshall","doi":"10.1016/j.amjms.2024.12.008","DOIUrl":"10.1016/j.amjms.2024.12.008","url":null,"abstract":"Asthma is a complex clinical syndrome characterized by airway inflammation that can cause variable, usually reversible airway obstruction and bronchial hyperreactivity. This illness has a spectrum from intermittent to persistent that has mild, medium or severe intensity. As our understanding of the underling inflammatory pathway grows, so too does our catalogue of advanced treatments (such as monoclonal antibodies), opening the path for treatment individually curated for patients. The current approved therapies are directed against IgE, interleukin (IL)-5, IL-5 receptor, IL-4 receptor subunit-α and most recently thymic stromal lymphopoietin (TSLP). These therapies all have demonstrated efficacies that make them variably effective in patients with moderate to severe persistent disease. More recently, other inflammatory molecules have been therapeutically targeted and are currently under clinical investigation for future potential use. However, a significant concern remains: the high financial costs for these advanced therapies continues to pose a significant burden both to patients and the healthcare system. Novel uses of long-acting bronchodilator-corticosteroids inhalers may reduce the use of highly priced biologics in many patients with comparatively less severe disease. Furthermore, the variability in patient response demands further research into to identify which patients will best respond to which specific therapy.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between Type 2 myocardial infarction and short-term cardiovascular outcomes in glycemic diabetic emergencies patients: Relationship between T2MI and Glycemic Diabetes Emergencies. 急诊血糖性糖尿病患者2型心肌梗死与短期心血管预后的关系

The American journal of the medical sciences Pub Date : 2024-12-16 DOI: 10.1016/j.amjms.2024.12.007

Hadeer Elsharnoby, Tsungyen Chen, Osama Alsara, Ahmed Maraey, Alina Brener

引用次数: 0