[播散性组织浆菌病的诊断方法]。

Revue medicale de Liege Pub Date : 2025-07-01
Andrea Manto, Marie-Pierre Hayette, Jean-Baptiste Giot, Géraldine Delporte, Orphal Colleye, Philippe Léonard
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引用次数: 0

摘要

弥散性组织胞浆菌病是一种具有非特异性临床症状的疾病。在接受抗肿瘤坏死因子α治疗的患者发烧的情况下,全面的病史,包括到高流行地区旅行,可以提高感染的怀疑。当怀疑时,通过检测尿液和血液中的抗原(如果有这种分析)进行诊断,进行血清学检查,并获得标本进行培养,直接显微镜检查和组织病理学分析。也可以对组织浆进行PCR。如果及早开始治疗,绝大多数病例的结果都是有利的。治疗需要静脉注射两性霉素B,然后口服伊曲康唑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Diagnostic approach to disseminated histoplasmosis].

Disseminated histoplasmosis is a condition with nonspecific clinical signs. In case of fever in a patient receiving anti-TNF alpha therapy, a thorough history that includes travel to areas of high endemicity can raise suspicion of infection. When suspected, diagnosis is made by detecting antigens in urine and blood (if this analysis is available), conducting serology, and obtaining a specimen for culture, direct microscopy, and histopathological analysis. PCR for Histoplasma can also be performed. When treatment is initiated early, the outcome is favourable in the vast majority of cases. Treatment requires intravenous administration of amphotericin B followed by oral itraconazole.

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