The American journal of the medical sciences最新文献_第7页

Refeeding hypophosphatemia is a common cause of delirium in critically ill patients: A retrospective study. 重症患者谵妄的常见原因之一是再进食性低磷酸盐血症：一项回顾性研究。

The American journal of the medical sciences Pub Date : 2024-07-20 DOI: 10.1016/j.amjms.2024.07.027

Ying Xu, Yajun Qian, Pei Liang, Ning Liu, Danjiang Dong, Qin Gu, Jian Tang

{"title":"Refeeding hypophosphatemia is a common cause of delirium in critically ill patients: A retrospective study.","authors":"Ying Xu, Yajun Qian, Pei Liang, Ning Liu, Danjiang Dong, Qin Gu, Jian Tang","doi":"10.1016/j.amjms.2024.07.027","DOIUrl":"10.1016/j.amjms.2024.07.027","url":null,"abstract":"Background: The purpose was to explore the correlation between refeeding hypophosphatemia and delirium and analyze the related factors in critically ill patients.Methods: We conducted a retrospective review of critically ill patients admitted to Nanjing Drum Tower Hospital between September 2019 and March 2021. The patients were divided into delirium and nondelirium groups. Demographic data, underlying diseases, laboratory findings, comorbidities, nutritional intake and overall prognosis were collected and analyzed.Results: In total, 162 patients were included and divided into delirium (n=54) and nondelirium (n=108) groups. Serum phosphorus levels in the two groups decreased significantly in the first three days (P1, P2, P3) after nutrient intake compared with baseline before nutrient intake (Ppre). P1 and P2 were significantly lower in the delirium group compared to the nondelirium group. The maximum blood phosphorus reduction (Pmax) in the first three days after nutrient intake was significantly higher in the delirium group than in the nondelirium group. The time of Pmax in the delirium group was on the first day after nutrient intake. Multivariable logistic regression analysis identified starting route of nutrition and P1< 0.845 mmol/L as the independent predictors of delirium development in critically ill patients.Conclusion: The incidence of delirium in critically ill patients is high and associated with refeeding hypophosphatemia. Delirium may occur with serum phosphorus levels less than 0.845 mmol/L on the first day.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematically investigate the mechanism underlying the therapeutic effect of Astragalus membranaceus in ulcerative colitis. 系统研究黄芪对溃疡性结肠炎的治疗作用机制。

The American journal of the medical sciences Pub Date : 2024-07-14 DOI: 10.1016/j.amjms.2024.07.019

Jingxin Mao, Lihong Tan, Cheng Tian, Wenxiang Wang, YanLin Zou, Zhaojing Zhu, Yan Li

{"title":"Systematically investigate the mechanism underlying the therapeutic effect of Astragalus membranaceus in ulcerative colitis.","authors":"Jingxin Mao, Lihong Tan, Cheng Tian, Wenxiang Wang, YanLin Zou, Zhaojing Zhu, Yan Li","doi":"10.1016/j.amjms.2024.07.019","DOIUrl":"10.1016/j.amjms.2024.07.019","url":null,"abstract":"Background: Whether Astragalus membranaceus is an effective drug in treatment of ulcerative colitis (UC) and how it exhibit activity effect on UC is unclear.Methods: TCMSP, GeneCards, String, and DAVID database were used to screening target genes construct PPI network and performed for GO and KEGG pathway enrichment analysis respectively. Molecular docking and animal experiment were performed. The body weight and disease activity index (DAI) of mice were recorded. ELISA kits were used to detect the levels of CAT, SOD, MDA and IL-6, IL-10, TNF-α in the blood of mice. Western blot kits were utilized to measured the expressions of MAPK14, RB1, MAPK1, JUN, ATK1, and IL2 proteins.Results: The active components of Astragalus membranaceus mainly including 7-O-methylisomucronulatol, quercetin, kaempferol, formononetin and isrhamnetin. Astragalus membranaceus may inhibited the expression of TNF-α, IL-6, MDA, and promoted the expression of CAT, SOD, IL-10. The expression levels of MAPK14, RB1, MAPK1, JUN and ATK1 proteins were significantly decreased while IL2 protein increased administrated with Astragalus membranaceus.Conclusions: Astragalus membranaceus is an effective drug in treatment of UC according to related to above targets that may exhibits the anti-UC effect via its antioxidant pathway and regulating the balance of pro-inflammatory and anti-inflammatory factors.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of mycophenolate mofetil for the treatment of fibrotic hypersensitivity pneumonitis. 使用霉酚酸酯（Mycophenolate mofetil）治疗纤维化超敏性肺炎。

The American journal of the medical sciences Pub Date : 2024-07-14 DOI: 10.1016/j.amjms.2024.07.021

Ana Casal, Juan Suárez-Antelo, Francisco Gude, Óscar Lado-Baleato, Borja Otero, María E Toubes, Lucía Ferreiro, Nuria Rodríguez-Núñez, Luis Valdés

{"title":"Use of mycophenolate mofetil for the treatment of fibrotic hypersensitivity pneumonitis.","authors":"Ana Casal, Juan Suárez-Antelo, Francisco Gude, Óscar Lado-Baleato, Borja Otero, María E Toubes, Lucía Ferreiro, Nuria Rodríguez-Núñez, Luis Valdés","doi":"10.1016/j.amjms.2024.07.021","DOIUrl":"10.1016/j.amjms.2024.07.021","url":null,"abstract":"Introduction: The optimal treatment of fibrosing hypersensitivity pneumonitis (fHP) is not well understood. The aim of the study was to obtain information about the usefulness of mycophenolate mofetil (MMF) in its treatment.Material and methods: Quasi-experimental analysis of patients diagnosed with fHP and treated with MMF for one year, in a single centre. From the start of treatment, data collection was prospective.Results: 73 were included and 58 completed the study. FVC% and DLCO% decreased until starting MMF (year -1 to year 0). After completion of treatment (year 1), FVC% stabilised (p=0.336) and DLCO% improved significantly (p=0.004) compared to year 0. Dyspnoea, number of patients without corticosteroids and mean corticosteroid dose also improved significantly (p<0.001 in all cases). Being male and having a history of tuberculosis were predictors of poor drug response [AUC = 0.89 (95% CI: 0.80-0.98)]. 45 adverse effects were observed in 34 patients (46.6%). In 4 cases (5.5%), the adverse effect was severe and required discontinuation of treatment.Conclusions: In patients with fHP, MMF improves lung function and dyspnoea and reduces both the number of patients requiring oral corticosteroids and their mean dose in those who completed 1 year of treatment. The model constructed predicts which patients will respond poorly to treatment, with good discriminative ability and only a small percentage of patients will not tolerate treatment. Further prospective, randomised clinical trials are needed to define the role of this treatment in fHP.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes with GLP-1R polymorphism (rs3765467) accompanied by myotonic dystrophy: A case of myotonic dystrophy with p.R131Q polymorphism at the glucagon-like peptide-1 receptor (rs3765467) resulting in marked effects of its agonist, dulaglutide. 糖尿病患者GLP-1R多态性（rs3765467）伴肌营养不良：一例胰高血糖素样肽-1 受体（rs3765467）p.R131Q 多态性导致其激动剂度拉鲁肽效果显著的肌营养不良患者。

The American journal of the medical sciences Pub Date : 2024-07-08 DOI: 10.1016/j.amjms.2024.06.030

Kanako Kato, Teruo Jojima, Takahiko Kogai, Dai Tanuma, Takafumi Niitani, Shintaro Sakurai, Toshie Iijima, Takuya Tomaru, Isao Usui, Yoshimasa Aso

引用次数: 0

Single nucleotide polymorphisms of GEMIN3 modify the risk of primary Sjögren's syndrome in female patients. GEMIN3 的单核苷酸多态性改变了女性患者罹患原发性斯约格伦综合征的风险。

The American journal of the medical sciences Pub Date : 2024-07-04 DOI: 10.1016/j.amjms.2024.07.001

Dong Wang, Jingjing Zhang, Yufei Zhao, Ruijie Cao, Yingnan Wang, Iren Guo, Chenxing Peng, Yanrong Song, Shasha Zhang

{"title":"Single nucleotide polymorphisms of GEMIN3 modify the risk of primary Sjögren's syndrome in female patients.","authors":"Dong Wang, Jingjing Zhang, Yufei Zhao, Ruijie Cao, Yingnan Wang, Iren Guo, Chenxing Peng, Yanrong Song, Shasha Zhang","doi":"10.1016/j.amjms.2024.07.001","DOIUrl":"10.1016/j.amjms.2024.07.001","url":null,"abstract":"Background: MicroRNA (miRNA)-processing machinery may modify the risk of primary Sjögren's syndrome (pSS) by altering miRNA expression profiles. Inflammatory cytokines and reactive oxygen species (ROS) are also involved in pSS; however, the role of altered miRNAs expression in its pathogenesis is still unclear. We aimed to evaluate the relationship between single-nucleotide polymorphisms (SNPs) in miRNA processing machinery genes, including XPO5 (rs11077), RAN (rs14035), Dicer (rs3742330), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), and the risk of pSS in female patients. The potential associations of cytokines and ROS with pSS-susceptible SNPs were also evaluated.Materials and methods: The SNPs confirmed by polymerase chain reaction ligase detection reaction were genotyped in 74 female patients with pSS and 77 controls. The relationship was analyzed by Student's t-test, Wilcoxon rank-sum test, chi-square test, Pearson's correlation test, and binary logistic regression analysis.Results: For rs197412 of the GEMIN3 gene, the genotype TT carrier was associated with a 2.172-fold increased risk for pSS when compared with that of CT+CC carrier (odds ratio: 2.172, 95% CI, 1.133-4.166, p=0.019). Simultaneously, the pSS-susceptible TT carriers were associated with increased interferon-γ (IFN-γ) (P < 0.001) and tumor necrosis factor-α (TNF-α) (P = 0.003) levels when compared with that of CT+CC genotype carriers in female patients with pSS. The subsequent analysis also showed a weak positive correlation between IFN-γ and TNF-α levels (r=0.271, P = 0.019).Conclusion: The predictors of GEMIN3 SNPs might modify pSS development in females by mediating the expression of miRNAs and therefore regulate the levels of IFN-γ and TNF-α.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pamiparib, a novel intervention with anti-neoplastic activity for the treatment of glioblastoma. 帕米帕利（Pamiparib），一种具有抗肿瘤活性的治疗胶质母细胞瘤的新型干预方法。

The American journal of the medical sciences Pub Date : 2024-07-03 DOI: 10.1016/j.amjms.2024.07.007

Sehar Ul Duaa, Eeshal Fatima, Zaheer Qureshi

引用次数: 0

Ultrasound-guided lumbar sympathetic nerve block for an intractable abdominal pain and intestinal obstruction. 超声引导下腰部交感神经阻滞治疗顽固性腹痛和肠梗阻。

The American journal of the medical sciences Pub Date : 2024-06-25 DOI: 10.1016/j.amjms.2024.06.021

Heyu Ji, Di Xia, Xulei Cui, Yuguang Huang

引用次数: 0

Congenital giant pelvic arteriovenous malformation. 先天性巨大骨盆动静脉畸形。

The American journal of the medical sciences Pub Date : 2024-06-21 DOI: 10.1016/j.amjms.2024.06.018

Leizhi Ku, Xiaojing Ma

引用次数: 0

Corrigendum to ‘748 - Experiences of menopausal transition among populations exposed to chronic psychosocial stress in the United States: a scoping review’ The American Journal of the Medical Sciences, Volume 367, Supplement 1, February 2024, Pages S470-S471 美国医学科学杂志》（The American Journal of Medical Sciences），第 367 卷，第 1 号增刊，2024 年 2 月，第 S470-S471 页，"748--美国遭受慢性社会心理压力人群的绝经过渡期经历：范围审查 "的更正。

The American journal of the medical sciences Pub Date : 2024-06-01 DOI: 10.1016/j.amjms.2024.05.001

CT McCarthy, E. Blackson, A. Bazzano, C. Bell, S. Ramirez

引用次数: 0

Association Between Neck Circumference and Bone Mineral Loss: A Cross-sectional Study in Sichuan Province in China. 颈围与骨矿物质流失的关系：一项在中国四川省进行的横断面研究。

The American journal of the medical sciences Pub Date : 2024-05-01 DOI: 10.1016/j.amjms.2024.05.004

Qing Wen, Xiaoran Zhang, Yunjiao Yang, Huizhen Chen, Xuke Han, Qiu Chen

引用次数: 0