[Rhino-sinusal mucormycosis in a solid organ transplant recipient].

Revue medicale de Liege Pub Date : 2025-07-01
Lucie Moulan, Philippe Léonard, Marie-Pierre Hayette, Nancy Detrembleur, Catherine Bonvoisin, Laurent Weekers, Florence Rogister, François Jouret, Antoine Bouquegneau
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引用次数: 0

Abstract

We report on a 46-year-old female patient with a recent history of kidney transplantation who presented with acute sinusitis. Further investigation revealed rhino-sinusal mucormycosis. Surgical debridement and a five-month antifungal treatment along with the cessation of the immunosuppressive therapy were needed. This approach led to clinical improvement but unfortunately resulted in the loss of the allograft. More than two years after this infection, the clinical and endoscopic outcomes remain favourable. Mucormycosis is a rare opportunistic infection caused by fungi of the Mucorales order, characterized by angio-invasive properties that lead to thrombosis, necrosis and infarction of the affected tissues. Diagnosis primarily relies on imaging, microbiological studies and histopathological examination. Early detection and prompt management are crucial given the poor prognosis of mucormycosis. Treatment involves a combination of surgical debridement, antifungal therapy and management of risk factors such as immunosuppression. Despite an appropriate treatment, mucormycosis remains a serious and potentially life-threatening condition.

[实体器官移植受者的鼻-鼻窦毛霉菌病]。
我们报告一个46岁的女性患者近期肾移植史谁提出急性鼻窦炎。进一步调查发现鼻-鼻窦毛霉病。需要手术清创和5个月的抗真菌治疗,同时停止免疫抑制治疗。这种方法导致临床改善,但不幸的是导致同种异体移植物的丢失。感染后两年多,临床和内窥镜检查结果仍然良好。毛霉菌病是由毛霉菌目真菌引起的一种罕见的机会性感染,其特征是血管侵入性,导致受影响组织的血栓形成、坏死和梗死。诊断主要依靠影像学、微生物学研究和组织病理学检查。鉴于毛霉病预后不良,早期发现和及时治疗至关重要。治疗包括手术清创、抗真菌治疗和免疫抑制等危险因素的管理。尽管进行了适当的治疗,毛霉病仍然是一种严重的、可能危及生命的疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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