Carbohydrate Research最新文献_第4页

Selenocyanate-functionalized chitosan derivatives: Preparation, characterization, and evaluation of antioxidant activity 硒氰酸酯功能化壳聚糖衍生物：制备、表征和抗氧化活性评价

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-03-01 Epub Date: 2025-12-22 DOI: 10.1016/j.carres.2025.109807

Linqing Wang , Xiangru Han , Bing Ma , Yuting Yuan , Lijie Wei , Jingjing Zhang , Yingqi Mi , Zhanyong Guo , Fang Dong

{"title":"Selenocyanate-functionalized chitosan derivatives: Preparation, characterization, and evaluation of antioxidant activity","authors":"Linqing Wang , Xiangru Han , Bing Ma , Yuting Yuan , Lijie Wei , Jingjing Zhang , Yingqi Mi , Zhanyong Guo , Fang Dong","doi":"10.1016/j.carres.2025.109807","DOIUrl":"10.1016/j.carres.2025.109807","url":null,"abstract":"<div><div>This work describes the preparation of chitosan derivatives grafted with selenocyanate functional groups through a nucleophilic substitution reaction, with the objective of improving both their water solubility and antioxidant performance. Organic selenocyanate compounds were generated by reacting nicotinic acid and isonicotinic acid derivatives with 3-selenocyanatopropylamine, which were subsequently grafted onto chitosan molecules through nucleophilic substitution. The structures of the derivatives and their selenium content were characterized using Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (<sup>1</sup>H NMR), and inductively coupled plasma mass spectrometry (ICP-MS). <em>In vitro</em> evaluation confirmed the superior antioxidant activity of the synthesized derivatives. Specifically, they exhibited excellent DPPH radical scavenging rates of over 70 % at 0.4 mg/mL, indicating a significant enhancement compared to native chitosan. Cytotoxicity assays (MTT method) indicated that most derivatives possessed good biocompatibility. In particular, derivatives 3a, 3b, 3f, and 4c showed cell viability rates above 80 % within the tested concentration range, suggesting their potential as novel antioxidants and selenium supplements. This study offers a novel approach to broaden the utilization of chitosan in food, nutraceutical, and pharmaceutical applications.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"561 ","pages":"Article 109807"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145838689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water-soluble conjugates with antitumor activity from starch, phenolic antioxidant and calcium salt 淀粉、酚类抗氧化剂和钙盐的水溶性抗肿瘤结合物。

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-03-01 Epub Date: 2025-12-22 DOI: 10.1016/j.carres.2025.109806

V.V. Spiridonov , M.A. Torlopov , I. Yu Chukicheva , A.V. Kutchin , D.V. Pozdyshev , V.I. Muronetz , A.A. Yaroslavov

引用次数: 0

Structural analysis, pharmacological mechanism, pharmaceutics, and comparison of differences between raw and processed product of polysaccharide from Rehmannia glutinosa: A review 地黄多糖的结构分析、药理机制、药理作用及生制品与加工制品的差异比较

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-03-01 Epub Date: 2025-12-15 DOI: 10.1016/j.carres.2025.109794

Chunni Zhao , Lianyuan Tang , Xin Guo , Huan Liang , Ding Tian , Mei Zhang

{"title":"Structural analysis, pharmacological mechanism, pharmaceutics, and comparison of differences between raw and processed product of polysaccharide from Rehmannia glutinosa: A review","authors":"Chunni Zhao , Lianyuan Tang , Xin Guo , Huan Liang , Ding Tian , Mei Zhang","doi":"10.1016/j.carres.2025.109794","DOIUrl":"10.1016/j.carres.2025.109794","url":null,"abstract":"<div><div><em>Rehmannia glutinosa</em> (RG) is a widely used medicinal plant, which was included in China's Medicine Food Homology list in 2024. <em>Rehmannia glutinosa</em> polysaccharide (RGP) is one of the primary and most representative pharmacologically active macromolecules of RG, which has been shown in numerous in vitro and in vivo pharmacological studies to exhibit a variety of pharmacological activities, including immunological regulation, intestinal protection, anti-osteoporosis, anti-anemia, liver and kidney protection, anti-hyperthyroidism, reproductive protection, treatment of cataract, anti-anxiety, anti-aging, and anti-mutagenic properties. To support their therapeutic potential and health functions, this review aims to thoroughly and methodically sort the information on the structural characteristics, biological activities and potential mechanisms of action, pharmaceutics research, and differences between raw and processed RGP. At the same time, it offers fresh, insightful information for further RGP research in the areas of medicinal agents and functional foods.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"561 ","pages":"Article 109794"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural diversity of cyclodextrin metal-organic frameworks enables their diverse applications 环糊精金属-有机框架结构的多样性使其具有广泛的应用前景。

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-03-01 Epub Date: 2025-12-30 DOI: 10.1016/j.carres.2025.109810

Edgar Clyde R. Lopez

{"title":"Structural diversity of cyclodextrin metal-organic frameworks enables their diverse applications","authors":"Edgar Clyde R. Lopez","doi":"10.1016/j.carres.2025.109810","DOIUrl":"10.1016/j.carres.2025.109810","url":null,"abstract":"<div><div>Cyclodextrin-based metal-organic frameworks (CD-MOFs) constitute a distinctive family of porous solids that combine the modularity of coordination networks with the host-guest chemistry of renewable cyclic oligosaccharides. This review consolidates advances in the synthesis, structural diversity, and functional performance of CD-MOFs derived from α-, β-, and γ-cyclodextrins. Comparative structural analysis shows that framework topology and pore accessibility arise from coupled effects of cyclodextrin cavity size, metal coordination geometry, and synthetic route. Alkali-metal-linked frameworks generally form hydrophilic and biocompatible networks favorable for biomedical and environmental uses, while transition-metal incorporation improves mechanical strength and catalytic activity. Assessment of reported applications in gas storage, water purification, catalysis, and drug delivery demonstrates that performance trends correlate more strongly with accessible pore volume and chemical functionality than with crystallographic complexity. Constraints related to scale-up and hydrolytic stability continue to hinder practical adoption. This review advances transferable design principles that emphasize pore continuity, chemical resilience, and application-relevant metrics rather than structural intricacy. Progress in this field will depend on systematic benchmarking against established sorbents and the development of structure-property correlations grounded in realistic operating environments.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"561 ","pages":"Article 109810"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A short synthesis of p-nitrophenyl α-d-xylofuranoside and β-d-arabinofuranoside employing a Mitsunobu glycosylation 用Mitsunobu糖基化法合成了对硝基苯α-d-木呋喃苷和β-d-阿拉伯呋喃苷。

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-03-01 Epub Date: 2025-12-19 DOI: 10.1016/j.carres.2025.109802

Zongjia Chen, Adam W.E. Stewart, Spencer J. Williams

引用次数: 0

Efficient conversion of biomass-derived xylose into furfural over boron phosphate solid acid in LiBr⋅3H2O/DCM biphasic system 在LiBr⋅3H2O/DCM双相体系中，磷酸硼固体酸催化生物质木糖高效转化为糠醛

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.carres.2026.109812

Wang Zhao , Jiansong Chen , Haishun Du , Zhiqiang Pang , Weiqi Wei , Xuejun Pan

{"title":"Efficient conversion of biomass-derived xylose into furfural over boron phosphate solid acid in LiBr⋅3H2O/DCM biphasic system","authors":"Wang Zhao , Jiansong Chen , Haishun Du , Zhiqiang Pang , Weiqi Wei , Xuejun Pan","doi":"10.1016/j.carres.2026.109812","DOIUrl":"10.1016/j.carres.2026.109812","url":null,"abstract":"<div><div>Furfural is a pivotal intermediate in the biomass conversion. Therefore, the production of furfural from xylose or xylose-rich biomass has received extensive attention. Herein, a series of boron phosphate solid acid catalysts (BPs) were synthesized by self-assembly and high-temperature calcination, and used for the production of furfural from xylose or xylose-rich biomass. The results showed that the synthesized BPs was spherical nanoparticles and containing both Lewis acid and Brønsted acid sites, which was excellent for xylose conversion to furfural. The maximum furfural yield of this work was 82.8 % and achieved through 95.7 % xylose conversion by using 20 mg BP<sub>1.25</sub> at a reaction temperature of 130 °C for 120 min with a LiBr⋅3H<sub>2</sub>O/dichloromethane (DCM) biphasic system. Noteworthy, the recycling experiments indicated that both the BP<sub>1.25</sub> catalyst and the LiBr⋅3H<sub>2</sub>O can be reused at least four times with a furfural yield remaining ≥61.7 %. Last but not least, the prepared BP<sub>1.25</sub> catalyst also displayed high efficiency for xylose-rich natural biomass such as corncob and bagasse conversion into furfural. The work not only developed a new system for easy conversion of xylose into furfural, but also realized the high yield production of furfural from natural biomass without components separation.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"561 ","pages":"Article 109812"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145922249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced antibacterial performance of chitosan via quaternary ammonium modification 季铵改性增强壳聚糖的抗菌性能。

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-03-01 Epub Date: 2025-12-31 DOI: 10.1016/j.carres.2025.109811

Peixuan Wu , Hao Zhuang , Yang Zhou , Gaobo Yu , Zhendong Zhao , Tawfik Khattab , Xianghui Wang , Yuanyuan Liu

{"title":"Enhanced antibacterial performance of chitosan via quaternary ammonium modification","authors":"Peixuan Wu , Hao Zhuang , Yang Zhou , Gaobo Yu , Zhendong Zhao , Tawfik Khattab , Xianghui Wang , Yuanyuan Liu","doi":"10.1016/j.carres.2025.109811","DOIUrl":"10.1016/j.carres.2025.109811","url":null,"abstract":"<div><div>Chitosan (CS) exhibits pH- and concentration-dependent antimicrobial activity, underscoring the need to develop CS-based materials with more stable and robust antibacterial performance. In this work, dimethyloctadecyl-(3-trimethoxysilylpropyl) ammonium (TSA) was chemically grafted onto the hydroxyl and amino groups of CS to synthesize TSA-CS derivatives. Two forms of microspheres—designated as GA-TSA-CS-12 and STPP-TSA-CS-12—were subsequently fabricated via emulsion cross-linking and ionic cross-linking methods, respectively. The resulting TSA-CS materials were thoroughly characterized by FT-IR, TGA, GPC, SEM, and XPS, confirming successful grafting, modified thermal properties, and altered molecular weight. Antibacterial evaluation revealed that TSA-CS-12 achieved high inhibition rates of 97.7% against <em>E. coli</em> and 98.7% against <em>S. aureus</em>, while the corresponding microsphere formulations maintained up to 93% antibacterial activity. These findings demonstrate that TSA-functionalized chitosan materials exhibit enhanced and more stable antibacterial performance, showing promising potential for biomedical applications.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"561 ","pages":"Article 109811"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Carbohydrate Derivatives in multicomponent reactions: Approaches and applications 多组分反应中碳水化合物衍生物的合成：方法和应用

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-03-01 Epub Date: 2025-12-29 DOI: 10.1016/j.carres.2025.109809

Isadora Maria Gouveia Andrade , Edson de Oliveira Lima Filho , Mariana de Oliveira Leal Desmarais, Caio Luiz Festas Valadão, Luana da Silva Magalhães Forezi, Fernando de Carvalho da Silva

{"title":"Synthesis of Carbohydrate Derivatives in multicomponent reactions: Approaches and applications","authors":"Isadora Maria Gouveia Andrade , Edson de Oliveira Lima Filho , Mariana de Oliveira Leal Desmarais, Caio Luiz Festas Valadão, Luana da Silva Magalhães Forezi, Fernando de Carvalho da Silva","doi":"10.1016/j.carres.2025.109809","DOIUrl":"10.1016/j.carres.2025.109809","url":null,"abstract":"<div><div>This review presents a comprehensive overview of the principal strategies in the synthesis of carbohydrate derivatives through multicomponent reactions (MCRs), highlighting the significant potential of these methodologies in medicinal chemistry and the development of biocompatible materials. The inherent efficiency, atom economy, and modularity of MCRs make them particularly well-suited for assembling the structurally complex architectures characteristic of carbohydrate. These reactions facilitate the rapid generation of molecular diversity, enabling the design and synthesis of bioactive compounds with promising pharmacological profiles. In particular, the combination of carbohydrate scaffolds with diverse functional motifs through MCRs has opened new avenues for the discovery of novel therapeutic agents, including enzyme inhibitors, antimicrobial agents, and vaccine adjuvants. The review also addresses key stereochemical challenges associated with glycosylation and the formation of anomerically pure products, which remain central concerns in carbohydrate chemistry. Several representative examples from recent literature are discussed, demonstrating how MCR-based strategies have been successfully applied to the synthesis pseudo-glycopeptides, pseudo-glycolipids, and other carbohydrate derivatives of particular structures. These studies underscore the relevance of MCRs not only as a synthetic tool but also as a platform for innovation in drug development. Overall, the integration of MCRs into carbohydrate synthesis represents a powerful and versatile approach that aligns with current demands for more sustainable, efficient, and high-throughput methodologies in modern organic synthesis.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"561 ","pages":"Article 109809"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards recycling of ionic liquids in fiber spinning process –Carbohydrate transformation products in aqueous ionic liquid solutions studied by liquid chromatography/quadrupole time-of-flight mass spectrometry 纤维纺丝过程中离子液体的回收利用——液相色谱/四极杆飞行时间质谱法研究离子液体水溶液中碳水化合物转化产物

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-03-01 Epub Date: 2025-12-29 DOI: 10.1016/j.carres.2025.109808

Leena Pitkänen , Monika Tuominen , Behnaz Asadzadeh , Petri Uusi-Kyyny , Kalle Kaipanen , Petri Kilpeläinen , Michael Hummel , Herbert Sixta

{"title":"Towards recycling of ionic liquids in fiber spinning process –Carbohydrate transformation products in aqueous ionic liquid solutions studied by liquid chromatography/quadrupole time-of-flight mass spectrometry","authors":"Leena Pitkänen , Monika Tuominen , Behnaz Asadzadeh , Petri Uusi-Kyyny , Kalle Kaipanen , Petri Kilpeläinen , Michael Hummel , Herbert Sixta","doi":"10.1016/j.carres.2025.109808","DOIUrl":"10.1016/j.carres.2025.109808","url":null,"abstract":"<div><div>New technologies for the production of man-made cellulose fibers are being developed to produce fibers sustainably for various textile applications. The Ioncell® process uses an ionic liquid in which cellulose is dissolved to form a spinning solution. This spinning solution is spun into an aqueous coagulation bath using dry-jet wet spinning technology to produce Ioncell fibres. In order to develop a sustainable and economically viable process, the ionic liquid must be efficiently recycled in the process. Organic compounds resulting from degradation reactions of the cellulosic materials used for fiber production might accumulate in the ionic liquid over time and reduce its dissolution power. This study aimed to tentatively identify the main carbohydrate transformation products from aqueous ionic liquid solution. In addition to the actual coagulation bath sample, carbohydrate transformation reactions were studied using model samples. The main monomeric carbohydrate constituents of a hardwood pulp, glucose and xylose, were mixed with an ionic liquid and water and heated to 90 °C for 8 h to accelerate the transformation reactions. Most of the original monosaccharides were converted into other compounds, so that after the heat treatment only 11 wt% of the glucose and 1.1 wt% of the xylose remained. The liquid chromatography/time-of-flight mass spectrometry analyses revealed that both the spin bath sample and model samples contained mainly hydroxycarboxylic acids and carboxylic acids. The superbase of ionic liquid catalyzed the alkaline transformation reactions of carbohydrates.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"561 ","pages":"Article 109808"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and engineering of Drosophila melanogaster β1-3-galactosyltransferase for glycoengineering applications 黑胃果蝇β1-3-半乳糖基转移酶的表征与工程应用。

IF 2.5 3区化学

Carbohydrate Research Pub Date : 2026-02-01 Epub Date: 2025-12-12 DOI: 10.1016/j.carres.2025.109791

Linhan Wang , Jichao Wei , Fang Yuan , Yongheng Rong , Wanqian Du , Wenjing Shi , Xintan Wang , Mei Wang , Yankang Wang , Anran Liu , Junqiao Zhao , Yun Kong , Na Sun , Wenzhu Tang , Shengjun Wang

{"title":"Characterization and engineering of Drosophila melanogaster β1-3-galactosyltransferase for glycoengineering applications","authors":"Linhan Wang , Jichao Wei , Fang Yuan , Yongheng Rong , Wanqian Du , Wenjing Shi , Xintan Wang , Mei Wang , Yankang Wang , Anran Liu , Junqiao Zhao , Yun Kong , Na Sun , Wenzhu Tang , Shengjun Wang","doi":"10.1016/j.carres.2025.109791","DOIUrl":"10.1016/j.carres.2025.109791","url":null,"abstract":"<div><div>β1-3-Galactosyltransferase from <em>Drosophila melanogaster</em> (<em>Dm</em>C1GalT1) plays a key role in O-glycan synthesis and holds considerable potential for glycoengineering applications. In this study, we achieved high-yield expression and purification of <em>Dm</em>C1GalT1 in <em>Escherichia coli,</em> obtaining over 5 mg of protein per liter of culture. Similar with the enzyme expressed from <em>Pichia pastoris</em>, this enzyme exhibited strict donor specificity towards UDP-Gal and efficiently galactosylated human CD74-derived Tn-glycopeptides. Structural analysis identified key residues involved in substrate binding and catalysis. Site-directed mutagenesis of active-site residues yielded variants with altered activity and stability profiles. Notably, the N108G and Y325W mutants retained high activity towards UDP-Gal but lost the ability to utilize UDP-GalNH<sub>2</sub>, while N108A mutants retained 61.77 % of its activity toward UDP-Gal but maintained similar activity levels towards UDP-GalNH<sub>2</sub>, while gaining weak but detectable activity toward UDP-Glc. These findings highlight the critical roles of residues N108 and Y325 in donor recognition. Thermal stability predictions using ProStab indicated that certain mutations affected enzyme stability without compromising activity. This work establishes an efficient platform for the expression, characterization, and engineering of <em>Dm</em>C1GalT1, facilitating the development of glycosyltransferase variants with tailored properties for synthetic glycobiology.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"560 ","pages":"Article 109791"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0