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Revue medicale de Liege最新文献

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[Clinical reasoning put to the test of real-world practice]. [临床推理在现实世界实践中的检验]。
Revue medicale de Liege Pub Date : 2026-02-01
Patrizio Lancellotti
{"title":"[Clinical reasoning put to the test of real-world practice].","authors":"Patrizio Lancellotti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This issue illustrates how diagnostic innovations are integrated into daily clinical practice, highlighting the central role of clinical reasoning.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 2","pages":"64"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Real-world diagnostic performance of the «Allogenomics» predictive score in a cohort of 185 patients with suspected inherited kidney disease]. [在185名疑似遗传性肾病患者的队列中，“同种异体基因组学”预测评分的真实诊断性能]。
Revue medicale de Liege Pub Date : 2026-02-01
Cédric Ilbert, Laura Massoz, Bernard Grisart, Laurence Seidel, Adeline Jacquinet, François-Guillaume Debray, Laurent Weekers, Vinciane Dideberg, François Jouret
{"title":"[Real-world diagnostic performance of the «Allogenomics» predictive score in a cohort of 185 patients with suspected inherited kidney disease].","authors":"Cédric Ilbert, Laura Massoz, Bernard Grisart, Laurence Seidel, Adeline Jacquinet, François-Guillaume Debray, Laurent Weekers, Vinciane Dideberg, François Jouret","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nephrogenetics provides an innovative etiological approach to chronic kidney disease (CKD). However, genetic testing remains complex, costly, and generates a large number of data, requiring targeted use. In 2023, Doreille A. et coll. proposed the Allogenomics Score (SAG) predictive for a positive molecular diagnosis, based on age, CKD stage, family history, and nosological category. A SAG below -2.230916 was associated with a negative predictive value (NPV) of 94 %. We test the SAG in a monocentric study (2023-2025), including 185 patients who underwent exome sequencing filtered on a 304-gene panel. Variants were ACMG-classified, and the individual SAG was calculated. Concordance between the a priori clinical hypothesis and the a posteriori molecular diagnosis was assessed using κ Cohen's coefficient. The median SAG was -1.32 (-2.14; -0.35), corresponding to a predicted probability of positive test of 21 %, with an observed diagnostic yield of 28 %. Clinico-molecular concordance was excellent (92.3 %, κ = 0.86). The probability of a positive genetic diagnosis was significantly associated with SAG (p = 0.042), but no significant association was observed with the -2.230916 threshold (which showed NPV of 84 % in our cohort). These findings indicate excellent clinico-molecular concordance but suboptimal performance of the proposed SAG threshold in clinical routine.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 2","pages":"119-126"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The value of the Test of Masticating and Swallowing Solids (TOMASS) in screening for dysphagia and malnutrition]. [咀嚼和吞咽固体试验（TOMASS）在筛查吞咽困难和营养不良中的价值]。
Revue medicale de Liege Pub Date : 2026-02-01
Erica Marcondes Gonçalves Leite, Mélanie Poncelet, Adeline Claude, Philippe Lefèbvre, Aude Lagier
{"title":"[The value of the Test of Masticating and Swallowing Solids (TOMASS) in screening for dysphagia and malnutrition].","authors":"Erica Marcondes Gonçalves Leite, Mélanie Poncelet, Adeline Claude, Philippe Lefèbvre, Aude Lagier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Test of Masticating and Swallowing Solids (TOMASS) measures the number of bites, chewing cycles, swallows, and the total time required to swallow a standardized saltine cracker. The objective was to evaluate the relevance of TOMASS as a screening tool for dysphagia and malnutrition. This prospective study compared TOMASS results with nutritional status in a group of 30 dysphagic subjects and a control group of 30 matched participants. The TOMASS results (number of chewing cycles, swallows, and total time) were significantly higher in the dysphagic group than in the control group, and in malnourished patients in both groups: higher number of chewing cycles, swallows, and longer total time. Measuring the total TOMASS time has the highest sensitivity and specificity for distinguishing dysphagic subjects from undernourished subjects. However, it is less effective for distinguishing undernourished subjects from dysphagic subjects. In conclusion, our results suggest that measuring the total TOMASS time has acceptable diagnostic performance for screening both for the risk of dysphagia and malnutrition risk.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 2","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Grisel syndrome following Mycoplasma pneumoniae infection]. [肺炎支原体感染后的Grisel综合征]。
Revue medicale de Liege Pub Date : 2026-02-01
Jeanne Lambert, Isabelle Delpierre, Nancy Vitali, Sarah Jourdain
{"title":"[Grisel syndrome following Mycoplasma pneumoniae infection].","authors":"Jeanne Lambert, Isabelle Delpierre, Nancy Vitali, Sarah Jourdain","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Grisel syndrome is an underrecognized clinical entity characterized by non-traumatic rotational subluxation of the atlanto-axial joint, which is caused by inflammatory contracture of the paravertebral muscles near an infectious focus, typically within the ear nose and throat region. This condition is more prevalent among the pediatric population, primarily due to the higher incidence of upper airway infections and anatomical factors in children. Neurological complications of varying severity may occur in the absence of adequate management. Diagnosis is based on clinical presentation and radiological imaging, with 3D reconstructed computed tomography considered as the gold standard. Currently, no established guidelines are available as this condition is rare. Treatment is mainly conservative with cervical immobilization and pain management. However, more invasive procedures are occasionally necessary. We describe here a case of Grisel syndrome in a 10-year-old child during a Mycoplasma pneumoniae infection.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 2","pages":"70-74"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bacterial dermato-zoonoses]. (细菌dermato-zoonoses)。
Revue medicale de Liege Pub Date : 2026-02-01
Amandine Bouillenne, Bernard Mignon, Arjen Nikkels
{"title":"[Bacterial dermato-zoonoses].","authors":"Amandine Bouillenne, Bernard Mignon, Arjen Nikkels","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The transmission of bacterial, viral, fungal, or parasitic agents from vertebrate animals to humans constitutes a group of diseases called zoonoses. The frequency of these zoonoses is increasing, and new zoonoses are emerging due to travel, factory farming, biodiversity loss, climate change, and deforestation. These diseases have a significant impact on public health, both human and animal, as well as on food, environmental management and the economy. This article reviews bacterial zoonoses with cutaneous manifestations, known as dermato-zoonoses. A second section will address viral, fungal, and parasitic dermato-zoonoses.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 2","pages":"103-109"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Frédérique Depierreux. Lauréate du Prix de la Fondation Docteurs Désiré et Maurice Jaumain 2025]. [frederique Depierreux。基金会Docteurs Desire和Maurice Jaumin 2025奖得主]。
Revue medicale de Liege Pub Date : 2026-01-01
Jacques Boniver
{"title":"[Frédérique Depierreux. Lauréate du Prix de la Fondation Docteurs Désiré et Maurice Jaumain 2025].","authors":"Jacques Boniver","doi":"","DOIUrl":"","url":null,"abstract":"<p><p></p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 1","pages":"6-7"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Éditorial. En marche vers des changements inévitables qu'il conviendra de bien appréhender]. [社论。在走向不可避免的变化的过程中，必须充分理解。
Revue medicale de Liege Pub Date : 2026-01-01
André Scheen
{"title":"[Éditorial. En marche vers des changements inévitables qu'il conviendra de bien appréhender].","authors":"André Scheen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p></p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Osteoarthritis and cellular therapeutics]. [骨关节炎和细胞疗法]。
Revue medicale de Liege Pub Date : 2026-01-01
Margaux Gritten, Jean-François Kaux
{"title":"[Osteoarthritis and cellular therapeutics].","authors":"Margaux Gritten, Jean-François Kaux","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Osteoarthritis, a degenerative disorder of the osteoarticular system, leads to progressive cartilage deterioration, resulting in pain and functional impairment. Its clinical presentation is heterogeneous, reflecting a diversity of phenotypes and molecular profiles. Risk factors include advanced age, female sex, obesity and joint trauma. Among emerging therapeutic strategies, mesenchymal stem cells (MSCs) offer promising prospects. These cells, derived from bone marrow, adipose tissue, and umbilical tissues, exhibit regenerative and immunomodulatory properties. In parallel, MSC-derived exosomes, which carry regenerative bioactive factors, represent another avenue of innovation, though their clinical application still requires further validation.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 1","pages":"44-49"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Functional assessment of coronary artery disease in the interventional cardiology suite]. 介入心脏病组冠状动脉疾病的功能评估
Revue medicale de Liege Pub Date : 2026-01-01
Victor Weerts, Cédric Davidsen, Mathieu Lempereur, Patrick Maréchal, Christophe Martinez, Adil Salihu, Laurent Davin, Patrizio Lancellotti
{"title":"[Functional assessment of coronary artery disease in the interventional cardiology suite].","authors":"Victor Weerts, Cédric Davidsen, Mathieu Lempereur, Patrick Maréchal, Christophe Martinez, Adil Salihu, Laurent Davin, Patrizio Lancellotti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ischemic heart disease, the main clinical expression of atherosclerotic cardiovascular disease, remains a leading global health challenge. While coronary angiography is the gold standard for anatomical assessment, it has limitations in determining the functional relevance of coronary lesions. Invasive physiological techniques - such as Fractional Flow Reserve (FFR) and its resting equivalents (iFR, RFR) - enable an objective hemodynamic evaluation, particularly useful in intermediate or multivessel diseases. Emerging imaging-derived tools, including QFR and FFRCT, offer less invasive alternatives that may play an increasing role in the upstream decision-making process. This article provides a practical overview of the available modalities, their physiological rationale, and their integration into interventional practice.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hommage. André Scheen, une vie éditoriale guidée par la rigueur]. [致敬。Andre Scheen，严谨的编辑生活]。
Revue medicale de Liege Pub Date : 2026-01-01
Patrizio Lancellotti, Régis Radermecker, François Jouret
{"title":"[Hommage. André Scheen, une vie éditoriale guidée par la rigueur].","authors":"Patrizio Lancellotti, Régis Radermecker, François Jouret","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>/.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 1","pages":"4-5"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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