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Revue medicale de Liege最新文献

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[How I treat… severe «T2-high» asthma]. [我如何治疗…严重的“t2高”哮喘]。
Revue medicale de Liege Pub Date : 2026-09-01
Anna Denis, Mare Sabbe, Doriane Calmés, Renaud Louis, Florence Schleich
{"title":"[How I treat… severe «T2-high» asthma].","authors":"Anna Denis, Mare Sabbe, Doriane Calmés, Renaud Louis, Florence Schleich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Severe asthma refers to uncontrolled asthma despite optimal inhaled treatment combining high-dose inhaled corticosteroids and a long-acting β2 agonist. This condition is characterized by significant clinical and pathophysiological heterogeneity, particularly in terms of inflammation. Understanding the role of type 2 inflammation (\"T2-high\") has led to the development of biologic therapies targeting cytokines or their receptors, such as interleukin 5 (IL-5), IL-4/IL-13, thymic stromal lymphopoietin (TSLP) and immunoglobulin E (IgE), the impact of which varies depending on the asthma phenotype. Phenotyping is based on the identification of biomarkers such as fractional exhaled nitric oxide, blood eosinophilia and serum IgE levels. Biotherapies have demonstrated a significant reduction in exacerbations, as well as improved symptom control and quality of life. Six molecules are available on the market. The choice of treatment is based primarily on the biomarker profile and associated comorbidities.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"488-495"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute anterior ischemic optic neuropathy in the context of mitochondrial disease]. [线粒体疾病背景下急性前缺血性视神经病变]。
Revue medicale de Liege Pub Date : 2026-09-01
Adrien Mathot, Florence Maraite
{"title":"[Acute anterior ischemic optic neuropathy in the context of mitochondrial disease].","authors":"Adrien Mathot, Florence Maraite","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mitochondrial diseases can lead to highly heterogeneous clinical manifestations, including optic neuropathies, the prototypical form of which is Leber's hereditary optic neuropathy. We report the case of a 47-year-old man carrying a mitochondrial DNA mutation (m.13513G>A in the MT-ND5 gene), who, after exclusion of differential diagnoses, including Leber's hereditary optic neuropathy, presented with unilateral non-arteritic anterior ischemic optic neuropathy in the absence of cardiovascular risk factors. In this context, the hypothesis of a pathophysiological link between mitochondrial cytopathy and ischemia of the optic nerve head is discussed. Indeed, mitochondrial angiopathy, known to be associated with certain mitochondrial diseases, could represent a contributory mechanism through the microcirculatory disturbances it induces. This case suggests that certain mitochondrial mutations may represent an independent vascular risk factor and highlights the importance of considering a mitochondrial etiology in cases of atypical ischemic optic neuropathy, particularly in young patients without cardiovascular risk factors.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"536-543"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Congenitally corrected Transposition of the Great Arteries (ccTGA) : Recent research and clinical implications in congenital cardiology]. 先天性大动脉转位（ccTGA）：先天性心脏病学的最新研究和临床意义。
Revue medicale de Liege Pub Date : 2026-09-01
Orianne de la Brassinne Bonardeaux, Marie-Christine Seghaye, Patrizio Lancellotti
{"title":"[Congenitally corrected Transposition of the Great Arteries (ccTGA) : Recent research and clinical implications in congenital cardiology].","authors":"Orianne de la Brassinne Bonardeaux, Marie-Christine Seghaye, Patrizio Lancellotti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Congenitally corrected transposition of the great arteries (ccTGA) represents a complex anomaly of cardiac embryogenesis, posing significant challenges in both diagnosis and management within congenital cardiology. This review examines the latest literature in ccTGA, spanning from embryological origins to contemporary treatment strategies. Through an analysis of recent literature, the pathophysiological mechanisms underlying ccTGA, including the associated anomalies and their implications for patient prognosis are analysed. Furthermore, diagnostic modalities are discussed, emphasizing advanced imaging techniques. Importantly, this review synthesizes recent evidence on therapeutic interventions, highlighting the evolving landscape of surgical and interventional approaches tailored to individual patient needs.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"500-528"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Austrian Syndrome : when Pneumococcus strikes three times]. [奥氏综合症：肺炎球菌袭击三次]。
Revue medicale de Liege Pub Date : 2026-07-01
Anne-Sophie Schwab, Vincent Collin
{"title":"[Austrian Syndrome : when Pneumococcus strikes three times].","authors":"Anne-Sophie Schwab, Vincent Collin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Austrian syndrome is characterized by the triad of pneumonia, meningitis, and endocarditis due to Streptococcus pneumoniae («pneumococcus»). Endocarditis, often occurring in the background, is frequently diagnosed late and requires prompt medical and sometimes surgical management. We report the case of a 51-year-old man admitted for confusion. The initial evaluation revealed bacterial meningitis documented by purulent cerebrospinal fluid, associated with right basal pneumonia. Blood cultures and cerebrospinal fluid cultures identified Streptococcus pneumoniae. The clinical course was marked by hemodynamic deterioration with circulatory shock, multiorgan failure, and cardiac arrhythmias, prompting the performance of transoesophageal echocardiography. This revealed aortic valve endocarditis complicated by a mitro-aortic curtain abscess and severe aortic regurgitation due to valvular perforation. Intensive care management with targeted antibiotic therapy and urgent valve surgery was required. This case illustrates the importance of systematically investigating for endocarditis in any patient with pneumococcal meningitis, particularly when pneumonia is present, to avoid diagnostic delay with potentially fatal consequences.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 7-8","pages":"428-432"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gradenigo's syndrome as a complication of acute otitis media in adolescent]. [青少年急性中耳炎伴格雷迪尼戈综合征]。
Revue medicale de Liege Pub Date : 2026-07-01
Loïs Delvaux, Sandrine Machiels, Julie Gilmaire, Yves Goffart
{"title":"[Gradenigo's syndrome as a complication of acute otitis media in adolescent].","authors":"Loïs Delvaux, Sandrine Machiels, Julie Gilmaire, Yves Goffart","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gradenigo's Syndrome is a rare but potentially serious complication of an otitis media. It associates an otitis media, along with retro-orbital pain and abducens nerve palsy. We report the case of a thirtheen-year-old female adolescent, with no particular medical history, who presented with this syndrome in the context of acute otitis media evolving over 8 days. The infection also caused a facial palsy and a mixed hearing loss. Early medical and surgical management led to a favourable outcome. This case highlights the need to keep in mind the potential neurological complications of acute otitis media, even though they have become extremely rare with the advent of antibiotic therapy.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 7-8","pages":"433-437"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pulmonary embolism following smoke inhalation]. [吸入烟雾引起肺栓塞]。
Revue medicale de Liege Pub Date : 2026-07-01
Jad Yassine, Mathias Faniel, Peter Germonpré
{"title":"[Pulmonary embolism following smoke inhalation].","authors":"Jad Yassine, Mathias Faniel, Peter Germonpré","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Carbon monoxide poisoning is one of the most common types of intoxication and is linked to a high mortality rate when not managed appropriately. We are discussing the case of a patient found unconscious after a house fire, presenting a smoke inhalation injury and particularly carbon monoxide poisoning. The clinical course was marked by the development of a massive bilateral pulmonary embolism despite thromboprophylaxis. This case highlights the increased thromboembolic risk, which can persist up to 90 days after carbon monoxide poisoning. We analyse the cardiovascular manifestations while focusing on the thromboembolic risks. Finally, we provide a brief overview of the pathophysiology and management of this condition.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 7-8","pages":"420-423"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Migration of a contraceptive implant into the pulmonary artery]. [将避孕植入物移入肺动脉]。
Revue medicale de Liege Pub Date : 2026-07-01
Pascal Finianos, Marc Radermecker, Gilles Parzibut
{"title":"[Migration of a contraceptive implant into the pulmonary artery].","authors":"Pascal Finianos, Marc Radermecker, Gilles Parzibut","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Each year, in Belgium and Europe, thousands of contraceptive implants are inserted, representing an effective and long-lasting method of contraception. Their ease of use and prolonged duration of action make them a preferred choice for many women. However, although complications are rare, they do exist. Among these, implant migration is one of the most concerning. Its incidence remains extremely low, estimated at approximately 1 case per 100,000. In most cases, this migration is asymptomatic, but it can sometimes cause alarming symptoms. These may include dyspnea, hemoptysis, or, in rare cases, potentially serious vascular injuries. Once the implant becomes endothelialized, its removal becomes more complex. In such situations, therapeutic management must be tailored to the patient's clinical profile and the precise location of the implant. Options range from active surveillance to complex surgical interventions, especially in cases where attempts at removal using endovascular techniques, such as interventional radiology, have failed.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 7-8","pages":"424-427"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Management of post-traumatic tibiotalar osteoarthritis following a failed osteosynthesis : retrograde plantar nailing]. [骨植入失败后创伤性胫跖骨关节炎的治疗：逆行足底钉]。
Revue medicale de Liege Pub Date : 2026-07-01
Marc Reda, Zoé Szecel, Grégory Lambeaux
{"title":"[Management of post-traumatic tibiotalar osteoarthritis following a failed osteosynthesis : retrograde plantar nailing].","authors":"Marc Reda, Zoé Szecel, Grégory Lambeaux","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tibiotalar osteoarthritis, uncommon and often of post-traumatic origin, leads to functional limitations, chronic pain and significantly impairs the quality of life. Both tibiotalar arthrodesis and arthroplasty have been proven effective. Tibiotalocalcaneal (TTC) arthrodesis is generally reserved for ankle osteoarthritis associated with severe degeneration of the subtalar joint and hindfoot. Nevertheless, new data showed good outcomes regardless of the subtalar joint state. We present the clinical case of an 86-year-old female patient with severe tibiotalar osteoarthritis after a failed osteosynthesis. She underwent successfully TTC arthrodesis using a retrograde intramedullary nail.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 7-8","pages":"462-466"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From clinical cases to daily practice]. 【从临床案例到日常实践】。
Revue medicale de Liege Pub Date : 2026-07-01
Patrizio Lancellotti
{"title":"[From clinical cases to daily practice].","authors":"Patrizio Lancellotti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This issue of the Revue Médicale de Liège highlights the diversity of clinical situations encountered in daily practice, ranging from life-threatening emergencies to rare complications of modern therapies. These reports emphasize the importance of rigorous clinical reasoning, multimodality imaging and multidisciplinary management in optimizing patient care and safety.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 7-8","pages":"409-410"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Femoral neck stress fracture in a young female runner]. [一例年轻女性跑步者股骨颈应力性骨折]。
Revue medicale de Liege Pub Date : 2026-07-01
Sarah Pirnay, William Kurth
{"title":"[Femoral neck stress fracture in a young female runner].","authors":"Sarah Pirnay, William Kurth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stress fractures of the femoral neck account for 2-5 % of all stress fractures in athletes, and generally affect military recruits and endurance athletes. The initial symptomatology is insidious, with atraumatic coxalgia, not always inguinal, occurring in a context of intensifying sports activity and relieved by rest. After standard X-ray, MRI is the second-line examination of choice for early diagnosis of this type of fracture. Non-surgical management consists of a period of unloading, followed by a gradual resumption of physical activity in the broad sense, and then of the activity in question. Surgical management involves osteosynthesis by triple screw fixation or Dynamic Hip Screw (DHS). If left untreated, secondary displacement may occur, with delayed or non-union callus or avascular osteonecrosis of the femoral head. These fractures are high-risk stress fractures, with a high risk of complications. This underlines the importance of correct, early diagnosis and treatment, given the potentially dramatic consequences, especially in young patients, with a long time to full recovery.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 7-8","pages":"454-461"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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