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[PARP inhibitors (poly-ADP-ribose polymerase) : newcomers in the management of prostate cancers]. [PARP抑制剂（聚adp核糖聚合酶）：前列腺癌治疗的新成员]。
Revue medicale de Liege Pub Date : 2025-09-01
Émeline Petit, Guy Jerusalem, Chloé Denis, Manon Wick, Pierre Frères, Christine Gennigens, Brieuc Sautois
{"title":"[PARP inhibitors (poly-ADP-ribose polymerase) : newcomers in the management of prostate cancers].","authors":"Émeline Petit, Guy Jerusalem, Chloé Denis, Manon Wick, Pierre Frères, Christine Gennigens, Brieuc Sautois","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review aims to describe the role of poly-ADP-ribose polymerase inhibitors (PARPi) in the treatment of metastatic castration-resistant prostate cancer (mCRPC), an aggressive and lethal form of the disease. The introduction of PARPi has led to improved prognosis, particularly in patients with at least one somatic or germline mutation in DNA damage repair genes such as BRCA1 or BRCA2. Several recent studies have shown that PARPi, used alone or in combination with abiraterone or enzalutamide, improve progression-free survival and overall survival in patients with mCRPC. However, whether the three PARPi evaluated in phase 3 trials are therapeutically equivalent, and whether combination therapies should be recommended as first-line treatment for all mCRPC patients or reserved for those carrying mutations, particularly BRCA1/2, remain to be determined.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 9","pages":"592-597"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Identification of an adenocarcinoma in the context of non-infectious paraneoplastic endocarditis]. [非感染性副肿瘤心内膜炎中腺癌的鉴定]。
Revue medicale de Liege Pub Date : 2025-07-01
Kassandra Moll, Noman Bajwa, Raluca Elena Dulgheru, Sandrine Michaux, Fréderic Lifrange, Nicolas Meurisse, Marc Radermecker
{"title":"[Identification of an adenocarcinoma in the context of non-infectious paraneoplastic endocarditis].","authors":"Kassandra Moll, Noman Bajwa, Raluca Elena Dulgheru, Sandrine Michaux, Fréderic Lifrange, Nicolas Meurisse, Marc Radermecker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Non infectious thrombotic endocarditis represent 2.5 % of negative blood culture endocarditis cases. These conditions are most often diagnosed post-mortem, but can be revealed following a complication. Among the most common causes are cancers, specifically pancreatic, pulmonary, colon and prostate adenocarcinomas. We present the case of a 59-year old woman with a diagnosis of endocarditis during an etiological assessment of stroke. She underwent aortic valve replacement due to a major embolic risk. During this etiological assessment, a hypermetabolic site was found in the pancreas on PET-scan, which turned out to be a pancreatic adenocarcinoma. Paraneoplastic non-infectious endocarditis complicates 19 % of cancers and has a poor prognosis due to late diagnosis, often revealing advanced cancer. Treatment relies on low molecular weight heparin anticoagulation, combined with treatment of the underlying cancer. We present an updated review of the literature and most recent data accounting for the formation of valve thrombus.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"512-516"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lemierre's syndrome : the invisible threat behind a simple sore throat]. [勒米尔综合症：简单的喉咙痛背后的无形威胁]。
Revue medicale de Liege Pub Date : 2025-07-01
Aline Bialas, Maxime Goffinet, Antoine Dumont, Nicolas Bleus, Marine Stoffels, Gilles Terlonge
{"title":"[Lemierre's syndrome : the invisible threat behind a simple sore throat].","authors":"Aline Bialas, Maxime Goffinet, Antoine Dumont, Nicolas Bleus, Marine Stoffels, Gilles Terlonge","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lemierre's syndrome is a growing disorder that is little known in emergency department. However, its diagnosis can prevent from a fatal outcome. It is a septic venous thrombosis of the neck complicating an acute oropharyngeal infection, and can give rise to multiple septic emboli. It most often occurs among young, healthy patients in the aftermath of bacterial angina, a condition which is frequently encountered in daily practice. The aim of this article is to explain this syndrome to clinicians so that they know when to look for it, how to diagnose it and what its therapeutic implications are.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"549-552"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tularemia in Belgium : A zoonotic disease more common than you might think]. [比利时的兔热病：一种比你想象的更常见的人畜共患疾病]。
Revue medicale de Liege Pub Date : 2025-07-01
Vincent Infantino, Jean-Baptiste Giot, Raphaël Schils
{"title":"[Tularemia in Belgium : A zoonotic disease more common than you might think].","authors":"Vincent Infantino, Jean-Baptiste Giot, Raphaël Schils","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tularemia, a zoonosis caused by Francisella tularensis, is highly virulent and classified as a category A bioterrorism agent. Although rare in Belgium, tularemia is likely underdiagnosed, due to its frequent unfamiliarity among clinicians. This article reports two cases treated at the University Hospital of Liège. The first case involves a 61-year-old man presenting with oropharyngeal symptoms and cervical lymphadenopathy, diagnosed after the failure of conventional antibiotic treatments and confirmed by PCR. The second case concerns a 70-year old woman with systemic symptoms and mediastinal lymphadenopathy, initially suspected to be neoplastic, before tularemia was confirmed by serology and PCR. Without treatment, tularemia can become chronic and debilitating, and lead to complications such as suppuration of lymph nodes. Besides describing the two clinical cases, we will cover the epidemiology, diagnosis, and treatment of the disease. Early recognition of tularemia remains challenging due to the lack of awareness among clinicians and the diverse clinical manifestations of the disease.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"500-505"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Visual impairment related to an isolated paracentral cotton wool spot revealing an atypical presentation of Bartonella henselae retinitis]. [与孤立的中心旁棉毛斑相关的视力损害，显示非典型表现 亨selae巴尔通体视网膜炎]。
Revue medicale de Liege Pub Date : 2025-07-01
Martin Vantomme, Pauline Sambon, Grégory Laruelle, Anouchka De Fays, Alexandre Léonard, Éric Deflandre
{"title":"[Visual impairment related to an isolated paracentral cotton wool spot revealing an atypical presentation of Bartonella henselae retinitis].","authors":"Martin Vantomme, Pauline Sambon, Grégory Laruelle, Anouchka De Fays, Alexandre Léonard, Éric Deflandre","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cat scratch disease is a bacterial infection due to Bartonella henselae. The microbial agent is most frequently transmitted to humans through a scratch or bite of an infected cat. Ocular involvement occurs in approximately 6% of human infections. We report the case of a healthy 27-year old patient presenting with unilateral scotoma. Multimodal imaging revealed an isolated cotton wool spot (CWS) with no other inflammatory signs on ophthalmological examination. Medical history was unremarkable, although the patient reported living with a cat. Biological and cardiovascular evaluations were normal, except for evidence of recent Bartonella henselae infection. Follow up showed significant resolution of the CWS under antibiotic treatment along with a reduction of the subjective scotoma. Cat scratch disease may cause different ocular manifestations such as uveitis, choroiditis, neuroretinitis, Parinaud oculoglandular syndrome, exudative maculopathy or retinal vascular occlusions. Based on our literature review, an isolated CWS as the sole sign of cat scratch disease is a very rare presentation. Eye care professionals should be aware of this atypical presentation in order to investigate and treat properly those patients.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"539-544"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[MIRM (Mycoplasma pneumoniae-Induced Rash and Mucositis), a little known entity]. [MIRM（肺炎支原体引起的皮疹和粘膜炎），一个鲜为人知的实体]。
Revue medicale de Liege Pub Date : 2025-07-01
Céline Conard, Xavier Bertrand, Charlotte Doalto
{"title":"[MIRM (Mycoplasma pneumoniae-Induced Rash and Mucositis), a little known entity].","authors":"Céline Conard, Xavier Bertrand, Charlotte Doalto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mycoplasma pneumoniae is a common respiratory infection, principally in children and young adults. Approximately 25 % of the cases present extrapulmonary signs such as skin and mucous rashes. In 2015, MIRM (Mycoplasma pneumoniae-Induced Rash and Mucositis) was individualized as a new entity. The clinical case of a 20-year old man is presented with atypical pneumonia and majormucositis.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"478-482"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cardiac arrest secondary to thyroid storm]. [甲状腺风暴引起的心脏骤停]。
Revue medicale de Liege Pub Date : 2025-07-01
David Napolitano, Vinciane Corman, Xavier Bertrand
{"title":"[Cardiac arrest secondary to thyroid storm].","authors":"David Napolitano, Vinciane Corman, Xavier Bertrand","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thyroid storm is a rare but severe complication of thyrotoxicosis, posing a life-threatening risk to patients. The causes are numerous, ranging from Graves' disease and toxic goiter to amiodarone use or even following trauma. In the event of a thyroid storm, clinical manifestations may be multiple. Cardiovascular complications are the most critical and may lead to cardio-respiratory arrest. This clinical entity is difficult to diagnose, often resulting in delayed management. In addition to symptomatic management, treatment primarily includes antithyroid drugs and beta-blockers as well in case of thyroid storm glucocorticoids to block the conversion of T4 to T3. Thyroid surgery or radioactive iodine therapy are also part of the therapeutic armamentarium. Hemodynamic support via extracorporeal membrane oxygenation (ECMO) may be considered in cases of collapse. Given the severity of thyroid storm, it is essential to consider this diagnosis in any patient presenting with symptoms compatible with hyperthyroidism.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"522-528"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Post-traumatic cyclodialysis clefts]. [创伤后睫状体透析唇裂]。
Revue medicale de Liege Pub Date : 2025-07-01
Cyril Bourguignon, Maxime Dequinze, Sophie Marchand
{"title":"[Post-traumatic cyclodialysis clefts].","authors":"Cyril Bourguignon, Maxime Dequinze, Sophie Marchand","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cyclodialysis cleft is a rare complication (2 %) in the spectrum of blunt trauma presenting ocular hypotony. This is a separation between the ciliary body and the sclera. This results in the formation of a new space between the anterior chamber and a suprachoroidal space, often inducing major ocular hypotony. Treatment requires medical treatment or even surgical treatment for severe cases. A certain degree of recession of the iridocorneal angle could persist after closure of the cleft of cyclodialysis, causing at short- or at long-term ocular hypertonia.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"473-477"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Metronidazole-induced neurotoxicity]. [Metronidazole-induced神经毒性)。
Revue medicale de Liege Pub Date : 2025-07-01
Julia Tebache, Maxime Gudelj
{"title":"[Metronidazole-induced neurotoxicity].","authors":"Julia Tebache, Maxime Gudelj","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Metronidazole, an antiparasitic treatment with bactericidal activity, may be neurotoxic. The exact pathophysiology of this complication is unknown. While it is related to the cumulative dose, it does vary from patient to patient. We are describing the case of a 43-year-old woman, who was admitted into the hospital for treatment of a liver abscess and an ascitic fluid infection. This patient presented with cerebellar syndrome and motor slowing 29 days after starting metronidazole. Cerebral MRI showed a FLAIR hypersignal of the dentate nuclei without associated enhancement or diffusion restriction. This is typical of metronidazole toxic encephalopathy. Treatment had to be stopped. The patient's clinical course rapidly improved. A follow-up MRI scan after 10 days showed the complete resolution of dentate nuclei lesions.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"545-548"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prolonged fever in an adolescent with a positive blood culture : is it a chronic meningococcemia ?] [青少年血培养阳性持续发热：是慢性脑膜炎球菌血症吗？]
Revue medicale de Liege Pub Date : 2025-07-01
Caroline Hardy, Catherine Vandendaele
{"title":"[Prolonged fever in an adolescent with a positive blood culture : is it a chronic meningococcemia ?]","authors":"Caroline Hardy, Catherine Vandendaele","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the case of a 15-year old boy admitted for febrile episodes lasting over 4 months without any other clinical signs. On the basis of a positive blood culture, chronic Neisseria meningitidis bacteremia, without associated meningitis, was highly suspected. Further work-up revealed no immunosuppression or terminal complement deficiency. A 7-day intravenous treatment of ceftriaxone resulted in complete recovery. This case highlights chronic Neisseria meningitidis as a rarely encountered pathology and describes an atypical presentation, compared with descriptions in the literature.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"80 7-8","pages":"496-499"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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