The American journal of the medical sciences最新文献_第5页

Laxative selection in constipated patients with heart failure: clinical considerations, safety concerns, and current evidence. 便秘心衰患者的泻药选择：临床考虑、安全问题和当前证据。

IF 1.8

The American journal of the medical sciences Pub Date : 2026-08-16 DOI: 10.1016/j.amjms.2026.08.004

Yalcin Velibey, Erkan Kahraman, Bilal Cakir, Edibe Betul Borklu, Ilham Gafarli, Gokturk Ipek, Tolga Sinan Guvenc, Osman Bolca

引用次数: 0

Heparin-induced thrombocytopenia and its impact on inpatient outcomes in inflammatory bowel disease. 肝素诱导的血小板减少症及其对炎症性肠病住院预后的影响

IF 1.8

The American journal of the medical sciences Pub Date : 2026-08-15 DOI: 10.1016/j.amjms.2026.08.003

Ayobami Olafimihan, Chiamaka Nwachukwu, Praise Fawehinmi, Hafeez Shaka, Benjamin Mba, Marwah Wafa Farooqui

{"title":"Heparin-induced thrombocytopenia and its impact on inpatient outcomes in inflammatory bowel disease.","authors":"Ayobami Olafimihan, Chiamaka Nwachukwu, Praise Fawehinmi, Hafeez Shaka, Benjamin Mba, Marwah Wafa Farooqui","doi":"10.1016/j.amjms.2026.08.003","DOIUrl":"10.1016/j.amjms.2026.08.003","url":null,"abstract":"Introduction: Hospitalizations with inflammatory bowel disease (IBD) are at increased risk of venous thromboembolism (VTE), and current guidelines recommend routine pharmacological thromboprophylaxis during admission. However, there is limited evidence regarding the occurrence of Heparin-induced thrombocytopenia (HIT) in this population. We examined the incidence and risk of HIT among hospitalizations with IBD.Methods: A retrospective cohort study using the National Inpatient Sample dataset spanning ten years. We identified the predictive factors of HIT and assessed its impact on inpatient outcomes of IBD hospitalizations. We included hospitalizations aged ≥18 years with any discharge diagnosis (primary or secondary) of IBD, identified using ICD-CM codes.Results: Among 3,093,632 hospitalizations with IBD, 2,218 (0.07%) were diagnosed with HIT. IBD hospitalizations had 40% higher odds of developing HIT (AOR: 1.42; 95% CI: 1.28-1.56). Compared with those without HIT, IBD hospitalizations with HIT had higher odds of mortality (AOR: 3.23; 95% CI: 2.21-4.74), longer mean length of stay (β: 7.3, 95% CI: 6.07-8.49), and higher mean total hospital charges (β: $97,211, 95% CI: $83,540-$129,417). Additionally, they had increased odds of both venous and arterial thromboembolic events, as well as significant bleeding events.Conclusions: Hospitalizations with IBD had increased risk of HIT, which is subsequently associated with worse in-hospital outcomes. While recognizing the benefits of VTE prophylaxis in this population, further investigation is necessary to better understand the observed risk of HIT. Utilizing innovative methods, such as clinical decision support tools combined with established HIT prevention and management practices, may help improve patient outcomes.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A modified definition of Lemierre syndrome to unify existing variation: An observation study and brief review of the literature (2012-2024). 修改Lemierre综合征定义以统一现有变异：观察研究及文献综述（2012-2024）

IF 1.8

The American journal of the medical sciences Pub Date : 2026-08-14 DOI: 10.1016/j.amjms.2026.08.002

Ho-Man Yeung, Johnson Liu

{"title":"A modified definition of Lemierre syndrome to unify existing variation: An observation study and brief review of the literature (2012-2024).","authors":"Ho-Man Yeung, Johnson Liu","doi":"10.1016/j.amjms.2026.08.002","DOIUrl":"10.1016/j.amjms.2026.08.002","url":null,"abstract":"Background: Wide variability of how clinicians diagnose Lemierre Syndrome (LS) exists within the literature leading to \"Lemierre-like\" conditions. Some clinicians use Fusobacterium bacteremia as key defining feature, while some use internal jugular septic thrombophlebitis. The source of infection varies as well between oropharyngeal and skin and soft tissue infection.Methods: This literature-based observational analysis utilized existing case reports to find common clinical patterns in diagnosis to construct a clinical decision tree framework. 149 LS cases from PubMed and Google Scholar over a 13-year period between January 2012 and December 2024 were obtained. A novel clinical framework was constructed based on a testing cohort of 111 cases and applied to a separate cohort of 38 cases.Results: LS has been rising in recent years, with 88 cases within the past five years. Among all included cases, the most common findings included bacteremia (123/149;82.6%), internal jugular venous septic thrombophlebitis (123/149;82.6%), pulmonary septic emboli/cavitary lesion (99/149;66.4%). Fusobacteria species comprised 39.6% (59/149) of positive blood cultures. 74.5% of 149 cases were oropharyngeal infections while 25.5% were skin and soft tissue infections. Based on these patterns, we organized a clinical framework consisting of \"Presumed Lemierre,\" \"LS Type I,\" \"Type II,\" \"Type III,\" and \"Type IV/Variant\". Compared to the historical definition, our proposed modified definition of LS effectively assigned reported LS cases from the literature into a subtype based on clinical features.Conclusions: Our study is hypothesis-generating and offered a modified definition of LS and incorporated clinical observations into a unifying framework to address the existing ambiguity and variation with this entity.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and in-hospital outcomes of alcohol-related pancreatitis in the setting of concomitant alcohol-related hepatitis: A retrospective cohort study. 伴有酒精性肝炎的酒精性胰腺炎的临床和住院结局：一项回顾性队列研究

IF 1.8

The American journal of the medical sciences Pub Date : 2026-08-11 DOI: 10.1016/j.amjms.2026.08.001

Adham Obeidat, Abdalrahman Sallam, Christopher Chang

{"title":"Clinical and in-hospital outcomes of alcohol-related pancreatitis in the setting of concomitant alcohol-related hepatitis: A retrospective cohort study.","authors":"Adham Obeidat, Abdalrahman Sallam, Christopher Chang","doi":"10.1016/j.amjms.2026.08.001","DOIUrl":"10.1016/j.amjms.2026.08.001","url":null,"abstract":"Background: Alcohol misuse is a major cause of acute pancreatitis. When alcohol related hepatitis coexists, the combination of hepatic and pancreatic injury may exacerbate systemic inflammation and organ dysfunction. We evaluated whether concurrent AH influences in hospital outcomes among adults admitted with alcohol induced AP.Methods: We performed a retrospective cohort study using the NIS database from 2019-2021, identifying adults with alcohol induced AP by ICD 10 codes. Patients were stratified by the presence of concurrent AH. The primary outcome was in hospital mortality. Secondary outcomes were sepsis, acute kidney injury, respiratory failure, pulmonary edema, hepatic encephalopathy, cardiac arrest, pulmonary embolism, malnutrition, length of stay and total hospital charges. Multivariable logistic regression adjusted for demographics and comorbidities.Results: Among 74,756 admissions for alcohol induced AP, 15.2% had coexistent AH. Patients with AH were younger, more often female, white, and had a longer LOS and higher total charges. In hospital mortality was more prevalent in the AH group. AH remained the strongest predictor of death. AH was independently associated with higher odds of sepsis, AKI, respiratory failure, pulmonary edema, hepatic encephalopathy, cardiac arrest, malnutrition and prolonged LOS. Pulmonary embolism was less frequent in the AH cohort.Conclusions: Concurrent AH identifies a high risk subset of patients with alcohol induced AP. The presence of AH increases the odds of in hospital death and significantly increases the risk of multiple organ complications and resource utilization. Early recognition of AH, careful supportive care, and multidisciplinary management may mitigate adverse outcomes in this vulnerable population.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148715167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLP-1 receptor agonists and colorectal neoplasia: Interpreting the evidence. GLP-1受体激动剂与结直肠肿瘤：解释证据。

IF 1.8

The American journal of the medical sciences Pub Date : 2026-07-30 DOI: 10.1016/j.amjms.2026.07.011

Ayesha Nasir Khan, Summaya Maqsood, Dua Jabbar, Rehman Rasheed, Fnu Ghansam

引用次数: 0

GLP-1 receptor agonist initiation and risk of colorectal cancer and colonic polyps. GLP-1受体激动剂的起始和结直肠癌和结肠息肉的风险。

IF 1.8

The American journal of the medical sciences Pub Date : 2026-07-30 DOI: 10.1016/j.amjms.2026.07.010

Anwar Alshaakh Moh'd Mari, Minh Anh Le, Ali Rizvi, Ishak Mansi

引用次数: 0

Five-decade trends in chronic kidney disease mortality across demographic and geographic subgroups in the US. 美国人口和地理亚群中慢性肾脏疾病死亡率的50年趋势

IF 1.8

The American journal of the medical sciences Pub Date : 2026-07-30 DOI: 10.1016/j.amjms.2026.07.012

Arshalooz Mahfooz, Ammaar Ali Khan, Zainab Binte Ahmad, Syed Azfar Hussain, Marium Ali Meghani

引用次数: 0

Red lunula: A reflection of systemic disease. 红色月牙：全身性疾病的反映。

IF 1.8

The American journal of the medical sciences Pub Date : 2026-07-29 DOI: 10.1016/j.amjms.2026.07.008

Christopher G Karim, Robert A Schwartz

引用次数: 0

Prognostic nutritional index and outcomes in stable coronary artery disease: a systematic review. 稳定性冠状动脉疾病的预后营养指数和预后：一项系统综述。

IF 1.8

The American journal of the medical sciences Pub Date : 2026-07-22 DOI: 10.1016/j.amjms.2026.07.007

Samir Vanani, Tanisha Mishra, Ajinkya Mahorkar, Rupak Desai

引用次数: 0

Interplay between triglyceride-glucose index, cardiometabolic risk, and premature/early-onset major adverse cardiovascular and cerebrovascular events. 甘油三酯-葡萄糖指数、心脏代谢风险和过早/早发的主要不良心脑血管事件之间的相互作用

IF 1.8

The American journal of the medical sciences Pub Date : 2026-07-17 DOI: 10.1016/j.amjms.2026.01.014

Lakshmi Sai Meghana Kodali, Krishna R Suresh, Diksha Sanjana Pasnoor, Hemanth Dhananjaya, Neeharika John Madhavaram, Venkata Akhil Makarla, Shefali P Mody, Krishidhar Nunna, Rupak Desai

{"title":"Interplay between triglyceride-glucose index, cardiometabolic risk, and premature/early-onset major adverse cardiovascular and cerebrovascular events.","authors":"Lakshmi Sai Meghana Kodali, Krishna R Suresh, Diksha Sanjana Pasnoor, Hemanth Dhananjaya, Neeharika John Madhavaram, Venkata Akhil Makarla, Shefali P Mody, Krishidhar Nunna, Rupak Desai","doi":"10.1016/j.amjms.2026.01.014","DOIUrl":"10.1016/j.amjms.2026.01.014","url":null,"abstract":"The increasing prevalence of cardiovascular diseases (CVD) and type 2 diabetes, particularly among younger populations, highlights the urgent need for early, cost-effective risk assessment tools. The Triglyceride-Glucose (TyG) index, derived from routine triglyceride and glucose levels, has emerged as a reliable predictor of insulin resistance and is gaining recognition for its role in forecasting cardiovascular risk, including Major Adverse Cardiac and Cerebrovascular Events (MACCE). Unlike more complex and costly insulin resistance tests, the TyG index offers a simpler approach to early detection, particularly in individuals without obvious clinical signs of metabolic disease. This narrative review synthesizes evidence on the association between the TyG index and various cardiovascular outcomes, focusing on early-onset conditions such as atherosclerotic cardiovascular disease (ASCVD), myocardial infarction (MI), coronary artery disease (CAD), stroke, heart failure, and all-cause mortality. Notably, the TyG index has shown predictive value across diverse patient populations, including those free from diabetes or dyslipidemia.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0