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Revue medicale de Liege最新文献

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[Metronidazole-induced neurotoxicity]. [Metronidazole-induced神经毒性)。
Revue medicale de Liege Pub Date : 2025-07-01
Julia Tebache, Maxime Gudelj
{"title":"[Metronidazole-induced neurotoxicity].","authors":"Julia Tebache, Maxime Gudelj","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Metronidazole, an antiparasitic treatment with bactericidal activity, may be neurotoxic. The exact pathophysiology of this complication is unknown. While it is related to the cumulative dose, it does vary from patient to patient. We are describing the case of a 43-year-old woman, who was admitted into the hospital for treatment of a liver abscess and an ascitic fluid infection. This patient presented with cerebellar syndrome and motor slowing 29 days after starting metronidazole. Cerebral MRI showed a FLAIR hypersignal of the dentate nuclei without associated enhancement or diffusion restriction. This is typical of metronidazole toxic encephalopathy. Treatment had to be stopped. The patient's clinical course rapidly improved. A follow-up MRI scan after 10 days showed the complete resolution of dentate nuclei lesions.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"545-548"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prolonged fever in an adolescent with a positive blood culture : is it a chronic meningococcemia ?] [青少年血培养阳性持续发热：是慢性脑膜炎球菌血症吗？]
Revue medicale de Liege Pub Date : 2025-07-01
Caroline Hardy, Catherine Vandendaele
{"title":"[Prolonged fever in an adolescent with a positive blood culture : is it a chronic meningococcemia ?]","authors":"Caroline Hardy, Catherine Vandendaele","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the case of a 15-year old boy admitted for febrile episodes lasting over 4 months without any other clinical signs. On the basis of a positive blood culture, chronic Neisseria meningitidis bacteremia, without associated meningitis, was highly suspected. Further work-up revealed no immunosuppression or terminal complement deficiency. A 7-day intravenous treatment of ceftriaxone resulted in complete recovery. This case highlights chronic Neisseria meningitidis as a rarely encountered pathology and describes an atypical presentation, compared with descriptions in the literature.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"496-499"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Dupilumab for eosinophilic esophagitis refractory to standard triple therapy]. Dupilumab用于标准三联疗法难治性嗜酸性食管炎。
Revue medicale de Liege Pub Date : 2025-07-01
Rémi Gason, Jean-Baptiste Zeevaert, Floriane Ausloos, Fernand Weerts
{"title":"[Dupilumab for eosinophilic esophagitis refractory to standard triple therapy].","authors":"Rémi Gason, Jean-Baptiste Zeevaert, Floriane Ausloos, Fernand Weerts","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the case of a young man presenting with dysphagia and frequent food impactions, which led to the diagnosis of eosinophilic esophagitis based on endoscopic examination and confirmed anatomopathologically. Despite a triple therapy regimen including a high-dose proton pump inhibitor, an elimination of allergenic foods based on prick tests, and oral budesonide, there was no significant and sustained clinical or endoscopic improvement. In this context, through a compassionate use program, we initiated biotherapy with dupilumab, a monoclonal antibody targeting interleukin 4 and interleukin 13 receptors, which was recently approved for the treatment of refractory eosinophilic esophagitis by the European Medicines Agency. We report our experience over 6 months with this innovative treatment, which has been reimbursed in Belgium under certain conditions since November 1st, 2024.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"491-495"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Giant extracranial carotid artery aneurysm]. [巨颅外颈动脉动脉瘤]。
Revue medicale de Liege Pub Date : 2025-07-01
Maud Van Buggenhout, Natzi Sakalihasan, Bernard Otto
{"title":"[Giant extracranial carotid artery aneurysm].","authors":"Maud Van Buggenhout, Natzi Sakalihasan, Bernard Otto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Extracranial carotid artery aneurysms are extremely rare, representing less than 1 % of all peripheral arterial aneurysms. The main symptom is a pulsatile mass. Other symptoms are derived from compression of adjacent structures, cerebral events or rupture. Treatment can be surgical, endovascular or conservative. We report a clinical case of a 66-year-old woman who was diagnosed an extracranial left internal carotid artery aneurysm measuring 4 cm in the context of a pulsatile cervical mass. Treatment consisted of a total occlusion by the embolization of the left internal carotid after performing a balloon test occlusion. Outcome was favourable without stroke at 2 year.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"534-538"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The large cell anaplastic lymphoma associated with breast implants]. [与乳房植入物相关的大细胞间变性淋巴瘤]。
Revue medicale de Liege Pub Date : 2025-07-01
Virginie Van Boeckel, Ophélie Duysinx, Karlien Vrancken, Christophe Nizet, Xavier Nelissen, Jean-Luc Nizet
{"title":"[The large cell anaplastic lymphoma associated with breast implants].","authors":"Virginie Van Boeckel, Ophélie Duysinx, Karlien Vrancken, Christophe Nizet, Xavier Nelissen, Jean-Luc Nizet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare CD-30+/ALK- T-cell lymphoma. The combination of a textured breast implant, bacterial contamination and genetic predisposition appears to be necessary for the development of BIA-ALCL. The National Comprehensive Cancer Network (NCCN) has established guidelines for both diagnosis and treatment. Early detection of the disease is essential to ensure a cure. At an early stage and for the vast majority of patients, treatment consists of implant removal with associated total capsulectomy. We share our experience with the presentation of a case of BIA-ALCL discovered following the appearance of a periprosthetic seroma, 19 years after the fitting of breast implants.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"529-533"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Intestinal intussusception in adults]. [成人肠套叠]。
Revue medicale de Liege Pub Date : 2025-07-01
Sophie Dost, Pierre Milet
{"title":"[Intestinal intussusception in adults].","authors":"Sophie Dost, Pierre Milet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intestinal intussusception in adults is less common than in paediatric patients, and may be difficult to diagnose due to non-specific symptoms. Abdominal pain is the main clinical sign, but other symptoms such as nausea or transit disorders may also be present. Abdominal computerized tomography is the key investigation for the diagnosis, with sensitivity approaching 100 %. In 90 % of cases of intussusception in adults, a mass is at the origin of the intussusception. The causes may be benign (lipomas, Meckel's diverticulum) or malignant (metastases, digestive tumours). Management is surgical, with resection of the affected segment and the underlying lesion, due to the risk of serious complications such as perforation or tumour dissemination if a reduction is attempted.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"487-490"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ophtalmoplegia secondary to ponto-mesencephalic infarction : clinical-radiological correlation in the WEBINO syndrome]. [继发于桥-中脑梗死的眼麻痹：WEBINO综合征的临床-影像学相关性]。
Revue medicale de Liege Pub Date : 2025-07-01
Éléonore Defraigne-Peigneur, Mélody Félix, Géraldine Dasnoy-Sumell, Martin Moïse
{"title":"[Ophtalmoplegia secondary to ponto-mesencephalic infarction : clinical-radiological correlation in the WEBINO syndrome].","authors":"Éléonore Defraigne-Peigneur, Mélody Félix, Géraldine Dasnoy-Sumell, Martin Moïse","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report on a case of posterior midbrain stroke revealed by WEBINO (\"Wall-Eyed Bilateral InterNuclear Ophthalmoplegia\") syndrome, a relatively rare neuro-ophthalmological clinical entity combining bilateral internuclear ophthalmoplegia and exotropia. Encephalic MRI unraveled a bilateral paramedian ischemic lesion located at the posterior area of the ponto-mesencephalic junction, perfectly correlating to the theoretical localization of the medial longitudinal fasciculi. Clinical identification of this syndrome is key to efficiently guide MRI reading and proper management.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"483-486"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diagnostic approach to disseminated histoplasmosis]. [播散性组织浆菌病的诊断方法]。
Revue medicale de Liege Pub Date : 2025-07-01
Andrea Manto, Marie-Pierre Hayette, Jean-Baptiste Giot, Géraldine Delporte, Orphal Colleye, Philippe Léonard
{"title":"[Diagnostic approach to disseminated histoplasmosis].","authors":"Andrea Manto, Marie-Pierre Hayette, Jean-Baptiste Giot, Géraldine Delporte, Orphal Colleye, Philippe Léonard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Disseminated histoplasmosis is a condition with nonspecific clinical signs. In case of fever in a patient receiving anti-TNF alpha therapy, a thorough history that includes travel to areas of high endemicity can raise suspicion of infection. When suspected, diagnosis is made by detecting antigens in urine and blood (if this analysis is available), conducting serology, and obtaining a specimen for culture, direct microscopy, and histopathological analysis. PCR for Histoplasma can also be performed. When treatment is initiated early, the outcome is favourable in the vast majority of cases. Treatment requires intravenous administration of amphotericin B followed by oral itraconazole.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"506-511"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Rhino-sinusal mucormycosis in a solid organ transplant recipient]. [实体器官移植受者的鼻-鼻窦毛霉菌病]。
Revue medicale de Liege Pub Date : 2025-07-01
Lucie Moulan, Philippe Léonard, Marie-Pierre Hayette, Nancy Detrembleur, Catherine Bonvoisin, Laurent Weekers, Florence Rogister, François Jouret, Antoine Bouquegneau
{"title":"[Rhino-sinusal mucormycosis in a solid organ transplant recipient].","authors":"Lucie Moulan, Philippe Léonard, Marie-Pierre Hayette, Nancy Detrembleur, Catherine Bonvoisin, Laurent Weekers, Florence Rogister, François Jouret, Antoine Bouquegneau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report on a 46-year-old female patient with a recent history of kidney transplantation who presented with acute sinusitis. Further investigation revealed rhino-sinusal mucormycosis. Surgical debridement and a five-month antifungal treatment along with the cessation of the immunosuppressive therapy were needed. This approach led to clinical improvement but unfortunately resulted in the loss of the allograft. More than two years after this infection, the clinical and endoscopic outcomes remain favourable. Mucormycosis is a rare opportunistic infection caused by fungi of the Mucorales order, characterized by angio-invasive properties that lead to thrombosis, necrosis and infarction of the affected tissues. Diagnosis primarily relies on imaging, microbiological studies and histopathological examination. Early detection and prompt management are crucial given the poor prognosis of mucormycosis. Treatment involves a combination of surgical debridement, antifungal therapy and management of risk factors such as immunosuppression. Despite an appropriate treatment, mucormycosis remains a serious and potentially life-threatening condition.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"517-521"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical Practice Guidelines in complex situations : better prioritisation using the GOC approach]. [复杂情况下的临床实践指南：使用GOC方法更好地确定优先级]。
Revue medicale de Liege Pub Date : 2025-05-01
Isabelle Heymans, Jean-Luc Belche, Amandine Stassen, Hélène Kersten, Laeticia Buret
{"title":"[Clinical Practice Guidelines in complex situations : better prioritisation using the GOC approach].","authors":"Isabelle Heymans, Jean-Luc Belche, Amandine Stassen, Hélène Kersten, Laeticia Buret","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The application of clinical practice guidelines faces specific challenges in complex or multi-morbid situations. In these cases, the proposal is to shift the focus from disease-oriented care to patient's goal-oriented care, in which disease management becomes a means of supporting the achievement of the person's life goals. The GOC approach (\"Goal Oriented Care\") offers a method and tools for implementing this approach. The approach also implies a series of conditions for implementation. The GOC involves shared decision-making, with healthcare professionals translating the patient's personal goals into realistic professional objectives. It promotes better coordination of care, improves patient compliance and responds to various challenges in the current healthcare system. It complements other approaches that already exist in the practices. Concrete examples and current initiatives illustrate the application of this method.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 5-6","pages":"288-295"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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