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[Metastatic or recurrent cervical cancer : current management and therapeutic perspectives]. 转移性或复发性宫颈癌：目前的管理和治疗观点。
Revue medicale de Liege Pub Date : 2026-10-01
Lysa Goffinet, Alizée Lebeau, Élodie Gonne, Denis Danthine, Pierre Lovinfosse, Éleonore Partoune, Athanasios Kakkos, Frédéric Goffin, Lionel Navez, Frédéric Kridelka, Christine Gennigens
{"title":"[Metastatic or recurrent cervical cancer : current management and therapeutic perspectives].","authors":"Lysa Goffinet, Alizée Lebeau, Élodie Gonne, Denis Danthine, Pierre Lovinfosse, Éleonore Partoune, Athanasios Kakkos, Frédéric Goffin, Lionel Navez, Frédéric Kridelka, Christine Gennigens","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cervical cancer is the fourth most common cancer in women. Despite advances in screening and vaccination against human papillomavirus (HPV), some patients are still initially diagnosed at a metastatic stage, while others subsequently develop a disseminated disease, associated with a particularly poor prognosis. Until recently, first-line treatment was only based on platinum-based chemotherapy combined, in the absence of contraindications, with bevacizumab, a monoclonal antibody that inhibits angiogenesis. However, this approach has recently evolved with the introduction of immunotherapy and the development of other innovative therapies currently under study, offering hope for improving survival in these patients.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 10","pages":"562-568"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chlormequat chloride poisoning]. [氯草枯中毒]。
Revue medicale de Liege Pub Date : 2026-09-01
Simon Sente, Pierre Milet
{"title":"[Chlormequat chloride poisoning].","authors":"Simon Sente, Pierre Milet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In Europe, cases of deliberate pesticide poisoning are rare and account for only a small percentage (around 4 %) of total suicides. This ratio differs greatly from that in developing countries. Agricultural populations and rural residents are more vulnerable. Symptoms vary depending on the type of pesticides and the route of administration, ranging from mild irritation to serious and potentially fatal neurological consequences. This article discusses the case of a 60-year-old man who administered Cycocel®, a growth regulator used in agriculture, intramuscularly. This poisoning induces a cholinergic crisis via direct action on nicotinic and muscarinic receptors but does not result in inhibition of cholinesterase activity, unlike organophosphate poisoning.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"496-499"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Perioperative management of antithrombotic medications in preparation for a locoregional anesthesia technique in patients coming from home to the hospital: the state of play]. [从家到医院的患者在局部麻醉技术准备阶段抗血栓药物的围手术期管理：现状]。
Revue medicale de Liege Pub Date : 2026-09-01
Murielle Lamy, Jean-Pierre Lecoq, Vincent Bonhomme
{"title":"[Perioperative management of antithrombotic medications in preparation for a locoregional anesthesia technique in patients coming from home to the hospital: the state of play].","authors":"Murielle Lamy, Jean-Pierre Lecoq, Vincent Bonhomme","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Locoregional anesthesia (LRA) techniques play an important role in the perioperative management of patients, providing benefits in terms of analgesia and postoperative recovery. Their main risk is hematoma, which is rare but potentially devastating, particularly during neuraxial techniques and deep peripheral nerve blocks. In patients receiving antithrombotic medications, this risk is higher. Recent recommendations on the management of these antithrombotic agents in the context of LRA distinguish between superficial blocks, which are at low risk, and deep or neuraxial blocks, for which drug-induced coagulopathies require appropriate interruption of treatment. This narrative review describes the preoperative discontinuation times of antithrombotic medications in patients coming from home, before neuraxial or deep peripheral LRA. These delays vary depending on the molecules, their dose, as well as the age, weight and renal function of patients. The different classes of antithrombotic medications and medicinal plants are considered. Possible antidotes will be discussed but have no indication to authorize an elective LRA. In the absence of absolute consensus, the discontinuation of antithrombotic medications before an LRA must be individualized, according to the type of surgery, block, treatment, age and comorbidities. The risk/benefit ratio guides the decision.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"507-514"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[More precise, not simpler]. [更精确，而不是更简单]。
Revue medicale de Liege Pub Date : 2026-09-01
Patrizio Lancellotti
{"title":"[More precise, not simpler].","authors":"Patrizio Lancellotti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This issue of the Revue Médicale de Liège brings together diverse contributions reflecting the reality of clinical practice, from rare conditions and emergencies to chronic diseases and organizational innovations. Beyond this diversity, a common thread emerges: the need for rigorous assessment and individualized care, integrating scientific evidence, clinical experience and patient expectations.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"483-484"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Type 1 diabetes, towards new horizons]. [1型糖尿病，迈向新视野]。
Revue medicale de Liege Pub Date : 2026-09-01
Madeleine Wéra, Juliette Rulmont, Nicolas Paquot, Régis Radermecker
{"title":"[Type 1 diabetes, towards new horizons].","authors":"Madeleine Wéra, Juliette Rulmont, Nicolas Paquot, Régis Radermecker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β-cells, leading to lifelong insulin dependence. Although significant advances have been made in insulin therapy and glucose monitoring, these approaches are implemented at a late stage of the disease, when β-cell destruction is already well underway. Recent advances in the understanding of its pathophysiology have highlighted the complexity of interactions between genetic, environmental, and immunological factors, as well as the existence of distinct endotypes that may influence disease progression. These developments have paved the way for innovative therapeutic strategies aimed at modulating the immune response at early stages of the disease to preserve residual β-cell function. Maintaining endogenous insulin secretion may help delay disease progression and improve clinical outcomes. These new approaches mark a paradigm shift in the management of type 1 diabetes, moving from a purely substitutive strategy toward a preventive and disease-modifying approach.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"515-520"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Exceptional cardiopulmonary triad revealing an endometrial stromal sarcoma]. [异常心肺三联征显示子宫内膜间质肉瘤]。
Revue medicale de Liege Pub Date : 2026-09-01
Ludovic Miserotti, Raluca Elena Dulgheru, Patrizio Lancellotti
{"title":"[Exceptional cardiopulmonary triad revealing an endometrial stromal sarcoma].","authors":"Ludovic Miserotti, Raluca Elena Dulgheru, Patrizio Lancellotti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 27-year-old woman presented with right proximal pulmonary embolism associated with thrombosis of the right inferior pulmonary vein extending into the left atrium as an atrial mass. The etiological work-up revealed a BCOR-rearranged endometrial stromal sarcoma. Clinical evolution was favorable under anticoagulation, except for the atrial lesion, whose thrombotic or tumoral nature could not be definitively established despite multimodality imaging. This clinical case highlights the limitations of noninvasive characterization of intracardiac masses in an oncologic setting and their impact on therapeutic decision-making.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"485-487"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparison of multidisciplinary spine rehabilitation programs for patients with chronic low back pain in French-speaking Belgium]. [比利时法语区慢性腰痛患者多学科脊柱康复方案的比较]。
Revue medicale de Liege Pub Date : 2026-09-01
Christophe Demoulin, Anaëlle Lucas, Morgane Jan, Marc Vanderthommen, Jean-François Kaux, Stéphanie Grosdent
{"title":"[Comparison of multidisciplinary spine rehabilitation programs for patients with chronic low back pain in French-speaking Belgium].","authors":"Christophe Demoulin, Anaëlle Lucas, Morgane Jan, Marc Vanderthommen, Jean-François Kaux, Stéphanie Grosdent","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic low back pain is one of the leading causes of disability worldwide and generates substantial socioeconomic costs. In Belgium, a specific reimbursement framework allows hospitals to offer multidisciplinary rehabilitation programs consisting of 36 sessions. The aim of this study is to compare the structure and content of the programs offered in French-speaking Belgian centers and to assess the degree of heterogeneity among these programs. A descriptive cross-sectional study was conducted using semi-structured interviews with the centers. Of the 37 centers contacted, 31 participated (83.8 %). Despite the presence of common components, significant variability was observed in the organization of the programs, particularly regarding session assessment, the number of hours devoted to education and physical reconditioning, and the content of the sessions. These results highlight the need for greater harmonization of practices in order to optimize patient care and facilitate multicenter research.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"543-549"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluation of the use of virtual reality hypnosis during Port-a-cath® placement in adult oncology patients as an effective alternative to intravenous sedation : a pilot study]. [评估成人肿瘤患者在Port-a-cath®放置期间使用虚拟现实催眠作为静脉镇静的有效替代：一项试点研究]。
Revue medicale de Liege Pub Date : 2026-09-01
Virginie Van Boeckel, Catherine Kestens, Claudia Charry, Jean-François Maillart
{"title":"[Evaluation of the use of virtual reality hypnosis during Port-a-cath® placement in adult oncology patients as an effective alternative to intravenous sedation : a pilot study].","authors":"Virginie Van Boeckel, Catherine Kestens, Claudia Charry, Jean-François Maillart","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Virtual reality hypnosis (VRH) is a promising tool for managing pain and anxiety during medical procedures. This study evaluated the feasibility of using VRH instead of intravenous sedation (IVS) for implanting a Port-a-cath® (PAC) under local anesthesia in oncology patients. Methods : twenty adults were randomly assigned to receive either IVS (n = 10) or VRH (n = 10) during the procedure. The primary outcome was the successful implantation of the PAC, while secondary outcomes included the need for rescue medication, procedure duration and levels of anxiety. PAC implantation was successful in all patients, with no significant differences in perceived or actual procedure duration between groups. All IVS patients required sedation without rescue medication, while only one patient in the VRH group requested rescue medication. There was no significant difference in procedural anxiety reduction between the two groups and no post-operative complications were reported. VRH is a feasible and safe alternative to IVS for PAC placement under local anesthesia in oncology patients. This innovative tool may become essential in clinical practice by avoiding the potential side effects associated with pharmacological sedation while ensuring a similar patient experience.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"521-527"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Anaphylaxis to MMR vaccine gelatin : practical recommendations]. [对MMR明胶疫苗的过敏反应：实用建议]。
Revue medicale de Liege Pub Date : 2026-09-01
Mihai Iordachescu, Kamal El Abd
{"title":"[Anaphylaxis to MMR vaccine gelatin : practical recommendations].","authors":"Mihai Iordachescu, Kamal El Abd","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article reports two pediatric cases of anaphylaxis to the M-M-RVaxPro® vaccine, attributable to porcine gelatin used as a stabilizer (14.5 mg/dose). Both patients developed severe reactions after the booster dose, with positive skin and blood tests for gelatin. The first case had hereditary alpha-tryptasemia as an aggravating factor. Investigations ruled out the responsibility of neomycin, latex, and chlorhexidine. Key recommendations include avoidance of gelatin-containing vaccines and medications, substitution with gelatin-free alternatives (Priorix®), evaluation of food tolerance through an oral challenge test, and provision of an emergency kit with epinephrine. Hospital monitoring is recommended for future vaccinations in patients with mast cell disorders. The study highlights gelatin as the primary culprit in vaccine anaphylaxis, emphasizing the importance of systematic testing for vaccine components and proper management of sensitized patients.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"528-535"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Major depressive episode with psychotic features and vitamin B12 deficiency : a neuropsychiatric interplay]. [伴有精神病特征和维生素B12缺乏症的重度抑郁发作：神经精神的相互作用]。
Revue medicale de Liege Pub Date : 2026-09-01
Lisa Meyers, Catherine Piette, Gabrielle Scantamburlo
{"title":"[Major depressive episode with psychotic features and vitamin B12 deficiency : a neuropsychiatric interplay].","authors":"Lisa Meyers, Catherine Piette, Gabrielle Scantamburlo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Psychotic depression is a high-risk clinical entity associated with increased morbidity, mortality, and suicide risk, yet it remains frequently underdiagnosed. We report the case of a patient hospitalized for a depressive episode that evolved into psychotic symptoms and a catatonic episode in the context of vitamin B12 deficiency without anemia. This case highlights the difficulty of differentiating psychotic depression from neuropsychiatric manifestations related to cobalamin deficiency, which may mimic, trigger, or exacerbate depressive, psychotic, and catatonic symptoms. Diagnostic investigations revealed vitamin B12 malabsorption associated with neurological involvement. Combined treatment with vitamin B12 supplementation and antidepressant-antipsychotic therapy led to clinical improvement. This vignette underscores the importance of targeted screening for vitamin B12 deficiency in atypical, treatment-resistant, or neurologically associated psychiatric presentations.</p>","PeriodicalId":94201,"journal":{"name":"Revue medicale de Liege","volume":"81 9","pages":"550-556"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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