Zeynep Ture Assoc. Prof. Dr. , Gülşen İskender Assoc. Prof. Dr. , Mustafa Serhat Şahinoğlu MD , Ezel Beste Özkara MD , Ayşe Kaya Kalem Assoc. Prof. Dr. , Esma Eryılmaz Eren Assoc. Prof. Dr. , Fatma Yekta Ürkmez Assoc. Prof. Dr. , Sinan Çetin Assoc. Prof. Dr. , Emel Azak Assoc. Prof. Dr. , İlknur Erdem Prof. Dr. , Jordi Rello Prof. Dr. , Emine Alp Prof. Dr. , The following are the members of EPSCAP (Epidemiology and Prognosis of Sepsis in Cancer Patients) Study Group
{"title":"癌症患者败血症的流行病学和预后:多中心前瞻性观察研究》。","authors":"Zeynep Ture Assoc. Prof. Dr. , Gülşen İskender Assoc. Prof. Dr. , Mustafa Serhat Şahinoğlu MD , Ezel Beste Özkara MD , Ayşe Kaya Kalem Assoc. Prof. Dr. , Esma Eryılmaz Eren Assoc. Prof. Dr. , Fatma Yekta Ürkmez Assoc. Prof. Dr. , Sinan Çetin Assoc. Prof. Dr. , Emel Azak Assoc. Prof. Dr. , İlknur Erdem Prof. Dr. , Jordi Rello Prof. Dr. , Emine Alp Prof. Dr. , The following are the members of EPSCAP (Epidemiology and Prognosis of Sepsis in Cancer Patients) Study Group","doi":"10.1016/j.amjms.2025.02.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the epidemiology and prognosis of sepsis in cancer patients and the influence of sepsis on the mortality of cancer patients.</div></div><div><h3>Methods</h3><div>In this multicenter, prospective, observational study, cancer patients hospitalized without sepsis followed up until discharge or a maximum of 90 days were included. The incidence of sepsis in the follow-up period, risk factors for sepsis, risk factors for 28-day mortality in patients with sepsis and 90-day mortality in the entire group were determined.</div></div><div><h3>Results</h3><div>During the study, 790 cancer patients were included. Sepsis developed in 72 patients (9.1 %) during the follow-up. Older age, hospitalization due to any infection, graft versus host diseases (GVHD), the presence of a urethral catheter, and previous bacterial infection in the last three months were risk factors of sepsis. Among all cancer patients, sepsis was found to be the most important factor influencing 90-day mortality (OR 13.42(1.79–6.83)). Mortality among the sepsis cohort was independently associated with an infection with a carbapenem-resistant bacterium (OR 15.47(1.45–64.17)), appropriateness of empirical treatment (OR 5.02 (0.17–7.61)) and having a clinical improvement on the fifth day of the treatment (OR 10.58(0.39–28.25)).</div></div><div><h3>Conclusions</h3><div>Sepsis was documented in one out of 11 hospitalized cancer patients and the mortality rate increases 13-fold when sepsis develops. Invasive devices, GVHD, and previous bacterial infections were related to sepsis and antibiotic resistance were the most important driver for mortality. Antimicrobial stewardship, rational use of catheters (if necessary, in accordance with asepsis/antisepsis, short-term use) is important to save lives in cancer patients.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 6","pages":"Pages 679-688"},"PeriodicalIF":2.3000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epidemiology and prognosis of sepsis in cancer patients: A multicenter prospective observational study\",\"authors\":\"Zeynep Ture Assoc. Prof. Dr. , Gülşen İskender Assoc. Prof. Dr. , Mustafa Serhat Şahinoğlu MD , Ezel Beste Özkara MD , Ayşe Kaya Kalem Assoc. Prof. Dr. , Esma Eryılmaz Eren Assoc. Prof. Dr. , Fatma Yekta Ürkmez Assoc. Prof. Dr. , Sinan Çetin Assoc. Prof. Dr. , Emel Azak Assoc. Prof. Dr. , İlknur Erdem Prof. Dr. , Jordi Rello Prof. Dr. , Emine Alp Prof. Dr. , The following are the members of EPSCAP (Epidemiology and Prognosis of Sepsis in Cancer Patients) Study Group\",\"doi\":\"10.1016/j.amjms.2025.02.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>To determine the epidemiology and prognosis of sepsis in cancer patients and the influence of sepsis on the mortality of cancer patients.</div></div><div><h3>Methods</h3><div>In this multicenter, prospective, observational study, cancer patients hospitalized without sepsis followed up until discharge or a maximum of 90 days were included. The incidence of sepsis in the follow-up period, risk factors for sepsis, risk factors for 28-day mortality in patients with sepsis and 90-day mortality in the entire group were determined.</div></div><div><h3>Results</h3><div>During the study, 790 cancer patients were included. Sepsis developed in 72 patients (9.1 %) during the follow-up. Older age, hospitalization due to any infection, graft versus host diseases (GVHD), the presence of a urethral catheter, and previous bacterial infection in the last three months were risk factors of sepsis. Among all cancer patients, sepsis was found to be the most important factor influencing 90-day mortality (OR 13.42(1.79–6.83)). Mortality among the sepsis cohort was independently associated with an infection with a carbapenem-resistant bacterium (OR 15.47(1.45–64.17)), appropriateness of empirical treatment (OR 5.02 (0.17–7.61)) and having a clinical improvement on the fifth day of the treatment (OR 10.58(0.39–28.25)).</div></div><div><h3>Conclusions</h3><div>Sepsis was documented in one out of 11 hospitalized cancer patients and the mortality rate increases 13-fold when sepsis develops. Invasive devices, GVHD, and previous bacterial infections were related to sepsis and antibiotic resistance were the most important driver for mortality. Antimicrobial stewardship, rational use of catheters (if necessary, in accordance with asepsis/antisepsis, short-term use) is important to save lives in cancer patients.</div></div>\",\"PeriodicalId\":55526,\"journal\":{\"name\":\"American Journal of the Medical Sciences\",\"volume\":\"369 6\",\"pages\":\"Pages 679-688\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of the Medical Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0002962925009231\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of the Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002962925009231","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Epidemiology and prognosis of sepsis in cancer patients: A multicenter prospective observational study
Objectives
To determine the epidemiology and prognosis of sepsis in cancer patients and the influence of sepsis on the mortality of cancer patients.
Methods
In this multicenter, prospective, observational study, cancer patients hospitalized without sepsis followed up until discharge or a maximum of 90 days were included. The incidence of sepsis in the follow-up period, risk factors for sepsis, risk factors for 28-day mortality in patients with sepsis and 90-day mortality in the entire group were determined.
Results
During the study, 790 cancer patients were included. Sepsis developed in 72 patients (9.1 %) during the follow-up. Older age, hospitalization due to any infection, graft versus host diseases (GVHD), the presence of a urethral catheter, and previous bacterial infection in the last three months were risk factors of sepsis. Among all cancer patients, sepsis was found to be the most important factor influencing 90-day mortality (OR 13.42(1.79–6.83)). Mortality among the sepsis cohort was independently associated with an infection with a carbapenem-resistant bacterium (OR 15.47(1.45–64.17)), appropriateness of empirical treatment (OR 5.02 (0.17–7.61)) and having a clinical improvement on the fifth day of the treatment (OR 10.58(0.39–28.25)).
Conclusions
Sepsis was documented in one out of 11 hospitalized cancer patients and the mortality rate increases 13-fold when sepsis develops. Invasive devices, GVHD, and previous bacterial infections were related to sepsis and antibiotic resistance were the most important driver for mortality. Antimicrobial stewardship, rational use of catheters (if necessary, in accordance with asepsis/antisepsis, short-term use) is important to save lives in cancer patients.
期刊介绍:
The American Journal of The Medical Sciences (AJMS), founded in 1820, is the 2nd oldest medical journal in the United States. The AJMS is the official journal of the Southern Society for Clinical Investigation (SSCI). The SSCI is dedicated to the advancement of medical research and the exchange of knowledge, information and ideas. Its members are committed to mentoring future generations of medical investigators and promoting careers in academic medicine. The AJMS publishes, on a monthly basis, peer-reviewed articles in the field of internal medicine and its subspecialties, which include:
Original clinical and basic science investigations
Review articles
Online Images in the Medical Sciences
Special Features Include:
Patient-Centered Focused Reviews
History of Medicine
The Science of Medical Education.