多价Siglec配体

IF 2.4 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Carbohydrate Research Pub Date : 2025-05-09 DOI:10.1016/j.carres.2025.109520

Roland J. Pieters

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引用次数: 0

摘要

Siglecs是一种发挥重要生物学作用的蛋白质，尤其是在免疫系统中。Siglec识别干预有可能调节免疫系统。特异性Siglec配体的发现以及这些配体的多价平台的使用取得了进展，可以在各种情况下进行有效的干预。本文讨论了这些系统，并着重讨论了这些多价系统的性质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Multivalent Siglec ligands

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Multivalent Siglec ligands

Siglecs are proteins that play important biological roles, especially in the immune system. Intervention with Siglec recognition has potential for modulation of the immune system. Progress in the discovery of specific Siglec ligands combined with the use of multivalent platforms for these ligands has allowed effective intervention in various scenarios. This review discusses these systems and focuses on the nature of these multivalent systems.

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来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".