Carbohydrate Research最新文献_第4页

Synthesis and characterization of coumarin containing fluorescent sugar based gelators 含香豆素荧光糖凝胶的合成与表征

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-14 DOI: 10.1016/j.carres.2025.109526

Guijun Wang, Surya B. Adhikari, Pramod Aryal, Ifeanyi Okafor, Anji Chen, Anna Duffney

{"title":"Synthesis and characterization of coumarin containing fluorescent sugar based gelators","authors":"Guijun Wang, Surya B. Adhikari, Pramod Aryal, Ifeanyi Okafor, Anji Chen, Anna Duffney","doi":"10.1016/j.carres.2025.109526","DOIUrl":"10.1016/j.carres.2025.109526","url":null,"abstract":"<div><div>Carbohydrate based self-assembling systems containing coumarin functional groups are interesting class of materials. The unique fluorescence properties can be useful for many practical applications especially as biological probes. Coumarin containing low molecular weight gelators are especially interesting compounds with great potentials for new advanced molecular systems with multiple functions. We have synthesized and characterized a series of eleven coumarin based glucose and glucosamine derivatives. The structures of these compounds are based on the existing good performing supramolecular gelators through rational designs. These include three coumarin derivatives linked to anomeric positons of per-acetylated D-glucose and D-glucosamine via 1,2,3-triazole linkage , and eight4,6-benzylidene acetal protected D-glucosamine derivatives with various coumarin moieties attached to the C-2 positions through several different linkers. The gelation properties and fluorescence properties of these novel coumarin derivatives are studied and several self-assembling coumarin derivatives are also molecular gelators, which may have wide range of applications.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"554 ","pages":"Article 109526"},"PeriodicalIF":2.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in synthesis of carbohydrate-based surfactants: Comprehensive review and future perspective 碳水化合物表面活性剂合成研究进展综述及展望

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-14 DOI: 10.1016/j.carres.2025.109521

Raju R. Kale , Nitin K. Jadhav , Sanchayita Rajkhowa , Bhausaheb B. Muntode , Vikram A. Dhere , Nitin D. Gaikwad , Vaishali S. Shinde

{"title":"Recent advances in synthesis of carbohydrate-based surfactants: Comprehensive review and future perspective","authors":"Raju R. Kale , Nitin K. Jadhav , Sanchayita Rajkhowa , Bhausaheb B. Muntode , Vikram A. Dhere , Nitin D. Gaikwad , Vaishali S. Shinde","doi":"10.1016/j.carres.2025.109521","DOIUrl":"10.1016/j.carres.2025.109521","url":null,"abstract":"<div><div>This review aims to explore the rapid development of carbohydrate-based surfactants (CBS) as sustainable, biocompatible, and eco-friendly alternatives to conventional petrochemical-derived surfactants. It aims to assess how CBS, derived from renewable resources, are redefining the landscape of surfactant technologies in the context of increasing global demand for environmentally responsible materials. The review presents a comprehensive analysis of recent innovations in the synthesis of CBS, focusing on strategies that utilize abundant carbohydrate-rich feedstocks such as cellulose, pectin, hemicellulose, and starch. It discusses the physicochemical principles underlying CBS design and examines current synthesis approaches, structural modifications, and functional performance trends. The findings highlight that the unique amphiphilic nature of CBS facilitates the formation of stable emulsions, micelles, and other self-assembled systems critical for industrial and biomedical applications. These advances demonstrate CBS's growing utility and versatility and underscore their potential as green, multifunctional materials poised to play a significant role in future sustainable technologies. This review concisely delves into the most recent synthetic developments in carbohydrate-based surfactants (CBS), particularly emphasizing molecular design strategies that exploit the inherent structural diversity and functionality of renewable carbohydrate feedstocks and also highlights emerging structure-function paradigms and delineates future directions for scalable, bio-based surfactant design in industrial and biomedical sectors.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"554 ","pages":"Article 109521"},"PeriodicalIF":2.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous one-pot multienzymatic synthesis and purification of Uridine-5′-Diphosphate-α-D-glucuronide and Uridine-5′-Diphosphate-α-d-xylose 尿苷-5′-二磷酸-α-d-葡萄糖醛酸和尿苷-5′-二磷酸-α-d-木糖的单锅多酶同时合成纯化

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-13 DOI: 10.1016/j.carres.2025.109516

Arnaud Pâris, Tiffany Rundstadler , Pierre Lafite

引用次数: 0

Building block approach for the convenient synthesis of resorcinol alkyl C-glucoside 构建块法合成间苯二酚烷基c -葡萄糖苷

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-12 DOI: 10.1016/j.carres.2025.109522

Amudala Subramanyam, Sumit, Indrapal Singh Aidhen

引用次数: 0

Detection of the unique sugars virenose and dihydrohydroxystreptose from Coxiella burnetii using alditol acetylation and liquid chromatography mass spectroscopy 糖醇乙酰化和液相色谱质谱法检测伯纳氏考克氏菌中独特的病毒糖和二氢羟基链糖

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-10 DOI: 10.1016/j.carres.2025.109524

Lawrence Webb , Stephen R. Graves , John Stenos , Karren M. Plain , Xavier A. Conlan

引用次数: 0

Novel polysaccharide-based fluorescent polymer drug delivery systems with natural extracts for squamous cell carcinoma treatment 含天然提取物的新型多糖类荧光高分子药物传递系统用于治疗鳞状细胞癌

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-10 DOI: 10.1016/j.carres.2025.109525

Jianchuan Wu, Kun Yang, Jinfan Zhou, Lincen He, Yujie Zhou, Bei Yu

{"title":"Novel polysaccharide-based fluorescent polymer drug delivery systems with natural extracts for squamous cell carcinoma treatment","authors":"Jianchuan Wu, Kun Yang, Jinfan Zhou, Lincen He, Yujie Zhou, Bei Yu","doi":"10.1016/j.carres.2025.109525","DOIUrl":"10.1016/j.carres.2025.109525","url":null,"abstract":"<div><div>This study introduces a novel synthesis method for a new coordination polymer (CP) based on N-donor and O-donor organic ligands. The polymer, with the chemical formula <strong>Co(ptda)(bib)</strong> (where <strong>H<sub>2</sub>pdta = 5'-(pyridine-2-yl)-[1,1':3′,1′-terphenyl]-4,4′-dicarboxylic acid</strong>, <strong>bib = 4,4′-bis(1-imidazolyl) biphenyl</strong>), was synthesized via solvothermal methods. The structure of the polymer was characterized using <strong>single-crystal X-ray diffraction</strong> and <strong>elemental analysis</strong>. Subsequently, a biodegradable polymer-based drug delivery system was constructed, consisting of <strong>polyvinyl alcohol (PVA)</strong> and <strong>polygalacturonic acid (PGA)</strong>, with potential biomedical applications. For this purpose, <strong>PVA-PGA</strong> was utilized as the carrier shell in the development of a drug delivery system for <strong>compound 1</strong> and <strong>Brazilin-loaded CP1</strong> (<strong>PVA-PGA@CP1@1@Brazilin</strong>). The potential of <strong>PVA-PGA@CP1@1@Brazilin</strong> as a drug delivery carrier was explored, highlighting its distinct advantages. Furthermore, <strong>in vitro cell experiments</strong> were conducted to evaluate the therapeutic efficacy of <strong>PVA-PGA@CP1@1@Brazilin</strong> in the treatment of <strong>squamous cell carcinoma (SCC)</strong>, offering a promising approach for targeted SCC therapy and providing a novel strategy for clinical development.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"554 ","pages":"Article 109525"},"PeriodicalIF":2.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-assisted click synthesis of levoglucosan triazolyl glycoconjugates using ascorbyl palmitate sodium salt (Asp-Na) as a green Co-catalyst

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-10 DOI: 10.1016/j.carres.2025.109511

Nishant Pandey , Pratibha Dwivedi , Alisha , Bhuwan B. Mishra

引用次数: 0

Analysis of CD22 cis-ligands using a synthetic sialoside binding to CD22 with ultra-high affinity 利用合成涎苷结合CD22的超高亲和力分析CD22顺式配体

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-09 DOI: 10.1016/j.carres.2025.109519

Amin Alborzian Deh Sheikh , Wang Long , Naoko Matsubara , Takeshi Futamura , Akihiro Imamura , Hiromune Ando , Shiho Ohno , Hajjaj H.M. Abdu-Allah , Hiromu Takematsu , Masatake Asano , Yoshiki Yamaguchi , Hideharu Ishida , Takeshi Tsubata

{"title":"Analysis of CD22 cis-ligands using a synthetic sialoside binding to CD22 with ultra-high affinity","authors":"Amin Alborzian Deh Sheikh , Wang Long , Naoko Matsubara , Takeshi Futamura , Akihiro Imamura , Hiromune Ando , Shiho Ohno , Hajjaj H.M. Abdu-Allah , Hiromu Takematsu , Masatake Asano , Yoshiki Yamaguchi , Hideharu Ishida , Takeshi Tsubata","doi":"10.1016/j.carres.2025.109519","DOIUrl":"10.1016/j.carres.2025.109519","url":null,"abstract":"<div><div>CD22 (also known as Siglec-2), an inhibitory receptor expressed in B lymphocytes (cells), recognizes the glycan structure α2,6-sialylated <em>N</em>-acetyllactosamine, and constitutively associates with various α2,6-sialylated membrane proteins expressed on the same cell (<em>cis</em>-ligands) although CD22 can bind to α2,6-sialylated molecules expressed in other cells (<em>trans</em>-ligands). The inhibitory activity of CD22 is regulated by the <em>cis</em>-ligands, and CD22 regulates B cells through the <em>cis</em>-ligands. Because of fast dissociation kinetics of the binding of CD22 with the ligands, systematic identification of CD22 ligands is not possible by conventional methods such as immunoprecipitation. Previously, we showed that proximity labeling using tyramide efficiently labels CD22-associated molecules. However, whether this association depends on the recognition of sialic acid by CD22 needs to be demonstrated to identify the <em>cis</em>-ligands. Here we develop the synthetic sialoside GSC-932 in which modification of the C5 position of the sialic acid core with a guanidyl group improves the affinity to mouse CD22 by 50 folds probably by generating the interaction of the guanidyl group with several amino acid residues in mouse CD22 such as E136 and R137, thereby efficiently inhibiting the binding of mouse CD22 with the α2,6-sialylated ligands. Application of GSC-932 to the proximity labeling clearly distinguishes sialic acid-dependent association with CD22 and shows that CD22 associates with a variety of <em>cis</em>-ligands. GSC-932 may be a useful tool to study ligand interaction of CD22.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"554 ","pages":"Article 109519"},"PeriodicalIF":2.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivalent Siglec ligands 多价Siglec配体

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-09 DOI: 10.1016/j.carres.2025.109520

Roland J. Pieters

引用次数: 0

From structure to function: Decoding peptidoglycan O-acetylation in pathogenic bacteria 从结构到功能：解码致病菌中的肽聚糖o -乙酰化

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-05-09 DOI: 10.1016/j.carres.2025.109517

Alexander C. Anderson , Tyler Malloch , Anthony J. Clarke

引用次数: 0