The American journal of the medical sciences最新文献_第4页

Unexpected renal side effects of mRNA COVID-19 vaccines; a single-center experience and short review. mRNA - COVID-19疫苗的意外肾副作用单中心体验和简短回顾。

The American journal of the medical sciences Pub Date : 2025-01-07 DOI: 10.1016/j.amjms.2025.01.002

Ákos Pethő, Deján Dobi, Magdolna Kardos, Karolina Schnabel

{"title":"Unexpected renal side effects of mRNA COVID-19 vaccines; a single-center experience and short review.","authors":"Ákos Pethő, Deján Dobi, Magdolna Kardos, Karolina Schnabel","doi":"10.1016/j.amjms.2025.01.002","DOIUrl":"10.1016/j.amjms.2025.01.002","url":null,"abstract":"Background: In late 2019, the World Health Organization declared Coronavirus disease 2019 a global emergency. Since then, many vaccines have been developed to combat the pandemic. Millions of people have received one of the approved COVID-19 vaccines; unfortunately, some adverse events also have been recorded.Methods: In the local health system, patients could get either mRNA vaccines (either Pfizer-BioNTech or Moderna), adenoviral vector vaccine (AstraZeneca), or the vaccine based on inactivated virus (Sinovac). We investigated what immune-mediated adverse events occurred in our department after the COVID-19 vaccination.Results: We evaluated six patients from our center who received mRNA vaccines and developed suspected immune-mediated adverse events. The immune-mediated adverse events are characterized by de novo or relapsing glomerular diseases and are further confirmed with percutaneous kidney biopsies. During A follow-up of more than two years, remission occurred in five patients, and glomerulonephritis persisted in one of them.Conclusion: Vaccinations are pivotal in effectively protecting and preventing various epidemics. As such, it is essential to maintain a high level of vigilance concerning post-vaccination adverse events. This heightened level of suspicion leads to earlier detection, better understanding, and optimal prevention and management of these events. To this end, developing a specific vaccine/patient risk profile is necessary to categorize the target population selectively.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between left ventricular outflow tract velocity timed integral and left ventricular ejection fraction in patients with sepsis or septic shock. 脓毒症或感染性休克患者左心室流出道流速积分与左心室射血分数的相关性

The American journal of the medical sciences Pub Date : 2025-01-07 DOI: 10.1016/j.amjms.2025.01.003

Marwa Tarbaghia, Abdelrahman Nanah, Marcos Garcia, Talha Saleem, Ryota Sato, Siddharth Dugar

引用次数: 0

The prognosis of patients with co-morbid diabetes and hepatitis B and strategies for improving outcome. 合并糖尿病和乙型肝炎患者的预后及改善预后的策略。

The American journal of the medical sciences Pub Date : 2024-12-20 DOI: 10.1016/j.amjms.2024.12.011

Xiyu Liu, Xiaohong Wang

引用次数: 0

Changing paradigms in asthma management. 哮喘管理模式的改变。

The American journal of the medical sciences Pub Date : 2024-12-19 DOI: 10.1016/j.amjms.2024.12.008

Charles E Grogan, Marlee Wadsworth, Gailen D Marshall

{"title":"Changing paradigms in asthma management.","authors":"Charles E Grogan, Marlee Wadsworth, Gailen D Marshall","doi":"10.1016/j.amjms.2024.12.008","DOIUrl":"10.1016/j.amjms.2024.12.008","url":null,"abstract":"Asthma is a complex clinical syndrome characterized by airway inflammation that can cause variable, usually reversible airway obstruction and bronchial hyperreactivity. This illness has a spectrum from intermittent to persistent that has mild, medium or severe intensity. As our understanding of the underling inflammatory pathway grows, so too does our catalogue of advanced treatments (such as monoclonal antibodies), opening the path for treatment individually curated for patients. The current approved therapies are directed against IgE, interleukin (IL)-5, IL-5 receptor, IL-4 receptor subunit-α and most recently thymic stromal lymphopoietin (TSLP). These therapies all have demonstrated efficacies that make them variably effective in patients with moderate to severe persistent disease. More recently, other inflammatory molecules have been therapeutically targeted and are currently under clinical investigation for future potential use. However, a significant concern remains: the high financial costs for these advanced therapies continues to pose a significant burden both to patients and the healthcare system. Novel uses of long-acting bronchodilator-corticosteroids inhalers may reduce the use of highly priced biologics in many patients with comparatively less severe disease. Furthermore, the variability in patient response demands further research into to identify which patients will best respond to which specific therapy.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical care and prescription medication affordability by age group in the US, 2019 to 2023. 2019年至2023年美国按年龄组划分的医疗保健和处方药负担能力

The American journal of the medical sciences Pub Date : 2024-12-17 DOI: 10.1016/j.amjms.2024.12.009

Guodong Ding, Chaochao Wen, Yan Chen, Angela Vinturache, Yongjun Zhang

引用次数: 0

Meta analysis of the influencing factors of sarcopenia in patients with Crohn's disease. 克罗恩病患者肌肉减少症影响因素的Meta分析。

The American journal of the medical sciences Pub Date : 2024-12-17 DOI: 10.1016/j.amjms.2024.12.010

Zhihui Yu, Qing Liu, Yan Chen, Danlei Chen, Ting Pan, Fang Kong

{"title":"Meta analysis of the influencing factors of sarcopenia in patients with Crohn's disease.","authors":"Zhihui Yu, Qing Liu, Yan Chen, Danlei Chen, Ting Pan, Fang Kong","doi":"10.1016/j.amjms.2024.12.010","DOIUrl":"10.1016/j.amjms.2024.12.010","url":null,"abstract":"Objective: To conduct a meta-analysis of the factors influencing sarcopenia in patients with Crohn's disease and provide evidence-based findings for early clinical detection and prevention.Methods: The study was registered on PROSPERO(CRD42023470300). A systematic review was performed on literature pertaining to sarcopenia in patients with Crohn's disease utilizing eight Chinese and English databases, which consist of CNKI, Wanfang, VIP, CBM, PubMed, Web of Science, Embase, and The Cochrane Library. The search was carried out from the inception of each database until October 8, 2023. Data analysis was carried out using the Stata 14.0 software.Results: A total of 603 Chinese and English literature sources were reviewed, and following the application of the inclusion and exclusion criteria, 9 articles were selected. These 9 articles take into account a total of 22 factors that may influence the occurrence of sarcopenia in Crohn's disease patients. The results of the meta-analysis demonstrate that gender (OR=5.49, 95% CI [2.08,14.51]), BMI (OR=0.77, 95% CI [0.62,0.95]), age (OR=1.03, 95% CI [1.01,1.05]), and low albumin levels (OR=1.08, 95% CI [1.01,1.15]) have significant impacts on the emergence of sarcopenia in patients with Crohn's disease.Conclusions: The occurrence of sarcopenia in Crohn's disease patients is mainly influenced by gender, BMI, age, and low albumin levels. Additional factors that may influence the condition require further research to verify.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between Type 2 myocardial infarction and short-term cardiovascular outcomes in glycemic diabetic emergencies patients: Relationship between T2MI and Glycemic Diabetes Emergencies. 急诊血糖性糖尿病患者2型心肌梗死与短期心血管预后的关系

The American journal of the medical sciences Pub Date : 2024-12-16 DOI: 10.1016/j.amjms.2024.12.007

Hadeer Elsharnoby, Tsungyen Chen, Osama Alsara, Ahmed Maraey, Alina Brener

引用次数: 0

Vasculitis in patients treated with direct oral anticoagulants. 直接口服抗凝剂治疗患者的血管炎。

The American journal of the medical sciences Pub Date : 2024-12-14 DOI: 10.1016/j.amjms.2024.11.013

Giuseppe Famularo, Chiara Dell'Unto

引用次数: 0

The relationship between dietary niacin intake and the incidence of all-cause and cardiovascular mortality among chronic kidney disease patients. 慢性肾病患者饮食烟酸摄入量与全因死亡率及心血管死亡率的关系

The American journal of the medical sciences Pub Date : 2024-12-10 DOI: 10.1016/j.amjms.2024.11.004

Hongxi Chen, Xu He, Junming Fan, Yongjie Mi, Feiyan Li

{"title":"The relationship between dietary niacin intake and the incidence of all-cause and cardiovascular mortality among chronic kidney disease patients.","authors":"Hongxi Chen, Xu He, Junming Fan, Yongjie Mi, Feiyan Li","doi":"10.1016/j.amjms.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.amjms.2024.11.004","url":null,"abstract":"Background: Chronic kidney disease (CKD) is a major cause of human mortality and cardiovascular disease (CVD)-related death. Niacin can treat dyslipidemia and can lower overall cardiovascular event incidence and mortality rates. The present study was designed to clarify the link between dietary consumption of niacin and cardiovascular mortality.Methods: This study enrolled subjects ≥18 years of age from the National Health and Nutrition Examination Survey 2009-2014 and excluded any individuals for whom data regarding their CKD status, dietary niacin intake, or other covariate information was unavailable. Relationships between dietary niacin intake levels and overall or CVD-related mortality among these CKD patients were assessed using univariate and multivariate Cox regression analyses.Results: The study included 1,798 subjects and recorded 514 and 186 instances of all-cause and cardiovascular death, respectively. Males comprised 51.8% of the study cohort, and the mean age of these subjects was 65. Cox proportional hazard model analyses revealed no relationship between dietary niacin intake and all-cause or cardiovascular death risk among the overall CKD patient population (P > 0.05). However, in age-stratified analyses, those subjects <60 years of age exhibiting the highest levels of dietary niacin consumption (≥ 38 mg/day) were found to face a significantly higher risk of all-cause mortality, and this association remained intact in sensitivity analyses.Conclusion: These results do not support any link between the dietary intake of niacin and all-cause or cardiovascular mortality risk among patients with CKD. Age and niacin intake exhibited a significant interaction related to all-cause mortality.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of preoperative depression on in-hospital outcomes in coronary artery bypass grafting: A propensity-matched analysis of National Inpatient Sample from 2015-2020. 术前抑郁对冠状动脉旁路移植术住院结果的影响：2015-2020年全国住院患者样本的倾向匹配分析

The American journal of the medical sciences Pub Date : 2024-12-09 DOI: 10.1016/j.amjms.2024.12.001

Renxi Li, Deyanira J Prastein, Brian G Choi

{"title":"The impact of preoperative depression on in-hospital outcomes in coronary artery bypass grafting: A propensity-matched analysis of National Inpatient Sample from 2015-2020.","authors":"Renxi Li, Deyanira J Prastein, Brian G Choi","doi":"10.1016/j.amjms.2024.12.001","DOIUrl":"10.1016/j.amjms.2024.12.001","url":null,"abstract":"Background: Depression has a high prevalence among patients undergoing coronary artery bypass grafting (CABG). However, there is a scarcity of literature on the association between preoperative depression and CABG outcomes. This study aimed to explore the effects of preoperative major depression disorder (MDD) on in-hospital outcomes following CABG.Methods: Patients who underwent CABG were identified in National Inpatient Sample from the last quarter of 2015 to 2020. Patients were stratified based on the diagnosis of MDD, followed by a 1:3 propensity-score matching of demographics, socioeconomic status, comorbidities, relevant diagnosis, admission status, and hospital characteristics between MDD and non-MDD patients. In-hospital perioperative outcomes, total length of stay (LOS), time from admission to operation, and total hospital charge were compared.Results: There were 908 patients with MDD and 170,830 patients without MDD who underwent CABG. After propensity-score matching, 2,796 non-MDD were matched with all 908 MDD patients. While MDD patients have no difference in-hospital mortality or MACE, they had higher hemorrhage/hematoma (65.97 % vs 60.17 %, p < 0.01) and pacemaker implantation (2.53 % vs 1.43 %, p = 0.04). MDD patients had longer time from admission to operation (3.2 ± 0.1 vs 2.6 ± 0.2 days, p < 0.01), longer total LOS (12.6 ± 0.5 vs 10.5 ± 0.2 days, p < 0.01), and higher total hospital charge (272,255.0 ± 8930.1 vs 230,133.0 ± 3861.1 US dollars, p < 0.01).Conclusion: Potential barriers could exist for MDD patients seeking access to CABG. Preoperative MDD is a risk factor for complications following CABG including hemorrhage/hematoma and pacemaker implantation. Enhanced attention to coagulation function is advisable for MDD patients prior to CABG.","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0