The American journal of the medical sciences最新文献_第6页

The impact of preoperative depression on in-hospital outcomes in coronary artery bypass grafting: A propensity-matched analysis of National Inpatient Sample from 2015-2020. 术前抑郁对冠状动脉旁路移植术住院结果的影响：2015-2020年全国住院患者样本的倾向匹配分析

The American journal of the medical sciences Pub Date : 2024-12-09 DOI: 10.1016/j.amjms.2024.12.001

Renxi Li, Deyanira J Prastein, Brian G Choi

{"title":"The impact of preoperative depression on in-hospital outcomes in coronary artery bypass grafting: A propensity-matched analysis of National Inpatient Sample from 2015-2020.","authors":"Renxi Li, Deyanira J Prastein, Brian G Choi","doi":"10.1016/j.amjms.2024.12.001","DOIUrl":"10.1016/j.amjms.2024.12.001","url":null,"abstract":"Background: Depression has a high prevalence among patients undergoing coronary artery bypass grafting (CABG). However, there is a scarcity of literature on the association between preoperative depression and CABG outcomes. This study aimed to explore the effects of preoperative major depression disorder (MDD) on in-hospital outcomes following CABG.Methods: Patients who underwent CABG were identified in National Inpatient Sample from the last quarter of 2015 to 2020. Patients were stratified based on the diagnosis of MDD, followed by a 1:3 propensity-score matching of demographics, socioeconomic status, comorbidities, relevant diagnosis, admission status, and hospital characteristics between MDD and non-MDD patients. In-hospital perioperative outcomes, total length of stay (LOS), time from admission to operation, and total hospital charge were compared.Results: There were 908 patients with MDD and 170,830 patients without MDD who underwent CABG. After propensity-score matching, 2,796 non-MDD were matched with all 908 MDD patients. While MDD patients have no difference in-hospital mortality or MACE, they had higher hemorrhage/hematoma (65.97 % vs 60.17 %, p < 0.01) and pacemaker implantation (2.53 % vs 1.43 %, p = 0.04). MDD patients had longer time from admission to operation (3.2 ± 0.1 vs 2.6 ± 0.2 days, p < 0.01), longer total LOS (12.6 ± 0.5 vs 10.5 ± 0.2 days, p < 0.01), and higher total hospital charge (272,255.0 ± 8930.1 vs 230,133.0 ± 3861.1 US dollars, p < 0.01).Conclusion: Potential barriers could exist for MDD patients seeking access to CABG. Preoperative MDD is a risk factor for complications following CABG including hemorrhage/hematoma and pacemaker implantation. Enhanced attention to coagulation function is advisable for MDD patients prior to CABG.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial disparity among Native Americans in coronary artery bypass grafting: An analysis of national inpatient sample from 2015 to 2020. 美洲原住民在冠状动脉搭桥术中的种族差异：2015 - 2020年全国住院患者样本分析

The American journal of the medical sciences Pub Date : 2024-12-03 DOI: 10.1016/j.amjms.2024.12.004

Renxi Li, Deyanira J Prastein, Brian G Choi

{"title":"Racial disparity among Native Americans in coronary artery bypass grafting: An analysis of national inpatient sample from 2015 to 2020.","authors":"Renxi Li, Deyanira J Prastein, Brian G Choi","doi":"10.1016/j.amjms.2024.12.004","DOIUrl":"10.1016/j.amjms.2024.12.004","url":null,"abstract":"Background: Disparities have been shown in the outcomes of coronary artery bypass grafting (CABG) in racial minorities. Although Native Americans are known to have a higher risk for cardiovascular diseases, the current literature on CABG outcomes for Native Americans remains notably limited, probably due to their limited population size. Thus, this study aimed to investigate racial disparities in CABG outcomes among Native Americans.Methods: Patients who underwent CABG were identified in National Inpatient Sample database from last quarter of 2015 to 2020. A 1:2 propensity score matching was conducted between Native Americans and Caucasians to address preoperative differences in demographics, socioeconomic status, comorbidity, and hospital characteristics. In-hospital outcomes, length of stay (LOS), time from admission to operation, and total hospital charge were compared.Results: There were 905 (0.54 %) Native Americans and 125,983 (74.91 %) Caucasians, where 1,838 Caucasians were matched to all the Native Americans. The in-hospital mortality rate was elevated in Native Americans but was not statistically different (2.87 % vs. 2.23 %, p = 0.43). However, Native Americans had a higher risk of cardiogenic shock (8.51 % vs. 6.2 %, p = 0.03). There was no difference in time from admission to operation (2.55 ± 0.11 vs. 2.73 ± 0.08 days, p = 0.20), LOS (9.82 ± 0.23 vs. 9.95 ± 0.20 days, p = 0.65), or the total hospital charge between the two groups (205,594 ± 5192.8 vs. 213,961 ± 4150.9 US dollars, p = 0.20).Conclusion: Native Americans had a significantly higher risk of cardiogenic shock after CABG. However, in-house mortality and other parameters were not affected. These disparities highlight challenges that Native Americans encounter and emphasize the need for targeted interventions to ensure health equity.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The closed loop of the circCLIP2/miR-361-3p/STAT2 signaling axis regulates the progression of cervical cancer. circCLIP2/miR-361-3p/STAT2信号轴的闭环调节宫颈癌的进展。

The American journal of the medical sciences Pub Date : 2024-08-07 DOI: 10.1016/j.amjms.2024.08.002

Qian Zhang, Wang Cai

{"title":"The closed loop of the circCLIP2/miR-361-3p/STAT2 signaling axis regulates the progression of cervical cancer.","authors":"Qian Zhang, Wang Cai","doi":"10.1016/j.amjms.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.amjms.2024.08.002","url":null,"abstract":"Background: Circular RNAs (circRNAs) are involved in tumorigenesis and the progression of cancer through various pathways. However, the detailed regulatory mechanisms of circRNAs in cervical cancer are not fully understood. The present study was designed to explore the biological functions and potential mechanisms of circCLIP2 (has_circ_0001717) in cervical cancer.Methods: The expression profiles of circRNAs in cancerous and adjacent normal tissues of cervical cancer patients were examined using RNA sequencing. Gain- and loss-of-function experiments were carried out to determine the biological functions of circCLIP2 in the proliferation, invasion, migration and apoptosis of cervical cancer cells. qRT-PCR was also used to evaluate the expression of circCLIP2, miR-361-3p and STAT2 in cervical cancer cells. The protein levels of STAT2 were determined by western blotting.Results: CircCLIP2 was identified as the most down-regulated molecule in the cancerous tissues of cervical cancer patients compared to the adjacent normal tissues. Moreover, the levels of circCLIP2 was decreased in cervical cancer patients with metastasis and advanced tumour stage, and patients with high-circCLIP2-expression exhibited poorer survival rate. In addition, over-expression of circCLIP2 suppressed the proliferation, invasion and migration of cervical cancer cells, whereas cell apoptosis was enhanced. Moreover, down-regulated circCLIP2 functioned as the sponge of miR-361-3p, which reduced the expression of STAT2. Furthermore, knockdown of STAT2 inhibited the expression of circCLIP2 at the transcriptional level.Conclusion: The circCLIP2/miR-361-3p/STAT2 signalling could mediate the progression of cervical cancer. CircCLIP2 may become a novel target for the diagnosis and treatment of cervical cancer.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Neck Circumference and Bone Mineral Loss: A Cross-sectional Study in Sichuan Province in China. 颈围与骨矿物质流失的关系：一项在中国四川省进行的横断面研究。

The American journal of the medical sciences Pub Date : 2024-05-01 DOI: 10.1016/j.amjms.2024.05.004

Qing Wen, Xiaoran Zhang, Yunjiao Yang, Huizhen Chen, Xuke Han, Qiu Chen

引用次数: 0

Assessing AI-driven tools as a method for cardiopulmonary resuscitation for non-healthcare workers 评估将人工智能驱动工具作为非医护人员心肺复苏方法的情况

The American journal of the medical sciences Pub Date : 2024-02-08 DOI: 10.1016/s0002-9629(24)00610-4

M Al Akeel, SN Notta, L AlHuneafat, A Hashem, M Jbara

引用次数: 0

An unsual case of a positive lupus anticoagulant loculated pericardial and pleural effusion 狼疮抗凝剂阳性定位心包和胸腔积液的罕见病例

The American journal of the medical sciences Pub Date : 2024-02-08 DOI: 10.1016/s0002-9629(24)00205-2

S Ali, H Assi, O Aboudawoud, S Chaudhry, C Vu, S Prakash, M Hassan, S Nadella, MA Cazares Parson, M Rondla, JJ Bies, M Porres-Aguilar

引用次数: 0

Left Ventricular Assist Device (LVAD) implantations in children in the United States; a 5 year analysis from the National Inpatient Sample 美国儿童左心室辅助装置（LVAD）植入情况；全国住院病人抽样五年分析

The American journal of the medical sciences Pub Date : 2024-02-01 DOI: 10.1016/s0002-9629(24)00209-x

M. Almasri, A. F. I. Masri, R. Dachepally

引用次数: 0

Optimizing Hepatitis B screening strategies in the pediatric population: addressing non-responders and waning antibody levels 优化儿科人群的乙肝筛查策略：解决无应答者和抗体水平下降问题

The American journal of the medical sciences Pub Date : 2024-02-01 DOI: 10.1016/s0002-9629(24)00590-1

C. Yost, FJ Whitaker, D. Mills, K. Duvall

引用次数: 0

Impact of race on renal recovery in patients with new diagnosis of multiple myeloma and acute kidney injury requiring dialysis 种族对新诊断为多发性骨髓瘤且急性肾损伤需要透析的患者肾功能恢复的影响

The American journal of the medical sciences Pub Date : 2024-02-01 DOI: 10.1016/s0002-9629(24)00685-2

S. Kanduri, D. Patel, K. Kovvuru, J. Velez

引用次数: 0

Hypertensive medication use in patients with hypertrophic cardiomyopathy 肥厚型心肌病患者的降压药物使用情况

The American journal of the medical sciences Pub Date : 2024-02-01 DOI: 10.1016/s0002-9629(24)00604-9

HP Mace, N. Foxworth, A. Rizwan, A. Hamid, WF Campbell, MR McMullan, M. Hall

引用次数: 0